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Conserved domains on  [gi|612339318|ref|NP_001278382|]
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leucine-rich repeat-containing protein 7 isoform 3 [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12156045)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.05e-49

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 181.29  E-value: 3.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFselpevLDQIQNLRELWMDN 221
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886   123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  302 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQRLRVLNLS 381
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 612339318  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886   281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PDZ_canonical super family cl49608
canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs ...
 1365-1396 1.32e-16

canonical PDZ domain; Canonical PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain. PDZ domains usually bind to short specific peptide sequences located at the C-terminal end of their partner proteins known as PDZ binding motifs. These domains can also interact with internal peptide motifs and certain lipids, and can take part in a head-to-tail oligomerization with other PDZ domains. The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. The canonical PDZ domain contains six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


The actual alignment was detected with superfamily member cd06749:

Pssm-ID: 483948 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.32e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 612339318 1365 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1396
Cdd:cd06749     1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PRK15370 super family cl33128
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 2.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


The actual alignment was detected with superfamily member PRK15370:

Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSSLPTSIASLvnLKELDI 104
Cdd:PRK15370  199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370  270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612339318  185 MHklAQLERLDLGNNEFSELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370  344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.05e-49

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 181.29  E-value: 3.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFselpevLDQIQNLRELWMDN 221
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886   123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  302 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQRLRVLNLS 381
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 612339318  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886   281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-413 4.34e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.49  E-value: 4.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   61 NQIEELPKQLFNCQALRKLSIPDNDLS-SLPTSIASLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPD 137
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPV 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  138 GFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEF-SELPEVLDQIQN 213
Cdd:PLN00113  327 ALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRS 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  214 LRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN----RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKV 288
Cdd:PLN00113  406 LRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnlqgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDL 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  289 DDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpptigylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLP 366
Cdd:PLN00113  483 SRNQFSgAVPRKLGSLSELMQLKLSENKLSG----------------------EIPDELSSCKKLVSLDLSHNQLSgQIP 540

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 612339318  367 EEIGQMQRLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 413
Cdd:PLN00113  541 ASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHGSLP 588
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1365-1396 1.32e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.32e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 612339318 1365 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1396
Cdd:cd06749     1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-310 1.53e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.22  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  114 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 193
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  194 LDLGNNEFSELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 266
Cdd:cd21340    73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 612339318  267 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 310
Cdd:cd21340   151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 2.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSSLPTSIASLvnLKELDI 104
Cdd:PRK15370  199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370  270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612339318  185 MHklAQLERLDLGNNEFSELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370  344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-218 9.12e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 9.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   56 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSSLPtSIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 135
Cdd:cd21340     7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  136 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFSELPEVL 208
Cdd:cd21340    84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                         170
                  ....*....|
gi 612339318  209 DQIQNLRELW 218
Cdd:cd21340   162 DLLSSWPSLR 171
LRR_8 pfam13855
Leucine rich repeat;
144-201 3.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.74e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   144 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 201
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
51-107 2.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 2.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318    51 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSSL-PTSIASLVNLKELDISKN 107
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
142-418 3.05e-49

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 181.29  E-value: 3.05e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  142 LLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFselpevLDQIQNLRELWMDN 221
Cdd:COG4886    49 LTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEE------LSNLTNLESLDLSG 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  222 NALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 301
Cdd:COG4886   123 NQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  302 NLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPrEIGSCKNVTVMSLRSNKLEFLPEEiGQMQRLRVLNLS 381
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPL-ANLTNLKTLDLS 280

                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 612339318  382 DNRLKNLpfsftKLKELAALWLSDNQSKALIPLQTEA 418
Cdd:COG4886   281 NNQLTDL-----KLKELELLLGLNSLLLLLLLLNLLE 312
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
48-467 1.96e-47

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 175.89  E-value: 1.96e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   48 NFERTLEELYLDANQIEELPKQLFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDISKNgvqefpenikcckcltiiea 127
Cdd:COG4886    47 LLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------------------- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  128 svnpisklpDGFTQLLNLTQLYLNDafleflpanfgrlvklrilelreNHLKTLPKSMHKLAQLERLDLGNNEFSELPEV 207
Cdd:COG4886   107 ---------EELSNLTNLESLDLSG-----------------------NQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  208 LDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLK 287
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  288 VDDNQLTMLPNtIGNLSLLEEFDCSCNELESLPPtIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPE 367
Cdd:COG4886   235 LSNNQLTDLPE-LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  368 EIGQMQRLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQSKALIPLQTEAHPETKQRVLTNYMFPQQPRGDEDFQSDSD 447
Cdd:COG4886   313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392

                         410       420
                  ....*....|....*....|
gi 612339318  448 SFNPTLWEEQRQQRMTVAFE 467
Cdd:COG4886   393 LLTTTAGVLLLTLALLDAVN 412
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
140-407 1.22e-44

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 167.80  E-value: 1.22e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  140 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEVLDQIQNLRELWM 219
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  220 DNNALQVLPGSIGKLKMLVYLDMSKNRietvdmDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNT 299
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  300 IGNLSLLEEFDCSCNELESLPPTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQRLRVLN 379
Cdd:COG4886   155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234

                         250       260
                  ....*....|....*....|....*...
gi 612339318  380 LSDNRLKNLPfSFTKLKELAALWLSDNQ 407
Cdd:COG4886   235 LSNNQLTDLP-ELGNLTNLEELDLSNNQ 261
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-413 4.34e-26

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 116.49  E-value: 4.34e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   61 NQIEELPKQLFNCQALRKLSIPDNDLS-SLPTSIASLVNLKELDISKNGVQ-EFPENIKCCKCLTIIEASVNPIS-KLPD 137
Cdd:PLN00113  247 NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPV 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  138 GFTQL--LNLTQLYLNDaFLEFLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEF-SELPEVLDQIQN 213
Cdd:PLN00113  327 ALTSLprLQVLQLWSNK-FSGEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRS 405

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  214 LRELWMDNNALQ-VLPGSIGKLKMLVYLDMSKN----RIETVDMDISGCEALEdlLLSSNMLQQLPDSIGLlKKLTTLKV 288
Cdd:PLN00113  406 LRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNnlqgRINSRKWDMPSLQMLS--LARNKFFGGLPDSFGS-KRLENLDL 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  289 DDNQLT-MLPNTIGNLSLLEEFDCSCNELESlpptigylhslrtlavdenflpELPREIGSCKNVTVMSLRSNKLE-FLP 366
Cdd:PLN00113  483 SRNQFSgAVPRKLGSLSELMQLKLSENKLSG----------------------EIPDELSSCKKLVSLDLSHNQLSgQIP 540

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*...
gi 612339318  367 EEIGQMQRLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 413
Cdd:PLN00113  541 ASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLHGSLP 588
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-414 7.88e-22

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 103.00  E-value: 7.88e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   53 LEELYLDANQIE-ELPKQLFNCQALRKLSIPDNDLSS-LPTSIASLVNLKELDISKNG-VQEFPENIKCCKCLTIIEASV 129
Cdd:PLN00113  142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIYLGY 221

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  130 NPIS-KLPDGFTQLLNLTQLYL--NDAFLEfLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEFS-EL 204
Cdd:PLN00113  222 NNLSgEIPYEIGGLTSLNHLDLvyNNLTGP-IPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEI 300

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  205 PEVLDQIQNLRELWMDNN--------------ALQVL-----------PGSIGKLKMLVYLDMSKNRIeTVDMDISGCEA 259
Cdd:PLN00113  301 PELVIQLQNLEILHLFSNnftgkipvaltslpRLQVLqlwsnkfsgeiPKNLGKHNNLTVLDLSTNNL-TGEIPEGLCSS 379

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  260 --LEDLLLSSNMLQ-QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELESLPPTIGY-LHSLRTLAV 334
Cdd:PLN00113  380 gnLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQGRINSRKWdMPSLQMLSL 459

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  335 DEN-FLPELPREIGScKNVTVMSLRSNKL-EFLPEEIGQMQRLRVLNLSDNRLKN-LPFSFTKLKELAALWLSDNQSKAL 411
Cdd:PLN00113  460 ARNkFFGGLPDSFGS-KRLENLDLSRNQFsGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSGQ 538


                  ...
gi 612339318  412 IPL 414
Cdd:PLN00113  539 IPA 541
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
56-300 1.94e-18

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 91.30  E-value: 1.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   56 LYLDANQIEELPKqlfNCQA-LRKLSIPDNDLSSLPTSIASlvNLKELDISKNGVQEFPENIKccKCLTIIEASVNPISK 134
Cdd:PRK15370  204 LILDNNELKSLPE---NLQGnIKTLYANSNQLTSIPATLPD--TIQEMELSINRITELPERLP--SALQSLDLFHNKISC 276

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  135 LPDGftqllnltqlylndaflefLPAnfgrlvKLRILELRENHLKTLPKsmHKLAQLERLDLGNNEFSELPEVLDqiQNL 214
Cdd:PRK15370  277 LPEN-------------------LPE------ELRYLSVYDNSIRTLPA--HLPSGITHLNVQSNSLTALPETLP--PGL 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  215 RELWMDNNALQVLPGSIGklKMLVYLDMSKNRIETVDMDISgcEALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDNQLT 294
Cdd:PRK15370  328 KTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPEN--LPAALQIMQASRNNLV 401


                  ....*.
gi 612339318  295 MLPNTI 300
Cdd:PRK15370  402 RLPESL 407
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 89-413 3.45e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 3.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   89 LPTSIASLVNLKELDISKNGVQ-EFPENI-KCCKCLTIIEASVNPIS-KLPDGFTQLLNLTQLYlNDAFLEFLPANFGRL 165
Cdd:PLN00113   85 ISSAIFRLPYIQTINLSNNQLSgPIPDDIfTTSSSLRYLNLSNNNFTgSIPRGSIPNLETLDLS-NNMLSGEIPNDIGSF 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  166 VKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEFS-ELPEVLDQIQNLRELWMDNNALQ-VLPGSIGKLKMLVYLDM 242
Cdd:PLN00113  164 SSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDL 243

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  243 SKNrietvdmdisgcealedlllssNMLQQLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLP 320
Cdd:PLN00113  244 VYN----------------------NLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgEIP 301

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  321 PTIGYLHSLRTLAV-DENFLPELPREIGSCKNVTVMSLRSNKLEF-LPEEIGQMQRLRVLNLSDNRLK-NLPFSFTKLKE 397
Cdd:PLN00113  302 ELVIQLQNLEILHLfSNNFTGKIPVALTSLPRLQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGN 381

                         330
                  ....*....|....*.
gi 612339318  398 LAALWLSDNQSKALIP 413
Cdd:PLN00113  382 LFKLILFSNSLEGEIP 397
PDZ_densin_erbin-like cd06749
PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95) ...
 1365-1396 1.32e-16

PDZ domain of densin, erbin, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain of densin, erbin, and related domains. Densin (also known as leucine-rich repeat-containing protein 7, LRRC7, densin-180, protein LAP1) and erbin (also known as densin-180-like protein, Erbb2-interacting protein, protein LAP2) belong to the LAP (leucine-rich repeat and PDZ domain) family of scaffolding proteins that play roles in the maintenance of cell shape and apical-basal polarity. Densin and erbin are components of the excitatory postsynaptic compartment and are regulators of dendritic morphology and postsynaptic structure. The densin PDZ domain binds CaV1.3 alpha1 subunit, delta-catenin, and MAGUIN-1. Binding partners of the erbin PDZ domain include ErbB receptor tyrosine kinase ErbB2, HTLV-1 Tax1, Cav1.3 Ca2+channels, and constituents of the cadherin:catenin cell adhesion complex, in particular delta-catenin, p0071 and ARVCF. The erbin PDZ domain binds Smad3, a transductor of the TGFbeta pathway, possibly by a novel interface of binding. Erbin and two other LAP proteins (scribble and lano) redundantly regulate epithelial polarity and apical adhesion complex. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This densin and erbin-like family domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged as beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467231 [Multi-domain]  Cd Length: 87  Bit Score: 76.21  E-value: 1.32e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 612339318 1365 FCVRIEKNPGLGFSISGGISGQGNPFKPSDKG 1396
Cdd:cd06749     1 IRVRIEKNPGLGFSISGGIGSQGNPFRPDDDG 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-310 1.53e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 80.22  E-value: 1.53e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  114 ENIKCCKCLTIIEASVNPISKLPdGFTQLLNLTQLYLNDAFLEFLPaNFGRLVKLrilelrenhlktlpksmhklaqlER 193
Cdd:cd21340    18 DNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNL-----------------------KK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  194 LDLGNNEFSELpEVLDQIQNLRELWMDNNALQ------VLPGSIGKLKM-LVYLDMSKNRIETVDmDISGCEALEDLLLS 266
Cdd:cd21340    73 LYLGGNRISVV-EGLENLTNLEELHIENQRLPpgekltFDPRSLAALSNsLRVLNISGNNIDSLE-PLAPLRNLEQLDAS 150

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 612339318  267 SNMLQQLPDSIGLLKK---LTTLKVDDNQLTMLP----NTIGNLSLLEEFD 310
Cdd:cd21340   151 NNQISDLEELLDLLSSwpsLRELDLTGNPVCKKPkyrdKIILASKSLEVLD 201
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
26-247 2.16e-16

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 84.75  E-value: 2.16e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   26 EEIIS-VLDYSHcsLQQVPKevfNFERTLEELYLDANQIEELPKQLFNCQALRKLSIpdNDLSSLPTSIASLvnLKELDI 104
Cdd:PRK15370  199 EQITTlILDNNE--LKSLPE---NLQGNIKTLYANSNQLTSIPATLPDTIQEMELSI--NRITELPERLPSA--LQSLDL 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  105 SKNGVQEFPENIKccKCLTIIEASVNPISKLPDGFTQllNLTQLYLNDAFLEFLPANFGrlVKLRILELRENHLKTLPKS 184
Cdd:PRK15370  270 FHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP--PGLKTLEAGENALTSLPAS 343

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 612339318  185 MHklAQLERLDLGNNEFSELPEVLDqiQNLRELWMDNNALQVLPGSIGklKMLVYLDMSKNRI 247
Cdd:PRK15370  344 LP--PELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPENLP--AALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 142-384 7.62e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 75.21  E-value: 7.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  142 LLNLTQLYLNDAFLEFLPaNFGRLVKLRILELRENHLKTLPKsMHKLAQLERLDLGNNEFSELpEVLDQIQNLRELWMDN 221
Cdd:cd21340     1 LKRITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  222 NALQVLPGsigklkmlvyLDmsknrietvdmdisGCEALEDLLLSSnmlQQL---------PDSI-GLLKKLTTLKVDDN 291
Cdd:cd21340    78 NRISVVEG----------LE--------------NLTNLEELHIEN---QRLppgekltfdPRSLaALSNSLRVLNISGN 130

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  292 QLTMLpNTIGNLSLLEEFDCSCNELESLP---PTIGYLHSLRTLAVDENFLPELPREigsCKNVTVMSLRsnkLEFLPE- 367
Cdd:cd21340   131 NIDSL-EPLAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDLTGNPVCKKPKY---RDKIILASKS---LEVLDGk 203

                         250
                  ....*....|....*..
gi 612339318  368 EIGQMQRLRVLNLSDNR 384
Cdd:cd21340   204 EITDTERQFLKRLKARK 220
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 56-218 9.12e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 9.12e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   56 LYLDANQIEELPKqLFNCQALRKLSIPDNDLSSLPtSIASLVNLKELDISKNGVQEFpENIKCCKCLTIIEASVNPISKL 135
Cdd:cd21340     7 LYLNDKNITKIDN-LSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVV 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  136 pDGFTQLLNLTQLYL------NDAFLEFLPANFGRLVK-LRILELRENHLKTLpKSMHKLAQLERLDLGNNEFSELPEVL 208
Cdd:cd21340    84 -EGLENLTNLEELHIenqrlpPGEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELL 161

                         170
                  ....*....|
gi 612339318  209 DQIQNLRELW 218
Cdd:cd21340   162 DLLSSWPSLR 171
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
212-424 7.39e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 73.19  E-value: 7.39e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  212 QNLRELWMDNNALQVLPGSIGKLKMLVYLDmsKNRIETVDMDISGceALEDLLLSSNMLQQLPDSigLLKKLTTLKVDDN 291
Cdd:PRK15370  178 NNKTELRLKILGLTTIPACIPEQITTLILD--NNELKSLPENLQG--NIKTLYANSNQLTSIPAT--LPDTIQEMELSIN 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  292 QLTMLPNTIGnlSLLEEFDCSCNELESLPPTIGylHSLRTLAVDENFLPELPREIGSckNVTVMSLRSNKLEFLPEEIGq 371
Cdd:PRK15370  252 RITELPERLP--SALQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPAHLPS--GITHLNVQSNSLTALPETLP- 324

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 612339318  372 mQRLRVLNLSDNRLKNLPFSFTklKELAALWLSDNQskalIPLQTEAHPETKQ 424
Cdd:PRK15370  325 -PGLKTLEAGENALTSLPASLP--PELQVLDVSKNQ----ITVLPETLPPTIT 370
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
79-304 4.42e-12

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 70.96  E-value: 4.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   79 LSIPDNDLSSLPtsiASLVNLKELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLL--------------N 144
Cdd:PRK15387  227 LVIPDNNLTSLP---ALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWifgnqltslpvlppG 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  145 LTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSmhklaqLERLDLGNNEFSELPEVLDQiqnLRELWMDNNAL 224
Cdd:PRK15387  304 LQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSG------LQELSVSDNQLASLPTLPSE---LYKLWAYNNRL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  225 QVLPGSIGKLKMLVyldMSKNRIETVDMDISgceALEDLLLSSNMLQQLPdsiGLLKKLTTLKVDDNQLTMLPNTIGNLS 304
Cdd:PRK15387  375 TSLPALPSGLKELI---VSGNRLTSLPVLPS---ELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLS 445
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 32-300 3.39e-09

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 61.81  E-value: 3.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   32 LDYSHCS-LQQVPKEVFNFERtLEELYLD-ANQIEELPKQLfNCQALRKLSIPD-NDLSSLPtSIASlvNLKELDISKNG 108
Cdd:PLN03210  662 LKLSDCSsLVELPSSIQYLNK-LEDLDMSrCENLEILPTGI-NLKSLYRLNLSGcSRLKSFP-DIST--NISWLDLDETA 736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  109 VQEFPENIKCCKCLTII--EASVNPISKLPDGFTQLL-----NLTQLYLND--AFLEfLPANFGRLVKLRILELRE-NHL 178
Cdd:PLN03210  737 IEEFPSNLRLENLDELIlcEMKSEKLWERVQPLTPLMtmlspSLTRLFLSDipSLVE-LPSSIQNLHKLEHLEIENcINL 815

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  179 KTLPKSMHkLAQLERLDLGNneFSELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSK-NRIETVDMDISGC 257
Cdd:PLN03210  816 ETLPTGIN-LESLESLDLSG--CSRLRTFPDISTNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKL 892

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 612339318  258 EALEDLLLSSnmLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTI 300
Cdd:PLN03210  893 KHLETVDFSD--CGALTEASWNGSPSEVAMATDNIHSKLPSTV 933
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 166-406 9.06e-08

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 55.44  E-value: 9.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  166 VKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFSELPEvldqiqnlrelwmdnnALQVLPGSIGKLKMLVYLDMSKN 245
Cdd:cd00116    28 LRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPR----------------GLQSLLQGLTKGCGLQELDLSDN 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  246 RIEtvdmdISGCEALEDLLLSSNmLQQLpdsigllkKLTTLKVDDNQLTMLPNTIGNLSL-LEEFDCSCNEL-----ESL 319
Cdd:cd00116    92 ALG-----PDGCGVLESLLRSSS-LQEL--------KLNNNGLGDRGLRLLAKGLKDLPPaLEKLVLGRNRLegascEAL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  320 PPTIGYLHSLRTLAVDENFL-----PELPREIGSCKNVTVMSLRSNKLE-----FLPEEIGQMQRLRVLNLSDNRLKNLP 389
Cdd:cd00116   158 AKALRANRDLKELNLANNGIgdagiRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTDAG 237

                         250       260
                  ....*....|....*....|...
gi 612339318  390 FS------FTKLKELAALWLSDN 406
Cdd:cd00116   238 AAalasalLSPNISLLTLSLSCN 260
LRR_8 pfam13855
Leucine rich repeat;
144-201 3.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 3.74e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   144 NLTQLYLNDAFLEFL-PANFGRLVKLRILELRENHLKTL-PKSMHKLAQLERLDLGNNEF 201
Cdd:pfam13855    2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
212-270 2.63e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 2.63e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 612339318   212 QNLRELWMDNNALQVL-PGSIGKLKMLVYLDMSKNRIETVDMD-ISGCEALEDLLLSSNML 270
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 272-347 2.84e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 2.84e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318  272 QLPDSIGLLKKLTTLKVDDNQLT-MLPNTIGNLSLLEEFDCSCNELE-SLPPTIGYLHSLRTLAVDENFLP-ELPREIG 347
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAALG 511
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 140-386 3.12e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.82  E-value: 3.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  140 TQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSMH-------KLAQLERLDLGNNEFSELP----EVL 208
Cdd:cd00116    25 LQVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQsllqgltKGCGLQELDLSDNALGPDGcgvlESL 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  209 DQIQNLRELWMDNNALQVLPG--SIGKLKM----LVYLDMSKNRIETvdmdiSGCEALEDLLLSsnmlqqlpdsiglLKK 282
Cdd:cd00116   105 LRSSSLQELKLNNNGLGDRGLrlLAKGLKDlppaLEKLVLGRNRLEG-----ASCEALAKALRA-------------NRD 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  283 LTTLKVDDNQLtmlpNTIGNLSLLEEFDCSCNeleslpptigylhsLRTLAVDENFLpelpREIG---------SCKNVT 353
Cdd:cd00116   167 LKELNLANNGI----GDAGIRALAEGLKANCN--------------LEVLDLNNNGL----TDEGasalaetlaSLKSLE 224

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 612339318  354 VMSLRSNKL------EFLPEEIGQMQRLRVLNLSDNRLK 386
Cdd:cd00116   225 VLNLGDNNLtdagaaALASALLSPNISLLTLSLSCNDIT 263
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
132-406 3.55e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 51.70  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  132 ISKLPDGFTQllNLTQLYLNDAFLEFLPAnfgRLVKLRILELRENHLKTLPKSMHKLAQLErldLGNNEFSELPEVldqI 211
Cdd:PRK15387  213 LTTLPDCLPA--HITTLVIPDNNLTSLPA---LPPELRTLEVSGNQLTSLPVLPPGLLELS---IFSNPLTHLPAL---P 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  212 QNLRELWMDNNALQVLPGSIGKLKMLvylDMSKNRIETVDMDISgceALEDLLLSSNMLQQLPDsigLLKKLTTLKVDDN 291
Cdd:PRK15387  282 SGLCKLWIFGNQLTSLPVLPPGLQEL---SVSDNQLASLPALPS---ELCKLWAYNNQLTSLPT---LPSGLQELSVSDN 352

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  292 QLTMLPNTIGNLSLLEEFDCSCNELESLPPtigylhSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEigq 371
Cdd:PRK15387  353 QLASLPTLPSELYKLWAYNNRLTSLPALPS------GLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSG--- 423

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 612339318  372 mqrLRVLNLSDNRLKNLPFSFTKLKELAALWLSDN 406
Cdd:PRK15387  424 ---LLSLSVYRNQLTRLPESLIHLSSETTVNLEGN 455
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
53-143 3.89e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 3.89e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   53 LEELYLDANQIEELPKQLfnCQALRKLSIPDNDLSSLPTSIASlvNLKELDISKNGVQEFPENIKCCkcLTIIEASVNPI 132
Cdd:PRK15370  327 LKTLEAGENALTSLPASL--PPELQVLDVSKNQITVLPETLPP--TITTLDVSRNALTNLPENLPAA--LQIMQASRNNL 400

                          90
                  ....*....|.
gi 612339318  133 SKLPDGFTQLL 143
Cdd:PRK15370  401 VRLPESLPHFR 411
LRR_8 pfam13855
Leucine rich repeat;
167-224 6.12e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 6.12e-06
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   167 KLRILELRENHLKTLPKSM-HKLAQLERLDLGNNEFSEL-PEVLDQIQNLRELWMDNNAL 224
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
351-407 7.38e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 7.38e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318   351 NVTVMSLRSNKLEFLPEEI-GQMQRLRVLNLSDNRLKNL-PFSFTKLKELAALWLSDNQ 407
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNR 60
PLN03150 PLN03150
hypothetical protein; Provisional
 319-385 9.70e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 50.20  E-value: 9.70e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318  319 LPPTIGYLHSLRTLAVDENFLP-ELPREIGSCKNVTVMSLRSNKLE-FLPEEIGQMQRLRVLNLSDNRL 385
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 29-217 1.90e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   29 ISVLDYSHCSLQQVPKEVF-NFER--TLEELYLDANQIEELP-----KQLFNCQ-ALRKLSIPDNDLSSLPTSIASLV-- 97
Cdd:cd00116    83 LQELDLSDNALGPDGCGVLeSLLRssSLQELKLNNNGLGDRGlrllaKGLKDLPpALEKLVLGRNRLEGASCEALAKAlr 162

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   98 ---NLKELDISKNGVQEFpenikcckcltiieasvnPISKLPDGFTQLLNLTQLYLNDAFLE-----FLPANFGRLVKLR 169
Cdd:cd00116   163 anrDLKELNLANNGIGDA------------------GIRALAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLE 224

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318  170 ILELRENHLK-----TLPKSMHKLAQ-LERLDLGNNE-----FSELPEVLDQIQNLREL 217
Cdd:cd00116   225 VLNLGDNNLTdagaaALASALLSPNIsLLTLSLSCNDitddgAKDLAEVLAEKESLLEL 283
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
270-416 1.92e-05

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.39  E-value: 1.92e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  270 LQQLPDSigLLKKLTTLKVDDNQLTMLPNTIGNLSLLEefdCSCNELESLPPTIGYLHSLRTLAVDENFLPELPReiGSC 349
Cdd:PRK15387  213 LTTLPDC--LPAHITTLVIPDNNLTSLPALPPELRTLE---VSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPS--GLC 285

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612339318  350 KnvtvMSLRSNKLEFLPEEIGQMQRLRVlnlSDNRLKNLPfsfTKLKELAALWLSDNQSKALIPLQT 416
Cdd:PRK15387  286 K----LWIFGNQLTSLPVLPPGLQELSV---SDNQLASLP---ALPSELCKLWAYNNQLTSLPTLPS 342
LRR_8 pfam13855
Leucine rich repeat;
51-107 2.01e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.28  E-value: 2.01e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318    51 RTLEELYLDANQIEELPKQLF-NCQALRKLSIPDNDLSSL-PTSIASLVNLKELDISKN 107
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFkGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGN 59
LRR_8 pfam13855
Leucine rich repeat;
237-293 3.19e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.90  E-value: 3.19e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 612339318   237 LVYLDMSKNRIETVDMDI-SGCEALEDLLLSSNMLQQL-PDSIGLLKKLTTLKVDDNQL 293
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
328-385 4.81e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 4.81e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   328 SLRTLAVDENFLPELPREI-GSCKNVTVMSLRSNKLEFL-PEEIGQMQRLRVLNLSDNRL 385
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 217-305 2.56e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 45.58  E-value: 2.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  217 LWMDNNALQ-VLPGSIGKLKMLVYLDMSKNRIE-TVDMDISGCEALEDLLLSSNMLQ-QLPDSIGLLKKLTTLKVDDNQL 293
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                          90
                  ....*....|...
gi 612339318  294 T-MLPNTIGNLSL 305
Cdd:PLN03150  503 SgRVPAALGGRLL 515
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
53-294 4.97e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.77  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   53 LEELYLDANQIEELPkqlFNCQALRKLSIPDNDLSSLPTSIASLVNLKELDiskNGVQEFPenikcckcltiieasvnpi 132
Cdd:PRK15387  284 LCKLWIFGNQLTSLP---VLPPGLQELSVSDNQLASLPALPSELCKLWAYN---NQLTSLP------------------- 338

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  133 sKLPDGftqllnLTQLYLNDAFLEFLPanfgrlvklrilelrenhlkTLPKSMHKLAQLerldlgNNEFSELPEVldqIQ 212
Cdd:PRK15387  339 -TLPSG------LQELSVSDNQLASLP--------------------TLPSELYKLWAY------NNRLTSLPAL---PS 382

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  213 NLRELWMDNNALQVLPGSIGKLKMLVyldMSKNRIETVDMDISGceaLEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQ 292
Cdd:PRK15387  383 GLKELIVSGNRLTSLPVLPSELKELM---VSGNRLTSLPMLPSG---LLSLSVYRNQLTRLPESLIHLSSETTVNLEGNP 456


                  ..
gi 612339318  293 LT 294
Cdd:PRK15387  457 LS 458
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 373-406 7.93e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 38.38  E-value: 7.93e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 612339318   373 QRLRVLNLSDNRLKNLPFsFTKLKELAALWLSDN 406
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGN 33
PDZ4_Scribble-like cd06701
PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 ...
 1367-1396 1.39e-03

PDZ domain 4 of Drosophila Scribble, human Scribble homolog, and related domains; PDZ (PSD-95 (Postsynaptic density protein 95), Dlg (Discs large protein), and ZO-1 (Zonula occludens-1)) domain 4 of Drosophila Scribble (also known as LAP4), human Scribble homolog (also known as hScrib, LAP4, CriB1, ScrB1 and Vartul), and related domains. They belong to the LAP family, which describes proteins that contain either one or four PDZ domains and 16 LRRs (leucine-rich repeats) and function in controlling cell shape, size and subcellular protein localization. In Drosophila, the Scribble complex, comprising Scribble, discs large, and lethal giant larvae, plays a role in apico-basal cell polarity, in other forms of polarity, including regulation of the actin cytoskeleton, cell signaling and vesicular trafficking, and in tumor development. Mammalian Scribble is important in many aspects of cancer development. Scribble and its homologs can be downregulated or overexpressed in cancer; they have a role in cancer beyond their function in loss of cell polarity. PDZ domains usually bind in a sequence-specific manner to short peptide sequences located at the C-terminal end of their partner proteins (known as PDZ binding motifs). The PDZ superfamily includes canonical PDZ domains as well as those with circular permutations and domain swapping mediated by beta-strands. This Scribble-like family PDZ4 domain is a canonical PDZ domain containing six beta-strands A-F and two alpha-helices (alpha-helix 1 and 2), arranged in the order: beta-strands A, B, C, alpha-helix 1, beta-strands D, E, alpha-helix 2 and beta-strand F.


Pssm-ID: 467185 [Multi-domain]  Cd Length: 98  Bit Score: 39.52  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 612339318 1367 VRIEKNPG--LGFSISGGISGQ-GNPFKPSDKG 1396
Cdd:cd06701     7 LTIVKEPGekLGISIRGGAKGHaGNPLDPTDEG 39
PLN03150 PLN03150
hypothetical protein; Provisional
 364-413 2.05e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 2.05e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 612339318  364 FLPEEIGQMQRLRVLNLSDNRLK-NLPFSFTKLKELAALWLSDNQSKALIP 413
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIP 483
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 35-294 2.14e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318   35 SHCSLQQVPKEVFNFERTLEELYLDANQIEELPKQLFnCQALRKlsipdndlsslPTSIASLVnLKELDISKNGVQEFPE 114
Cdd:COG5238   164 RLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEEL-AEALTQ-----------NTTVTTLW-LKRNPIGDEGAEILAE 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  115 NIKCCKCLTIIEASVNPISKlpDGFTQLL-------NLTQLYLNdafleflpanfGRlvklrilELRENHLKTLPKSMHK 187
Cdd:COG5238   231 ALKGNKSLTTLDLSNNQIGD--EGVIALAealknntTVETLYLS-----------GN-------QIGAEGAIALAKALQG 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 612339318  188 LAQLERLDLGNNEFSE-----LPEVLDQIQNLRELWMDNNALQV-----LPGSIGKLKMLVYLDMSKNRIETVDMD---- 253
Cdd:COG5238   291 NTTLTSLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGIGAqgaiaLAKALQENTTLHSLDLSDNQIGDEGAIalak 370

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 612339318  254 -ISGCEALEDLLLSSNML-----QQLPDSIgLLKKLTTLKVDDNQLT 294
Cdd:COG5238   371 yLEGNTTLRELNLGKNNIgkqgaEALIDAL-QTNRLHTLILDGNLIG 416
PLN03150 PLN03150
hypothetical protein; Provisional
 135-208 3.22e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.73  E-value: 3.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 612339318  135 LPDGFTQLLNLTQLYLNDAFLE-FLPANFGRLVKLRILELRENHLK-TLPKSMHKLAQLERLDLGNNEFS-ELPEVL 208
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 76-107 7.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 7.87e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 612339318    76 LRKLSIPDNDLSSLPtSIASLVNLKELDISKN 107
Cdd:pfam12799    3 LEVLDLSNNQITDIP-PLAKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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