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Conserved domains on  [gi|588282751|ref|NP_001277047|]
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mitochondrial import inner membrane translocase subunit Tim23B isoform 2 [Homo sapiens]

Protein Classification

Tim17/Tim22/Tim23/Pmp24 domain-containing protein( domain architecture ID 1013)

Tim17/Tim22/Tim23/Pmp24 domain-containing protein similar to Homo sapiens NADH:ubiquinone oxidoreductase subunit A11 and translocase of inner mitochondrial membrane 17B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIM22 super family cl02381
Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, ...
 46-123 6.22e-25

Mitochondrial import inner membrane translocase, subunit TIM22 [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member TIGR00983:

Pssm-ID: 470560  Cd Length: 149  Bit Score: 92.59  E-value: 6.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282751   46 LNVDPRYLVQDTDEFILPTGANKTWGRFELAFFTIGGCCMT--------------------------------------- 86
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTglaigalnglrlglketqsmpwtklrlnqilnmvtrrgp 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 588282751   87 ---------ALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCT 123
Cdd:TIGR00983  84 fwgntlgilALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKST 129
 
Name Accession Description Interval E-value
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 46-123 6.22e-25

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 92.59  E-value: 6.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282751   46 LNVDPRYLVQDTDEFILPTGANKTWGRFELAFFTIGGCCMT--------------------------------------- 86
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTglaigalnglrlglketqsmpwtklrlnqilnmvtrrgp 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 588282751   87 ---------ALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCT 123
Cdd:TIGR00983  84 fwgntlgilALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKST 129
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 87-121 5.45e-06

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 42.54  E-value: 5.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 588282751   87 ALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYK 121
Cdd:pfam02466  60 GGLYSGIECGLEKYRGKEDPWNSIAAGALTGALLR 94
 
Name Accession Description Interval E-value
3a0801s02tim23 TIGR00983
mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, ...
 46-123 6.22e-25

mitochondrial import inner membrane translocase subunit tim23; [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130056  Cd Length: 149  Bit Score: 92.59  E-value: 6.22e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 588282751   46 LNVDPRYLVQDTDEFILPTGANKTWGRFELAFFTIGGCCMT--------------------------------------- 86
Cdd:TIGR00983   4 LDKDPEYLVQEEDELSLLTGANPSRGWFEDLCFGTGTCYLTglaigalnglrlglketqsmpwtklrlnqilnmvtrrgp 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 588282751   87 ---------ALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCT 123
Cdd:TIGR00983  84 fwgntlgilALVYNGINSIIEATRGKHDDFNSVAAGALTGALYKST 129
Tim17 pfam02466
Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer ...
 87-121 5.45e-06

Tim17/Tim22/Tim23/Pmp24 family; The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA).


Pssm-ID: 460567  Cd Length: 109  Bit Score: 42.54  E-value: 5.45e-06
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 588282751   87 ALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYK 121
Cdd:pfam02466  60 GGLYSGIECGLEKYRGKEDPWNSIAAGALTGALLR 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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