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Conserved domains on  [gi|548923795|ref|NP_001271318|]
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nucleolar and coiled-body phosphoprotein 1 isoform 3 [Homo sapiens]

Protein Classification

nucleolar and coiled-body phosphoprotein 1 family protein( domain architecture ID 10523427)

nucleolar and coiled-body phosphoprotein 1 (NOLC1) family protein; similar to mammalian NOLC1 (also known as Nopp140) which may participate in the regulation of rRNA transcription by interacting with the largest subunit of RNA polymerase I, and to Saccharomyces cerevisiae suppressor protein Srp40 which is a weak suppressor of a mutant of the subunit AC40 of DNA dependent RNA polymerase I and III; may be a chaperone involved in nucleocytoplasmic transport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 625-697 1.71e-29

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


:

Pssm-ID: 461525  Cd Length: 75  Bit Score: 111.47  E-value: 1.71e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548923795  625 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSIKF 697
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 625-697 1.71e-29

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 111.47  E-value: 1.71e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548923795  625 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSIKF 697
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
 
Name Accession Description Interval E-value
SRP40_C pfam05022
SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae ...
 625-697 1.71e-29

SRP40, C-terminal domain; This presumed domain is found at the C-terminus of the S. cerevisiae SRP40 protein and its homologs. SRP40/nopp40 is a chaperone involved in nucleocytoplasmic transport. SRP40 is also a suppressor of mutant AC40 subunit of RNA polymerase I and III.


Pssm-ID: 461525  Cd Length: 75  Bit Score: 111.47  E-value: 1.71e-29
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 548923795  625 PFRRVREEEIEV--DSRVADNSFDAKrGAAGDWGERANQVLKFTKGKSFRHEKTKKKRGSYRGGSISVQ-VNSIKF 697
Cdd:pfam05022   1 PFQRVDPEDVVVfaDPRLADNSYEAK-GAEDDYGEKANEDLIVTRGKGFRKEKNKKKRGSYRGGAIDTNsVNSIKF 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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