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Conserved domains on  [gi|557786177|ref|NP_001273590|]
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DGAT1/2-independent enzyme synthesizing storage lipids isoform 4 [Homo sapiens]

Protein Classification

lysophospholipid acyltransferase family protein( domain architecture ID 10168420)

lysophospholipid acyltransferase (LPLAT) family protein may act as an acyltransferase of a de novo or remodeling pathway of glycerophospholipid biosynthesis, catalyzing the incorporation of an acyl group from either acyl-CoAs or acyl-acyl carrier proteins (acyl-ACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid

CATH:  1.10.1200.50
EC:  2.3.1.-
Gene Ontology:  GO:0016746|GO:0006644|GO:0008654
PubMed:  18718904|18931347|37611890
SCOP:  4003349

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 1-133 5.62e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


:

Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 166.31  E-value: 5.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   1 MEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLL 79
Cdd:cd07987   13 LENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRENCVRLLREGELV 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 557786177  80 AISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFRSLG 133
Cdd:cd07987   93 LIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLG 147
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 1-133 5.62e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 166.31  E-value: 5.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   1 MEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLL 79
Cdd:cd07987   13 LENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRENCVRLLREGELV 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 557786177  80 AISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFRSLG 133
Cdd:cd07987   93 LIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLG 147
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 1-120 8.22e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.84  E-value: 8.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177    1 MEKIPEDGPALIIFYHgAIPIDfYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLD----VFC------ALHGPREKCV 70
Cdd:pfam01553   7 LENLPRGGPAIVVANH-QSYLD-VLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRllgcIFIdrknrkDAAGTLEYLV 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 557786177   71 EILRSGHLLAISPGGVRealiSDETYniVWGHRRGFAQVAIDAKVPIIPM 120
Cdd:pfam01553  85 ELLREGKLVVIFPEGTR----SREGE--LLPFKKGAFRLAIEAGVPIVPV 128
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-120 2.43e-08

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 48.89  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177    20 PIDFYYFMAkIFIHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPRE----------KCVEILRSGHLLAISPGGVRea 89
Cdd:smart00563  10 FLDPLVLSA-LLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSngrkaraalrEAVELLKEGEWLLIFPEGTR-- 86

                           90       100       110
                   ....*....|....*....|....*....|.
gi 557786177    90 liSDETYNIVWghRRGFAQVAIDAKVPIIPM 120
Cdd:smart00563  87 --SRPGKLLPF--KKGAARLALEAGVPIVPV 113
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-130 7.56e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 49.24  E-value: 7.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   1 MEKIPEDGPALIIFYHgAIPIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF----------CALHGPREKCV 70
Cdd:COG0204   36 LENLPADGPVLIVANH-QSWLDILLLLA----ALPRPVRFVAKKELFKIPLLGWLLRALgaipvdrskrRAALRALRQAV 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177  71 EILRSGHLLAISPggvrEALISDEtyNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFR 130
Cdd:COG0204  111 EALKAGESLVIFP----EGTRSPD--GRLLPFKTGAARLALEAGVPIVPVAIDGTERALP 164
PLN02783 PLN02783
diacylglycerol O-acyltransferase
 16-122 5.48e-04

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 38.45  E-value: 5.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177  16 HGAIPIDFYYFMAKIFIHKGRTCRVVADHFVFKIPgFSLLLDVFCALHGPREKCV-EILRSGHLLAISPGGVREALISDE 94
Cdd:PLN02783 110 HSVLPIGVIALADLSGFLPLPKIRALASSAVFYTP-FLRHIWTWLGLDPASRKNFtSLLKAGYSCIIVPGGVQECLYMEH 188

                         90       100
                 ....*....|....*....|....*....
gi 557786177  95 TYNIVW-GHRRGFAQVAIDAKVPIIPMFT 122
Cdd:PLN02783 189 GSEVAYlKSRKGFVKIAMETGAPLVPVFC 217
 
Name Accession Description Interval E-value
LPLAT_MGAT-like cd07987
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ...
 1-133 5.62e-53

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.


Pssm-ID: 153249 [Multi-domain]  Cd Length: 212  Bit Score: 166.31  E-value: 5.62e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   1 MEKIPEDGPALIIFYHGAIPIDFYYFMAKIF-IHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPREKCVEILRSGHLL 79
Cdd:cd07987   13 LENIPDEGPALLVHPHGGLPIDGALLAAAFLlLFPGRLPRALADHFLFPLPGLRDLLRRLGAVPGSRENCVRLLREGELV 92

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 557786177  80 AISPGGVREALIS-DETYNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFRSLG 133
Cdd:cd07987   93 LIFPGGAREALKSkREEYYLLWKKRKGFARLALRAGAPIVPVFTFGEEELFRVLG 147
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 1-120 8.22e-14

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.84  E-value: 8.22e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177    1 MEKIPEDGPALIIFYHgAIPIDfYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLD----VFC------ALHGPREKCV 70
Cdd:pfam01553   7 LENLPRGGPAIVVANH-QSYLD-VLLLSLALYKRGRPLVFVAKKELFDIPLVGWLMRllgcIFIdrknrkDAAGTLEYLV 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 557786177   71 EILRSGHLLAISPGGVRealiSDETYniVWGHRRGFAQVAIDAKVPIIPM 120
Cdd:pfam01553  85 ELLREGKLVVIFPEGTR----SREGE--LLPFKKGAFRLAIEAGVPIVPV 128
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 20-120 2.43e-08

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 48.89  E-value: 2.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177    20 PIDFYYFMAkIFIHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPRE----------KCVEILRSGHLLAISPGGVRea 89
Cdd:smart00563  10 FLDPLVLSA-LLPRKLGRVRFVAKKELFYVPLLGWLLRLLGAIFIDRSngrkaraalrEAVELLKEGEWLLIFPEGTR-- 86

                           90       100       110
                   ....*....|....*....|....*....|.
gi 557786177    90 liSDETYNIVWghRRGFAQVAIDAKVPIIPM 120
Cdd:smart00563  87 --SRPGKLLPF--KKGAARLALEAGVPIVPV 113
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 1-130 7.56e-08

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 49.24  E-value: 7.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   1 MEKIPEDGPALIIFYHgAIPIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF----------CALHGPREKCV 70
Cdd:COG0204   36 LENLPADGPVLIVANH-QSWLDILLLLA----ALPRPVRFVAKKELFKIPLLGWLLRALgaipvdrskrRAALRALRQAV 110

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177  71 EILRSGHLLAISPggvrEALISDEtyNIVWGHRRGFAQVAIDAKVPIIPMFTQNIREGFR 130
Cdd:COG0204  111 EALKAGESLVIFP----EGTRSPD--GRLLPFKTGAARLALEAGVPIVPVAIDGTERALP 164
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 2-131 5.17e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 43.80  E-value: 5.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   2 EKIPEDGPALIIFYHGAIpIDFYYFMAkifiHKGRTCRVVADHFVFKIPGFSLLLDVF----------CALHGPREKCVE 71
Cdd:cd07989   18 ENLPPKGPVIIVANHQSY-LDPLVLGA----ALPRPIRFVAKKELFKIPFLGWLLRLLgaipidrgngRSAREALREAIE 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557786177  72 ILRSGHLLAISP-------GGVREAlisdetynivwghRRGFAQVAIDAKVPIIPMFTQNIREGFRS 131
Cdd:cd07989   93 ALKEGESVVIFPegtrsrdGELLPF-------------KSGAFRLAKEAGVPIVPVAISGTWGSLPK 146
LPLAT_ACT14924-like cd07986
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 2-121 9.50e-06

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.


Pssm-ID: 153248 [Multi-domain]  Cd Length: 210  Bit Score: 43.39  E-value: 9.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177   2 EKIPEDGPALIIFYH--GAI-PIDFYYFMAKIfihkGRTCRVVADHFVFKIPGfslLLDVFCAL------------HGPR 66
Cdd:cd07986   16 ENIPKDGPVVIVANHpfGILdGLILADLLGSV----RPDVRILANQLLSKIPE---LRDLFIPVdplegraalaknRESL 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557786177  67 EKCVEILRSGHLLAISPGGVrealISdeTYNIVWGH------RRGFAQVAIDAKVPIIPMF 121
Cdd:cd07986   89 REALRHLKNGGALIIFPAGR----VS--TASPPFGRvsdrpwNPFVARLARKAKAPVVPVY 143
PLN02783 PLN02783
diacylglycerol O-acyltransferase
 16-122 5.48e-04

diacylglycerol O-acyltransferase


Pssm-ID: 178380  Cd Length: 315  Bit Score: 38.45  E-value: 5.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786177  16 HGAIPIDFYYFMAKIFIHKGRTCRVVADHFVFKIPgFSLLLDVFCALHGPREKCV-EILRSGHLLAISPGGVREALISDE 94
Cdd:PLN02783 110 HSVLPIGVIALADLSGFLPLPKIRALASSAVFYTP-FLRHIWTWLGLDPASRKNFtSLLKAGYSCIIVPGGVQECLYMEH 188

                         90       100
                 ....*....|....*....|....*....
gi 557786177  95 TYNIVW-GHRRGFAQVAIDAKVPIIPMFT 122
Cdd:PLN02783 189 GSEVAYlKSRKGFVKIAMETGAPLVPVFC 217
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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