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Conserved domains on  [gi|1867163816|ref|NP_001277141|]
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tetraspanin-10 isoform a [Homo sapiens]

Protein Classification

tetraspanin family protein( domain architecture ID 13626529)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 172-291 4.74e-75

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


:

Pssm-ID: 239420  Cd Length: 120  Bit Score: 227.34  E-value: 4.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 172 VALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 251
Cdd:cd03167     1 VALWGPLQDGLEHTLRLAIAHYQDDPDLRFLIDQVQLGLQCCGASSYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1867163816 252 ASVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03167    81 AVVNDQCGFGALGLDEDAAQRVVHLGGCGPPLRRWLRGNL 120
Tetraspanin pfam00335
Tetraspanin family;
76-226 9.15e-21

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 88.14  E-value: 9.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816  76 VKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPADPMLGLALGGlVVSAVSLAGYLGALCENTCLLRGFSG 155
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGA-VIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1867163816 156 GILAFLVLEAVAGALVVALWGPLQDSLEHTLRVAI-AHYQDDPDLR----FLLDQVQLGLRCCG---AASYQDWQQNLY 226
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLYsclnSALDSLQSEFGCCGgckEKLLEWLRKNLK 158
 
Name Accession Description Interval E-value
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 172-291 4.74e-75

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 227.34  E-value: 4.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 172 VALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 251
Cdd:cd03167     1 VALWGPLQDGLEHTLRLAIAHYQDDPDLRFLIDQVQLGLQCCGASSYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1867163816 252 ASVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03167    81 AVVNDQCGFGALGLDEDAAQRVVHLGGCGPPLRRWLRGNL 120
Tetraspanin pfam00335
Tetraspanin family;
76-226 9.15e-21

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 88.14  E-value: 9.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816  76 VKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPADPMLGLALGGlVVSAVSLAGYLGALCENTCLLRGFSG 155
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGA-VIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1867163816 156 GILAFLVLEAVAGALVVALWGPLQDSLEHTLRVAI-AHYQDDPDLR----FLLDQVQLGLRCCG---AASYQDWQQNLY 226
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLYsclnSALDSLQSEFGCCGgckEKLLEWLRKNLK 158
 
Name Accession Description Interval E-value
oculospanin_like_LEL cd03167
Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. ...
 172-291 4.74e-75

Tetraspanin, extracellular domain or large extracellular loop (LEL), oculospanin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contains sequences similar to oculospanin, which is found to be expressed in retinal pigment epithelium, iris, ciliary body, and retinal ganglion cells.


Pssm-ID: 239420  Cd Length: 120  Bit Score: 227.34  E-value: 4.74e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 172 VALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 251
Cdd:cd03167     1 VALWGPLQDGLEHTLRLAIAHYQDDPDLRFLIDQVQLGLQCCGASSYQDWQQNLYFNCSSPGVQACSLPASCCIDPREDG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1867163816 252 ASVNDQCGFGVLRLDADAAQRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03167    81 AVVNDQCGFGALGLDEDAAQRVVHLGGCGPPLRRWLRGNL 120
penumbra_like_LEL cd03158
Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. ...
 179-291 2.12e-37

Tetraspanin, extracellular domain or large extracellular loop (LEL), penumbra_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Human Penumbra exhibits growth-suppressive activity in vitro and has been associated with myeloid malignancies.


Pssm-ID: 239411  Cd Length: 119  Bit Score: 130.50  E-value: 2.12e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 179 QDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQACSLPASCCIdPREDGASVNDQC 258
Cdd:cd03158     8 IDLLEENIRKAIVHYYDDLDLQNIIDFVQKEFKCCGGDDYRDWSKNMYFNCSSPNPEACGVPYSCCI-RAKDQEVINTMC 86

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1867163816 259 GFGVLRLDADAAQRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03158    87 GYGVQNLERLEASKLIYTRGCIDAVVLWIEDNL 119
TM4SF9_like_LEL cd03159
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. ...
 190-291 2.06e-24

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF9_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 9 (TM4SF9) or Tetraspanin-5 and related proteins. TM4SF9 is strongly expressed witin the central nervous system, and expression levels appear to correlate with differentiation status of particular neurons, hinting at a role in neuronal maturation.


Pssm-ID: 239412 [Multi-domain]  Cd Length: 121  Bit Score: 96.34  E-value: 2.06e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 190 IAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCS--SPGVQACSLPASCCI-DPREDgaSVNDQCGFGVLRLD 266
Cdd:cd03159    19 IRAYRDDIDLQNLIDFLQEYWQCCGARGPDDWNLNIYFNCTdsNPSRERCGVPFSCCVkDPAED--VVNTQCGYDVRKKP 96

                          90       100
                  ....*....|....*....|....*
gi 1867163816 267 ADAAQRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03159    97 ELELQHHIHTKGCVQAFEKWLQDNL 121
Tetraspanin pfam00335
Tetraspanin family;
76-226 9.15e-21

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 88.14  E-value: 9.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816  76 VKYLIFLSNFPFSLLGLLALAIGLWGLAVKGSLGSDLGGPLPADPMLGLALGGlVVSAVSLAGYLGALCENTCLLRGFSG 155
Cdd:pfam00335   1 LKYLLFLFNLLFWLLGLLLLGVGVWLLSAFSLLLLGLSEASAYIPILLIVLGA-VIFLVGFLGCCGALKENRCLLLTYFV 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1867163816 156 GILAFLVLEAVAGALVVALWGPLQDSLEHTLRVAI-AHYQDDPDLR----FLLDQVQLGLRCCG---AASYQDWQQNLY 226
Cdd:pfam00335  80 LLLLLFLAELAAGILAFVYRDKLSGLLSNWLKKSLeDGYRDWLDLYsclnSALDSLQSEFGCCGgckEKLLEWLRKNLK 158
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 173-291 1.26e-15

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.38  E-value: 1.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 173 ALWGPLQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNlyfncsspgvqACSLPASCCIDPredga 252
Cdd:cd03127     2 VYRDQLESLVSDTLNDAWDEYYVDDDFQEAMDALQSTFECCGVNGPTDYLDL-----------RLLVPSSCCKGT----- 65

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1867163816 253 svNDQCGfgvlrldadaaqRVVYLEGCGPPLRRWLRANL 291
Cdd:cd03127    66 --DGNCG------------LNLYTEGCLEKLVDFLRSNL 90
CD63_LEL cd03166
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins ...
 182-291 6.47e-14

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD63 family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD63 is present in platelets, neutrophils, and endothelial cells, amongst others. In platelets it associates with the integrin alphaIIBbeta3 and may modulate alphaIIbbeta3-dependent cytoskeletal reorganization.


Pssm-ID: 239419  Cd Length: 99  Bit Score: 66.73  E-value: 6.47e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 182 LEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQnlyfncsSPGVQACSLPASCCIdpredgaSVNDQCGfg 261
Cdd:cd03166    11 FNDSFNQMISNYNKTNDFRKILDRMQKDLKCCGANNYTDWEN-------IPSLDTDSVPDSCCI-------NVTKGCG-- 74

                          90       100       110
                  ....*....|....*....|....*....|
gi 1867163816 262 vlrLDADAAqrVVYLEGCGPPLRRWLRANL 291
Cdd:cd03166    75 ---INFDEK--VIHLEGCVTKIEGWLKKNI 99
TM4SF2_6_like_LEL cd03161
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. ...
 178-279 4.22e-12

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF2_6_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 2 (TM4SF2) or Tspan-7, transmembrane 4 superfamily 6 (TM4SF6) or Tspan-6, and related proteins. TM4SF2 has been identified as involved in some forms of X-linked mental retardation.


Pssm-ID: 239414  Cd Length: 104  Bit Score: 61.99  E-value: 4.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 178 LQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSspgvqacSLPASCCIDPRedGASVNDq 257
Cdd:cd03161     7 IKGTFLRTYNEAVSNYNGDDERSDAVDTVQRTLHCCGVENYTDWLNSPYFLEK-------GIPLSCCKNRS--DCSPQD- 76

                          90       100
                  ....*....|....*....|..
gi 1867163816 258 cgfgvLRlDADAAQRVVYLEGC 279
Cdd:cd03161    77 -----LK-NLTKAATKVYQQGC 92
CD151_like_LEL cd03155
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. ...
 178-256 4.50e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD151_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD151strongly associates with integrins, especially alpha3beta1, alpha6beta1, alpha7beta1, and alpha6beta4; it may play roles in cell-cell adhesion, cell migration, platelet aggregation, and angiogenesis. For example, CD151 is is involved in regulation of migration of neutrophils, endothelial cells, and various tumor cell lines; it associates specifically with laminin-binding integrins and strengthens alpha6beta1 integrin-mediated adhesion to laminin-1; CD151 also specifically attenuates adhesion-dependent activation of Ras and correspdonding downstream effects, and is involved in epithelial cell-cell adhesion as a modulator of PKC- and Cdc42-dependent actin cytoskeletal reorganization.


Pssm-ID: 239408 [Multi-domain]  Cd Length: 110  Bit Score: 53.51  E-value: 4.50e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 178 LQDSLEHTLRVAIAHY--QD-DPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVQAcsLPASCCIDPREDGASV 254
Cdd:cd03155     7 LEDELKESLKRTMQENygQSgEEALTLTVDELQQEFKCCGSNNYTDWQDSEWINSNEANGRL--VPDSCCKTVVDRCGCL 84


                  ..
gi 1867163816 255 ND 256
Cdd:cd03155    85 RD 86
uroplakin_I_like_LEL cd03156
Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. ...
 192-288 9.73e-09

Tetraspanin, extracellular domain or large extracellular loop (LEL), uroplakin_I_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Uroplakin Ia and Ib are components of the 16nm protein particles, which are packed hexagonally to form 2D crystals of asymmetric unit membranes, and cover the apical surface of mammalian urothelium, contributing to the urinay bladder's permeability barrier function. Uroplakins Ia and Ib are maturation facilitators. They trigger conformational changes in their single-transmembrane-domain binding partner proteins uroplakin II and IIIa, which in turn may lead to ER-exit, stabilization, and cell-surface expression.


Pssm-ID: 239409  Cd Length: 114  Bit Score: 52.92  E-value: 9.73e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 192 HYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNLYFNCSSPGVqACSLPASCCIDpredgaSVNDQCGFGVLRLDADAAQ 271
Cdd:cd03156    24 YNSTGDAITSTWNRVMIELKCCGVNGPTDFVDSTSFFRQKNEP-NSPYPESCCKR------NSNSQIVDLDCPKLGSPNS 96

                          90
                  ....*....|....*..
gi 1867163816 272 RvvYLEGCGPPLRRWLR 288
Cdd:cd03156    97 Y--NKKGCYEKLSNPIE 111
peripherin_like_LEL cd03162
Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. ...
 173-244 9.10e-07

Tetraspanin, extracellular domain or large extracellular loop (LEL), peripherin_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". Peripherin, or RDS (retinal degradation slow) is a glycoprotein expressed in vertebrate photoreceptors, located at the rim of the disc membranes of the photoreceptor outer segments. RDS is thought to play a major role in folding and stacking of the discs. Mutations in RDS have been linked to hereditary retinal dystrophies, which typically exhibit a wide phenotypic spectrum.


Pssm-ID: 239415  Cd Length: 143  Bit Score: 47.81  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 173 ALWGPLQDSLEHTLRVAIAHYQDD--PDLRFL---LDQVQLGLRCCGAASYQDWQQ-----NLYFNCSSPGVQAC----- 237
Cdd:cd03162     2 IMRGSLEESLKTGLKNAMKFYKDTdtPGRCFLkktIDMLQIEFQCCGNNGYRDWFEiqwisNRYLDFSSKEVKDRiksnv 81

                          90
                  ....*....|....
gi 1867163816 238 -------SLPASCC 244
Cdd:cd03162    82 dgryltdGVPFSCC 95
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 204-291 3.04e-06

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 45.84  E-value: 3.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 204 DQVQLGLRCCGAASYQDWQQN-LYFNCSSPGVqacslPASCCIDPREDGASV--NDQCgfgvlrlDADAAQR-VVYLEGC 279
Cdd:cd03160    37 DYVQFQLQCCGWTGPQDWTDNsLIKNSSEPLY-----PCSCCNSSATADSPRpsKGFC-------EAPASLDwPVYQEGC 104

                          90
                  ....*....|..
gi 1867163816 280 GPPLRRWLRANL 291
Cdd:cd03160   105 MEKLQSWLNENL 116
NET-5_like_LEL cd03165
Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. ...
 204-291 1.06e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), NET-5_like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This sub-family contains proteins similar to human tetraspan NET-5.


Pssm-ID: 239418 [Multi-domain]  Cd Length: 98  Bit Score: 43.51  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 204 DQVQLGLRCCGAASYQDWQQNLYFNcsspgvqacSLPASCCIDPREDgasvndqCGfgvlRLDADaaqrVVYLEGCGPPL 283
Cdd:cd03165    35 DITQTEFRCCGVTNYTDWYEVLGEN---------RVPDSCCQEDSQD-------CG----RNPTE----LWWKTGCYEKV 90


                  ....*...
gi 1867163816 284 RRWLRANL 291
Cdd:cd03165    91 QQWLVDNL 98
TM4SF8_like_LEL cd03163
Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. ...
 204-288 2.37e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), TM4SF8_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". This subfamily contaions transmembrane 4 superfamily 8 (TM4SF8) or Tspan-3 and related proteins. Tspan-3 has been reported to form a complex with integrin beta1 and OSP/claudin-11, which may be involved in oligodendrocyte proliferation and migration.


Pssm-ID: 239416  Cd Length: 105  Bit Score: 42.80  E-value: 2.37e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 204 DQVQLGLRCCGAASYQDWQQNLYFNCSSPGvqacSLPASCCidpREDGASVNdqcgfGVLRLDADaaqrvVYLEGCGPPL 283
Cdd:cd03163    34 DYLQRQLQCCGIHNYTDWENTPWFKESKNN----SVPLSCC---KETFTSCT-----GSLTQPKD-----LYQEGCEAKL 96


                  ....*
gi 1867163816 284 RRWLR 288
Cdd:cd03163    97 VKKLQ 101
CD53_like_LEL cd03164
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ...
 178-295 2.58e-05

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway.


Pssm-ID: 239417 [Multi-domain]  Cd Length: 86  Bit Score: 42.08  E-value: 2.58e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1867163816 178 LQDSLEHTLRVAIAHYQDDPDLRFLLDQVQLGLRCCGAASYQDWQQNlyfncsspgvqacsLPASCCIDPREdgasvndq 257
Cdd:cd03164     7 LNNYVKEGLTDSLEQYHKDNNTSEAWDMIQSNLQCCGINGTTDWGSG--------------VPSSCCSSDTE-------- 64

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1867163816 258 cgfgvlrldadaaqrvVYLEGCGPPLRRWLRANLAASG 295
Cdd:cd03164    65 ----------------YKVEGCYKKLKNWFESNFLYTG 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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