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Conserved domains on  [gi|550544195|ref|NP_001272379|]
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pyridoxal-dependent decarboxylase domain-containing protein 1 isoform 7 [Homo sapiens]

Protein Classification

pyridoxal phosphate-dependent decarboxylase family protein( domain architecture ID 1903557)

pyridoxal phosphate-dependent decarboxylase family protein is primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but it is also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GadA super family cl43018
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 194-371 4.36e-21

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


The actual alignment was detected with superfamily member COG0076:

Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 94.90  E-value: 4.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 194 DVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsssvLAAA------ 267
Cdd:COG0076  203 DPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA------AYG------GFALpspelr 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 268 -------KCDSMTMTPGPWLGLPAVPAVTLYKhdDPAL-------------TLVAGLTSnkPTDK-------LRALPLWL 320
Cdd:COG0076  271 hlldgieRADSITVDPHKWLYVPYGCGAVLVR--DPELlreafsfhasylgPADDGVPN--LGDYtlelsrrFRALKLWA 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550544195 321 SLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSspVVVFRF 371
Cdd:COG0076  347 TLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELN--IVCFRY 395
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 194-371 4.36e-21

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 94.90  E-value: 4.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 194 DVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsssvLAAA------ 267
Cdd:COG0076  203 DPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA------AYG------GFALpspelr 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 268 -------KCDSMTMTPGPWLGLPAVPAVTLYKhdDPAL-------------TLVAGLTSnkPTDK-------LRALPLWL 320
Cdd:COG0076  271 hlldgieRADSITVDPHKWLYVPYGCGAVLVR--DPELlreafsfhasylgPADDGVPN--LGDYtlelsrrFRALKLWA 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550544195 321 SLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSspVVVFRF 371
Cdd:COG0076  347 TLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELN--IVCFRY 395
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 172-371 4.39e-19

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 88.03  E-value: 4.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 172 KKPVIYLSAAARPGL---GQYLCNQ------------DVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKEL 236
Cdd:cd06450   94 DKLVIVCSDQAHVSVekaAAYLDVKvrlvpvdedgrmDPEALEAAIDEDKAEGLNPIMVVATAGTTDTGAIDPLEEIADL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 237 CEQYGIWLHVEGvnlatlALGyvsSSVLaaakcdsMTMTPGPWL-GLPAVPAVT------LYKHDDPALTLVagltsnkp 309
Cdd:cd06450  174 AEKYDLWLHVDA------AYG---GFLL-------PFPEPRHLDfGIERVDSISvdphkyGLVPLGCSAVLV-------- 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550544195 310 tdklRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELssPVVVFRF 371
Cdd:cd06450  230 ----RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
198-370 5.80e-11

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.59  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195  198 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAAAKCDSMTMTP 276
Cdd:pfam00282 185 LEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNP 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195  277 GPWLGLPAvPAVTLYKHDDPALTLVAGL------TSNKPTD----------KLRALPLWLSLQYLGLDGFVERIKHACQL 340
Cdd:pfam00282 265 HKWMLVLL-DCSAVWVKDKEALQQAFQFnplylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVEL 343

                         170       180       190
                  ....*....|....*....|....*....|
gi 550544195  341 SQRLQESLKKVNYIKILVEDELssPVVVFR 370
Cdd:pfam00282 344 AQYLEALIRKDGRFEICAEVGL--GLVCFR 371
PLN02880 PLN02880
tyrosine decarboxylase
 198-406 2.81e-05

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 46.05  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 198 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlalGYVSSSVL---------AAAK 268
Cdd:PLN02880 226 LSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDA--------AYAGSACIcpeyrhyidGVEE 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 269 CDSMTMTPGPWLgLPAVPAVTLYKHDDPALTLVAG----LTSNKPTD----------------KLRALPLWLSLQYLGLD 328
Cdd:PLN02880 298 ADSFNMNAHKWF-LTNFDCSLLWVKDRNALIQSLStnpeFLKNKASQansvvdykdwqiplgrRFRSLKLWMVLRLYGVE 376

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550544195 329 GFVERIKHACQLSQRLQEslkkvnyikiLVEDELSSPVVVFRFFqelpgSDPVFKAVPVPNMTPSGVGRERHSCDALN 406
Cdd:PLN02880 377 NLQSYIRNHIKLAKEFEQ----------LVAQDSRFEVVTPRIF-----SLVCFRLVPPKNNEDNGNKLNHDLLDAVN 439
 
Name Accession Description Interval E-value
GadA COG0076
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ...
 194-371 4.36e-21

Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis


Pssm-ID: 439846 [Multi-domain]  Cd Length: 460  Bit Score: 94.90  E-value: 4.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 194 DVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlALGyvsssvLAAA------ 267
Cdd:COG0076  203 DPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDA------AYG------GFALpspelr 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 268 -------KCDSMTMTPGPWLGLPAVPAVTLYKhdDPAL-------------TLVAGLTSnkPTDK-------LRALPLWL 320
Cdd:COG0076  271 hlldgieRADSITVDPHKWLYVPYGCGAVLVR--DPELlreafsfhasylgPADDGVPN--LGDYtlelsrrFRALKLWA 346

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 550544195 321 SLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELSspVVVFRF 371
Cdd:COG0076  347 TLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAPPELN--IVCFRY 395
DOPA_deC_like cd06450
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 172-371 4.39e-19

DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.


Pssm-ID: 99743 [Multi-domain]  Cd Length: 345  Bit Score: 88.03  E-value: 4.39e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 172 KKPVIYLSAAARPGL---GQYLCNQ------------DVAFLEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKEL 236
Cdd:cd06450   94 DKLVIVCSDQAHVSVekaAAYLDVKvrlvpvdedgrmDPEALEAAIDEDKAEGLNPIMVVATAGTTDTGAIDPLEEIADL 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 237 CEQYGIWLHVEGvnlatlALGyvsSSVLaaakcdsMTMTPGPWL-GLPAVPAVT------LYKHDDPALTLVagltsnkp 309
Cdd:cd06450  174 AEKYDLWLHVDA------AYG---GFLL-------PFPEPRHLDfGIERVDSISvdphkyGLVPLGCSAVLV-------- 229

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 550544195 310 tdklRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKILVEDELssPVVVFRF 371
Cdd:cd06450  230 ----RALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELLGEPNL--SLVCFRL 285
Pyridoxal_deC pfam00282
Pyridoxal-dependent decarboxylase conserved domain;
198-370 5.80e-11

Pyridoxal-dependent decarboxylase conserved domain;


Pssm-ID: 395219  Cd Length: 373  Bit Score: 63.59  E-value: 5.80e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195  198 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLALG-YVSSSVLAAAKCDSMTMTP 276
Cdd:pfam00282 185 LEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAAYGGSAFICpEFRHWLFGIERADSITFNP 264

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195  277 GPWLGLPAvPAVTLYKHDDPALTLVAGL------TSNKPTD----------KLRALPLWLSLQYLGLDGFVERIKHACQL 340
Cdd:pfam00282 265 HKWMLVLL-DCSAVWVKDKEALQQAFQFnplylgHTDSAYDtghkqiplsrRFRILKLWFVIRSLGVEGLQNQIRRHVEL 343

                         170       180       190
                  ....*....|....*....|....*....|
gi 550544195  341 SQRLQESLKKVNYIKILVEDELssPVVVFR 370
Cdd:pfam00282 344 AQYLEALIRKDGRFEICAEVGL--GLVCFR 371
PLN02880 PLN02880
tyrosine decarboxylase
 198-406 2.81e-05

tyrosine decarboxylase


Pssm-ID: 215475 [Multi-domain]  Cd Length: 490  Bit Score: 46.05  E-value: 2.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 198 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGvnlatlalGYVSSSVL---------AAAK 268
Cdd:PLN02880 226 LSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDA--------AYAGSACIcpeyrhyidGVEE 297

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 269 CDSMTMTPGPWLgLPAVPAVTLYKHDDPALTLVAG----LTSNKPTD----------------KLRALPLWLSLQYLGLD 328
Cdd:PLN02880 298 ADSFNMNAHKWF-LTNFDCSLLWVKDRNALIQSLStnpeFLKNKASQansvvdykdwqiplgrRFRSLKLWMVLRLYGVE 376

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 550544195 329 GFVERIKHACQLSQRLQEslkkvnyikiLVEDELSSPVVVFRFFqelpgSDPVFKAVPVPNMTPSGVGRERHSCDALN 406
Cdd:PLN02880 377 NLQSYIRNHIKLAKEFEQ----------LVAQDSRFEVVTPRIF-----SLVCFRLVPPKNNEDNGNKLNHDLLDAVN 439
PLN02590 PLN02590
probable tyrosine decarboxylase
 198-385 1.56e-04

probable tyrosine decarboxylase


Pssm-ID: 178200 [Multi-domain]  Cd Length: 539  Bit Score: 43.93  E-value: 1.56e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 198 LEKLIKDDIERGRLPLLLVANAGTAAVGHTDKIGRLKELCEQYGIWLHVEGVNLATLAL-GYVSSSVLAAAKCDSMTMTP 276
Cdd:PLN02590 274 LEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPLGNIAKKYGIWLHVDAAYAGNACIcPEYRKFIDGIENADSFNMNA 353

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 277 GPWLgLPAVPAVTLYKHDDPALtlvagltsnkpTDKLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQeSLKKVNYIKI 356
Cdd:PLN02590 354 HKWL-FANQTCSPLWVKDRYSL-----------IDALKTNPEYLEFKVSKKDTVVNYKDWQISLSRRFR-SLKLWMVLRL 420

                        170       180       190
                 ....*....|....*....|....*....|...
gi 550544195 357 LVEDELSS----PVVVFRFFQELPGSDPVFKAV 385
Cdd:PLN02590 421 YGSENLRNfirdHVNLAKHFEDYVAQDPSFEVV 453
PLN03032 PLN03032
serine decarboxylase; Provisional
 212-391 5.19e-04

serine decarboxylase; Provisional


Pssm-ID: 166673 [Multi-domain]  Cd Length: 374  Bit Score: 42.12  E-value: 5.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 212 PLLLVANAGTAAVGHTDKIGRLKELCEQYGI-----WLHVEGVnLATLALGYVSSSVLAAAK--CDSMTMTPGPWLGLPa 284
Cdd:PLN03032 162 PAILNVNIGTTVKGAVDDLDRILRILKELGYtedrfYIHCDGA-LFGLMMPFVSRAPEVTFRkpIGSVSVSGHKFLGCP- 239

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544195 285 VP---AVTLYKHDDPALTLVAGLTSNKPT-----DKLRALPLWLSLQYLGLDGFVERIKHACQLSQRLQESLKKVNYIKI 356
Cdd:PLN03032 240 MPcgvALTRKKHVKALSQNVEYLNSRDATimgsrNGHAPLYLWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTEAGLTCR 319

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 550544195 357 LveDELSSPVVVFRFFQE-------LPGSDPVFKAVPVPNMT 391
Cdd:PLN03032 320 L--NELSSTVVFERPMDEafikkwqLACEGDIAHVVVMPNVT 359
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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