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Conserved domains on  [gi|602152744|ref|NP_001278201|]
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small ribosomal subunit protein mS23 isoform b [Mus musculus]

Protein Classification

mS23 family ribosomal protein( domain architecture ID 10564645)

mS23 family ribosomal protein such as mammalian mitochondrial 28S ribosomal protein MRPS23

Gene Ontology:  GO:0003735|GO:0006412
PubMed:  24524803

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 1-111 2.29e-54

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


:

Pssm-ID: 463108  Cd Length: 128  Bit Score: 167.44  E-value: 2.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744    1 MRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYGSGQKAFDLFNPNFKSTCQ 78
Cdd:pfam10484  19 LRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYGNGPRAFNLLDPNFKSTCQ 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 602152744   79 RFVEKYTELQNLGETDEEKLFVETGKALLAEGI 111
Cdd:pfam10484  96 RFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 1-111 2.29e-54

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 167.44  E-value: 2.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744    1 MRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYGSGQKAFDLFNPNFKSTCQ 78
Cdd:pfam10484  19 LRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYGNGPRAFNLLDPNFKSTCQ 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 602152744   79 RFVEKYTELQNLGETDEEKLFVETGKALLAEGI 111
Cdd:pfam10484  96 RFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 1-88 7.19e-15

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 65.71  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744   1 MRAGVlKEKPLWYDIYKAFPPLREPVFRRPRlrygkakadIQDIFYQEDQIRAKFFATYGsgqkafdlfNPNFKSTCQRF 80
Cdd:cd23701   11 LRGGV-IEKPLWLDAVERFPPPTPPRRNLGK---------PPKITYPEDRLRKKFYKKHP---------EEAYDVAEQEF 71


                 ....*...
gi 602152744  81 VEKYTELQ 88
Cdd:cd23701   72 YEERQELE 79
 
Name Accession Description Interval E-value
MRP-S23 pfam10484
Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ...
 1-111 2.29e-54

Mitochondrial ribosomal protein S23; MRP-S23 is one of the proteins that makes up the 55S ribosome in eukaryotes from nematodes to humans. It does not appear to carry any common motifs, either RNA binding or ribosomal protein motifs. All of the mammalian MRPs are encoded in nuclear genes that are evolving more rapidly than those encoding cytoplasmic ribosomal proteins. The MRPs are imported into mitochondria where they assemble coordinately with mitochondrially transcribed rRNAs into ribosomes that are responsible for translating the 13 mRNAs for essential proteins of the oxidative phosphorylation system. MRP-S23 is significantly up-regulated in uterine cancer cells.


Pssm-ID: 463108  Cd Length: 128  Bit Score: 167.44  E-value: 2.29e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744    1 MRAGVLK--EKPLWYDIYKAFPPLREPVFRRPRLRYgkaKADIQDIFYQEDQIRAKFFATYGSGQKAFDLFNPNFKSTCQ 78
Cdd:pfam10484  19 LRSGVLKeeEKPLWYDVYEAFPPKREPLYNRPAPRI---EDPVREIFYEEDVIRAKFYKVYGNGPRAFNLLDPNFKSTCQ 95

                          90       100       110
                  ....*....|....*....|....*....|...
gi 602152744   79 RFVEKYTELQNLGETDEEKLFVETGKALLAEGI 111
Cdd:pfam10484  96 RFVEKYQELKKQGELDEEELFEETEKALLEEGI 128
At1g26750 cd23701
Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a ...
 1-88 7.19e-15

Arabidopsis thaliana At1g26750 and similar proteins; At1g26750, also known as mS23, is a component of the small subunit (SSU) in RNA-rich Arabidopsis thaliana mitochondrial ribosome.


Pssm-ID: 467914  Cd Length: 83  Bit Score: 65.71  E-value: 7.19e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744   1 MRAGVlKEKPLWYDIYKAFPPLREPVFRRPRlrygkakadIQDIFYQEDQIRAKFFATYGsgqkafdlfNPNFKSTCQRF 80
Cdd:cd23701   11 LRGGV-IEKPLWLDAVERFPPPTPPRRNLGK---------PPKITYPEDRLRKKFYKKHP---------EEAYDVAEQEF 71


                 ....*...
gi 602152744  81 VEKYTELQ 88
Cdd:cd23701   72 YEERQELE 79
MRP-S25 pfam13741
Mitochondrial ribosomal protein S25; This is the family of fungal 37S mitochondrial ribosomal ...
 1-71 4.70e-06

Mitochondrial ribosomal protein S25; This is the family of fungal 37S mitochondrial ribosomal S25 proteins.


Pssm-ID: 433447  Cd Length: 221  Bit Score: 44.54  E-value: 4.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 602152744    1 MRAGVLKEKPLWYDIYKAFPPL----REPVFR-----RPRLRYGKAKADIQDIF-----------------------YQE 48
Cdd:pfam13741  12 LKSGLLKKKPAWYDVVASIPPStlltRQPPPRsdpstRQRTKTLPGKSNNQGLYktrtnksdrkkknnplfrppklkYLE 91

                          90       100
                  ....*....|....*....|...
gi 602152744   49 DQIRAKFFAtygsgQKAFDLFNP 71
Cdd:pfam13741  92 DQLRKQFFR-----DHPWELARP 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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