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Conserved domains on  [gi|547235063|ref|NP_001271286|]
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leucine-rich repeat-containing protein 49 isoform 4 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 107-303 8.50e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 142.62  E-value: 8.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 107 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 186
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 187 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 258
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 547235063 259 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 303
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 107-303 8.50e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 142.62  E-value: 8.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 107 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 186
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 187 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 258
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 547235063 259 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 303
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-284 9.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 9.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  84 RLSLERQKLTVCPI-INGEDHLRLLNFQHNFITRIQN-ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKK 160
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 161 ISN-LENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH 238
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 547235063 239 LFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQN 284
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR_9 pfam14580
Leucine-rich repeat;
173-304 1.17e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  173 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 249
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 547235063  250 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 304
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 107-303 8.50e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 142.62  E-value: 8.50e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 107 LNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITKIENI 186
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 187 NHLCELRVLNLARN-------FLSHVDNLNGL-DSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADS 258
Cdd:cd21340   87 ENLTNLEELHIENQrlppgekLTFDPRSLAALsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDLLSS 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 547235063 259 -SSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRM 303
Cdd:cd21340  167 wPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLDGKEITDTERQF 212
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-284 9.02e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 9.02e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  84 RLSLERQKLTVCPI-INGEDHLRLLNFQHNFITRIQN-ISNLQKLISLDLYDNQIEEIS-GLSTLRCLRVLLLGKNRIKK 160
Cdd:COG4886  117 SLDLSGNQLTDLPEeLANLTNLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITD 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 161 ISN-LENLKSLDVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH 238
Cdd:COG4886  197 LPEpLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKT 276

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 547235063 239 LFLSFNNISSFDSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQN 284
Cdd:COG4886  277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
13-271 2.67e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 93.84  E-value: 2.67e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  13 LVIQTSSLPEKNKVEFKLNKDTSSFPGRLLQHDLERNYSSRQGDHINLVSSSLSSFPILQRSSEEKILYSDRLSLERQKL 92
Cdd:COG4886    2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  93 TVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEI-SGLSTLRCLRVLLLGKNRIKKI-SNLENLKSL 170
Cdd:COG4886   82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 171 DVLDLHGNQITKI-ENINHLCELRVLNLARNFLSHV-DNLNGLDSLTELNLRHNQITFV-RDVDNLPCLQHLFLSFNNIS 247
Cdd:COG4886  162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                        250       260
                 ....*....|....*....|....
gi 547235063 248 SFDSVSCLadsSSLSDITFDGNPI 271
Cdd:COG4886  242 DLPELGNL---TNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
104-251 2.60e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 2.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 104 LRLLNFQHNFITRI-QNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIKKISNLENLKSLDVLDLHGNQITK 182
Cdd:COG4886  207 LEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 547235063 183 IeNINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDS 251
Cdd:COG4886  287 L-KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLL 354
LRR_9 pfam14580
Leucine-rich repeat;
173-304 1.17e-09

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 57.85  E-value: 1.17e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  173 LDLHGNQITKIENIN-HLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRD--VDNLPCLQHLFLSFNNISSF 249
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEglGEALPNLTELILTNNNLQEL 103

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 547235063  250 DSVSCLADSSSLSDITFDGNPIAQESWYKHTVLQNMMQLRQLDMKRITEEERRMA 304
Cdd:pfam14580 104 GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKVPQLRLLDFRKVKQKERQAA 158
LRR_8 pfam13855
Leucine rich repeat;
191-246 9.37e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 9.37e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  191 ELRVLNLARNFLSHVD--NLNGLDSLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNI 246
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
103-284 1.39e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 54.17  E-value: 1.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 103 HLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLRCLRVLLLGKNRIK--KISNLENLKSLDVLDLHGNQI 180
Cdd:COG4886  229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLL 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 181 TKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFLSFNNISSFDSVSCLADSSS 260
Cdd:COG4886  309 NLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLT 388

                        170       180
                 ....*....|....*....|....
gi 547235063 261 LSDITFDGNPIAQESWYKHTVLQN 284
Cdd:COG4886  389 LLLLLLTTTAGVLLLTLALLDAVN 412
LRR_8 pfam13855
Leucine rich repeat;
169-224 1.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 1.01e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  169 SLDVLDLHGNQITKI--ENINHLCELRVLNLARNFLSHVDN--LNGLDSLTELNLRHNQI 224
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 148-188 2.04e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 42.23  E-value: 2.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 547235063  148 LRVLLLGKNRIKKISNLENLKSLDVLDLHGN-QITKIENINH 188
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
84-264 5.03e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 46.08  E-value: 5.03e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  84 RLSLERQKLTVCPIINGEDHLRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEIS--GLSTLRCLRVLLLGKNRIKKI 161
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKlkELELLLGLNSLLLLLLLLNLL 311

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 162 SNLENLKSLDVLDLHGNQITKIENINHLCELRVLNLARNFLSHVDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQHLFL 241
Cdd:COG4886  312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                        170       180
                 ....*....|....*....|...
gi 547235063 242 SFNNISSFDSVSCLADSSSLSDI 264
Cdd:COG4886  392 LLLTTTAGVLLLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-183 1.60e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 104 LRLLNFQHNFITRIQNISNLQKLISLDLYDNQIEEISGLSTLrclrvlllgknrikkisnLENLKSLDVLDLHGNQITKI 183
Cdd:cd21340  122 LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLDL------------------LSSWPSLRELDLTGNPVCKK 183
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 128-225 1.85e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 44.40  E-value: 1.85e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 128 SLDLYDNQIEE------ISGLSTLRCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IENINHL 189
Cdd:COG5238  268 TLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDegaialAEGLQGNKTLHTLNLAYNGIGAqgaialAKALQEN 347

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 547235063 190 CELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQIT 225
Cdd:COG5238  348 TTLHSLDLSDNQIGDegaialAKYLEGNTTLRELNLGKNNIG 389
LRR_8 pfam13855
Leucine rich repeat;
213-271 2.08e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 2.08e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 547235063  213 SLTELNLRHNQITFVRDV--DNLPCLQHLFLSFNNISSFDSVScLADSSSLSDITFDGNPI 271
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPGA-FSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 168-213 2.39e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.39e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 547235063  168 KSLDVLDLHGNQITKIENINHLCELRVLNLARNFLshVDNLNGLDS 213
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 124-166 2.43e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 547235063  124 QKLISLDLYDNQIEEISGLSTLRCLRVL-LLGKNRIKKISNLEN 166
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLdLSGNNKITDLSDLAN 44
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 125-247 1.36e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 125 KLISLDLYDNQI-----EEISG-LSTLRCLRVLLLGKN--------RIKKIsnLENLKSLDVLDLHGNQITKI------E 184
Cdd:cd00116  138 ALEKLVLGRNRLegascEALAKaLRANRDLKELNLANNgigdagirALAEG--LKANCNLEVLDLNNNGLTDEgasalaE 215

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 547235063 185 NINHLCELRVLNLARNFLSHVD-------NLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNIS 247
Cdd:cd00116  216 TLASLKSLEVLNLGDNNLTDAGaaalasaLLSPNISLLTLSLSCNDITddgakdLAEVLAEKESLLELDLRGNKFG 291
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 213-245 1.52e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.52e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 547235063  213 SLTELNLRHNQITFVRDVDNLPCLQHLFLSFNN 245
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNN 34
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 103-143 2.59e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.59e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 547235063  103 HLRLLNFQHNFITRIQNISNLQKLISLDLYDN-QIEEISGLS 143
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLA 43
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 117-274 2.95e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 40.54  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 117 IQNISNLQKLISLDLYDNQI--EEISGLSTL----RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK-- 182
Cdd:COG5238  229 AEALKGNKSLTTLDLSNNQIgdEGVIALAEAlknnTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDeg 308

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 183 ----IENINHLCELRVLNLARNFLSHV------DNLNGLDSLTELNLRHNQIT------FVRDVDNLPCLQHLFLSFNNI 246
Cdd:COG5238  309 aialAEGLQGNKTLHTLNLAYNGIGAQgaialaKALQENTTLHSLDLSDNQIGdegaiaLAKYLEGNTTLRELNLGKNNI 388

                        170       180       190
                 ....*....|....*....|....*....|.
gi 547235063 247 SSfDSVSCLADSS---SLSDITFDGNPIAQE 274
Cdd:COG5238  389 GK-QGAEALIDALqtnRLHTLILDGNLIGAE 418
LRR_8 pfam13855
Leucine rich repeat;
103-158 3.54e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 3.54e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063  103 HLRLLNFQHNFITRI--QNISNLQKLISLDLYDNQIEEISG--LSTLRCLRVLLLGKNRI 158
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 124-247 9.25e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.00  E-value: 9.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547235063 124 QKLISLDLYDNQIEEiSGLSTL-------RCLRVLLLGKNRIKK------ISNLENLKSLDVLDLHGNQITK------IE 184
Cdd:COG5238  180 NSVETVYLGCNQIGD-EGIEELaealtqnTTVTTLWLKRNPIGDegaeilAEALKGNKSLTTLDLSNNQIGDegvialAE 258

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 547235063 185 NINHLCELRVLNLARNFLSH------VDNLNGLDSLTELNLRHNQITFVRDVDNLPCLQH------LFLSFNNIS 247
Cdd:COG5238  259 ALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGnktlhtLNLAYNGIG 333
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 192-234 9.89e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 9.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 547235063  192 LRVLNLARNFLSHVDNLNGLDSLTELNLRHNqiTFVRDVDNLP 234
Cdd:pfam12799   3 LEVLDLSNNQITDIPPLAKLPNLETLDLSGN--NKITDLSDLA 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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