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Conserved domains on  [gi|665388991|ref|NP_001284755|]
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SKP1-related A, isoform I [Drosophila melanogaster]

Protein Classification

SKP1 family protein( domain architecture ID 13034557)

SKP1 family protein may be a component of E3 ubiquitin ligase SCF complex involved in ubiquitination and subsequent proteasomal degradation of target proteins; similar to Homo sapiens S-phase kinase-associated protein 1 (SKP1)

CATH:  3.30.710.10
Gene Ontology:  GO:0006511
PubMed:  35345853|12678488
SCOP:  4001926|4001139

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-126 1.39e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349631  Cd Length: 120  Bit Score: 193.19  E-value: 1.39e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   4 IKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDEnaiVPLPNVNSTILRKVLTWAHYHKDDPqPTEDDESKEKRTDD 83
Cdd:cd18322    2 IKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDDDP---IPLPNVTSKILKKVIEWCEHHKDDP-PPEIDLDSEKRTDD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 665388991  84 IISWDADFLKVDQGTLFELILAANYLDIKGLLELTCKTVANMI 126
Cdd:cd18322   78 IPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
Skp1 pfam01466
Skp1 family, dimerization domain;
112-159 9.72e-25

Skp1 family, dimerization domain;


:

Pssm-ID: 460222  Cd Length: 48  Bit Score: 89.87  E-value: 9.72e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 665388991  112 KGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWC 159
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEEIRKENAWA 48
 
Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-126 1.39e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 193.19  E-value: 1.39e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   4 IKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDEnaiVPLPNVNSTILRKVLTWAHYHKDDPqPTEDDESKEKRTDD 83
Cdd:cd18322    2 IKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDDDP---IPLPNVTSKILKKVIEWCEHHKDDP-PPEIDLDSEKRTDD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 665388991  84 IISWDADFLKVDQGTLFELILAANYLDIKGLLELTCKTVANMI 126
Cdd:cd18322   78 IPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 1-162 3.55e-50

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 158.18  E-value: 3.55e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   1 MPSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGmedDENAIVPLPNVNSTILRKVLTWAHYHKDDPQPTEDDESKEKR 80
Cdd:COG5201    1 MSMIELESIDGEIFRVDENIAERSILIKNMLCDST---ACNYPIPAPNVRSSVLMKVQEWMEHHTSSLSEDENDLEIRKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991  81 TDdIISWDADFLKVDQGTLFELILAANYLDIKGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWCE 160
Cdd:COG5201   78 KP-SDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDFTPEEERRIRKENEWAE 156


                 ..
gi 665388991 161 EK 162
Cdd:COG5201  157 DR 158
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 1-111 7.19e-40

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 130.11  E-value: 7.19e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991     1 MPSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDENAIVPLPNVNSTILRKVLTWAHYHKDDPQPTEDDeskekr 80
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNNPIPLPNVTSKILSKVIEYCEHHVDDPPSVADK------ 74

                           90       100       110
                   ....*....|....*....|....*....|.
gi 665388991    81 tDDIISWDADFLKVDQGTLFELILAANYLDI 111
Cdd:smart00512  75 -DDIPTWDAEFLKIDQETLFELILAANYLDI 104
Skp1 pfam01466
Skp1 family, dimerization domain;
112-159 9.72e-25

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 89.87  E-value: 9.72e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 665388991  112 KGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWC 159
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEEIRKENAWA 48
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
2-66 7.94e-22

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 82.73  E-value: 7.94e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665388991    2 PSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMeddenAIVPLPNVNSTILRKVLTWAHYHKD 66
Cdd:pfam03931   1 PKIVLQSSDGESFEVEEAVARKSKTIKHMIEDDGD-----DPIPLPNVTSKILEKVIEYCKHHRV 60
 
Name Accession Description Interval E-value
BTB_POZ_SKP1 cd18322
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-126 1.39e-64

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in S-phase kinase-associated protein 1 (SKP1) and similar proteins; SKP1 is also called cyclin-A/CDK2-associated protein p19 (p19A), organ of Corti protein 2 (OCP-2), organ of Corti protein II (OCP-II), RNA polymerase II elongation factor-like protein, transcription elongation factor B polypeptide 1-like, or p19skp1. It is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SKP1 serves as an adaptor protein that links the F-box protein to CUL1. SKP1 and CUL1 are invariant components of all SCF complexes, while F-box proteins are variable substrate binding modules that determine specificity. SKP1 belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349631  Cd Length: 120  Bit Score: 193.19  E-value: 1.39e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   4 IKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDEnaiVPLPNVNSTILRKVLTWAHYHKDDPqPTEDDESKEKRTDD 83
Cdd:cd18322    2 IKLQSSDGEIFEVDEEVARQSVTIKNMLEDLGYDDDP---IPLPNVTSKILKKVIEWCEHHKDDP-PPEIDLDSEKRTDD 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 665388991  84 IISWDADFLKVDQGTLFELILAANYLDIKGLLELTCKTVANMI 126
Cdd:cd18322   78 IPEWDAEFLKVDQDTLFELILAANYLDIKGLLDLTCKTVANMI 120
SKP1 COG5201
SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, ...
 1-162 3.55e-50

SCF ubiquitin ligase, SKP1 component [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227528 [Multi-domain]  Cd Length: 158  Bit Score: 158.18  E-value: 3.55e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   1 MPSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGmedDENAIVPLPNVNSTILRKVLTWAHYHKDDPQPTEDDESKEKR 80
Cdd:COG5201    1 MSMIELESIDGEIFRVDENIAERSILIKNMLCDST---ACNYPIPAPNVRSSVLMKVQEWMEHHTSSLSEDENDLEIRKS 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991  81 TDdIISWDADFLKVDQGTLFELILAANYLDIKGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWCE 160
Cdd:COG5201   78 KP-SDFWDRFFMEVDQEMLLEICLAANYLEIKPLLDLGCKIVAEMIRGKSPEEIRETFNIENDFTPEEERRIRKENEWAE 156


                 ..
gi 665388991 161 EK 162
Cdd:COG5201  157 DR 158
Skp1 smart00512
Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle ...
 1-111 7.19e-40

Found in Skp1 protein family; Family of Skp1 (kinetochore protein required for cell cycle progression) and elongin C (subunit of RNA polymerase II transcription factor SIII) homologues.


Pssm-ID: 214704  Cd Length: 104  Bit Score: 130.11  E-value: 7.19e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991     1 MPSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMEDDENAIVPLPNVNSTILRKVLTWAHYHKDDPQPTEDDeskekr 80
Cdd:smart00512   1 SKYIKLISSDGEVFEVEREVARQSKTIKAMIEDLGVDDENNNPIPLPNVTSKILSKVIEYCEHHVDDPPSVADK------ 74

                           90       100       110
                   ....*....|....*....|....*....|.
gi 665388991    81 tDDIISWDADFLKVDQGTLFELILAANYLDI 111
Cdd:smart00512  75 -DDIPTWDAEFLKIDQETLFELILAANYLDI 104
Skp1 pfam01466
Skp1 family, dimerization domain;
112-159 9.72e-25

Skp1 family, dimerization domain;


Pssm-ID: 460222  Cd Length: 48  Bit Score: 89.87  E-value: 9.72e-25
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 665388991  112 KGLLELTCKTVANMIKGKTPEEIRKTFNIKKDFSPAEEEQVRKENEWC 159
Cdd:pfam01466   1 KGLLDLTCKTVADMIKGKTPEEIREIFNIENDFTPEEEEEIRKENAWA 48
Skp1_POZ pfam03931
Skp1 family, tetramerization domain;
2-66 7.94e-22

Skp1 family, tetramerization domain;


Pssm-ID: 397838  Cd Length: 60  Bit Score: 82.73  E-value: 7.94e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665388991    2 PSIKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMeddenAIVPLPNVNSTILRKVLTWAHYHKD 66
Cdd:pfam03931   1 PKIVLQSSDGESFEVEEAVARKSKTIKHMIEDDGD-----DPIPLPNVTSKILEKVIEYCKHHRV 60
BTB_POZ_EloC cd18321
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 4-111 6.20e-12

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Elongin-C (EloC) and similar proteins; Elongin-C is also called elongin 15 kDa subunit, RNA polymerase II transcription factor SIII subunit C, SIII p15, or transcription elongation factor B polypeptide 1 (TCEB1). It is a component of SIII (also known as elongin), which is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. It forms a regulatory complex with subunit B or elongin-B (BC) that enhances the activity of the transcriptionally active subunit A. The BC complex also functions as an adaptor protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC (VHL) and the suppressors of cytokine signaling (SOCS) box ubiquitin ligase family. Elongin-C belongs to the BTB/POZ domain family; the domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349630  Cd Length: 95  Bit Score: 58.37  E-value: 6.20e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   4 IKLQSSDEEIFDTDIQIAKCSGTIKTMLEDCGMED-DENAIVPLPNVNSTILRKVLTWAHYHKddpqpteddeSKEKRTD 82
Cdd:cd18321    2 VKLISSDGHEFIVDREAAMVSGTIKAMLSGPGQFAeNETNEVRFPEISSHILEKVCEYFYYKV----------RYTNSST 71

                         90       100
                 ....*....|....*....|....*....
gi 665388991  83 DIISWDADflkvDQGTLfELILAANYLDI 111
Cdd:cd18321   72 EIPEFPIP----PEIAL-ELLMAANFLDC 95
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 4-109 1.42e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 51.90  E-value: 1.42e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991   4 IKLQSSDEEiFDTDIQIAKCSGTIKTMLEDCGMEDDENAIVPLPNVNSTILRKVLTWAHYHKDDpqpteddeskekrtdd 83
Cdd:cd01165    1 VVLVVEGEK-FHVNKELLAQSSEYFRALFRGGFRESGQAEINLRDISPEDFRALLEFLYGGKRD---------------- 63

                         90       100
                 ....*....|....*....|....*.
gi 665388991  84 iiswdadflkVDQGTLFELILAANYL 109
Cdd:cd01165   64 ----------LDASNLLELLEAANFL 79
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 21-120 6.54e-04

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 37.29  E-value: 6.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665388991    21 AKCSGTIKTMLEDCGMEDDENaIVPLPNVNSTILRKVLTWAhyhkddpqpteddeskekRTDDIIswdadflkVDQGTLF 100
Cdd:smart00225  19 AAHSPYFKALFSSDFKESDKS-EIYLDDVSPEDFRALLNFL------------------YTGKLD--------LPEENVE 71

                           90       100
                   ....*....|....*....|
gi 665388991   101 ELILAANYLDIKGLLELTCK 120
Cdd:smart00225  72 ELLELADYLQIPGLVELCEE 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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