NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|584458460|ref|NP_001276881|]
View 

zinc finger protein 761 isoform a [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.40e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 4.40e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 584458460    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-617 6.22e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 6.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 584458460 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
648-673 2.77e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 584458460  648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 651-737 6.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                 ....*....
gi 584458460 729 QKSNLTCHR 737
Cdd:COG5189  410 NLNGLKYHR 418
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.40e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 4.40e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 584458460    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 1.47e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.47e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 584458460     8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 8.32e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 8.32e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 584458460   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-617 6.22e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 6.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 584458460 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 584458460  480 NLERHRRIHTGEKPYKCNECGKTFSR 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
648-673 2.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 584458460  648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 651-737 6.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                 ....*....
gi 584458460 729 QKSNLTCHR 737
Cdd:COG5189  410 NLNGLKYHR 418
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.40e-25

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 97.93  E-value: 4.40e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 584458460    7 LLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-48 1.47e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 96.89  E-value: 1.47e-24
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 584458460     8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLD 48
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 8.32e-22

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 88.38  E-value: 8.32e-22
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 584458460   8 LTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSL 47
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
242-617 6.22e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 71.65  E-value: 6.22e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 242 YKCDVCGKLFNQKRNLACHRRCHTGENPYKCN--ECGKTFSQTSSLTCHRRLHTGEKPYKCE-ECDKAFHFKSILERHRI 318
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 319 IHTEEKPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNEC----------------------GKTFSHKSSLTCHHRLH 376
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 377 TGEKPYKCNECGKTFSHKSSLTCHRRLHTGEKPYKCEECDKAYSFRSNFEIHRKIHTEDNAYKCNECG------KTFSRT 450
Cdd:COG5048  194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPrsslptASSQSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 451 SSLTCHRRRHTG-EQPYKCEECDKAFRFKSNLERHRR--IHTGE--KPYKCNE--CGKTFSRKSYLTCHHRLHTGEKAYK 523
Cdd:COG5048  274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 524 CNEC-------GKTFSWKSSLTCHRRLHSGEKPYKC--KECGKTFNQQLTLKRHRRLHSGENPYKCEDS--DKAYSFKSN 592
Cdd:COG5048  354 EKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPpcSKSFNRHYN 433

                        410       420
                 ....*....|....*....|....*
gi 584458460 593 LEIHQKIHTEENPYKCNECGKTFSR 617
Cdd:COG5048  434 LIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
324-741 5.57e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 62.41  E-value: 5.57e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 324 KPYKCNECGKTFRQKSILTRHHRLHTGEKPYKCNECGktfshkssltchhrlhtgekpykcneCGKTFSHKSSLTCHRRL 403
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 404 HTGEKPYKCE-ECDKAYSFRSNFEIHRKIHTEDNAYKCNECGKTFSRTSSLTCHRRRHTGEQPYKCEEC--DKAFRFKSN 480
Cdd:COG5048   86 HHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsSSVNTPQSN 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 481 LERHRRIHtgekpykcNECGKTFSRKSYLTCHHRLHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFN 560
Cdd:COG5048  166 SLHPPLPA--------NSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 561 QQLTLKRHRRLHSGENPYKCEDSDKAYSFKSNLEIHQKIHTEE-------NPYKCNECGKTFSRTSSLTCHRR--LHTGE 631
Cdd:COG5048  238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 632 --KPYKCEE--CDKAFRVKSNLEGHRRIHTGEKPYKC--NECGKTFSRKSY-----FICHHRLHTGEKPYKC--NECGKN 698
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRN 397

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*
gi 584458460 699 FSQKSSLICHHRLHTGEKP--YKCNECGKTFSQKSNLTCHRRLHT 741
Cdd:COG5048  398 FKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 379-485 3.40e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 3.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 379 EKPYKCNECGKTFSHKSSLTCH---RRLHT-GEKPYKCE--ECDKAYSFRSNFEIHRKiHtednaykcNECGKTFSRTSS 452
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYKNQNGLKYHML-H--------GHQNQKLHENPS 385

                         90       100       110
                 ....*....|....*....|....*....|...
gi 584458460 453 LTCHRRRHTGEQPYKCEECDKAFRFKSNLERHR 485
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
480-505 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*.
gi 584458460  480 NLERHRRIHTGEKPYKCNECGKTFSR 505
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 337-435 3.05e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 3.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 337 QKSILTRHHRLHT-GEKPYKCN--ECGKTFSHKSSLTcHHRLHtGEKPYKCNECGKTFSHKSsltchrrLHTGEKPYKCE 413
Cdd:COG5189  332 ERNIDTPSRMLKVkDGKPYKCPveGCNKKYKNQNGLK-YHMLH-GHQNQKLHENPSPEKMNI-------FSAKDKPYRCE 402

                         90       100
                 ....*....|....*....|..
gi 584458460 414 ECDKAYSFRSNFEIHRKiHTED 435
Cdd:COG5189  403 VCDKRYKNLNGLKYHRK-HSHD 423
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 266-349 1.21e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 266 GENPYKCN--ECGKTFSQTSSLTCHRrLHTGEKPYKCEECDKafhfksilERHRIIHTEEKPYKCNECGKTFRQKSILtR 343
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGL-K 415


                 ....*.
gi 584458460 344 HHRLHT 349
Cdd:COG5189  416 YHRKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 574-653 2.52e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 574 GENPYKCE--DSDKAYSFKSNLEIHqKIHTEENPykcnecgkTFSRTSSLTCHRRLHTGEKPYKCEECDKAFRVKSNLEG 651
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYH-MLHGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 584458460 652 HR 653
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
648-673 2.77e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.77e-03
                          10        20
                  ....*....|....*....|....*.
gi 584458460  648 NLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
438-742 4.17e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 4.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 438 YKCNECGKTFSRTSSLTCHRRRHTGEQPYKC--EECDKAFRFKSNLERHRRIHTGEKPYKCN-ECGKTFSRKSYLTCHHR 514
Cdd:COG5048   34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSS 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 515 LHTGEKAYKCNECGKTFSWKSSLTCHRRLHSGEKPYKCKEC-GKTFNQQLTLKRHRRLHSGENpykcedSDKAYSFKSNL 593
Cdd:COG5048  114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSL------SKDPSSNLSLL 187

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 594 EIHQKIHTEENPYKCNECGKTFSRTSSLTcHRRLHTGEKPYKCEECDKAFRVKSNLEGHRRIHTGEKPYKCNECGKTFSR 673
Cdd:COG5048  188 ISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 674 KSYFICHHRLHTGE-------KPYKCNECGKNFSQKSSLICH--HRLHTGE--KPYKCNE--CGKTFSQKSNLTCHRRLH 740
Cdd:COG5048  267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346


                 ..
gi 584458460 741 TG 742
Cdd:COG5048  347 TS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-365 5.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.72e-03
                          10        20
                  ....*....|....*....|....*
gi 584458460  341 LTRHHRLHTGEKPYKCNECGKTFSH 365
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 651-737 6.24e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 651 GHRRIHTGEKPYKCN--ECGKTFsRKSYFICHHRLHtgekpykcNECGKNFSQKSSLICHHRLHTGEKPYKCNECGKTFS 728
Cdd:COG5189  339 SRMLKVKDGKPYKCPveGCNKKY-KNQNGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYK 409


                 ....*....
gi 584458460 729 QKSNLTCHR 737
Cdd:COG5189  410 NLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 490-573 6.30e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 6.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584458460 490 GEKPYKCN--ECGKTFSRKSYLTcHHRLHtgekaykcNECGKTFSWKSSLTCHRRLHSGEKPYKCKECGKTFNQQLTLKR 567
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLK-YHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 584458460 568 HRRlHS 573
Cdd:COG5189  417 HRK-HS 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH