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Conserved domains on  [gi|619328954|ref|NP_001278651|]
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cytoplasmic FMR1-interacting protein 2 isoform c [Homo sapiens]

Protein Classification

FragX_IP domain-containing protein( domain architecture ID 10532330)

FragX_IP domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 388-1246 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


:

Pssm-ID: 461799  Cd Length: 842  Bit Score: 1414.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   388 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 467
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   468 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 547
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   548 RRAVGPSSTQacqwspralfhptggtqgrrgcrslLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFF 625
Cdd:pfam05994  160 RRAVGPSSTQ-------------------------LYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFF 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   626 FTHLLNISEALQQCCDLSQLWFREFFLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTK 705
Cdd:pfam05994  215 FPYLLNLSETLQECCDLSQLWFREFYLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTK 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   706 FKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGR 784
Cdd:pfam05994  293 LKSQFLYDEIEAEVNLCFDQFVYKLSEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGR 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   785 SIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGR 862
Cdd:pfam05994  373 SIDLNRLIAQRLNAAFRKSLDIAIGRFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGR 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   863 ITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTIC 942
Cdd:pfam05994  453 ITLHVFSELNYDFLPNYCYNSTTQRFVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIV 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   943 RLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLR 1022
Cdd:pfam05994  533 RLLGYGGIAVLIEELLKIVSNKIQGFLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFR 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1023 EVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQ 1095
Cdd:pfam05994  613 ELGNIILFCLLLDQALSQEEVTDLLQAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQ 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1096 IAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQ 1175
Cdd:pfam05994  692 SAIAEEADLLTKERLCCGLSLFEVVLARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEE 771

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 619328954  1176 CFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1246
Cdd:pfam05994  772 LFGDGLMWAGCAIIALLGQQRRFEALDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 388-1246 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1414.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   388 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 467
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   468 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 547
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   548 RRAVGPSSTQacqwspralfhptggtqgrrgcrslLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFF 625
Cdd:pfam05994  160 RRAVGPSSTQ-------------------------LYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFF 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   626 FTHLLNISEALQQCCDLSQLWFREFFLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTK 705
Cdd:pfam05994  215 FPYLLNLSETLQECCDLSQLWFREFYLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTK 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   706 FKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGR 784
Cdd:pfam05994  293 LKSQFLYDEIEAEVNLCFDQFVYKLSEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGR 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   785 SIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGR 862
Cdd:pfam05994  373 SIDLNRLIAQRLNAAFRKSLDIAIGRFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGR 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   863 ITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTIC 942
Cdd:pfam05994  453 ITLHVFSELNYDFLPNYCYNSTTQRFVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIV 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   943 RLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLR 1022
Cdd:pfam05994  533 RLLGYGGIAVLIEELLKIVSNKIQGFLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFR 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1023 EVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQ 1095
Cdd:pfam05994  613 ELGNIILFCLLLDQALSQEEVTDLLQAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQ 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1096 IAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQ 1175
Cdd:pfam05994  692 SAIAEEADLLTKERLCCGLSLFEVVLARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEE 771

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 619328954  1176 CFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1246
Cdd:pfam05994  772 LFGDGLMWAGCAIIALLGQQRRFEALDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 5-1246 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 611.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954    5 VTLEDAlsnVDLLEELPLPDQQPCIEPPP---SSIMYQANFDTNFEDRNAFVTGIAryiEQATVHSSMNEMLEEGHEYAV 81
Cdd:PLN03099    3 VPVEEA---VAALSTFSLEDEQPDVQGLAvtlSAGRAATESPIDYSDVAAYQLSLS---EDTKAINQLNTLIQEGKEMVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   82 MLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTL 161
Cdd:PLN03099   77 ILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEIGRLREIQRWQSSAASKLAADMQRFSRPERRINGPTVTHMWSM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  162 GKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQES-QNLSMFLANHNRITQCLHQQLEVIPGYEELLA 239
Cdd:PLN03099  157 LKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMREElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  240 DIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLM---DGNVSNIYKldakkRINLSKIDKFFKQlqvvplfgdmqiela 316
Cdd:PLN03099  237 VLIVFCLESLESDFVLLYSERHILLRVLPVLVVLAtssEKEGESLFK-----RIKINRLINIFQR--------------- 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  317 ryiktsahyeenkskwtctqssispQYNICEQMVQIRDDH----IRFISELARYSNSEVVTGsgLDSQKSDEEYRELFDL 392
Cdd:PLN03099  297 -------------------------EYLIVNHMGAIRAEHddfcIRFASAMNQLQLLKSADG--VDTAWSREIKENMYDV 349

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  393 ALRGLQLLSKWSAHVMEVYSWKLVHPT-DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVF 471
Cdd:PLN03099  350 VVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVRCNYTAEERKALVELIGYIKGVGSMLERCDTLV 429

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  472 NQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNvLISVLQAIRKTICDWEGgreppndpclrgekdpkggfdiKVPRRAV 551
Cdd:PLN03099  430 ADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAADWMA----------------------NTRPEEK 486

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  552 GPSSTQACQWSPRALFHP--TGGTQGRRGCrsLLYMVRTMLESLIADKSGSKKTlRSSLDGPI--VLAIEDFHKQSFFFT 627
Cdd:PLN03099  487 MPSRQRENDESRPNFFYPrpVAPTAAQLHC--LQFLIHELVSGGSPKKPGGFFG-NNGSEIPVndLKQLETFFNKLAFFP 563

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  628 HLLNISEALQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFK 707
Cdd:PLN03099  564 HILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDSAQHALRVLK 641

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  708 KQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKN---YGViipypPSNRYETLLKQRHVQLLGR 784
Cdd:PLN03099  642 QRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDNgekFSV-----QPKRYDALFKMRRVKILGR 716

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  785 SIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGR 862
Cdd:PLN03099  717 TIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISlvSFSSR 796

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  863 ITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTIC 942
Cdd:PLN03099  797 LASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLPHMFAIV 876

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  943 RLLGYQGIAVVMEELLKIVKSLLQGtILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYaELKTDVFQSLR 1022
Cdd:PLN03099  877 KLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSEVLRGLK 954

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1023 EVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRvyiKEGErlevrMKRLEAKYAPL---------HLVPLIERLGTP 1093
Cdd:PLN03099  955 EIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQ-----LQQADDNESPLvslfkeatsAVVSSPGCLNPS 1026

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1094 QQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSYlqdpiWRGPPPTnGVMHVDECVEFHRLWSAMQFVYCI 1164
Cdd:PLN03099 1027 AFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSK-----WSAPPKT-GFIDITTSKDFYRIYSGLQYVYLE 1100

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1165 PVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQ---RQDGKDEIIK--------NVPLKKMADRIR 1233
Cdd:PLN03099 1101 EISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSeveSASASHTHRNerlkspsyHQGWEGFLENAR 1180

                        1290
                  ....*....|...
gi 619328954 1234 KYQILNNEVFAIL 1246
Cdd:PLN03099 1181 KARRLNNHVFSLL 1193
 
Name Accession Description Interval E-value
FragX_IP pfam05994
Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental ...
 388-1246 0e+00

Cytoplasmic Fragile-X interacting family; This entry includes Cytoplasmic fragile X mental retardation interacting proteins 1/2 (CYFIP1/2) from humans and their homologs, such as Sra-1 (specifically Rac1-associated protein 1) from Drosophila and PIROGI from Arabidopsis. CYFIP1/2 interact with FMRP (fragile X mental retardation protein) which is responsible for pathologic manifestations in the Fragile X Syndrome. CYFIP1 interacts with the small GTPase Rac1. CYFIP1 represses cap-dependent translation of mRNA by interacting with the initiation factor eIF4E. CYFIP1 and CYFIP2 are part of the Wiskott-Aldrich syndrome protein-family verprolin-homologous protein (WAVE) complex that regulates actin polymerization at synapses. Drosophila Sra-1 interacts with the Kette and Wasp. It is required for neuronal and bristle development in Drosophila. PIROGI is part of a WAVE complex that activates the ARP2/3 complex and is Involved in regulation of actin organization.


Pssm-ID: 461799  Cd Length: 842  Bit Score: 1414.74  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   388 ELFDLALRGLQLLSKWSAHVMEVYSWKLVHPTDKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRM 467
Cdd:pfam05994    1 KLYDLALRGLQLLSRWTSRIRELYAWKLLHPTDDYSNRNCPEDAEDYERAVRYNYSSEEKFALVEIIAMIKSLQSLLQRM 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   468 ESVFNQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNVLISVLQAIRKTICDWEGGREPPNDPCLRGEKDPKGgFDIKVP 547
Cdd:pfam05994   81 ETVLNDAIRRTIHAELQDFVQNTLREPLRKAIKKKKDLIKSILSSLRTLCADWMAGTEPPDDPALKGEKDPKG-FDIEVP 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   548 RRAVGPSSTQacqwspralfhptggtqgrrgcrslLYMVRTMLESLIADKSG--SKKTLRSSLDGPIVLAIEDFHKQSFF 625
Cdd:pfam05994  160 RRAVGPSSTQ-------------------------LYMVRTQLESLINDKSGlfGKKGLKKELDSNDLAQIETFLNKSFF 214

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   626 FTHLLNISEALQQCCDLSQLWFREFFLEltMGRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTK 705
Cdd:pfam05994  215 FPYLLNLSETLQECCDLSQLWFREFYLE--MGKRIQFPIEMSLPWILTDHILESKDPSLMEYILYPLDLYNDAAHYALTK 292

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   706 FKKQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKNYGV-IIPYPPSNRYETLLKQRHVQLLGR 784
Cdd:pfam05994  293 LKSQFLYDEIEAEVNLCFDQFVYKLSEQIFTYYKTLAASILLDKRFRAELKNAGIlIPPYPPANRYETLLQQRHVQLLGR 372

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   785 SIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGR 862
Cdd:pfam05994  373 SIDLNRLIAQRLNAAFRKSLDIAIGRFESQDLTSIVELEKLLDILRLTHKLLSEFLTLDPFEDMLNEANHNVSpvSPYGR 452

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   863 ITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTIC 942
Cdd:pfam05994  453 ITLHVFSELNYDFLPNYCYNSTTQRFVRSPPLFSQEVQREKAPKIKPSFLFGTKALNAAYSAILELYSGFIGIPHFRAIV 532

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   943 RLLGYQGIAVVMEELLKIVKSLLQGTILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYAELKTDVFQSLR 1022
Cdd:pfam05994  533 RLLGYGGIAVLIEELLKIVSNKIQGFLEPYVRRLMDGMPKSCKLPPFDYGSPGVLDYFQGQLKDIITYPELKTEVFQVFR 612

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1023 EVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRVYiKEGERLEVR------MKRLEAKYAPLH-LVPLIERLGTPQQ 1095
Cdd:pfam05994  613 ELGNIILFCLLLDQALSQEEVTDLLQAAPFLGIIPRPF-KEGEEEDDKfkdspyFKRLEKKYTSLQvLPPFIEKLGTEQQ 691

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  1096 IAIAREGDLLTKERLCCGLSMFEVILTRIRSYLQDPIWRGPPPTNGVMHVDECVEFHRLWSAMQFVYCIPVGTNEFTAEQ 1175
Cdd:pfam05994  692 SAIAEEADLLTKERLCCGLSLFEVVLARIKAILDDSIWSGPEPSNGVIDIDECTEFYRLWSALQFVYCIPVGDNEFTAEE 771

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 619328954  1176 CFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQRQDGKDEIIKNVPLKKMADRIRKYQILNNEVFAIL 1246
Cdd:pfam05994  772 LFGDGLMWAGCAIIALLGQQRRFEALDFCYHILNVNEADGKDAVISGDRLKKFVERIRKFQRLNNQIFSIL 842
PIR PLN03099
Protein PIR; Provisional
 5-1246 0e+00

Protein PIR; Provisional


Pssm-ID: 215574 [Multi-domain]  Cd Length: 1232  Bit Score: 611.57  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954    5 VTLEDAlsnVDLLEELPLPDQQPCIEPPP---SSIMYQANFDTNFEDRNAFVTGIAryiEQATVHSSMNEMLEEGHEYAV 81
Cdd:PLN03099    3 VPVEEA---VAALSTFSLEDEQPDVQGLAvtlSAGRAATESPIDYSDVAAYQLSLS---EDTKAINQLNTLIQEGKEMVS 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954   82 MLYTWRSCSRAIPQVKCNEQPNRVEIYEKTVEVLEPEVTKLMKFMYFQRKAIERFCSEVKRLCHAERRKDFVSEAYLLTL 161
Cdd:PLN03099   77 ILYTYRSCVKALPQLPESMKHSQADLYLETYQVLDLEIGRLREIQRWQSSAASKLAADMQRFSRPERRINGPTVTHMWSM 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  162 GKFINMFAVLDELKNMKCSVKNDHSAYKRA-AQFLRKMADPQSIQES-QNLSMFLANHNRITQCLHQQLEVIPGYEELLA 239
Cdd:PLN03099  157 LKLLDVLLQLDHLKNAKASIPNDFSWYKRTfTQVSTQWPDTDTMREElDDLQIFLSTRWAILLNLQAEMFRVNNVEDILQ 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  240 DIVNICVDYYENKMYLTPSEKHMLLKVMGFGLYLM---DGNVSNIYKldakkRINLSKIDKFFKQlqvvplfgdmqiela 316
Cdd:PLN03099  237 VLIVFCLESLESDFVLLYSERHILLRVLPVLVVLAtssEKEGESLFK-----RIKINRLINIFQR--------------- 296

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  317 ryiktsahyeenkskwtctqssispQYNICEQMVQIRDDH----IRFISELARYSNSEVVTGsgLDSQKSDEEYRELFDL 392
Cdd:PLN03099  297 -------------------------EYLIVNHMGAIRAEHddfcIRFASAMNQLQLLKSADG--VDTAWSREIKENMYDV 349

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  393 ALRGLQLLSKWSAHVMEVYSWKLVHPT-DKFCNKDCPGTAEEYERATRYNYTSEEKFAFVEVIAMIKGLQVLMGRMESVF 471
Cdd:PLN03099  350 VVEGFQLLSEWTGRIWEQCAWKFSRPAkDATPDPERSGSVTDYEKVVRCNYTAEERKALVELIGYIKGVGSMLERCDTLV 429

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  472 NQAIRNTIYAALQDFAQVTLREPLRQAVRKKKNvLISVLQAIRKTICDWEGgreppndpclrgekdpkggfdiKVPRRAV 551
Cdd:PLN03099  430 ADALWETIHAQVQDFVQNKLATMLRTTFRKKKE-LSRILSDMRTIAADWMA----------------------NTRPEEK 486

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  552 GPSSTQACQWSPRALFHP--TGGTQGRRGCrsLLYMVRTMLESLIADKSGSKKTlRSSLDGPI--VLAIEDFHKQSFFFT 627
Cdd:PLN03099  487 MPSRQRENDESRPNFFYPrpVAPTAAQLHC--LQFLIHELVSGGSPKKPGGFFG-NNGSEIPVndLKQLETFFNKLAFFP 563

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  628 HLLNISEALQQCCDLSQLWFREFFLELTmgRRIQFPIEMSMPWILTDHILETKEPSMMEYVLYPLDLYNDSAYYALTKFK 707
Cdd:PLN03099  564 HILDYRATIGHLTDLGFLWFREFYLETS--RVIQFPIECSLPWMLVDYILESQDAGLLESVLLPFDIYNDSAQHALRVLK 641

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  708 KQFLYDEIEAEVNLCFDQFVYKLADQIFAYYKAMAGSVLLDKRFRAECKN---YGViipypPSNRYETLLKQRHVQLLGR 784
Cdd:PLN03099  642 QRFLYDEIEAEVDLCFDQLVSKLSESIFTYYKSRAASKLLDPSFLAAVDNgekFSV-----QPKRYDALFKMRRVKILGR 716

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  785 SIDLNRLITQRISAAMYKSLDQAISRFESEDLTSIVELEWLLEINRLTHRLLCKHMTLDSFDAMFREANHNVS--APYGR 862
Cdd:PLN03099  717 TIDLASLIAQRMNKIFRENLDFLFERFESQDLCSVVELQRLVEILRLTHELLSEHLSIDPFSLMLGEMQENISlvSFSSR 796

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  863 ITLHVFWELNFDFLPNYCYNGSTNRFVRTAIPFTQEPQRDKPANVQPYYLYGSKPLNIAYSHIYSSYRNFVGPPHFKTIC 942
Cdd:PLN03099  797 LASQIWSEMQNDFLPNFILCNTTQRFVRSSKVPQRPTRRPSVPSAKPSFLCGTQDLNMAHQSFAELHSKFFGLPHMFAIV 876

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954  943 RLLGYQGIAVVMEELLKIVKSLLQGtILQYVKTLIEVMPKICRLPRHEYGSPGILEFFHHQLKDIIEYaELKTDVFQSLR 1022
Cdd:PLN03099  877 KLLGSRSLPWLIRALLDHLSQKITT-LEPMIEDLREAMPKAIGLPSFDGGVAGCMKIFREQLQWGTKY-EGKSEVLRGLK 954

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1023 EVGNAILFCLLIEQALSQEEVCDLLHAAPFQNILPRvyiKEGErlevrMKRLEAKYAPL---------HLVPLIERLGTP 1093
Cdd:PLN03099  955 EIGSLIFWMSLLDIAMREVETVQFMQVAPWLGLVPG---KEGQ-----LQQADDNESPLvslfkeatsAVVSSPGCLNPS 1026

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1094 QQIAIAREG---DLLTKERLCCG------LSMFEVILTRIRSYlqdpiWRGPPPTnGVMHVDECVEFHRLWSAMQFVYCI 1164
Cdd:PLN03099 1027 AFVSMSKQAevaDLLYKSNLNTGsvleytLAFTSAVLDRHRSK-----WSAPPKT-GFIDITTSKDFYRIYSGLQYVYLE 1100

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 619328954 1165 PVGTNEFTAEQCFGDGLNWAGCSIIVLLGQQRRFDLFDFCYHLLKVQ---RQDGKDEIIK--------NVPLKKMADRIR 1233
Cdd:PLN03099 1101 EISAEGSAFHERLGDSVAWGGCTIVYLLGQQLRFELLDFIYHVLSVSeveSASASHTHRNerlkspsyHQGWEGFLENAR 1180

                        1290
                  ....*....|...
gi 619328954 1234 KYQILNNEVFAIL 1246
Cdd:PLN03099 1181 KARRLNNHVFSLL 1193
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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