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Conserved domains on  [gi|563580255|ref|NP_001274124|]
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Esp6-Esp5 readthrough precursor [Mus musculus]

Protein Classification

ESP36_like domain-containing protein( domain architecture ID 11244303)

ESP36_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ESP pfam16590
Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting ...
 5-97 1.85e-41

Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting peptides that are produced by the male extraorbital lacrimal gland to be secreted into the tear fluid. Other mice including females detect these peptides through receptors in the vomeronasal organ, and the receptors report information on mouse-strain, sex and species. The peptides are short, all carrying an N-terminal signal-peptide to indicate they are for secretion which accounts for much of the common conservation.


:

Pssm-ID: 465187  Cd Length: 91  Bit Score: 133.39  E-value: 1.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580255    5 PVMFFLLTLLLPSMHTDGRVLTQTQNESTKSSNHKKNHKAVLDKTDRQDKgnKQAPEKVFCASIDDQTLVEDLATANQHK 84
Cdd:pfam16590   1 PVMLFLIILLLPSMLTEGRVLTQTQKEPTISADHKTNFKIVLDKTDCQNI--RDALEKVSCASDQDQTLLEDFANANQHK 78

                          90
                  ....*....|...
gi 563580255   85 LILSKNKISQSNC 97
Cdd:pfam16590  79 LNLSKNLTVLSKC 91
 
Name Accession Description Interval E-value
ESP pfam16590
Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting ...
 5-97 1.85e-41

Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting peptides that are produced by the male extraorbital lacrimal gland to be secreted into the tear fluid. Other mice including females detect these peptides through receptors in the vomeronasal organ, and the receptors report information on mouse-strain, sex and species. The peptides are short, all carrying an N-terminal signal-peptide to indicate they are for secretion which accounts for much of the common conservation.


Pssm-ID: 465187  Cd Length: 91  Bit Score: 133.39  E-value: 1.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580255    5 PVMFFLLTLLLPSMHTDGRVLTQTQNESTKSSNHKKNHKAVLDKTDRQDKgnKQAPEKVFCASIDDQTLVEDLATANQHK 84
Cdd:pfam16590   1 PVMLFLIILLLPSMLTEGRVLTQTQKEPTISADHKTNFKIVLDKTDCQNI--RDALEKVSCASDQDQTLLEDFANANQHK 78

                          90
                  ....*....|...
gi 563580255   85 LILSKNKISQSNC 97
Cdd:pfam16590  79 LNLSKNLTVLSKC 91
ESP1_like cd14249
Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones; ESP1 is a peptide pheromone ...
 53-98 3.47e-14

Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones; ESP1 is a peptide pheromone found in male mouse tear fluid, which is recognized by a specific G-protein-coupled receptor in the vomeronasal sensory neurons and affects female mouse sexual receptive behaviour. This small family appears restricted to rodents; the functions of members other than mouse ESP1 have not yet been determined.


Pssm-ID: 271208  Cd Length: 46  Bit Score: 62.44  E-value: 3.47e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 563580255  53 DKGNKQAPEKVFCASIDDQTLVEDLATANQHKLILSKNKISQSNCC 98
Cdd:cd14249    1 EGNIQEALERTLCASGQDQTLNEDQANANQHKLNLSKILTSLSKCC 46
 
Name Accession Description Interval E-value
ESP pfam16590
Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting ...
 5-97 1.85e-41

Exocrine gland-secreting peptide; ESP is a family of largely rodent exocrine gland-secreting peptides that are produced by the male extraorbital lacrimal gland to be secreted into the tear fluid. Other mice including females detect these peptides through receptors in the vomeronasal organ, and the receptors report information on mouse-strain, sex and species. The peptides are short, all carrying an N-terminal signal-peptide to indicate they are for secretion which accounts for much of the common conservation.


Pssm-ID: 465187  Cd Length: 91  Bit Score: 133.39  E-value: 1.85e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 563580255    5 PVMFFLLTLLLPSMHTDGRVLTQTQNESTKSSNHKKNHKAVLDKTDRQDKgnKQAPEKVFCASIDDQTLVEDLATANQHK 84
Cdd:pfam16590   1 PVMLFLIILLLPSMLTEGRVLTQTQKEPTISADHKTNFKIVLDKTDCQNI--RDALEKVSCASDQDQTLLEDFANANQHK 78

                          90
                  ....*....|...
gi 563580255   85 LILSKNKISQSNC 97
Cdd:pfam16590  79 LNLSKNLTVLSKC 91
ESP1_like cd14249
Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones; ESP1 is a peptide pheromone ...
 53-98 3.47e-14

Exocrine gland-secreting peptide 1 (ESP1) and similar pheromones; ESP1 is a peptide pheromone found in male mouse tear fluid, which is recognized by a specific G-protein-coupled receptor in the vomeronasal sensory neurons and affects female mouse sexual receptive behaviour. This small family appears restricted to rodents; the functions of members other than mouse ESP1 have not yet been determined.


Pssm-ID: 271208  Cd Length: 46  Bit Score: 62.44  E-value: 3.47e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 563580255  53 DKGNKQAPEKVFCASIDDQTLVEDLATANQHKLILSKNKISQSNCC 98
Cdd:cd14249    1 EGNIQEALERTLCASGQDQTLNEDQANANQHKLNLSKILTSLSKCC 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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