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Conserved domains on  [gi|545687403|ref|NP_001270164|]
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transport and Golgi organization protein 2 homolog isoform g [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 36-161 2.86e-45

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


:

Pssm-ID: 461729  Cd Length: 255  Bit Score: 149.33  E-value: 2.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545687403   36 ICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQG 115
Cdd:pfam05742 131 LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTG 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 545687403  116 GEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 210 PEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKVTFIERTLYD 255
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 36-161 2.86e-45

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 149.33  E-value: 2.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545687403   36 ICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQG 115
Cdd:pfam05742 131 LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTG 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 545687403  116 GEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 210 PEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKVTFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 37-178 4.86e-30

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 110.35  E-value: 4.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545687403  37 CYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVErsqalPKDVLIASLLDVLNNEE----AQLPDPAIe 112
Cdd:COG3332  124 FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVARLKAALAAALA-----PDDPDPDALFALLADRTpapdAELPDTGV- 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545687403 113 dqgGEYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFTERSmMDKDLSHWETRTYEFTLQS 178
Cdd:COG3332  198 ---GLEWERLLS---SIFIHGPGYGTRSSTLLALDADGRVEFAERR-FDADGPPCGTRRFRFTLLS 256
 
Name Accession Description Interval E-value
TANGO2 pfam05742
Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in ...
 36-161 2.86e-45

Transport and Golgi organization 2; In eukaryotes this family is predicted to play a role in protein secretion and Golgi organization. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit. Swiss:P54797 has been found to be expressed during early embryogenesis in mice. This protein contains a conserved NRDE motif. This gene has been characterized in Drosophila melanogaster and named as transport and Golgi organization 2, hence the name Tango2.


Pssm-ID: 461729  Cd Length: 255  Bit Score: 149.33  E-value: 2.86e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545687403   36 ICYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVERSQALPKDVLIASLLDVLNNEEaQLPDPAIEDQG 115
Cdd:pfam05742 131 LAYISNRGNPTPDQLSPGIHGLSNSLLDSPWPKVERGKRLFEELVEESVEDSEDQLIEELFDLLSDDT-LPRDPELPDTG 209

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 545687403  116 GEYVQPMlskyAAVCVRCPG----YGTRTNTIILVDADGHVTFTERSMMD 161
Cdd:pfam05742 210 PEWERLL----SSIFIPPIPpggrYGTRSQTVILVDKDGKVTFIERTLYD 255
Tango2 COG3332
Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, ...
 37-178 4.86e-30

Uncharacterized stress-responsive protein, TANGO2 (Transport and Golgi organisation 2) family, contains NRDE motif [General function prediction only];


Pssm-ID: 442561  Cd Length: 257  Bit Score: 110.35  E-value: 4.86e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 545687403  37 CYYGNRGEPDPIVLTPGTYGLSNALLETPWRKLCFGKQLFLEAVErsqalPKDVLIASLLDVLNNEE----AQLPDPAIe 112
Cdd:COG3332  124 FYLSNRGDALVRRLAPGVHGLSNALLDTPWPKVARLKAALAAALA-----PDDPDPDALFALLADRTpapdAELPDTGV- 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 545687403 113 dqgGEYVQPMLSkyaAVCVRCPGYGTRTNTIILVDADGHVTFTERSmMDKDLSHWETRTYEFTLQS 178
Cdd:COG3332  198 ---GLEWERLLS---SIFIHGPGYGTRSSTLLALDADGRVEFAERR-FDADGPPCGTRRFRFTLLS 256
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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