|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
7-48 |
4.40e-25 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation. :
Pssm-ID: 460171 Cd Length: 42 Bit Score: 97.93 E-value: 4.40e-25
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 584458454 7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
242-617 |
6.22e-13 |
|
FOG: Zn-finger [General function prediction only]; :
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 71.65 E-value: 6.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048 34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048 354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433
|
410 420
....*....|....*....|....*
gi 584458454 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048 434 LIPHKKIHTNHAPLLCSILKSFRRD 458
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
648-673 |
2.77e-03 |
|
Zinc-finger double domain; :
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 2.77e-03
10 20
....*....|....*....|....*.
gi 584458454 648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| SFP1 super family |
cl25788 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
651-737 |
6.24e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]; The actual alignment was detected with superfamily member COG5189:
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 39.70 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409
|
....*....
gi 584458454 729 QKSNLTCHR 737
Cdd:COG5189 410 NLNGLKYHR 418
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
7-48 |
4.40e-25 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 97.93 E-value: 4.40e-25
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 584458454 7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB |
smart00349 |
krueppel associated box; |
8-48 |
1.47e-24 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 96.89 E-value: 1.47e-24
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 584458454 8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
8-47 |
8.32e-22 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 88.38 E-value: 8.32e-22
10 20 30 40
....*....|....*....|....*....|....*....|
gi 584458454 8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
242-617 |
6.22e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 71.65 E-value: 6.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048 34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048 354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433
|
410 420
....*....|....*....|....*
gi 584458454 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048 434 LIPHKKIHTNHAPLLCSILKSFRRD 458
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
480-505 |
2.38e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 38.89 E-value: 2.38e-04
10 20
....*....|....*....|....*.
gi 584458454 480 NLERHRRIHTGEKPYKCNECGKTFSR 505
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
648-673 |
2.77e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 2.77e-03
10 20
....*....|....*....|....*.
gi 584458454 648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
651-737 |
6.24e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 39.70 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409
|
....*....
gi 584458454 729 QKSNLTCHR 737
Cdd:COG5189 410 NLNGLKYHR 418
|
|
|
|
Name |
Accession |
Description |
Interval |
E-value |
| KRAB |
pfam01352 |
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ... |
7-48 |
4.40e-25 |
|
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.
Pssm-ID: 460171 Cd Length: 42 Bit Score: 97.93 E-value: 4.40e-25
10 20 30 40
....*....|....*....|....*....|....*....|..
gi 584458454 7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352 1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
|
|
| KRAB |
smart00349 |
krueppel associated box; |
8-48 |
1.47e-24 |
|
krueppel associated box;
Pssm-ID: 214630 [Multi-domain] Cd Length: 61 Bit Score: 96.89 E-value: 1.47e-24
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 584458454 8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349 1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
|
|
| KRAB_A-box |
cd07765 |
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ... |
8-47 |
8.32e-22 |
|
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.
Pssm-ID: 143639 Cd Length: 40 Bit Score: 88.38 E-value: 8.32e-22
10 20 30 40
....*....|....*....|....*....|....*....|
gi 584458454 8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765 1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
242-617 |
6.22e-13 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 71.65 E-value: 6.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048 34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048 194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048 274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048 354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433
|
410 420
....*....|....*....|....*
gi 584458454 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048 434 LIPHKKIHTNHAPLLCSILKSFRRD 458
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
324-741 |
5.57e-10 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 62.41 E-value: 5.57e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 324 KPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNECGktfshkssltchhrlhtgekpykcneCGKTFSHKSSLTCHRRL 403
Cdd:COG5048 32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 404 HTGEKPYKCE-ECDKAYSFRSNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCHRRRHTGEQPYKCEEC--DKAFRFKSN 480
Cdd:COG5048 86 HHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSN 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 481 LERHRRIHtgekpykcNECGKTFSRKSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFN 560
Cdd:COG5048 166 SLHPPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 561 QQLTLKRHRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEE-------NPYKCNECGKTFSRTSSLTCHRR--LHTGE 631
Cdd:COG5048 238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 632 --KPYKCEE--CDKAFRVKSNLEGHRRIHTGEKPYKC--NECGKTFSRKSY-----FICHHRLHTGEKPYKC--NECGKN 698
Cdd:COG5048 318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRN 397
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 584458454 699 FSQKSSLICHHRLHTGEKP--YKCNECGKTFSQKSNLTCHRRLHT 741
Cdd:COG5048 398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
379-485 |
3.40e-05 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 47.02 E-value: 3.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 379 EKPYKCNECGKTFSHKSSLTCH---RRLHT-GEKPYKCE--ECDKAYSFRSNFEIHRKiHtednaykcNECGKTFSRTSS 452
Cdd:COG5189 315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPS 385
|
90 100 110
....*....|....*....|....*....|...
gi 584458454 453 LTCHRRRHTGEQPYKCEECDKAFRFKSNLERHR 485
Cdd:COG5189 386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
480-505 |
2.38e-04 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 38.89 E-value: 2.38e-04
10 20
....*....|....*....|....*.
gi 584458454 480 NLERHRRIHTGEKPYKCNECGKTFSR 505
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
337-435 |
3.05e-04 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 43.94 E-value: 3.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 337 QKSILTRHHRLHT-GEKPYKCN--ECGKTFSHKSSLTcHHRLHtGEKPYKCNECGKTFSHKSsltchrrLHTGEKPYKCE 413
Cdd:COG5189 332 ERNIDTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLK-YHMLH-GHQNQKLHENPSPEKMNI-------FSAKDKPYRCE 402
|
90 100
....*....|....*....|..
gi 584458454 414 ECDKAYSFRSNFEIHRKiHTED 435
Cdd:COG5189 403 VCDKRYKNLNGLKYHRK-HSHD 423
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
266-349 |
1.21e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 42.01 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 266 GENPYKCN--ECGKTFSQTSSLTCHRrLHTGEKPYKCEECDKafhfksilERHRIIHTEEKPYKCNECGKTFRQKSILtR 343
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415
|
....*.
gi 584458454 344 HHRLHT 349
Cdd:COG5189 416 YHRKHS 421
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
574-653 |
2.52e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 40.86 E-value: 2.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 574 GENPYKCE--DSDKAYSFKSNLEIHqKIHTEENPykcnecgkTFSRTSSLTCHRRLHTGEKPYKCEECDKAFRVKSNLEG 651
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
..
gi 584458454 652 HR 653
Cdd:COG5189 417 HR 418
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
648-673 |
2.77e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.81 E-value: 2.77e-03
10 20
....*....|....*....|....*.
gi 584458454 648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465 1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
|
|
| COG5048 |
COG5048 |
FOG: Zn-finger [General function prediction only]; |
438-742 |
4.17e-03 |
|
FOG: Zn-finger [General function prediction only];
Pssm-ID: 227381 [Multi-domain] Cd Length: 467 Bit Score: 40.45 E-value: 4.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 438 YKCNECGKTFSRTSSLTCHRRRHTGEQPYKC--EECDKAFRFKSNLERHRRIHTGEKPYKCN-ECGKTFSRKSYLTCHHR 514
Cdd:COG5048 34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 515 LHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKEC-GKTFNQQLTLKRHRRLHSGENpykcedSDKAYSFKSNL 593
Cdd:COG5048 114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLSLL 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 594 EIHQKIHTEENPYKCNECGKTFSRTSSLTcHRRLHTGEKPYKCEECDKAFRVKSNLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 674 KSYFICHHRLHTGE-------KPYKCNECGKNFSQKSSLICH--HRLHTGE--KPYKCNE--CGKTFSQKSNLTCHRRLH 740
Cdd:COG5048 267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346
|
..
gi 584458454 741 TG 742
Cdd:COG5048 347 TS 348
|
|
| zf-H2C2_2 |
pfam13465 |
Zinc-finger double domain; |
341-365 |
5.72e-03 |
|
Zinc-finger double domain;
Pssm-ID: 463886 [Multi-domain] Cd Length: 26 Bit Score: 35.04 E-value: 5.72e-03
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
651-737 |
6.24e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 39.70 E-value: 6.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189 339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409
|
....*....
gi 584458454 729 QKSNLTCHR 737
Cdd:COG5189 410 NLNGLKYHR 418
|
|
| SFP1 |
COG5189 |
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ... |
490-573 |
6.30e-03 |
|
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];
Pssm-ID: 227516 [Multi-domain] Cd Length: 423 Bit Score: 39.70 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458454 490 GEKPYKCN--ECGKTFSRKSYLTcHHRLHtgekaykcNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKR 567
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLK-YHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416
|
....*.
gi 584458454 568 HRRlHS 573
Cdd:COG5189 417 HRK-HS 421
|
|
|