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Conserved domains on  [gi|594542548|ref|NP_001277450|]
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WD repeat-containing protein 31 isoform 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 7.93e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 7.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 127 VLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594542548 287 LPKSTalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 7.93e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 7.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 127 VLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594542548 287 LPKSTalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-344 1.72e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 1.72e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  61 HVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQgSSHPR 139
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRG 219
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 220 LQMAHMFPTKQHIQTHCEVSVDGHTCISCSSgfggeGCEATLWDLRqTRDRMCEYKGHFQTVASCVFLPKSTalmpMIAT 299
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGY----LLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 594542548 300 SAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDISSLLCASF 344
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-331 1.18e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 159 SQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT-SEDKTIRLWD-SRGLQMAHMfPTKQHIqthC 236
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 237 EVSVDGHTCISCSsgFGGEGCEATLWDLRQTRDRMCEYKGHFQTVASCVFLPKSTalmpmIATSAHDSKVKIWNqdtgac 316
Cdd:PLN00181 622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSST-----LVSSSTDNTLKLWD------ 688

                        170
                 ....*....|....*....
gi 594542548 317 lstLSLDGSG----PLTSL 331
Cdd:PLN00181 689 ---LSMSISGinetPLHSF 704
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 1.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 594542548   135 SSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
138-174 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 594542548  138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 7.93e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 161.62  E-value: 7.93e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319  106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 127 VLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:COG2319  186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVF 286
Cdd:COG2319  265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS-----GSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAF 338

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 594542548 287 LPKSTalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  339 SPDGK----TLASGSDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFsPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
48-354 1.37e-43

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.45  E-value: 1.37e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIATLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTV 127
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 128 LMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTS 207
Cdd:COG2319  145 RLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 208 EDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVFL 287
Cdd:COG2319  224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS-----GSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFS 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 594542548 288 PKSTalmpMIATSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAVG-DISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  298 PDGK----LLASGSDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSpDGKTLASGSDDGTVRLWDLA 360
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-344 1.72e-43

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 152.10  E-value: 1.72e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  61 HVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQgSSHPR 139
Cdd:cd00200    8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRG 219
Cdd:cd00200   87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 220 LQMAHMFPTKQHIQTHCEVSVDGHTCISCSSgfggeGCEATLWDLRqTRDRMCEYKGHFQTVASCVFLPKSTalmpMIAT 299
Cdd:cd00200  167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS-----DGTIKLWDLS-TGKCLGTLRGHENGVNSVAFSPDGY----LLAS 236

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 594542548 300 SAHDSKVKIWNQDTGACLSTLSLdGSGPLTSLAV-GDISSLLCASF 344
Cdd:cd00200  237 GSEDGTIRVWDLRTGECVQTLSG-HTNSVTSLAWsPDGKRLASGSA 281
WD40 COG2319
WD40 repeat [General function prediction only];
77-313 2.75e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 2.75e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  77 ISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMVVTGLAVSP 156
Cdd:COG2319  178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSP 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 157 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHC 236
Cdd:COG2319  257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 594542548 237 EVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVFLPKSTalmpMIATSAHDSKVKIWNQDT 313
Cdd:COG2319  337 AFSPDGKTLAS-----GSDDGTVRLWDL-ATGELLRTLTGHTGAVTSVAFSPDGR----TLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
59-354 2.40e-39

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 144.28  E-value: 2.40e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  59 PVHVDTVSVIATLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGsSHP 138
Cdd:COG2319   34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLAT-GLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 139 RQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 219 GLQMAHMFPTKQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVFLPKSTalmpMIA 298
Cdd:COG2319  193 TGKLLRTLTGHTGAVRSVAFSPDGKLLAS-----GSADGTVRLWDL-ATGKLLRTLTGHSGSVRSVAFSPDGR----LLA 262

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 594542548 299 TSAHDSKVKIWNQDTGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  263 SGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFsPDGKLLASGSDDGTVRLWDLA 318
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-310 2.94e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.24  E-value: 2.94e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:cd00200   37 DLETGELLRTLKGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 127 VLMWDLQGSShPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:cd00200  117 IKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCISCSsgfggEGCEATLWDLRqTRDRMCEYKGHFQTVASCVF 286
Cdd:cd00200  196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS-----EDGTIRVWDLR-TGECVQTLSGHTNSVTSLAW 269

                        250       260
                 ....*....|....*....|....
gi 594542548 287 LPKSTALmpmiATSAHDSKVKIWN 310
Cdd:cd00200  270 SPDGKRL----ASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-343 2.73e-34

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.84  E-value: 2.73e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  95 MVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSSHPRqQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 175 VGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTcISCSSgfgG 254
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTF-VASSS---Q 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 255 EGCeATLWDLRQTRdRMCEYKGHFQTVASCVFLPKSTalmpMIATSAHDSKVKIWNQDTGACLSTLSLDgSGPLTSLAVG 334
Cdd:cd00200  156 DGT-IKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGE----KLLSSSSDGTIKLWDLSTGKCLGTLRGH-ENGVNSVAFS 228


                 ....*....
gi 594542548 335 DISSLLCAS 343
Cdd:cd00200  229 PDGYLLASG 237
WD40 COG2319
WD40 repeat [General function prediction only];
69-357 4.99e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 110.39  E-value: 4.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  69 ATLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMV 148
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGA-LLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 149 VTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPT 228
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 229 KQHIQTHCEVSVDGHTCIScssgfGGEGCEATLWDLRqTRDRMCEYKGHFQTVASCVFLPKSTalmpMIATSAHDSKVKI 308
Cdd:COG2319  161 HSGAVTSVAFSPDGKLLAS-----GSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGK----LLASGSADGTVRL 230

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 594542548 309 WNQDTGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVDHSQ 357
Cdd:COG2319  231 WDLATGKLLRTLT-GHSGSVRSVAFsPDGRLLASGSADGTVRLWDLATGE 279
WD40 COG2319
WD40 repeat [General function prediction only];
48-177 4.03e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.52  E-value: 4.03e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319  274 DLATGELLRTLTGHSGGVNSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 594542548 127 VLMWDLQGSShPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGT 177
Cdd:COG2319  354 VRLWDLATGE-LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
153-354 1.77e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 68.01  E-value: 1.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 153 AVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHI 232
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 233 QTHCEVSVDGHTCIScssgfGGEGCEATLWDLrQTRDRMCEYKGHFQTVASCVFLPKSTalmpMIATSAHDSKVKIWNQD 312
Cdd:COG2319   81 VLSVAFSPDGRLLAS-----ASADGTVRLWDL-ATGLLLRTLTGHTGAVRSVAFSPDGK----TLASGSADGTVRLWDLA 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 594542548 313 TGACLSTLSlDGSGPLTSLAV-GDISSLLCASFYRGVHLLRVD 354
Cdd:COG2319  151 TGKLLRTLT-GHSGAVTSVAFsPDGKLLASGSDDGTVRLWDLA 192
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 159-331 1.18e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.47  E-value: 1.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 159 SQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT-SEDKTIRLWD-SRGLQMAHMfPTKQHIqthC 236
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASgSDDGSVKLWSiNQGVSIGTI-KTKANI---C 621

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 237 EVSVDGHTCISCSsgFGGEGCEATLWDLRQTRDRMCEYKGHFQTVASCVFLPKSTalmpmIATSAHDSKVKIWNqdtgac 316
Cdd:PLN00181 622 CVQFPSESGRSLA--FGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSST-----LVSSSTDNTLKLWD------ 688

                        170
                 ....*....|....*....
gi 594542548 317 lstLSLDGSG----PLTSL 331
Cdd:PLN00181 689 ---LSMSISGinetPLHSF 704
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 1.20e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.20e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 594542548   135 SSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 101-218 3.15e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 3.15e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 101 GHEREITKIACIPKANQ-FFSASRDKTVLMWDL------QGSSHPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLLL 172
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 594542548 173 WDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
PTZ00421 PTZ00421
coronin; Provisional
 101-221 1.06e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 47.20  E-value: 1.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 594542548 101 GHEREITKIACIPKANQFF-SASRDKTVLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQ 179
Cdd:PTZ00421 123 GHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 594542548 180 CVERASVSRNLVTHLC-WVPSEPYIV----QTSEDKTIRLWDSRGLQ 221
Cdd:PTZ00421 202 IVSSVEAHASAKSQRClWAKRKDLIItlgcSKSQQRQIMLWDTRKMA 248
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 1.09e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.09e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 594542548    92 TGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWD 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
138-174 1.19e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.19e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 594542548  138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
93-131 1.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 594542548   93 GRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWD 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-216 3.68e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.68e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 594542548   177 TGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWD 216
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 140-196 3.74e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 41.98  E-value: 3.74e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 594542548  140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERAsvSRNLVTHLCW 196
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEFPR 172
WD40 pfam00400
WD domain, G-beta repeat;
178-216 4.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 4.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 594542548  178 GQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWD 216
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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