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Conserved domains on  [gi|659928110|ref|NP_001281211|]
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myb-related protein A isoform 3 [Homo sapiens]

Protein Classification

myb-related protein( domain architecture ID 13851054)

myb-related protein contains a SANT (SWI3, ADA2, N-CoR and TFIIIB)/Myb-like DNA-binding domain, binds DNA and functions as a transcription factor, such as human myb-related protein A that specifically recognizes the sequence 5'-YAAC[GT]G-3'

CATH:  1.20.58.1880
Gene Ontology:  GO:0006355|GO:0003700|GO:0003677
PubMed:  8882580
SCOP:  4000317

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 485-641 1.81e-76

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


:

Pssm-ID: 462753  Cd Length: 157  Bit Score: 241.88  E-value: 1.81e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  485 FSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 564
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 659928110  565 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLL 641
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 super family cl33633
hypothetical protein; Provisional
 84-270 4.62e-30

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03091:

Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 4.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  84 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 161
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110 162 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYlqdgikserssSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGN 241
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGI-----------DPNTHKPLSEVENGEDKNPPTDDKSDKASSVVSNELN 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 659928110 242 CIE--HVQPTSAFIQQPFIDEDPDKEKKIKE 270
Cdd:PLN03091 159 LLKadNSKPLAALQEKRSSSISPAGYQLEVE 189
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 38-98 3.25e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


:

Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.11  E-value: 3.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 659928110   38 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 98
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 485-641 1.81e-76

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 241.88  E-value: 1.81e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  485 FSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 564
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 659928110  565 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLL 641
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 PLN03091
hypothetical protein; Provisional
 84-270 4.62e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 4.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  84 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 161
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110 162 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYlqdgikserssSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGN 241
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGI-----------DPNTHKPLSEVENGEDKNPPTDDKSDKASSVVSNELN 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 659928110 242 CIE--HVQPTSAFIQQPFIDEDPDKEKKIKE 270
Cdd:PLN03091 159 LLKadNSKPLAALQEKRSSSISPAGYQLEVE 189
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 84-186 7.66e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 114.88  E-value: 7.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  84 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAE 163
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100
                 ....*....|....*....|...
gi 659928110 164 IAKLLPGRTDNSIKNHWNSTMRR 186
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 240-286 5.83e-21

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 86.47  E-value: 5.83e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 659928110  240 GNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKR 286
Cdd:pfam07988   1 LNCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 38-98 3.25e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.11  E-value: 3.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 659928110   38 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 98
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
87-135 3.65e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 72.64  E-value: 3.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 659928110    87 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNP 135
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 89-133 6.36e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.84  E-value: 6.36e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659928110  89 PWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHL 133
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
35-83 1.01e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.40  E-value: 1.01e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 659928110    35 RVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNP 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 37-81 2.67e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.22  E-value: 2.67e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659928110  37 KWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVL 81
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
 
Name Accession Description Interval E-value
Cmyb_C pfam09316
C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb ...
 485-641 1.81e-76

C-myb, C-terminal; Members of this family are predominantly found in the proto-oncogene c-myb and the viral transforming protein myb. Truncation of the domain results in 'activation' of c-myb and subsequent tumourigenesis.


Pssm-ID: 462753  Cd Length: 157  Bit Score: 241.88  E-value: 1.81e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  485 FSPSQFFNTCPGNEQLNIENPSFTSTPICGQKALITTPLHKETTPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAA 564
Cdd:pfam09316   1 FSPSQFLNESSGQENLPLENPTLTSTPVCGQKVFLTTPLHKDQTPKYQKENTGFRTPNIRRSILETTPRTPTPFKNALAA 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 659928110  565 QEKKYGPLKIVSQPLAFLEEDIREVLKEETGTDLFLKEEDEPAYKSCKQENTASGKKVRKSLVLDNWEKEESGTQLL 641
Cdd:pfam09316  81 QEKKYGPLKPLPQTPAHLEEDLQEVLKSEIGSDIEIGEDEKPWKQKIKQEHRSPNKKVRKSLWLDDWDKEHLTVQLF 157
PLN03091 PLN03091
hypothetical protein; Provisional
 84-270 4.62e-30

hypothetical protein; Provisional


Pssm-ID: 215570 [Multi-domain]  Cd Length: 459  Bit Score: 123.93  E-value: 4.62e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  84 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKhLKG--RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRW 161
Cdd:PLN03091  11 KLRKGLWSPEEDEKLLRHITKYGHGCWSSVPK-QAGlqRCGKSCRLRWINYLRPDLKRGTFSQQEENLIIELHAVLGNRW 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110 162 AEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYlqdgikserssSKLQHKPCAAMDHMQTQNQFYIPVQIPGYQYVSPEGN 241
Cdd:PLN03091  90 SQIAAQLPGRTDNEIKNLWNSCLKKKLRQRGI-----------DPNTHKPLSEVENGEDKNPPTDDKSDKASSVVSNELN 158

                        170       180       190
                 ....*....|....*....|....*....|.
gi 659928110 242 CIE--HVQPTSAFIQQPFIDEDPDKEKKIKE 270
Cdd:PLN03091 159 LLKadNSKPLAALQEKRSSSISPAGYQLEVE 189
PLN03212 PLN03212
Transcription repressor MYB5; Provisional
 87-192 8.00e-28

Transcription repressor MYB5; Provisional


Pssm-ID: 178751 [Multi-domain]  Cd Length: 249  Bit Score: 112.86  E-value: 8.00e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  87 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKG-RIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAEIA 165
Cdd:PLN03212  25 RGPWTVEEDEILVSFIKKEGEGRWRSLPKRAGLlRCGKSCRLRWMNYLRPSVKRGGITSDEEDLILRLHRLLGNRWSLIA 104

                         90       100
                 ....*....|....*....|....*..
gi 659928110 166 KLLPGRTDNSIKNHWNSTMRRKVEQEG 192
Cdd:PLN03212 105 GRIPGRTDNEIKNYWNTHLRKKLLRQG 131
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 84-186 7.66e-27

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 114.88  E-value: 7.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  84 ELIKGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDRIIYEAHKRLGNRWAE 163
Cdd:COG5147   17 KRKGGSWKRTEDEDLKALVKKLGPNNWSKVASLLISSTGKQSSNRWNNHLNPQLKKKNWSEEEDEQLIDLDKELGTQWST 96

                         90       100
                 ....*....|....*....|...
gi 659928110 164 IAKLLPGRTDNSIKNHWNSTMRR 186
Cdd:COG5147   97 IADYKDRRTAQQCVERYVNTLED 119
LMSTEN pfam07988
LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional ...
 240-286 5.83e-21

LMSTEN motif; This region of Myb proteins has previously been described as the transcriptional activation domain present in the vertebrate c-Myb and A-Myb, but neither vertebrate B-Myb proteins nor Myb proteins of invertebrates. Because vertebrate B-Myb (but neither A-Myb nor c-Myb) can partially complement Drosophila Myb null mutants, this region appears to have been a relatively recent insertion.


Pssm-ID: 462332  Cd Length: 47  Bit Score: 86.47  E-value: 5.83e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 659928110  240 GNCIEHVQPTSAFIQQPFIDEDPDKEKKIKELEMLLMSAENEVRRKR 286
Cdd:pfam07988   1 LNCLEHPQHSTAFIQQPFIDEDPDKEKRIKELELLLMSAENEVRRKQ 47
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 90-148 7.85e-18

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 77.74  E-value: 7.85e-18
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 659928110   90 WTKEEDQRVIELVQKYGPKrWSLIAKHLKGRIGKQCRERWHNHLNPEVKKSSWTEEEDR 148
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGND-WKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQ 58
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 87-133 6.03e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 6.03e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 659928110   87 KGPWTKEEDQRVIELVQKYGpKRWSLIAKHLKGRIGKQCRERWHNHL 133
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 139-182 6.65e-17

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 74.85  E-value: 6.65e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 659928110  139 KSSWTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNS 182
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLGNRWKKIAKLLPGRTDNQCKNRWQN 44
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 38-98 3.25e-16

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 73.11  E-value: 3.25e-16
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 659928110   38 WTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRV 98
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYG-NDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSKEEDQRL 60
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
87-135 3.65e-16

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 72.64  E-value: 3.65e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 659928110    87 KGPWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHLNP 135
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 89-133 6.36e-16

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 71.84  E-value: 6.36e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659928110  89 PWTKEEDQRVIELVQKYGPKRWSLIAKHLKGRIGKQCRERWHNHL 133
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
35-83 1.01e-14

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 68.40  E-value: 1.01e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 659928110    35 RVKWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNP 83
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGKNNWEKIAKELPGRTAEQCRERWRNLLKP 49
Myb_DNA-binding pfam00249
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 35-81 2.06e-14

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 459731 [Multi-domain]  Cd Length: 46  Bit Score: 67.53  E-value: 2.06e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 659928110   35 RVKWTRDEDDKLKKLVEQHGtDDWTLIASHLQNRSDFQCQHRWQKVL 81
Cdd:pfam00249   1 RGPWTPEEDELLLEAVEKLG-NRWKKIAKLLPGRTDNQCKNRWQNYL 46
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 37-81 2.67e-14

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 67.22  E-value: 2.67e-14
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659928110  37 KWTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVL 81
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGKNNWEKIAKELPGRTPKQCRERWRNLL 45
SANT smart00717
SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;
139-186 6.63e-13

SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains;


Pssm-ID: 197842 [Multi-domain]  Cd Length: 49  Bit Score: 63.40  E-value: 6.63e-13
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 659928110   139 KSSWTEEEDRIIYEAHKRLG-NRWAEIAKLLPGRTDNSIKNHWNSTMRR 186
Cdd:smart00717   1 KGEWTEEEDELLIELVKKYGkNNWEKIAKELPGRTAEQCRERWRNLLKP 49
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 141-181 7.37e-13

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 62.98  E-value: 7.37e-13
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 659928110 141 SWTEEEDRIIYEAHKRLG-NRWAEIAKLLPGRTDNSIKNHWN 181
Cdd:cd00167    1 PWTEEEDELLLEAVKKYGkNNWEKIAKELPGRTPKQCRERWR 42
Myb_DNA-bind_6 pfam13921
Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, ...
 142-195 8.38e-08

Myb-like DNA-binding domain; This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family.


Pssm-ID: 372817 [Multi-domain]  Cd Length: 60  Bit Score: 49.23  E-value: 8.38e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 659928110  142 WTEEEDRIIYEAHKRLGNRWAEIAKLLPGRTDNSIKNHWNSTMRRKVEQEGYLQ 195
Cdd:pfam13921   1 WTEEEDEKLLKLVEKYGNDWKQIAKELGRRTPKQCFDRWRRKLNPKISRGPWSK 54
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 83-129 7.31e-07

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 46.53  E-value: 7.31e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 659928110  83 PELIKGPWTKEEDQRVIELVQKYgPKRWSLIAKhLKGRIGKQCRERW 129
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLL-PTQWRTIAP-IVGRTAQQCLERY 45
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 89-131 1.10e-06

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 45.64  E-value: 1.10e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 659928110  89 PWTKEEDQRVIELVQKYGPKRWSLIAKH---LKGRIGKQCRERWHN 131
Cdd:cd11660    2 KWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKWRN 47
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 135-181 5.04e-05

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 41.14  E-value: 5.04e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 659928110 135 PEVKKSSWTEEEDRIIYEAHKRLGNRWAEIAKLLpGRTDNSIKNHWN 181
Cdd:cd11659    1 PSIKKTEWTREEDEKLLHLAKLLPTQWRTIAPIV-GRTAQQCLERYN 46
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 35-177 8.43e-05

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 45.55  E-value: 8.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  35 RVKWTRDEDDKLKKLVEQHGTdDWTLIaSHLQNRSDFQCQHRWQ--KVLNPELIKGPWTKEEDQRVIELV-------QKY 105
Cdd:COG5147  291 RGKWTKEEEQELAKLVVEHGG-SWTEI-GKLLGRMPNDCRDRWRdyVKCGDTLKRNRWSIEEEELLDKVVnemrleaQQS 368

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 659928110 106 GPKRWSLIAKHLKGRIGKQCreRWHNHLNPEVKK----SSWTEEEDRiIYEAHKRLGNR--WAEIAKLLPGRTDNSIK 177
Cdd:COG5147  369 SRILWLLIAQNIRNRLQHHC--RDKYGVLISNSSpfdaGAAIWLIER-YSNRKIQNGDLikWRNSVLDSARRRMRDLK 443
SANT_TRF cd11660
Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human ...
 36-77 5.75e-04

Telomere repeat binding factor-like DNA-binding domains of the SANT/myb-like family; Human telomere repeat binding factors, TRF1 and TRF2, function as part of the 6 component shelterin complex. TRF2 binds DNA and recruits RAP1 (via binding to the RAP1 protein c-terminal (RCT)) and TIN2 in the protection of telomeres from DNA repair machinery. Metazoan shelterin consists of 3 DNA binding proteins (TRF2, TRF1, and POT1) and 3 recruited proteins that bind to one or more of these DNA-binding proteins (RAP1, TIN2, TPP1). Schizosaccharomyces pombe TAZ1 is an orthlog and binds RAP1. Human TRF1 and TRF2 bind double-stranded DNA. hTRF2 consists of a basic N-terminus, a TRF homology domain, the RAP1 binding motif (RBM), the TIN2 binding motif (TBM) and a myb-like DNA binding domain, SANT, named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. Tandem copies of the domain bind telomeric DNA tandem repeats as part of the capping complex. The single myb-like domain of TRF-type proteins is similar to the tandem myb_like domains found in yeast RAP1.


Pssm-ID: 212558 [Multi-domain]  Cd Length: 50  Bit Score: 38.32  E-value: 5.75e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 659928110  36 VKWTRDEDDKLKKLVEQHGTDDWTLIASH---LQNRSDFQCQHRW 77
Cdd:cd11660    1 RKWTDEEDEALVEGVEKYGVGNWAKILKDyffVNNRTSVDLKDKW 45
REB1 COG5147
Myb superfamily proteins, including transcription factors and mRNA splicing factors ...
 75-172 4.67e-03

Myb superfamily proteins, including transcription factors and mRNA splicing factors [Transcription / RNA processing and modification / Cell division and chromosome partitioning];


Pssm-ID: 227476 [Multi-domain]  Cd Length: 512  Bit Score: 40.16  E-value: 4.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 659928110  75 HRWQKVLNPELIKGPWTKEEDQRVIELVQKYGpKRWSLIAKhLKGRIGKQCRERWHNHLNP--EVKKSSWTEEED----- 147
Cdd:COG5147  279 KHLRRKYNIFEQRGKWTKEEEQELAKLVVEHG-GSWTEIGK-LLGRMPNDCRDRWRDYVKCgdTLKRNRWSIEEEelldk 356

                         90       100
                 ....*....|....*....|....*...
gi 659928110 148 ---RIIYEAHKRLGNRWAEIAKLLPGRT 172
Cdd:COG5147  357 vvnEMRLEAQQSSRILWLLIAQNIRNRL 384
SANT_CDC5_II cd11659
SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, ...
 34-82 4.85e-03

SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II; In humans, cell division cycle 5-like protein (CDC5) functions in pre-mRNA splicing in cell cycle control. The DNA-binding, myb-like domain of CDC5 is a member of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 212557 [Multi-domain]  Cd Length: 53  Bit Score: 35.75  E-value: 4.85e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 659928110  34 NRVKWTRDEDDKLKKLVeQHGTDDWTLIAShLQNRSDFQCQHRWQKVLN 82
Cdd:cd11659    4 KKTEWTREEDEKLLHLA-KLLPTQWRTIAP-IVGRTAQQCLERYNKLLD 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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