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Conserved domains on  [gi|550544199|ref|NP_001272384|]
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microtubule-associated protein tau isoform 4 [Mus musculus]

Protein Classification

PHA02682 and Tubulin-binding domain-containing protein( domain architecture ID 13285099)

PHA02682 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 184-213 1.29e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 1.29e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  184 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 213
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 215-244 5.69e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.57  E-value: 5.69e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  215 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 244
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 246-276 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 4.13e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 550544199  246 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 276
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 161-182 9.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 44.71  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|..
gi 550544199  161 DLKNVRSKIGSTENLKHQPGGG 182
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA02682 super family cl31817
ORF080 virion core protein; Provisional
 61-163 3.23e-04

ORF080 virion core protein; Provisional


The actual alignment was detected with superfamily member PHA02682:

Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 41.77  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  61 ATPRGAA-SPAQKGTSNATRIPAkttPSPKTPPGSGE---PPKSGERSGYSSPGSPGTPGSRSRTPSLPTP---PTREPK 133
Cdd:PHA02682  89 AAPAPACpACAPAAPAPAVTCPA---PAPACPPATAPtcpPPAVCPAPARPAPACPPSTRQCPPAPPLPTPkpaPAAKPI 165

                         90       100       110
                 ....*....|....*....|....*....|
gi 550544199 134 KVAVVRTPPKSPSASKSRLQTAPVPMPDLK 163
Cdd:PHA02682 166 FLHNQLPPPDYPAASCPTIETAPAASPVLE 195
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 184-213 1.29e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 1.29e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  184 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 213
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 215-244 5.69e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.57  E-value: 5.69e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  215 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 244
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 246-276 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 4.13e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 550544199  246 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 276
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 161-182 9.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 44.71  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|..
gi 550544199  161 DLKNVRSKIGSTENLKHQPGGG 182
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 61-163 3.23e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 41.77  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  61 ATPRGAA-SPAQKGTSNATRIPAkttPSPKTPPGSGE---PPKSGERSGYSSPGSPGTPGSRSRTPSLPTP---PTREPK 133
Cdd:PHA02682  89 AAPAPACpACAPAAPAPAVTCPA---PAPACPPATAPtcpPPAVCPAPARPAPACPPSTRQCPPAPPLPTPkpaPAAKPI 165

                         90       100       110
                 ....*....|....*....|....*....|
gi 550544199 134 KVAVVRTPPKSPSASKSRLQTAPVPMPDLK 163
Cdd:PHA02682 166 FLHNQLPPPDYPAASCPTIETAPAASPVLE 195
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 48-137 6.76e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 37.95  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   48 KAKGADGKTGAKIATPRGAASPAqkgtsnatripakTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTP 127
Cdd:TIGR00601  76 KPKTGTGKVAPPAATPTSAPTPT-------------PSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSS 142

                          90
                  ....*....|
gi 550544199  128 PTREPKKVAV 137
Cdd:TIGR00601 143 GSDAASTLVV 152
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 184-213 1.29e-13

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 63.97  E-value: 1.29e-13
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  184 VQIINKKLDLSNVQSKCGSKDNIKHVPGGG 213
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 215-244 5.69e-10

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 53.57  E-value: 5.69e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 550544199  215 VQIVYKPVDLSKVTSKCGSLGNIHHKPGGG 244
Cdd:pfam00418   1 VKIESKKLDFSKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 246-276 4.13e-09

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 51.26  E-value: 4.13e-09
                          10        20        30
                  ....*....|....*....|....*....|.
gi 550544199  246 VEVKSEKLDFKdRVQSKIGSLDNITHVPGGG 276
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 161-182 9.40e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 44.71  E-value: 9.40e-07
                          10        20
                  ....*....|....*....|..
gi 550544199  161 DLKNVRSKIGSTENLKHQPGGG 182
Cdd:pfam00418   9 DFSKVQSKCGSKDNIKHKPGGG 30
PHA02682 PHA02682
ORF080 virion core protein; Provisional
 61-163 3.23e-04

ORF080 virion core protein; Provisional


Pssm-ID: 177464 [Multi-domain]  Cd Length: 280  Bit Score: 41.77  E-value: 3.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  61 ATPRGAA-SPAQKGTSNATRIPAkttPSPKTPPGSGE---PPKSGERSGYSSPGSPGTPGSRSRTPSLPTP---PTREPK 133
Cdd:PHA02682  89 AAPAPACpACAPAAPAPAVTCPA---PAPACPPATAPtcpPPAVCPAPARPAPACPPSTRQCPPAPPLPTPkpaPAAKPI 165

                         90       100       110
                 ....*....|....*....|....*....|
gi 550544199 134 KVAVVRTPPKSPSASKSRLQTAPVPMPDLK 163
Cdd:PHA02682 166 FLHNQLPPPDYPAASCPTIETAPAASPVLE 195
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 41-160 3.58e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.39  E-value: 3.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  41 RTGNDEKKAKGADGKTGAKIATPRGAASPAQKGTSNA--TRIPAKTTPSPKTPPGSGEPPKSGeRSGYSSPGSPGTPGSR 118
Cdd:PRK14951 365 KPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPapAAAPAAAASAPAAPPAAAPPAPVA-APAAAAPAAAPAAAPA 443

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 550544199 119 SRT--PSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMP 160
Cdd:PRK14951 444 AVAlaPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAAR 487
PHA03247 PHA03247
large tegument protein UL36; Provisional
 61-162 4.09e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 4.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   61 ATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPG---SPGTPGSR----SRTPSLPTPPTREP- 132
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGgsvAPGGDVRRrppsRSPAAKPAAPARPPv 2883

                          90       100       110
                  ....*....|....*....|....*....|
gi 550544199  133 KKVAVVRTPPKSPSASKSRLQTAPVPMPDL 162
Cdd:PHA03247 2884 RRLARPAVSRSTESFALPPDQPERPPQPQA 2913
PHA03378 PHA03378
EBNA-3B; Provisional
 63-160 5.46e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 41.98  E-value: 5.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  63 PRGAASPAQKGTSNATRIPakttpSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKvAVVRTPP 142
Cdd:PHA03378 707 PAAPPGRAQRPAAATGRAR-----PPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGA-PTPQPPP 780

                         90
                 ....*....|....*...
gi 550544199 143 KSPSASKSRLQTAPVPMP 160
Cdd:PHA03378 781 QAPPAPQQRPRGAPTPQP 798
PHA03247 PHA03247
large tegument protein UL36; Provisional
 46-152 7.25e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 7.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   46 EKKAKGADGKTGAKIATPRGAA-----------------SPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSgersgySS 108
Cdd:PHA03247  372 RHHPKRASLPTRKRRSARHAATpfargpggddqtrpaapVPASVPTPAPTPVPASAPPPPATPLPSAEPGSD------DG 445

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 550544199  109 PGSP--GTPGSRSRTPSLPTPPTREPKKVAVVRT--PPKSPSASKSRL 152
Cdd:PHA03247  446 PAPPpeRQPPAPATEPAPDDPDDATRKALDALRErrPPEPPGADLAEL 493
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 62-175 1.13e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  62 TPRGAASPAQkgTSNATRIPAKTTPSPKTPPGSGEPpksgersgysSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTP 141
Cdd:PRK14950 361 VPVPAPQPAK--PTAAAPSPVRPTPAPSTRPKAAAA----------ANIPPKEPVRETATPPPVPPRPVAPPVPHTPESA 428

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 550544199 142 PKSPSASkSRLQTAPV---PMPDLKNVRSKIGSTENL 175
Cdd:PRK14950 429 PKLTRAA-IPVDEKPKytpPAPPKEEEKALIADGDVL 464
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 31-151 2.46e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.77  E-value: 2.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   31 GLKARVASKDRTGNDEKKAKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPksGERSGYSSPG 110
Cdd:PHA03307  224 PGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSP--RERSPSPSPS 301

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 550544199  111 SPGTPGSRSRTPSLP---------TPPTRE----PKKVAVVRTPPKSPSASKSR 151
Cdd:PHA03307  302 SPGSGPAPSSPRASSsssssressSSSTSSssesSRGAAVSPGPSPSRSPSPSR 355
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-160 2.80e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 2.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   54 GKTGAKIATPRGAASPAQKGTSNATRIPAKTTPsPKTPPGSGEPPKSGERSGYSSPGSPGTP-----GSRSRTPSLPTPP 128
Cdd:PHA03247 2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPAR-PARPPTTAGPPAPAPPAAPAAGPPRRLTrpavaSLSESRESLPSPW 2802

                          90       100       110
                  ....*....|....*....|....*....|..
gi 550544199  129 TREPKKVAVvrtPPKSPSASKSRLQTAPVPMP 160
Cdd:PHA03247 2803 DPADPPAAV---LAPAAALPPAASPAGPLPPP 2831
PHA03247 PHA03247
large tegument protein UL36; Provisional
 78-160 3.30e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   78 TRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPgSRSRTPSLPTPPTREPKKVAVVRTPPKSPSASKSRLQTAPV 157
Cdd:PHA03247 2868 SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP-ERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPT 2946


                  ...
gi 550544199  158 PMP 160
Cdd:PHA03247 2947 TDP 2949
PHA03247 PHA03247
large tegument protein UL36; Provisional
 61-160 3.83e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 3.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   61 ATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSS-PGSPGTPGSRSRTPSLP----TPPTREPKKV 135
Cdd:PHA03247 2671 GRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSAtPLPPGPAAARQASPALPaapaPPAVPAGPAT 2750

                          90       100
                  ....*....|....*....|....*
gi 550544199  136 AVVRTPPKSPSASKSRLQTAPVPMP 160
Cdd:PHA03247 2751 PGGPARPARPPTTAGPPAPAPPAAP 2775
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 69-151 3.93e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 38.78  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  69 PAQKGTSNATRIPAKTTPSPKT--PPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPTrepKKVAVVRTPPKSPS 146
Cdd:PHA03291 199 PADVFVPATPRPTPRTTASPETtpTPSTTTSPPSTTIPAPSTTIAAPQAGTTPEAEGTPAPPT---PGGGEAPPANATPA 275


                 ....*
gi 550544199 147 ASKSR 151
Cdd:PHA03291 276 PEASR 280
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 49-173 5.33e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 39.00  E-value: 5.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   49 AKGADGKTGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPP--GSGEPPKSGERSGYSSPGSPGTPGSRSrTPSLPT 126
Cdd:PHA03307   58 GAAACDRFEPPTGPPPGPGTEAPANESRSTPTWSLSTLAPASPAreGSPTPPGPSSPDPPPPTPPPASPPPSP-APDLSE 136

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 550544199  127 PPTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTE 173
Cdd:PHA03307  137 MLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETA 183
PHA03247 PHA03247
large tegument protein UL36; Provisional
 61-160 5.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   61 ATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTPPtrePKKVAVVRT 140
Cdd:PHA03247 2718 ATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR---PAVASLSES 2794

                          90       100
                  ....*....|....*....|
gi 550544199  141 PPKSPSASKSRLQTAPVPMP 160
Cdd:PHA03247 2795 RESLPSPWDPADPPAAVLAP 2814
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 48-180 6.51e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.61  E-value: 6.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   48 KAKGADGKTGAKIATPRGAASPAQKGTSNAtriPAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTP 127
Cdd:PHA03307  276 NGPSSRPGPASSSSSPRERSPSPSPSSPGS---GPAPSSPRASSSSSSSRESSSSSTSSSSESSRGAAVSPGPSPSRSPS 352

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 550544199  128 PTREPKKVAVVRTPPKSPSASKSRLQTAPVPMPDLKNVRSKIGSTENLKHQPG 180
Cdd:PHA03307  353 PSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATG 405
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
56-160 6.62e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 38.32  E-value: 6.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  56 TGAKIATPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSGERSGysspGSPGTPGSRSRTPSLPTPPTREPkkV 135
Cdd:PRK12323 393 AAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASAR----GPGGAPAPAPAPAAAPAAAARPA--A 466

                         90       100
                 ....*....|....*....|....*
gi 550544199 136 AVVRTPPKSPSASKSRLQTAPVPMP 160
Cdd:PRK12323 467 AGPRPVAAAAAAAPARAAPAAAPAP 491
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 48-137 6.76e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 37.95  E-value: 6.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   48 KAKGADGKTGAKIATPRGAASPAqkgtsnatripakTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPGSRSRTPSLPTP 127
Cdd:TIGR00601  76 KPKTGTGKVAPPAATPTSAPTPT-------------PSPPASPASGMSAAPASAVEEKSPSEESATATAPESPSTSVPSS 142

                          90
                  ....*....|
gi 550544199  128 PTREPKKVAV 137
Cdd:TIGR00601 143 GSDAASTLVV 152
PRK14959 PRK14959
DNA polymerase III subunits gamma and tau; Provisional
 54-129 6.84e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184923 [Multi-domain]  Cd Length: 624  Bit Score: 38.51  E-value: 6.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  54 GKTGAKIATPRGAASP--AQKGTSNATRIPAKTTP---SPKTPPGSGEPPKSGERSGYSSPgSPGTPGSRSRTPSlpTPP 128
Cdd:PRK14959 401 GTQGPQGTAPAAGMTPssAAPATPAPSAAPSPRVPwddAPPAPPRSGIPPRPAPRMPEASP-VPGAPDSVASASD--APP 477


                 .
gi 550544199 129 T 129
Cdd:PRK14959 478 T 478
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 61-160 6.97e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.61  E-value: 6.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   61 ATPRGAASPAQKGTSNATRI-PAKTTPSPKTPPGSGEPPKSGERSGYSSPGSPGTPG-SRSRTPSLPTPPTREPKKVAVV 138
Cdd:PHA03307  807 PAADAASRTASKRKSRSHTPdGGSESSGPARPPGAAARPPPARSSESSKSKPAAAGGrARGKNGRRRPRPPEPRARPGAA 886

                          90       100
                  ....*....|....*....|..
gi 550544199  139 RTPPKSPSASKSRLQTAPVPMP 160
Cdd:PHA03307  887 APPKAAAAAPPAGAPAPRPRPA 908
PHA03247 PHA03247
large tegument protein UL36; Provisional
 62-158 7.77e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.38  E-value: 7.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   62 TPRGAASPAQKGTSNATRIPAKTTPSPKTPPGSGEPPKSgerSGYSSPGSPGTPGSRSRT--PSLPTPPTREPKKVAVVR 139
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP---AGPATPGGPARPARPPTTagPPAPAPPAAPAAGPPRRL 2783

                          90
                  ....*....|....*....
gi 550544199  140 TPPKSPSASKSRlQTAPVP 158
Cdd:PHA03247 2784 TRPAVASLSESR-ESLPSP 2801
PHA03291 PHA03291
envelope glycoprotein I; Provisional
 57-133 9.24e-03

envelope glycoprotein I; Provisional


Pssm-ID: 223033 [Multi-domain]  Cd Length: 401  Bit Score: 37.63  E-value: 9.24e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 550544199  57 GAKIATPRGAASPAQKGTSNATRIPakttPSPKTPPGSGEPPKSGERSGYSSPGSPG--TPGSRSRTPSLPTPPTREPK 133
Cdd:PHA03291 206 ATPRPTPRTTASPETTPTPSTTTSP----PSTTIPAPSTTIAAPQAGTTPEAEGTPAppTPGGGEAPPANATPAPEASR 280
PHA03247 PHA03247
large tegument protein UL36; Provisional
 62-156 9.40e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.00  E-value: 9.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199   62 TPRGAASPAQKGTSNATRIPAKTTPSPKTPPG-SGEP-PKSGERSGYSSPGSPGTPGSRSR-----TPSLPTPPTREPKK 134
Cdd:PHA03247 2684 RRRAARPTVGSLTSLADPPPPPPTPEPAPHALvSATPlPPGPAAARQASPALPAAPAPPAVpagpaTPGGPARPARPPTT 2763

                          90       100
                  ....*....|....*....|...
gi 550544199  135 VAVVR-TPPKSPSASKSRLQTAP 156
Cdd:PHA03247 2764 AGPPApAPPAAPAAGPPRRLTRP 2786
PHA03381 PHA03381
tegument protein VP22; Provisional
 25-158 9.51e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 37.30  E-value: 9.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 550544199  25 EGDMDHGLKARVASKDRTGNDEKKAKGADGKTGAKiATPRGAASPAQKGTSNATRIPAKTTPS----PKTPPGSGEPPKS 100
Cdd:PHA03381  18 EADVYYDFISPDASPARVSFEEPADRARRGAGQAR-GRSQAERRFHHYDEARADYPYYTGSSSederPADPRPSRRPHAQ 96

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 550544199 101 GERSGYSSP-GSPGTPGSRSRTPSLPTPPTREPK--KVAVVRTPPKSPSASKSRLQTAPVP 158
Cdd:PHA03381  97 PEASGPGPArGARGPAGSRGRGRRAESPSPRDPPnpKGASAPRGRKSACADSAALLDAPAP 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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