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Conserved domains on  [gi|560879455|ref|NP_001274022|]
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amphoterin-induced protein 1 isoform b precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12267147)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886  118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRRNT super family cl02423
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 34-63 9.78e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


The actual alignment was detected with superfamily member smart00013:

Pssm-ID: 413314 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 560879455    34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886  118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.09e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  30 SVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRL-TNLHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN---- 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370 281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 560879455 173 FPVELIkdgnklPKLMLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370 361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 560879455  110 PNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 1.37e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFLFsdLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340    2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 163 LYLSQNQISRF---------------------PVELIKDGNKL----PKLMLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340   73 LYLGGNRISVVeglenltnleelhienqrlppGEKLTFDPRSLaalsNSLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                        170       180
                 ....*....|....*....|.
gi 560879455 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340  149 ASNNQISDLEELLDLLSSWPS 169
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 9.78e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 560879455    34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-224 5.11e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 5.11e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  66 LDLSHNNLSRLRAEwtPTRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHLHTLDEFLfSDLQALEVLLLYNNH 145
Cdd:COG4886  118 LDLSGNQLTDLPEE--LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 146 IVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP-LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886  194 ITDLP-EPLGNLTNLEELDLSGNQLTDLPEPL----ANLTNLETLDLSNNQLTDLPeLGNLTNL-----EELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-235 8.48e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 8.48e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  44 ILSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTPtrLTNLHSLLLSHNHLNFISsEAFVPVPNLRYLDLSSNH 121
Cdd:COG4886  140 ELDLSNNQLTDLPEPLGNLTNLksLDLSNNQLTDLPEELGN--LTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ 216

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 122 LHTLDEFLfSDLQALEVLLLYNNHIVVVDrnAFEDMAQLQKLYLSQNQISRFPVELikdgnKLPKLMLLDLSSNKLKKLP 201
Cdd:COG4886  217 LTDLPEPL-ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA-----NLTNLKTLDLSNNQLTDLK 288

                        170       180       190
                 ....*....|....*....|....*....|....
gi 560879455 202 LTDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSH 235
Cdd:COG4886  289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTT 322
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-224 9.07e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 9.07e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  43 NILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLRAEWTPTRLTNLHSLLLSHNHLNFIsSEAFVPVPNLRYLDLSSNHL 122
Cdd:COG4886   70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 123 HTLDEFLfSDLQALEVLLLYNNHIVVVDrNAFEDMAQLQKLYLSQNQISRFPVELikdgNKLPKLMLLDLSSNKLKKLP- 201
Cdd:COG4886  149 TDLPEPL-GNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPEPL----GNLTNLEELDLSGNQLTDLPe 222

                        170       180
                 ....*....|....*....|....
gi 560879455 202 -LTDLQKLpawvkNGLYLHNNPLE 224
Cdd:COG4886  223 pLANLTNL-----ETLDLSNNQLT 241
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
30-213 1.09e-14

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 74.35  E-value: 1.09e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  30 SVVSCPANCLCASNILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRL-TNLHSLLLSHNHLNFISSEafvp 108
Cdd:PRK15370 210 ELKSLPENLQGNIKTLYANSNQLTSIPATLPDTIQEMELSINRITEL-----PERLpSALQSLDLFHNKISCLPEN---- 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 109 VPN-LRYLDLSSNHLHTLDE---------FLFSD-LQALEVLLLYNNHIVVVDRNAFEDM-----AQLQKLYLSQNQISR 172
Cdd:PRK15370 281 LPEeLRYLSVYDNSIRTLPAhlpsgithlNVQSNsLTALPETLPPGLKTLEAGENALTSLpaslpPELQVLDVSKNQITV 360

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 560879455 173 FPVELIkdgnklPKLMLLDLSSNKLKKLPltdlQKLPAWVK 213
Cdd:PRK15370 361 LPETLP------PTITTLDVSRNALTNLP----ENLPAALQ 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-247 3.47e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.58  E-value: 3.47e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  45 LSCSKQQLPNVPQSLPSYTAL--LDLSHNNLSRLRAEWTptRLTNLHSLLLSHNHLNFISSEaFVPVPNLRYLDLSSNHL 122
Cdd:COG4886  164 LDLSNNQLTDLPEELGNLTNLkeLDLSNNQITDLPEPLG--NLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 123 HTLDEFlfSDLQALEVLLLYNNHIVVVDRNAfeDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKLKKLPL 202
Cdd:COG4886  241 TDLPEL--GNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 560879455 203 TDLQKLPAWVKNGLYLHNNPLECDCKLYQLFSHWQYRQLSSVMDF 247
Cdd:COG4886  317 LLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR_8 pfam13855
Leucine rich repeat;
110-170 2.72e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 2.72e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 560879455  110 PNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQI 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-146 2.60e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 55.22  E-value: 2.60e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 560879455   86 TNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHLHTLDEFLFSDLQALEVLLLYNNHI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
66-122 1.39e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 1.39e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 560879455   66 LDLSHNNLSRLRAEWtPTRLTNLHSLLLSHNHLNFISSEAFVPVPNLRYLDLSSNHL 122
Cdd:pfam13855   6 LDLSNNRLTSLDDGA-FKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
136-197 1.56e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 560879455  136 LEVLLLYNNHIVVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDgnkLPKLMLLDLSSNKL 197
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG---LPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 83-238 1.37e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  83 TRLTNLHsllLSHNHLNFIssEAFVPVPNLRYLDLSSNHLHTLDEFLFsdLQALEVLLLYNNHIVVVDRnaFEDMAQLQK 162
Cdd:cd21340    2 KRITHLY---LNDKNITKI--DNLSLCKNLKVLYLYDNKITKIENLEF--LTNLTHLYLQNNQIEKIEN--LENLVNLKK 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 163 LYLSQNQISRF---------------------PVELIKDGNKL----PKLMLLDLSSNKLKKlpLTDLQKLPAWVKngLY 217
Cdd:cd21340   73 LYLGGNRISVVeglenltnleelhienqrlppGEKLTFDPRSLaalsNSLRVLNISGNNIDS--LEPLAPLRNLEQ--LD 148

                        170       180
                 ....*....|....*....|.
gi 560879455 218 LHNNPLECDCKLYQLFSHWQY 238
Cdd:cd21340  149 ASNNQISDLEELLDLLSSWPS 169
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 66-197 2.82e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 2.82e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  66 LDLSHNNLSRLRAEWTPTRL---TNLHSLLLSHNHLNFISSEAFVP----VPNLRYLDLSSNHLHTLD-EFLFSDLQA-- 135
Cdd:COG5238  269 LYLSGNQIGAEGAIALAKALqgnTTLTSLDLSVNRIGDEGAIALAEglqgNKTLHTLNLAYNGIGAQGaIALAKALQEnt 348

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 560879455 136 -LEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLPKLMLLDLSSNKL 197
Cdd:COG5238  349 tLHSLDLSDNQIgdegAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLILDGNLI 415
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 64-198 2.11e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  64 ALLDLSHNNLS----RLRAEWTPTRLTNLHSLLLSHNHLNFISSE----AFVPVPNLRYLDLSSNHLH-----TLDEFLf 130
Cdd:cd00116  111 QELKLNNNGLGdrglRLLAKGLKDLPPALEKLVLGRNRLEGASCEalakALRANRDLKELNLANNGIGdagirALAEGL- 189

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 560879455 131 SDLQALEVLLLYNNHI----VVVDRNAFEDMAQLQKLYLSQNQISRFPVELIKDGNKLP--KLMLLDLSSNKLK 198
Cdd:cd00116  190 KANCNLEVLDLNNNGLtdegASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPniSLLTLSLSCNDIT 263
LRR_8 pfam13855
Leucine rich repeat;
159-223 6.59e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 6.59e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 560879455  159 QLQKLYLSQNQISRFPVELIKDgnkLPKLMLLDLSSNKLKKLPLTDLQKLPAWVKngLYLHNNPL 223
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKG---LSNLKVLDLSNNLLTTLSPGAFSGLPSLRY--LDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
23-214 1.87e-03

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 39.76  E-value: 1.87e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  23 EVARAGRSVVSCPANCLCASN-ILSCSKQQLPNVPQSLPSYTALLDLSHNNLSRLraewtPTRLTNLHSLLLSHNHLnfi 101
Cdd:PRK15387 183 EESRGRAAVVQKMRACLNNGNaVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSL-----PALPPELRTLEVSGNQL--- 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455 102 SSEAFVPvPNLRYLDLSSN---HLHTLDE-----FLFSD-LQALEVLLLYNNHIVVVDrNAFEDM----AQLQKLYLSQN 168
Cdd:PRK15387 255 TSLPVLP-PGLLELSIFSNpltHLPALPSglcklWIFGNqLTSLPVLPPGLQELSVSD-NQLASLpalpSELCKLWAYNN 332

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 560879455 169 QISRFPVelikdgnkLPK-LMLLDLSSNKLKKLPLTDLQKLPAWVKN 214
Cdd:PRK15387 333 QLTSLPT--------LPSgLQELSVSDNQLASLPTLPSELYKLWAYN 371
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-174 5.60e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 5.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 560879455  66 LDLSHNNLSRLRAEwtpTRLTNLHSLLLSHNHLNfiSSEAFVPVPN--------LRYLDLSSNHLHTLDEflFSDLQALE 137
Cdd:cd21340   73 LYLGGNRISVVEGL---ENLTNLEELHIENQRLP--PGEKLTFDPRslaalsnsLRVLNISGNNIDSLEP--LAPLRNLE 145

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 560879455 138 VLLLYNNHIVVVDR--NAFEDMAQLQKLYLSQNQISRFP 174
Cdd:cd21340  146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKP 184
LRRNT smart00013
Leucine rich repeat N-terminal domain;
34-63 9.78e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 33.45  E-value: 9.78e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 560879455    34 CPANCLCASNILSCSKQQLPNVPQSLPSYT 63
Cdd:smart00013   2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDT 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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