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Conserved domains on  [gi|548923955|ref|NP_001271360|]
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U3 small nucleolar RNA-associated protein 15 homolog isoform 3 [Homo sapiens]

Protein Classification

U3 small nucleolar RNA-associated protein 15( domain architecture ID 11456900)

U3 small nucleolar RNA-associated protein 15 is involved in nucleolar processing of pre-18S ribosomal RNA

Gene Ontology:  GO:0042274|GO:0006364|GO:0003723

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 153-300 3.29e-62

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


:

Pssm-ID: 462782  Cd Length: 146  Bit Score: 194.62  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955  153 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 232
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923955  233 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 300
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
2-117 1.64e-17

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  231 WDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 117
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 153-300 3.29e-62

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 194.62  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955  153 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 232
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923955  233 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 300
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
2-117 1.64e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  231 WDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 117
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-125 1.54e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   1 MFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSL 78
Cdd:cd00200  119 VWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 548923955  79 DRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGMTNGILSV 125
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 48-86 7.19e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 548923955    48 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 86
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-86 1.77e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.77e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 548923955   48 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 86
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
UTP15_C pfam09384
UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar ...
 153-300 3.29e-62

UTP15 C terminal; U3 snoRNA is ubiquitous in eukaryotes and is required for nucleolar processing of pre-18S ribosomal RNA. It is a component of the ribosomal small subunit (SSU) processome. UTP15 is needed for optimal pre-ribosomal RNA transcription by RNA polymerase I, together with a subset of U3 proteins required for transcription (t-UTPs). This entry represents the C terminal of UTP15, and is found adjacent to WD40 repeats (pfam00400).


Pssm-ID: 462782  Cd Length: 146  Bit Score: 194.62  E-value: 3.29e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955  153 NYMKQRDDILINRPAKKHLELYDRDLKHFRISKALDRVLDPTctIKTPEITVSIIKELNRRGVLANALAGRDEKEISHVL 232
Cdd:pfam09384   1 DYKGEGDDIVVEGPKKKKLKKYDKLLRKFRYSKALDAVLEPG--VKSPEVTVAVLEELRHRGALRAALAGRDEESLEPLL 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 548923955  233 NFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQRELLETLGMMDML 300
Cdd:pfam09384  79 KFLIKHITDPRFTRLLVDVANVVLDIYGSVLGQSPELDKLFRRLRRKVREEIELQKELLELKGMLDML 146
WD40 COG2319
WD40 repeat [General function prediction only];
2-117 1.64e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.64e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  231 WDLATGKLLRTLTgHSGSVRSVAFSPDGRLLASGSAdGTVRLWD-LATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDD 309

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 117
Cdd:COG2319  310 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASG 348
WD40 COG2319
WD40 repeat [General function prediction only];
2-125 1.96e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.27  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  189 WDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASGSAdGTVRLWD-LATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSAD 267

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 548923955  80 RKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 125
Cdd:COG2319  268 GTVRLWDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGTVRL 314
WD40 COG2319
WD40 repeat [General function prediction only];
2-117 4.37e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 81.11  E-value: 4.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  105 WDLATGLLLRTLTgHTGAVRSVAFSPDGKTLASGSAdGTVRLWD-LATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVG 117
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKLLASG 222
WD40 COG2319
WD40 repeat [General function prediction only];
2-117 6.61e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 77.64  E-value: 6.61e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  273 WDLATGELLRTLTgHSGGVNSVAFSPDGKLLASGSDdGTVRLWD-LATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDD 351

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 117
Cdd:COG2319  352 GTVRLWDLATGELLRTLtGHTGAVTSVAFSPDGRTLASG 390
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-125 1.54e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.54e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   1 MFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSL 78
Cdd:cd00200  119 VWDVETGKCLTTLRgHTDWVNSVAFSPDGTFVASSSQdGTIKLWD-LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 548923955  79 DRKVKVYSTTSYKVVHSFDY-AASILSLALAHEDETIVVGMTNGILSV 125
Cdd:cd00200  198 DGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPDGYLLASGSEDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 15-117 1.88e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955  15 HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVV 93
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWD-LETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECV 86

                         90       100
                 ....*....|....*....|....*
gi 548923955  94 HSF-DYAASILSLALaHEDETIVVG 117
Cdd:cd00200   87 RTLtGHTSYVSSVAF-SPDGRILSS 110
WD40 COG2319
WD40 repeat [General function prediction only];
2-89 2.30e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 2.30e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:COG2319  315 WDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDdGTVRLWD-LATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393

                         90
                 ....*....|
gi 548923955  80 RKVKVYSTTS 89
Cdd:COG2319  394 GTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-125 2.88e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.90  E-value: 2.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955  13 VEHGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYK 91
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSdKTIRLWD-LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 548923955  92 VVHSFDY-AASILSLALAHEDETIVVGMTNGILSV 125
Cdd:cd00200  127 CLTTLRGhTDWVNSVAFSPDGTFVASSSQDGTIKL 161
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-86 7.64e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 7.64e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   1 MFDARTSESVLS-VEHGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSL 78
Cdd:cd00200  203 LWDLSTGKCLGTlRGHENGVNSVAFSPDGYLLASGSEdGTIRVWD-LRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSA 281


                 ....*...
gi 548923955  79 DRKVKVYS 86
Cdd:cd00200  282 DGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-117 9.49e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.36  E-value: 9.49e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   2 FDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDMLKGgQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 79
Cdd:cd00200   78 WDLETGECVRTLTgHTSYVSSVAFSPDGRILSSSSRdKTIKVWDVETG-KCLTTLRGHTDWVNSVAFSPDGTFVASSSQD 156

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  80 RKVKVYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 117
Cdd:cd00200  157 GTIKLWDLRTGKCVATLtGHTGEVNSVAFSPDGEKLLSS 195
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 1-116 4.92e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 62.35  E-value: 4.92e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   1 MFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAGG-RYVKVWDmLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSL 78
Cdd:cd00200  161 LWDLRTGKCVATLTgHTGEVNSVAFSPDGEKLLSSSSdGTIKLWD-LSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSE 239

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 548923955  79 DRKVKVYSTTSYKVVHSFD-YAASILSLALaHEDETIVV 116
Cdd:cd00200  240 DGTIRVWDLRTGECVQTLSgHTNSVTSLAW-SPDGKRLA 277
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 48-86 7.19e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 7.19e-08
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 548923955    48 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 86
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
48-86 1.77e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 1.77e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 548923955   48 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 86
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
4-117 1.29e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.44  E-value: 1.29e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923955   4 ARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVK 83
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 548923955  84 VYSTTSYKVVHSF-DYAASILSLALAHEDETIVVG 117
Cdd:COG2319  104 LWDLATGLLLRTLtGHTGAVRSVAFSPDGKTLASG 138
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-96 2.05e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.40  E-value: 2.05e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 548923955  50 LLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF 96
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL 47
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 40-100 8.31e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 34.95  E-value: 8.31e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 548923955   40 KVWDmlkggqllVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAA 100
Cdd:pfam12894  28 RVWT--------LSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGS 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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