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Conserved domains on  [gi|555943734|ref|NP_001273183|]
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kelch-like protein 32 isoform e [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 1015026)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
NanM super family cl34543
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-134 8.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3055:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.11  E-value: 8.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQR-KLYVLGGNDLDYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAV 80
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGANPSSTPL-NDVYVYDPATNTWTKLA-PMPTPRGGATALL 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 555943734  81 HNGRIYLVGGYSiwTNEPLACIQVLDVSREGKEEVfygPTLPFASNGIAACFLP 134
Cdd:COG3055  120 LDGKIYVVGGWD--DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLP 168
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-134 8.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.11  E-value: 8.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQR-KLYVLGGNDLDYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAV 80
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGANPSSTPL-NDVYVYDPATNTWTKLA-PMPTPRGGATALL 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 555943734  81 HNGRIYLVGGYSiwTNEPLACIQVLDVSREGKEEVfygPTLPFASNGIAACFLP 134
Cdd:COG3055  120 LDGKIYVVGGWD--DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLP 168
PHA03098 PHA03098
kelch-like protein; Provisional
 2-93 9.68e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 9.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGndLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVH 81
Cdd:PHA03098 410 CFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN 487

                         90
                 ....*....|..
gi 555943734  82 NgRIYLVGGYSI 93
Cdd:PHA03098 488 N-KIYVVGGDKY 498
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 19-65 2.42e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 2.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 555943734   19 RRVYHSMAAVQRKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRC 65
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKL 42
Kelch smart00612
Kelch domain;
31-83 1.29e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 1.29e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 555943734    31 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 83
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-134 8.31e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.11  E-value: 8.31e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQR-KLYVLGGNDLDYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAV 80
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAVAQDgKLYVFGGFTGANPSSTPL-NDVYVYDPATNTWTKLA-PMPTPRGGATALL 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 555943734  81 HNGRIYLVGGYSiwTNEPLACIQVLDVSREGKEEVfygPTLPFASNGIAACFLP 134
Cdd:COG3055  120 LDGKIYVVGGWD--DGGNVAWVEVYDPATGTWTQL---APLPTPRDHLAAAVLP 168
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
2-92 2.29e-12

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 62.87  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVrhidsYNIDTDQWTRCNfNLLTGQNE-SGVAV 80
Cdd:COG3055   94 VYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEV-----YDPATGTWTQLA-PLPTPRDHlAAAVL 167

                         90
                 ....*....|..
gi 555943734  81 HNGRIYLVGGYS 92
Cdd:COG3055  168 PDGKILVIGGRN 179
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
10-92 2.15e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 54.39  E-value: 2.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734  10 WISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRILVrhidsYNIDTDQWTRcnfnL----LTGQNESGVAVHNGRI 85
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEV-----YDPATNTWSE----LaplpGPPRHHAAAVAQDGKL 73


                 ....*..
gi 555943734  86 YLVGGYS 92
Cdd:COG3055   74 YVFGGFT 80
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
6-90 3.15e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 54.01  E-value: 3.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   6 NQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNdrilvrhIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRI 85
Cdd:COG3055  183 FSNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGFSDE-------VEAYDPATNTWTALG-ELPTPRHGHAAVLTDGKV 254


                 ....*
gi 555943734  86 YLVGG 90
Cdd:COG3055  255 YVIGG 259
PHA03098 PHA03098
kelch-like protein; Provisional
 2-93 9.68e-08

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 50.15  E-value: 9.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   2 VYEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGndLDYNNDRILVRHIDSYNIDTDQWTRCNFNLLTGQNESGVAVH 81
Cdd:PHA03098 410 CFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGG--ISYIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN 487

                         90
                 ....*....|..
gi 555943734  82 NgRIYLVGGYSI 93
Cdd:PHA03098 488 N-KIYVVGGDKY 498
PHA03098 PHA03098
kelch-like protein; Provisional
 5-97 1.04e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.07  E-value: 1.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   5 PNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDRIlvrhIDSYNIDTDQWTRCNFNLLTGQNESGVaVHNGR 84
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPCVVNVNNLIYVIGGISKNDELLKT----VECFSLNTNKWSKGSPLPISHYGGCAI-YHDGK 439

                         90
                 ....*....|...
gi 555943734  85 IYLVGGYSIWTNE 97
Cdd:PHA03098 440 IYVIGGISYIDNI 452
PLN02193 PLN02193
nitrile-specifier protein
 3-92 1.51e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 46.49  E-value: 1.51e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   3 YEPNQNKWISRSPMLQ---RRVYHSMAAVQRKLYVLGGndldyNNDRILVRHIDSYNIDTDQWTRCN--FNLLTGQNESG 77
Cdd:PLN02193 249 FDTTTNEWKLLTPVEEgptPRSFHSMAADEENVYVFGG-----VSATARLKTLDSYNIVDKKWFHCStpGDSFSIRGGAG 323

                         90
                 ....*....|....*
gi 555943734  78 VAVHNGRIYLVGGYS 92
Cdd:PLN02193 324 LEVVQGKVWVVYGFN 338
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 19-65 2.42e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.21  E-value: 2.42e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 555943734   19 RRVYHSMAAVQRKLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRC 65
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGG----FDGNQSL-NSVEVYDPETNTWSKL 42
PRK14131 PRK14131
N-acetylneuraminate epimerase;
25-92 9.80e-06

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 44.24  E-value: 9.80e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 555943734  25 MAAVQRKLYVLGGNDlDYNNDR--ILVRHIDSYNIDTDQWTRCNFNL---LTGQneSGVAVHNGRIYLVGGYS 92
Cdd:PRK14131  80 AAFIDGKLYVFGGIG-KTNSEGspQVFDDVYKYDPKTNSWQKLDTRSpvgLAGH--VAVSLHNGKAYITGGVN 149
PHA03098 PHA03098
kelch-like protein; Provisional
 3-63 1.68e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.68e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 555943734   3 YEPNQNKWISRSPMLQRRVYHSMAAVQRKLYVLGGNDLDYNNDrilvrHIDSYNIDTDQWT 63
Cdd:PHA03098 461 YNPVTNKWTELSSLNFPRINASLCIFNNKIYVVGGDKYEYYIN-----EIEVYDDKTNTWT 516
Kelch smart00612
Kelch domain;
31-83 1.29e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 1.29e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 555943734    31 KLYVLGGndldYNNDRILvRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNG 83
Cdd:smart00612   1 KIYVVGG----FDGGQRL-KSVEVYDPETNKWTPLP-SMPTPRSGHGVAVING 47
PLN02153 PLN02153
epithiospecifier protein
 3-92 5.63e-04

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 38.81  E-value: 5.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943734   3 YEPNQNKWISRSPM-----LQRRVYHSMAAVQRKLYVLGG---NDLDYNNDRIlvRHIDSYNIDTDQWTRC-----NFNL 69
Cdd:PLN02153 106 YDTVKNEWTFLTKLdeeggPEARTFHSMASDENHVYVFGGvskGGLMKTPERF--RTIEAYNIADGKWVQLpdpgeNFEK 183

                         90       100
                 ....*....|....*....|...
gi 555943734  70 LTGqneSGVAVHNGRIYLVGGYS 92
Cdd:PLN02153 184 RGG---AGFAVVQGKIWVVYGFA 203
Kelch smart00612
Kelch domain;
2-29 1.94e-03

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 34.46  E-value: 1.94e-03
                           10        20
                   ....*....|....*....|....*...
gi 555943734     2 VYEPNQNKWISRSPMLQRRVYHSMAAVQ 29
Cdd:smart00612  19 VYDPETNKWTPLPSMPTPRSGHGVAVIN 46
PHA03098 PHA03098
kelch-like protein; Provisional
 32-100 2.95e-03

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 37.05  E-value: 2.95e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 555943734  32 LYVLGGndldYNNDRILVRHIDSYNIDTDQWTRCNfNLLTGQNESGVAVHNGRIYLVGGysIWTNEPLA 100
Cdd:PHA03098 297 IYFIGG----MNKNNLSVNSVVSYDTKTKSWNKVP-ELIYPRKNPGVTVFNNRIYVIGG--IYNSISLN 358
Kelch_4 pfam13418
Galactose oxidase, central domain;
19-64 3.25e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.12  E-value: 3.25e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 555943734   19 RRVYHSMAAVQR-KLYVLGGndldYNNDRILVRHIDSYNIDTDQWTR 64
Cdd:pfam13418   1 PRAYHTSTSIPDdTIYLFGG----EGEDGTLLSDLWVFDLSTNEWTR 43
Kelch_6 pfam13964
Kelch motif;
20-65 7.39e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 33.08  E-value: 7.39e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 555943734   20 RVYHSMAAVQRKLYVLGGndldYNNDRILVRHIDSYNIDTDQWTRC 65
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGG----YTNASPALNKLEVYNPLTKSWEEL 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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