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Conserved domains on  [gi|575771793|ref|NP_001276556|]
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suppressor of tumorigenicity 7 protein isoform 6 [Mus musculus]

Protein Classification

ST7 domain-containing protein( domain architecture ID 11148215)

ST7 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
4-530 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


:

Pssm-ID: 461214  Cd Length: 532  Bit Score: 949.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793    4 AVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGvdnnssNNSNSSNGDSDSNRQS 83
Cdd:pfam04184  34 AVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHLSPLIGG------GDNASDNGENEENRQS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793   84 VSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEA 163
Cdd:pfam04184 108 VPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFTCDTDSGRPADEIMQKAWRERNPQARIKAAHQA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  164 LEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHR 243
Cdd:pfam04184 188 LEIN----------------------PDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQHLSSNHEAQHR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  244 RDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATI 323
Cdd:pfam04184 246 RDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  324 CYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL 403
Cdd:pfam04184 326 CYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHL 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  404 AHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 483
Cdd:pfam04184 406 QHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 485
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 575771793  484 ALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 530
Cdd:pfam04184 486 ALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
4-530 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 949.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793    4 AVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGvdnnssNNSNSSNGDSDSNRQS 83
Cdd:pfam04184  34 AVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHLSPLIGG------GDNASDNGENEENRQS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793   84 VSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEA 163
Cdd:pfam04184 108 VPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFTCDTDSGRPADEIMQKAWRERNPQARIKAAHQA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  164 LEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHR 243
Cdd:pfam04184 188 LEIN----------------------PDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQHLSSNHEAQHR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  244 RDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATI 323
Cdd:pfam04184 246 RDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  324 CYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL 403
Cdd:pfam04184 326 CYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHL 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  404 AHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 483
Cdd:pfam04184 406 QHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 485
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 575771793  484 ALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 530
Cdd:pfam04184 486 ALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
8-495 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 948.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793   8 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 87
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  88 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 167
Cdd:cd11557   73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 168 eirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTN 247
Cdd:cd11557  153 ----------------------PECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTN 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 248 VLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTA 327
Cdd:cd11557  211 VLVYIKRRLAMCARKLGRLKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 328 ALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWK 407
Cdd:cd11557  291 ALLKARAVADKFSPEVASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWK 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 408 RVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLT 487
Cdd:cd11557  371 RVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLT 450

                 ....*...
gi 575771793 488 HQFPELMG 495
Cdd:cd11557  451 HQFPEPMG 458
 
Name Accession Description Interval E-value
ST7 pfam04184
ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour ...
4-530 0e+00

ST7 protein; The ST7 (for suppression of tumorigenicity 7) protein is thought to be a tumour suppressor gene. The molecular function of this protein is uncertain.


Pssm-ID: 461214  Cd Length: 532  Bit Score: 949.63  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793    4 AVSMFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGvdnnssNNSNSSNGDSDSNRQS 83
Cdd:pfam04184  34 AVTVFLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLNHLSPLIGG------GDNASDNGENEENRQS 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793   84 VSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEA 163
Cdd:pfam04184 108 VPECKVWRNPLNLFRGAEYNRYLWVTGREPLTYYDMNLSAQDHQTFFTCDTDSGRPADEIMQKAWRERNPQARIKAAHQA 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  164 LEINeirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHR 243
Cdd:pfam04184 188 LEIN----------------------PDCATALVLLAEEEAETISDAEKLLRQALKAGESNYRKSQQSQHLSSNHEAQHR 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  244 RDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATI 323
Cdd:pfam04184 246 RDTNVLVYIKRRLAMCARKLGRTKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATI 325
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  324 CYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHL 403
Cdd:pfam04184 326 CYTAALLKARAVCDKFSPESASKRGLSTAEMTAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAVAYAFFHL 405
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  404 AHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 483
Cdd:pfam04184 406 QHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTENADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAML 485
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 575771793  484 ALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTR 530
Cdd:pfam04184 486 ALLTHQFPEPMGAFAKTFLGWLSAPFSFMVEKLESIIPANIWHQLTR 532
ST7 cd11557
Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor ...
8-495 0e+00

Suppression of tumorigenicity 7; ST7 is a metazoan protein that behaves as a tumor suppressor in human cancer cells. It appears to localize to the cytoplasm and plasma membrane, and may mediate tumor suppression by regulating genes that are involved in oncogenic pathways and/or maintain cellular structure. It has been suggested that the suppression of tumorigenicity is associated with a function in mediating the remodeling of the extracellular matrix. However, somatic mutations of ST7 have not been observed as being commonly associated with molecular pathogenesis in various human neoplasias.


Pssm-ID: 211407 [Multi-domain]  Cd Length: 458  Bit Score: 948.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793   8 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSsngdsdsnRQSVSEC 87
Cdd:cd11557    1 FLNTLTPKFYVALTGTSSLISGLILIFEWWYFRKYGTSFIEQVSLSHLSPLLGGVDLSNGGSNSS--------DQSVPEC 72
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793  88 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEIN 167
Cdd:cd11557   73 KVWRNPLNLFRGAEYNRYTWVTGREPLTYYDMNLSAQDHQTFFTCDADAGRPADEIMQKAWRERNPQARIKAAHEALELN 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 168 eirsrvevpliasstiweikllPKCATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTN 247
Cdd:cd11557  153 ----------------------PECATALILLAEEEAQTILEAEKLLKQALKAAEANYRKSQQLQHQDPQHEAVHRRDTN 210
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 248 VLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKSATICYTA 327
Cdd:cd11557  211 VLVYIKRRLAMCARKLGRLKEAVKMMRDLMKEFPLLSVLNIHENLIEALLELQAYADVQAVLAKYDDISLPKSATICYTA 290
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 328 ALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWK 407
Cdd:cd11557  291 ALLKARAVADKFSPEVASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLQHWK 370
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 575771793 408 RVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLT 487
Cdd:cd11557  371 RVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPSCTESADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTALLALLT 450

                 ....*...
gi 575771793 488 HQFPELMG 495
Cdd:cd11557  451 HQFPEPMG 458
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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