|
Name |
Accession |
Description |
Interval |
E-value |
| 2A1704 |
TIGR00926 |
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and ... |
145-776 |
0e+00 |
|
Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors); [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273343 [Multi-domain] Cd Length: 654 Bit Score: 613.69 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 145 FNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVLLTLGAIGPLN 224
Cdd:TIGR00926 1 FSYYGMRTILVLYFLNFLGFSESTSTVLFHTFTYLCYLTPLIGAIIADGWLGKFKTILYLSIVYVVGHALLSFGAIPSSG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 225 LP-METFTMLGLALIALGSGGIKPCVSAFGGDQFKVpEQVKQITSFFSLFYFSINAGSLISTTVTPILREDVSCFDDINC 303
Cdd:TIGR00926 81 HPlHDLLDLLGLALIALGTGGIKPCVSAFGGDQFEE-RQLSLRSRFFSFFYFAINAGSLISTIITPILRGDVGCFGCQDC 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 304 YPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKEKKTNPREHWLDYADKKYDRQLIDDVKV 383
Cdd:TIGR00926 160 YPLAFGVPAILMILALIVFMAGSKMYKKKPPKGNIVSKVIKCIVTALRKRFSTRSEHWPLHWLDYAKDKHDIRMIRSTKR 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 384 LMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR-RPLQ 462
Cdd:TIGR00926 240 LLRVLVLFIPLPMFWALFDQQGSRWTLQATRMDGDVGGFEIQPDQMQVVNPLLILIFVPIFDYIVYPAIAKCGTRfTSLR 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 463 KLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQNIQLRIFNADN--CDYFFTS---NIP---GAENVTVTSL--NAYTN 532
Cdd:TIGR00926 320 KMAVGGLLAALSFFVAALVQLKVNPTLPEEPSANEIFLQVLNTDCtiCDFSVLSkrvLPHdvyLHLDKKNTSGdqGLFTT 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 533 KDIYAPGSLDVEFS------LSSASEACTISADKIPKV----LTDNTAWSLFLN---PLNGsgyyweedfvdKPSQSHPL 599
Cdd:TIGR00926 400 KSSAKGWTLTYDLSydgacgLTGNCPKTTDAHELEPKIsyvlLLSQGGYQLTANtdkPTDA-----------KTEKGMGS 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 600 IRNVANVPQELSIRWEKASTGEVVYDDL----ASKTLLTRVNSAEYVVMVGERNVGTF---DVHTGGVYTLLIKDNNNI- 671
Cdd:TIGR00926 469 VRLVNTLNGEFGMISLCTSDSDSVTPCNprdpYDFYFRGTKYPANTCDRIDNAKSSTFlsnQLDMGIYYLIVITENSKId 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 672 -YEANLEEVTSPNSVKILWLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFES 750
Cdd:TIGR00926 549 eLQAQIVELVSVNTVSILWQIPQYVILTAGEVLFSVTGLEFSYSQAPPNMKSVLQALWLLTVAIGNLIVVVIAEFENFSV 628
|
650 660
....*....|....*....|....*.
gi 665389490 751 QASEFFLFAGLMFADMLIFMVMAYYY 776
Cdd:TIGR00926 629 QAAEFFLFASLMLVVMAIFSILAYFY 654
|
|
| MFS_SLC15A1_2_like |
cd17347 |
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ... |
130-781 |
0e+00 |
|
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340905 [Multi-domain] Cd Length: 427 Bit Score: 578.03 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:cd17347 1 PRAVPFIVGNEFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAIGPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQvKQITSFFSLFYFSINAGSLISTTVTP 289
Cdd:cd17347 81 LGHIVLAVTAIPPLGPPHVWGLLIGLLLIAIGTGGIKPCVSAFGGDQFGADQQ-HLLARFFSWFYFAINAGSLLSTFLTP 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 290 ILREDVSCFDDiNCYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttkckekktnprehwldya 369
Cdd:cd17347 160 ILRADVQFGGH-DCYPLAFGVPGVLMAVATLVFWLGRKHYK--------------------------------------- 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 370 dkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALY 449
Cdd:cd17347 200 ----------DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILILILIPLFDYVIY 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 450 PALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLEKTYPDLPYSQniqlrifnadncdyfftsnipgaenvtvtsln 528
Cdd:cd17347 270 PLLERCGIPlTPLRKMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPG-------------------------------- 317
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 529 aytnkdiyapgsldvefslssaseactisadkipkvltdntawslflnplngsgyyweedfvdkpsqshplirnvanvpq 608
Cdd:cd17347 --------------------------------------------------------------------------------
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 609 elsirwekastgevvyddlasktlltrvnsaeyvvmvgernvgtfdvhtggvytllikdnnniyEANLEEVTSPNSVKIL 688
Cdd:cd17347 318 ----------------------------------------------------------------EVTTFEDIEPNSVSIL 333
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 689 WLVPQYVVMTLGEVMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFESQASEFFLFAGLMFADMLI 768
Cdd:cd17347 334 WQLPQYVVLTAGEVLFSITGLEFAYTQAPKSMKSVVQAAWLLTVALGNLIVVIVAELIQFSSQAAEYFFFAGLMLVVAVV 413
|
650
....*....|...
gi 665389490 769 FMVMAYYYVPNDP 781
Cdd:cd17347 414 FALLARFYKYVTY 426
|
|
| MFS_SLC15A1 |
cd17412 |
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute ... |
130-783 |
7.58e-134 |
|
Solute Carrier family 15 member 1 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 1 (SLC15A1), also called peptide transporter 1 (PepT1), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A1, as well as SLC15A2, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1 is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. It is a high-capacity/low-affinity transporter that drives the transport of di-and tripeptides for metabolic purposes. It's expression is upregulated in the colon during chronic inflammation associated with inflammatory bowel disease. SLC15A1/PepT1 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340970 [Multi-domain] Cd Length: 415 Bit Score: 404.23 E-value: 7.58e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:cd17412 1 PLSIFFIVVNEFCERFSYYGMRAVLVLYFKYFLRWDDDLSTAIYHTFVALCYLTPILGAIIADSWLGKFKTIVYLSIVYT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAIG----------PLNLPME-TFTMLGLALIALGSGGIKPCVSAFGGDQFKvPEQVKQITSFFSLFYFSIN 278
Cdd:cd17412 81 IGQAVMAVSAIHdltdanrdgtPDNLTLHvALSMIGLLLIALGTGGIKPCVAAFGGDQFE-EHQEKQRSRFFSIFYLSIN 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 279 AGSLISTTVTPILR-EDVSCFDDINCYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttkckek 357
Cdd:cd17412 160 AGSLLSTIITPILRsQECGIHSKQKCYPLAFGVPAALMVVALIVFILGSKMYK--------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 358 ktnprehwldyadkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLI 437
Cdd:cd17412 213 ----------------------QIKMVLKVLFLYIPLPMFWALFDQQGSRWTLQATTMDGNFGAIQIQPDQMQTVNPILI 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 438 LIFIPLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLektypdlpysqniqlrifnadncdyfftsni 516
Cdd:cd17412 271 IIMVPIFDAVIYPLIKKCKINfTPLRKMTVGMFLAALAFVAAALLQIQM------------------------------- 319
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 517 pgaenvtvtslnaytnkdiyapgsldvefslssaseactisadkipkvltdntAWslflnplngsgyyweedfvdkpsqs 596
Cdd:cd17412 320 -----------------------------------------------------AW------------------------- 321
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 597 hplirnvaNVPQELSIrwekaSTGEVVyddlasktlltrvnsaeyvvmvgernvgtfdvhtggvytllikdnnniyeanl 676
Cdd:cd17412 322 --------QIPQYFLL-----TCGEVV----------------------------------------------------- 335
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 677 eevtspnsvkilwlvpqyvvmtlgevmFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFESQASEFF 756
Cdd:cd17412 336 ---------------------------FSVTGLEFSYSQAPSNMKSVLQAGWLLTVAVGNIIVLIVAEAGSISEQWAEYV 388
|
650 660
....*....|....*....|....*..
gi 665389490 757 LFAGLMFADMLIFMVMAYYYVPNDPNK 783
Cdd:cd17412 389 LFAALLVAVCIIFAIMAYFYTYVDPAE 415
|
|
| MFS_SLC15A2 |
cd17411 |
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute ... |
130-782 |
1.32e-127 |
|
Solute carrier family 15 member 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 2 (SLC15A2), also called peptide transporter 2 (PepT2), is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. SLC15A2, as well as SLC15A1, mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A2 is a high-affinity transporter and is abundantly expressed in the apical membrane of kidney proximal tubules and choroid plexus epithelial cells. It is the major transporter involved in the reclamation of peptide-bound amino acids and peptide-like drugs in the kidney, and is also called the renal isoform. In choroid plexus and the brain, it acts as an efflux transporter and plays a role in regulating peptide/neuropeptide homeostasis. SLC15A2/PepT2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340969 [Multi-domain] Cd Length: 403 Bit Score: 387.64 E-value: 1.32e-127
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:cd17411 1 PLSIAFIVVNEFCERFSYYGMKAVLTLYFLSFLHWDENLSTAIYHAFSGLCYFTPVLGALIADSWLGKFKTIIYLSIVYV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAI---GPLNLPMeTFTMLGLALIALGSGGIKPCVSAFGGDQFKvPEQVKQITSFFSLFYFSINAGSLISTT 286
Cdd:cd17411 81 VGHVIKSVGAIptvGDQQVHV-VLSMIGLFLIALGTGGIKPCVAAFGGDQFE-EEHARERSKFFSIFYLSINAGSLISTF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 287 VTPILREDVSCFDDiNCYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttkckekktnprehwl 366
Cdd:cd17411 159 VTPILRGDVQCFGG-DCYALAFGVPAALMVVALVVFIAGSGMYK------------------------------------ 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 367 dyadkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYDV 446
Cdd:cd17411 202 -------------EVKMVTRVLFLYIPLPMFWALFDQQGSRWTLQATRMNDFGGGFVLQPDQMQTLNPLLILVFIPIFDL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 447 ALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLektypdlpysqniqlrifnadncdyfftsnipgaenvtvt 525
Cdd:cd17411 269 GIYPLVSKCKINfTSLRKMATGMILAALAFAVAAAVEIKI---------------------------------------- 308
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 526 slnaytnkdiyapgsldvefslssaseactisadkipkvltdntAWSLflnplngsgyyweedfvdkpsqshplirnvan 605
Cdd:cd17411 309 --------------------------------------------AWQL-------------------------------- 312
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 606 vPQELSIrwekaSTGEVvyddlasktlltrvnsaeyvvmvgernvgtfdvhtggvytllikdnnniyeanleevtspnsv 685
Cdd:cd17411 313 -PQYVLL-----SAGEV--------------------------------------------------------------- 323
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 686 kilwlvpqyvvmtlgevMFSVTGLEFSYAQAPPSMKSVLQACWLLTVAFGNVIVVVIAEAALFeSQASEFFLFAGLMFAD 765
Cdd:cd17411 324 -----------------MFSITGLEFSYSQAPASMKSVLQAGWLLTVAFGNVIVLIVAQAAGM-AQWAEFLLFAALLLAV 385
|
650
....*....|....*..
gi 665389490 766 MLIFMVMAYYYVPNDPN 782
Cdd:cd17411 386 CIIFSIMGYFYVYVDPE 402
|
|
| PTR2 |
pfam00854 |
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ... |
198-504 |
1.09e-99 |
|
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.
Pssm-ID: 425909 [Multi-domain] Cd Length: 392 Bit Score: 314.64 E-value: 1.09e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 198 FKTILYLSLVYICGSVLLTLGAIGPLNLPME-TFTMLGLALIALGSGGIKPCVSAFGGDQFKvPEQVKQITSFFSLFYFS 276
Cdd:pfam00854 1 FRTIFLGSIIYAIGHILLALSAIPSLRPPVHvALFFIGLALIALGTGGIKPNVSSFGGDQFE-ETDPRRRSRFFSIFYFS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 277 INAGSLISTTVTPILREDVscfddinCYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGNMVVLVSSTIWTALTTKCKE 356
Cdd:pfam00854 80 INAGSLISTIITPYLQQNY-------GYPLGFGLPAVGMIIALLVFLLGSRMYKKKPPKGNVLTKVFKVLPVAAWNKVKL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 357 ---KKTNPREHWLD------------------YADKKYDRQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRM 415
Cdd:pfam00854 153 ngsSAGIKKLHWLDwareldaliilgivvpgiFFNIWCTKTKVEEVKRLLRVLPLFLPLIMFWALYDQMGTSWVLQARTM 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 416 DGDMGSWDIKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLEKTYPDLPY 494
Cdd:pfam00854 233 NRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGGlTPLQKMAVGLFLASLAFAIAAIVQLKRNDTGPEFPI 312
|
330
....*....|
gi 665389490 495 SQNIQLRIFN 504
Cdd:pfam00854 313 AQEVPISVLW 322
|
|
| PTR2 |
COG3104 |
Dipeptide/tripeptide permease [Amino acid transport and metabolism]; |
118-477 |
1.87e-72 |
|
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
Pssm-ID: 442338 [Multi-domain] Cd Length: 479 Bit Score: 245.11 E-value: 1.87e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 118 SETEGQQKKLPYPKSVFFIISNEFCERFNYYGMRTVLVLYL-----SRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISD 192
Cdd:COG3104 1 TTSAPQRTFFGHPKGLYTLFFTEMWERFSFYGMRAILVLYLtaslaDGGLGLSEADAAAIYGAYTALVYLTPLLGGWLAD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 193 SWLGKFKTILYLSLVYICGSVLLTLGAigplnlpMETFTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKQITSFFSL 272
Cdd:COG3104 81 RLLGQRRAILLGGILMALGHFLLALPG-------GVTLFYLGLALIAVGNGLFKPNISSLVGQLY--DPGDPRRDAGFTI 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 273 FYFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYK---------MKPPAGNMVVLVS 343
Cdd:COG3104 152 FYMGINIGAFLAPLLCGYLGEKYG-------WHYGFGAAAIGMLIGLIIFLLGRKYLGdiglepdnpLSKKERLIAVALG 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 344 STIWTALTTKCkeKKTNPREHWLDYA------------DKKYDRqliDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQ 411
Cdd:COG3104 225 ALLLVLVLAGL--LSNANIANYLLYViaiiayfifilrSKKLTK---EERKRLLAILILFLFSIVFWALYEQAGTSLNLF 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665389490 412 A-TRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYdVALYPALKLVGIR-RPLQKLTMGGILAGIAFII 477
Cdd:COG3104 300 AdRNVDRSLFGFEIPPSWFQSLNPLFIIILAPVF-AALWTKLGKRGKEpSTPTKFALGLLLLGLGFLV 366
|
|
| MFS_NPF |
cd17351 |
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ... |
134-482 |
3.52e-60 |
|
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340909 [Multi-domain] Cd Length: 445 Bit Score: 210.56 E-value: 3.52e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 134 FFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSV 213
Cdd:cd17351 2 PFILGNEFAERLAFYGIAVNLVTYLTKVMHLSNAKAANTVTNFSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 214 LLTLGAI---------------GPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQFKV--PEQVKQITSFFSLFYFS 276
Cdd:cd17351 82 LLTLSASvpslrpppcnpdspcEPASSTQLTVLYVGLYLIALGTGGIKPCVSAFGADQFDEtdPKEKKQKPSFFNWFYFS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 277 INAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYkmkppagnmvvlvsstiwtalttkcke 356
Cdd:cd17351 162 INLGSLLAVTLVVYIQDNVS-------WGWGFGIPAAAMALAVIVFVAGTPFY--------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 357 kktnpREhwldyadkkydrqliddVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMG-SWDIKPDQLQVLNPL 435
Cdd:cd17351 208 -----RE-----------------VKCLLRLLPIWATTILLSTVYAQMQTFFVQQGLTMDRRLGgSFEIPAASLSVFSTL 265
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 665389490 436 LILIFIPLYDVALYPAL-KLVGIRR---PLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17351 266 FVLLFIPLYDRVFVPFArRYTGNPRgitPLQRIGIGLVLSILAMAVAALVE 316
|
|
| MFS_POT |
cd06175 |
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ... |
136-490 |
1.93e-56 |
|
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340865 [Multi-domain] Cd Length: 422 Bit Score: 199.58 E-value: 1.93e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 136 IISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVLL 215
Cdd:cd06175 4 ILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGVAIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 216 TLGAIGPLNLPMET--------------FTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKqITSFFSLFYFSINAGS 281
Cdd:cd06175 84 TVSTIPPGLRPLRCnpshceqasgiqltGFYAALYLIALGTGGVKANVSPLGADQFDERGPSK-TQSFFNWFYFCINVGS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 282 LISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFvlgrslykmkppagnmvvlvsstiwtalttkckekktnp 361
Cdd:cd06175 163 LLAMLGTPYIQDNVG-------WAAAYGIPFVAILLALVVF--------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 362 rehwldyadkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLNPLLILIFI 441
Cdd:cd06175 197 ------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRSTGLFTIPPASMQAFNPILLLLLI 258
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 665389490 442 PLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVELSLEKTYP 490
Cdd:cd06175 259 PVLDKVVYPLIRRYGVGlSPLTKIGLGFFFGSLSMFVAGFLELKRLNTAH 308
|
|
| MFS_NPF5 |
cd17417 |
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ... |
131-482 |
5.34e-55 |
|
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340975 [Multi-domain] Cd Length: 452 Bit Score: 196.72 E-value: 5.34e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYIC 210
Cdd:cd17417 2 KACSFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 211 GSVLLTLGA-IGPLNLPME------------TFTMLGLALIALGSGGIKPCVSAFGGDQFKV--PEQVKQITSFFSLFYF 275
Cdd:cd17417 82 GLVLLTLSAsLPSLKPPECngtcskastlqvAFFFFSLYLVAIGQGGHKPCVQAFGADQFDEddPKEKKQKSSFFNWWYF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 276 SINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKMKppagnmvvlvsstiwtalttkck 355
Cdd:cd17417 162 SICAGSLTAVTVLVYIQDNVG-------WALGFGIPTIVMALALFVFLLGTPLYRYK----------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 356 ekktnprehwldyadkkydrqlIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGS-WDIKPDQLQVLNP 434
Cdd:cd17417 212 ----------------------VEEVKLVLRLIPIWFTTLVFTVVFAQSPTFFTKQGVTMDRTIGPnFKIPPASLQSFIT 269
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 665389490 435 LLILIFIPLYDVALYPALKLV-----GIRRpLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17417 270 LSILISIPIYDRVFVPIARKItgnprGITL-LQRIGIGMFLSILAMVIAALVE 321
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
130-477 |
5.51e-50 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 180.85 E-value: 5.51e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVL--GYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLV 207
Cdd:cd17346 1 PKGLYTLFFTEMWERFSYYGMRAILILYLTAQLgdGFSEADAASIYGAYTALVYLTPIIGGWLADKVLGARRTVFIGGIL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 208 YICGSVLLtlgAIGPLNLPMetfTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKQITSFFSLFYFSINAGSLISTTV 287
Cdd:cd17346 81 MALGYLLL---ALSPFSVSM---LYLGLALIIVGNGLFKPNISSLVGKLY--DENDPRRDSGFSIFYMGINLGAFLAPLL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 288 TPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKMKppagnmvvlvsSTIWTALttkckekktnprehwld 367
Cdd:cd17346 153 CGTLGDNYG-------YHYGFGLAAVGMLLGLLIFLLGRKKLLER-----------KKMLAII----------------- 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 368 yadkkydrqliddvkvlmrVLFLYlpLPVFWALFDQQGSRWTFQA-TRMDGDMGSWDIKPDQLQVLNPLLILIFIPLYdV 446
Cdd:cd17346 198 -------------------ILFLF--AVVFWAIYEQAGTSLALFAdENVDRLLGGFTIPPSWFQSLNPLFIILLAPIL-A 255
|
330 340 350
....*....|....*....|....*....|..
gi 665389490 447 ALYPALKLVGIR-RPLQKLTMGGILAGIAFII 477
Cdd:cd17346 256 ALWTKLGKRGKDpSIPTKFALGLLLLGLSFLL 287
|
|
| MFS_NPF8 |
cd17418 |
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ... |
131-503 |
1.15e-49 |
|
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340976 [Multi-domain] Cd Length: 447 Bit Score: 181.51 E-value: 1.15e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYIC 210
Cdd:cd17418 2 KACPFILGNECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 211 GSVLLTLGAIGPLNLPME--------------TFTMLGLALIALGSGGIKPCVSAFGGDQF---KVPEQVKQiTSFFSLF 273
Cdd:cd17418 82 GMVLLTLSASVPGLKPAScigslcppatsvqyAVFFLGLYLIALGTGGIKPCVSSFGADQFddtDPKEKVRK-SSFFNWF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 274 YFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttk 353
Cdd:cd17418 161 YFSINIGALISSSVLVWIQENVG-------WGWGFGIPTVFMGIAIVSFFFGTPLYR----------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 354 ckekktnprehwldyadkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQVLN 433
Cdd:cd17418 211 --------------------------EVKILIRLLPIWASGIVFATVYSQMSTMFVQQGRTMDRMGGNFEIPPASLSLFD 264
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389490 434 PLLILIFIPLYDVALYP-ALKLVGIRR---PLQKLTMGGILAGIAFIISGVVE---LSLEKTYPDLPYSQNIQLRIF 503
Cdd:cd17418 265 TLSVLIWVPIYDRFIVPlVRKFTGHERgftQLQRMGIGLFISVLSMVAAAIVEivrLQLARTHNLVESGPPVPMSIF 341
|
|
| MFS_NPF1_2 |
cd17416 |
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
135-482 |
2.58e-46 |
|
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340974 [Multi-domain] Cd Length: 444 Bit Score: 171.68 E-value: 2.58e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 135 FIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVL 214
Cdd:cd17416 3 FIIGNETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 215 LTLGAI------GPLNLPMET----------FTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQ--VKQITSFFSLFYFS 276
Cdd:cd17416 83 LTLTAAipslrpPPCETASSLcqspsklqlaVLYSALALLSIGAGGIRPCSLAFGADQFDKKTEsgKRGLESFFNWYYFT 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 277 INAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttkcke 356
Cdd:cd17416 163 FTVAQIISLTAIVYIQDNVS-------WKIGFGIPAALMLLSFILFLAGSRLYV-------------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 357 kktnprehwldyadkkydrqlIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMG-SWDIKPDQLQVLNPL 435
Cdd:cd17416 210 ---------------------VEDLKSLIRVIPIWSTGIILSLAMAQQMSLTVLQALVMDRHLGpSFQIPAGSITVFLLI 268
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 665389490 436 LILIFIPLYDVALYPAL-KLVGIRR---PLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17416 269 TLTIFIPLYDRVLVPLLrKITGRGRgltLLQRVGIGIVFSILSMAVAAIVE 319
|
|
| MFS_NPF7 |
cd17419 |
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ... |
130-482 |
2.73e-40 |
|
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340977 [Multi-domain] Cd Length: 447 Bit Score: 154.45 E-value: 2.73e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:cd17419 1 WKSAIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAIGPLNLPME----------------TFTMLGLALIALGSGGIKPCVSAFGGDQF--KVPEQVKQITSFFS 271
Cdd:cd17419 81 IGLLLLTLSSALPSLRPPQcgdgdlkcppasaaqtTFLYFSLYLIALGYGGYQPCIATLGADQFddEDPIEKASKSAFFS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 272 LFYFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYkmkppagnmvvlvsstiwtalt 351
Cdd:cd17419 161 YFYQALNLGSLFSNTILVYFEDNGS-------WGLGFGISAGAAFIGLVLFLAGTPFY---------------------- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 352 tkckekktnpREhwldyadkkydrqliddVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQV 431
Cdd:cd17419 212 ----------RE-----------------VKCILRLLPIWLSTIIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMSV 264
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 665389490 432 LNPLLILIFIPLYDVALYPAL-KLVGIRR---PLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17419 265 FEILSVAVGTVLYRKFLVPLLrKVTGHPKgitELQRMGIGLVIGILAMVVAALVE 319
|
|
| MFS_NPF3 |
cd17415 |
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ... |
131-482 |
6.32e-40 |
|
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340973 [Multi-domain] Cd Length: 448 Bit Score: 153.37 E-value: 6.32e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYIC 210
Cdd:cd17415 2 KTMPFIFGNEICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 211 GSVLLTLGAIGP-LNLP---------------METFTMLGLALIALGSGGIKPCVSAFGGDQF--KVPEQVKQITSFFSL 272
Cdd:cd17415 82 GMVLLTISAILPsLRPPpcnghevcacqassaQLSILYLSLLLTALGSGGIRPCVVAFGADQFdeSDPKQAKQTWNFFNW 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 273 FYFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtaltt 352
Cdd:cd17415 162 YYFCMGIAILLAVTVIVYIQDNVG-------WGWGFGIPTIAMAISVIAFVVGSPLYR---------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 353 kckekktnprehwldyadkkydrqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMG-SWDIKPDQLQV 431
Cdd:cd17415 213 ---------------------------ELKSIIRMLPIWAAGILLVTASSQQHTFSIQQARTMNRHLTpSFQIPPASMSV 265
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 665389490 432 LNPLLILIFIPLYDVALYP-ALKLVGIRR---PLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17415 266 FGILSLLTTVPLYDRVLMPvARKFTGNERgitFLQRMGIGLFISILATVVAAFVE 320
|
|
| MFS_NPF6 |
cd17413 |
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ... |
131-483 |
3.85e-39 |
|
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340971 [Multi-domain] Cd Length: 457 Bit Score: 151.45 E-value: 3.85e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYIC 210
Cdd:cd17413 2 KSAALILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQAL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 211 GSVLLTLGAIGP-LNLP----------------METFTMLGLALIALGSGGIKPCVSAFGGDQF--KVPEQVKQITSFFS 271
Cdd:cd17413 82 GVLVLTLSTTLPsLRPPpcnhttshhcepasgiQLTVLYLALYLIALGTGGIKSSVSGFGSDQFdeNDPKERKLMSYFFN 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 272 LFYFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAGnmvvlvsstiwtalT 351
Cdd:cd17413 162 RFFFCISVGSLLAVTVLVYIQDNVG-------RGWGYGICAAAMVLAIVVFLAGTKRYRFKKSIG--------------S 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 352 TKckekktnprehwldyadkkydrqlIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDMGSWDIKPDQLQV 431
Cdd:cd17413 221 TQ------------------------VEEVKMVVRMLPIWATTILFWTVYAQMTTFSVEQAETMDRNIGSFEIPPASMAV 276
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 665389490 432 LNPLLILIFIPLYDVALYPALKLV-----GIrRPLQKLTMGGILAGIAFIISGVVEL 483
Cdd:cd17413 277 FLVATILLTTAVYDRVIVPLCRKLtghpqGL-TTLQRIGVGLVFSCLAMAVAALVEL 332
|
|
| MFS_PTR2 |
cd17350 |
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ... |
130-482 |
3.69e-35 |
|
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340908 [Multi-domain] Cd Length: 438 Bit Score: 139.14 E-value: 3.69e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSR--------VLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTI 201
Cdd:cd17350 1 PWSAFLIAIVELCERFSYYGLTGPFQNYMQFgpddstpgALGLGEQGATGLSNFFTFWCYVTPVIGAYVADQFLGRYNTI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 202 LYLSLVYICGSVLLTLGAI---GPLNLPMETFtMLGLALIALGSGGIKPCVSAFGGDQFK---------------VPEQV 263
Cdd:cd17350 81 VCGAVIYFVGILILTCTSIpsvIDAGAGLGGF-VVAIIIIGLGTGGIKSNVSPLIADQLPkikpyvktlkngervIVDPV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 264 KQITSFFSLFYFSINAGSLiSTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPpagnmvvlvs 343
Cdd:cd17350 160 VTLSRIYMIFYWAINVGSL-SLLATTYLERTKG-------FWYAYLLPLCVFVIPLIILAFGKKFYKIRP---------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 344 stiwtalttkckekktnprEHWldyadkkydrqlIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDmgswD 423
Cdd:cd17350 222 -------------------DLF------------IDELKRALRACKVFLFYPIYWVCYGQMTSNFISQAGQMQLH----G 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 424 IKPDQLQVLNPLLILIFIPLYDVALYPALKLVGIR-RPLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17350 267 VPNDLFQAFDSIALIIFIPILENIIYPLLRKYNIPfKPITRITLGFMFASFSMIYAAVLQ 326
|
|
| MFS_NPF4 |
cd17414 |
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ... |
131-483 |
2.96e-32 |
|
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340972 [Multi-domain] Cd Length: 456 Bit Score: 130.99 E-value: 2.96e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYS-DDTATVVfhifTMFV---YFLCVFGAIISDSWLGKFKTILYLSL 206
Cdd:cd17414 2 RAAFFVLVVEALENMAYLANANNLVTYLINNMHYSlAKSANIV----TNFVgtaFLLALLGGFLSDSFLSSFKTIIIFGS 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 207 VYICGSVLLTLGAIGPLNLPME-----------------TFTMLGLALIALGSGGIKPCVSAFGGDQF--KVPEQVKQIT 267
Cdd:cd17414 78 IELLGLILLTVQAHIPSLQPPScnslgdltckepsgsqaAILFVGLYLVALGVGCIKPNLPSHGADQFdeNDPKGRRQLS 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 268 SFFSLFYFSINAGSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKMKppagnmvvlvsstiw 347
Cdd:cd17414 158 SFFNWYYFSFSLGALIAVTLVVWVEENKG-------WDWGFGVSAAVIAVGILVFVAGTPFYRNK--------------- 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 348 talttkckekktnprehwldyadkkydrQLIDDVKVLMRVLFLYLPLPVFWALFDQQGSRWTFQATRMDGDM-GSWDIKP 426
Cdd:cd17414 216 ----------------------------TQVEEVKIVLKMLPIFACTIILNCILAQLQTFSVQQGSTMNRTKiGSFNIPP 267
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389490 427 DQLQVLNPLLILIFIPLYDVALYP-ALKLVGIRR---PLQKLTMGGILAGIAFIISGVVEL 483
Cdd:cd17414 268 ASLQAIPVIFMLILVPLYDHLLVPfARKITGHESgitHLQRIGIGLVLSTLSMVVAALVET 328
|
|
| yjdL_sub1_fam |
TIGR00924 |
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes ... |
122-476 |
2.10e-29 |
|
amino acid/peptide transporter (Peptide:H+ symporter), bacterial; The model describes proton-dependent oligopeptide transporters in bacteria. This model is restricted in its range in recognizing bacterial proton-dependent oligopeptide transporters, although they are found in yeast, plants and animals. They function by proton symport in a 1:1 stoichiometry, which is variable in different species. All of them are predicted to contain 12 transmembrane domains, for which limited experimental evidence exists. [Transport and binding proteins, Amino acids, peptides and amines]
Pssm-ID: 273342 [Multi-domain] Cd Length: 475 Bit Score: 122.64 E-value: 2.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 122 GQQKKLPYPKSVFFIISNEFCERFNYYGMRTVLVLYL--SRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFK 199
Cdd:TIGR00924 1 GEKTFFGHPKPLFTLFFVELWERFSYYGMQGILAVYLvqQAGLGFSQEQAFIIFGAYSALVYLLTSVGWWFGDRVWGTKK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 200 TILYLSLVYICGSVLLTLgAIGPLNLpmetftMLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKQiTSFFSLFYFSINA 279
Cdd:TIGR00924 81 TMVLGGIVLMLGHFMLAM-SIYPDLI------FYGLGTIAVGSGLFKANPSSMVGKLYERGDMPRR-DGGFTLFYMSINI 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 280 GSLISTTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGR-------SLYKMKPPAGNMVVLVSSTIWTALTT 352
Cdd:TIGR00924 153 GSFISPLLAGVIAENYG-------YHVGFNLAAVGMVIGLLTFFAGRhmlrdigSVPDPLSGQGKTYGKLLLALLAALAL 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 353 KCKEKKTNPREHWLD-------------YADKKYDRQLIDDVKVLMRVLF-LYLPLPVFWALFDQQGSRWTFQA-TRMDG 417
Cdd:TIGR00924 226 VFFCAWLMHHVVIANillmtvtlaviifFFRLAFKPRLDAVARNKMYAYIvLFLEAVVFWVLYAQMPTSLNFFAdNNMHH 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389490 418 DMGSWDIKPDQLQVLNPLLILIFIPLYdVALYPALKLVG--IRRPLqKLTMGGILAGIAFI 476
Cdd:TIGR00924 306 EMLGMSVPVIWFQSLNPFWVVVGSPVL-AMIWTRLGRKGkdPTTPL-KFTLGMLFCGASFL 364
|
|
| tppB |
PRK09584 |
dipeptide/tripeptide permease DtpA; |
130-477 |
6.86e-23 |
|
dipeptide/tripeptide permease DtpA;
Pssm-ID: 181969 Cd Length: 500 Bit Score: 103.30 E-value: 6.86e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:PRK09584 20 PKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLGDKVLGTKRVIMLGAIVLA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAIGPlnlpmeTFTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKQITSFFSLFYFSINAGSLISTTVTP 289
Cdd:PRK09584 100 IGYALVAWSGHDA------GIVYMGMATIAVGNGLFKANPSSLLSTCY--EKDDPRLDGAFTMYYMSINIGSFFSMLATP 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 290 ILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYK--------MKPPAGNMV-VLVSSTIWTALTTKCKEKKTN 360
Cdd:PRK09584 172 WLAAKYG-------WSVAFALSVVGMLITVVNFAFCQRWVKqygskpdfEPINYRKLLlTIVGVVALIAIATWLLHNQEI 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 361 PRehW----------LDYADKKYDRQLIDDVKVLMRVLfLYLPLPVFWALFDQQGSRWTFQATR-MDGDMGSWDIKPDQL 429
Cdd:PRK09584 245 AR--MalgvvalgivVIFGKEAFAMKGAARRKMIVAFI-LMLEAIIFFVLYSQMPTSLNFFAIRnVEHSILGIAVEPEQY 321
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 665389490 430 QVLNPLLILIFIPLYdVALYPALklvGIRRPL-QKLTMGGILAGIAFII 477
Cdd:PRK09584 322 QALNPFWIMIGSPIL-AAIYNKM---GDRLPMpHKFAIGMVLCSGAFLV 366
|
|
| MFS_SLC15A3_4 |
cd17348 |
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ... |
140-482 |
8.69e-22 |
|
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340906 [Multi-domain] Cd Length: 435 Bit Score: 99.09 E-value: 8.69e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 140 EFCERFNYYGMRTVLVLYL-SRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVLLtlg 218
Cdd:cd17348 11 ELLERAAFYGITSNLVLFLnGSPFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLLF--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 219 aigplnlPMETF--TMLGLALIALGSGGIKPCVSAFGGDQFK--VPEQVKQitsFFSLFYFSINAGSLISTTVTPILRED 294
Cdd:cd17348 88 -------PATAApaLYAGLLLVGLGVGSVKANITPFGADQVKdrGPEATRR---FFNWFYWSINLGAILSLGGVAYIQQN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 295 VScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYKmkppagnmvvlvsstiwtalttkckekktnprehwldyadkkyd 374
Cdd:cd17348 158 VS-------FLIGYSIPAVCVGLAFLVFLCGQPVFI-------------------------------------------- 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 375 rqlidDVKVLMRVLFLYLPLPVFWALFDQQGSRW-----------TFQATRMDGDMGSWDIKPDQLQVLNPLLILIFIPL 443
Cdd:cd17348 187 -----DVKALVKILPVFLALIPYWTVYFQMQTTYvlqslhlkipnIFISNIAGITNSSHTFPAAWLTMFDAVLILILIPL 261
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 665389490 444 YDVALYPALKLVG-IRRPLQKLTMGGILAGIAFIISGVVE 482
Cdd:cd17348 262 KDKLVDPFLKRRGlLPSSLKRIAVGMFFVMCSAIAAGILE 301
|
|
| PRK15462 |
PRK15462 |
dipeptide permease; |
130-325 |
2.08e-20 |
|
dipeptide permease;
Pssm-ID: 237971 [Multi-domain] Cd Length: 493 Bit Score: 95.40 E-value: 2.08e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 130 PKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYI 209
Cdd:PRK15462 8 PRAIYYVVALQIWEYFSFYGMRALLILYLTNQLKYDDNHAYELFSAYCSLVYVTPILGGFLADKVLGNRMAVMLGALLMA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 210 CGSVLLTLGAIGPlnlpmeTFTMLGLALIALGSGGIKPCVSAFGGDQFKvPEQVKQiTSFFSLFYFSINAGSLISTTVTP 289
Cdd:PRK15462 88 IGHVVLGASEIHP------SFLYLSLAIIVCGYGLFKSNVSCLLGELYE-PTDPRR-DGGFSLMYAAGNVGSIIAPIACG 159
|
170 180 190
....*....|....*....|....*....|....*.
gi 665389490 290 ILREDVScfddincYPLAFGVPAVLMIVSVIIFVLG 325
Cdd:PRK15462 160 YAQEEYS-------WAMGFGLAAVGMIAGLVIFLCG 188
|
|
| PRK10207 |
PRK10207 |
dipeptide/tripeptide permease DtpB; |
127-330 |
2.01e-15 |
|
dipeptide/tripeptide permease DtpB;
Pssm-ID: 182306 Cd Length: 489 Bit Score: 79.86 E-value: 2.01e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 127 LPYPKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSL 206
Cdd:PRK10207 10 LQQPRPFFMIFFVELWERFGYYGVQGILAVFFVKQLGFSQEQAFITFGAFAALVYGLISIGGYVGDHLLGTKRTIVLGAI 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 207 VYICGSVLLTLGAIGPlnlpmeTFTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKQITSFFSLFYFSINAGSLISTT 286
Cdd:PRK10207 90 VLAIGYFMTGMSLLKP------DLIFIALGTIAVGNGLFKANPASLLSKCY--PPKDPRLDGAFTLFYMSINIGSLISLS 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 665389490 287 VTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGRSLYK 330
Cdd:PRK10207 162 LAPVIADKFG-------YSVTYNLCGAGLIIALLVYFACRGMVK 198
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
141-324 |
1.21e-10 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 64.12 E-value: 1.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 141 FCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKtilylsLVYICGSVLLTLGAI 220
Cdd:COG2271 190 FLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRK------LVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 221 GPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQFkvpeQVKQITSFFSLFYFSINAGSLISTTVTPILREDVScfdd 300
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF----PKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG---- 335
|
170 180
....*....|....*....|....
gi 665389490 301 incYPLAFGVPAVLMIVSVIIFVL 324
Cdd:COG2271 336 ---YQAAFLLLAALALLAALLALL 356
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
141-334 |
5.61e-10 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 62.06 E-value: 5.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 141 FCERFNYYGMRTVLVLYLsRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKfktilylsLVYICGSVLLTLGAI 220
Cdd:cd06174 6 FLTGLARGLISPLLPALL-QSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRR--------PVLLLGLLLFALGAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 221 GPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQVKqitsFFSLFYFSINAGSLISTTVTPILredvscfdd 300
Cdd:cd06174 77 LFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGR----ALGLLQAFGSVGGILGPLLGGIL--------- 143
|
170 180 190
....*....|....*....|....*....|....
gi 665389490 301 inCYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPP 334
Cdd:cd06174 144 --ASSLGFGWRAVFLIAAALALLAAILLLLVVPD 175
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
145-322 |
4.48e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 52.98 E-value: 4.48e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 145 FNYYGMRTVLVLYLSRVLGYSDDTATVVFhIFTMFVYFLCVFGA-IISDsWLGKFKTILYLSLVYICGSVLLTLgaIGPL 223
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLL-ALYFLAALLGAPLWpRLAK-RFGKKKAFIIGLLLAALGLLLLFF--LGPG 317
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 224 NLPMetfTMLGLALIALGSGGIKPCVSAFGGDqfkVPEQVKQIT------SFFSLFYFSINAGSLISTTVTPILReDVSC 297
Cdd:COG2211 318 NLWL---LLVLAALAGIGLGAILVLPWAMLAD---VVDYDEWKTgrrregLYFGIFTFAIKLGQALAGALAGLLL-ALFG 390
|
170 180 190
....*....|....*....|....*....|....
gi 665389490 298 FDDINCYP---------LAFGVPAVLMIVSVIIF 322
Cdd:COG2211 391 YVAGAAQSpsaltgirlLFFLLPAVLLLLAALLL 424
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
141-336 |
9.95e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 9.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 141 FCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKfktilylsLVYICGSVLLTLGAI 220
Cdd:pfam07690 6 FLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR--------RVLLIGLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 221 GPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQvkqiTSFFSLFYFSINAGSLISTTVTPILREDVScfdd 300
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEER----GRALGLVSAGFGLGAALGPLLGGLLASLFG---- 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 665389490 301 incYPLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAG 336
Cdd:pfam07690 150 ---WRAAFLILAILSLLAAVLLLLPRPPPESKRPKP 182
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
133-480 |
1.29e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.46 E-value: 1.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 133 VFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWlGKFKTILylslvyiCGS 212
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRF-GRKPVML-------AGL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 213 VLLTLGAIGPLNLPMETFTMLGLALIALGSGGIKPCVSAFGGDQfkVPEqvKQITSFFSLFYFSINAGSLISTTV-TPIL 291
Cdd:cd17329 73 LLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADV--TTP--ENRTRAFSLLYWAINLGVAIGPLLgGLLL 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 292 REDVScfddincypLAFGVPAVLMIVSVIIFVLGRSLYKMKPPAgnmvvlvsstiwtalttkckEKKTNPREhwlDYADK 371
Cdd:cd17329 149 LYSFR---------LLFLAAAVLFLLAALVLLFLLPETRPKRRA--------------------AEKTEILR---GYKIV 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 372 KYDRqliddvkVLMRVLFLYLplpVFWALFDQQGSRWTFQATRMDGDmGSWDIKPdqLQVLNPLLILIFiplydvaLYPA 451
Cdd:cd17329 197 LRDR-------AFLLFLLASF---LISLIYFQLESTLPVYVVEILGL-GESLLGL--LLALNALLIVLL-------QFPV 256
|
330 340
....*....|....*....|....*....
gi 665389490 452 LKLVGIRRPLQKLTMGGILAGIAFIISGV 480
Cdd:cd17329 257 ARLVERFRLRKILMIGILLFAIGFAVLAF 285
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
145-323 |
3.60e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 50.12 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 145 FNYYGMRTVLVLYLSRVLGYSDDTATVVFhIFTMFVYFLCVFgaiISDSWLGKFKTILYLslvYICGSVLLTLGAIGPLN 224
Cdd:cd06174 217 LAYYSFSTLLPLFLLDLGGLSVAVAGLLL-SLFGLAGALGSL---LLGLLSDRLIGRKPL---LLIGLLLMALGLALLLL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 225 LPMETFTMLGLALIALGSGGIKPCVSAFGGDQFkvpeQVKQITSFFSLFYFSINAGSLISTTVTPILredvscFDDINCY 304
Cdd:cd06174 290 APSLLLLLLLLLLLGFGLGGLLPLSFALIAELF----PPEIRGTAFGLLNTFGFLGGAIGPLLAGFL------LAATFGL 359
|
170
....*....|....*....
gi 665389490 305 PLAFGVPAVLMIVSVIIFV 323
Cdd:cd06174 360 TGAFLVLAVLLLLAAILLL 378
|
|
| MFS_SLC15A5 |
cd17349 |
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ... |
140-283 |
5.08e-06 |
|
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340907 [Multi-domain] Cd Length: 437 Bit Score: 49.75 E-value: 5.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 140 EFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWLGKFKTILYLSLVYICGSVLLTLGA 219
Cdd:cd17349 11 ELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHFLGTALLPVVA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 220 IgPL------------NLPMETFTML---GLALIALGSGGIKPCV---SAFGGDQFkvpeQVKQITSFFSLFYFSINAGS 281
Cdd:cd17349 91 F-PFedfyidthhiihTLAKREQTLLfyvALLTASLGTGGIRAIVcplSAYGLQDY----GSRKLMSFFNWFYWLVNLNS 165
|
..
gi 665389490 282 LI 283
Cdd:cd17349 166 AV 167
|
|
| rad23 |
TIGR00601 |
UV excision repair protein Rad23; All proteins in this family for which functions are known ... |
15-83 |
6.19e-06 |
|
UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273167 [Multi-domain] Cd Length: 378 Bit Score: 49.51 E-value: 6.19e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665389490 15 PAAEPVAEPEPSPAAEIAPASPDGSGPSAAAAEEVTPsvatvEDTTPIAAPAESQPSGESNGTAEAKKL 83
Cdd:TIGR00601 87 PAATPTSAPTPTPSPPASPASGMSAAPASAVEEKSPS-----EESATATAPESPSTSVPSSGSDAASTL 150
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
141-281 |
8.42e-06 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.82 E-value: 8.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 141 FCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDsWLGKFKTILYLSLVYICGSVLLTLGAI 220
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD-RFGRRRLLLIGLLLLALGLLLLALAGS 295
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665389490 221 GPLnlpmetfTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKqiTSFFSLFYFSINAGS 281
Cdd:COG2814 296 LWL-------LLLALFLLGFGFGLLFPLLQALVAELA--PPEAR--GRASGLYNSAFFLGG 345
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
131-324 |
1.11e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 48.43 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 131 KSVFFIISNEFCERFNYYGMRTVLVLyLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWlGKFKTILYLSLVYIC 210
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRF-GRRRVLLLGLLLFAL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 211 GSVLLTLgaigplnlpMETFTMLGLA--LIALGSGGIKPCVSAFGGDQFKvpeqVKQITSFFSLFYFSINAGSLISTTVT 288
Cdd:COG2814 88 GSLLCAL---------APSLWLLLAArfLQGLGAGALFPAALALIADLVP----PERRGRALGLLGAGLGLGPALGPLLG 154
|
170 180 190
....*....|....*....|....*....|....*.
gi 665389490 289 PILREDVScfddincYPLAFGVPAVLMIVSVIIFVL 324
Cdd:COG2814 155 GLLADLFG-------WRWVFLVNAVLALLALLLLLR 183
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
154-335 |
6.22e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.00 E-value: 6.22e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 154 LVLYLSRVLGYSDDTATVVFHIFTMFVyflcVFGAIISDSWLGKFKTILYLsLVYICGSVLLTLGAIgplNLPMETFTML 233
Cdd:COG0738 233 LPLYLKDVLGLSEATAALGLSLFWGGM----TIGRFLGGFLLKRFGPVRLL-RLSALLAAVGLLLAL---LAPGPWLALI 304
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 234 GLALIALGSGGIKPCVSAFGGDQFkvPEQVKQITSFFSLFYFsinAGSLISTTVTPILREDVScfddincYPLAFGVPAV 313
Cdd:COG0738 305 GLALVGLGLSLMFPTIFSLALDGL--GKRTAAAVSAVLIMGI---VGGAIGPPLIGFLADAFG-------LRAAFLVPLV 372
|
170 180
....*....|....*....|..
gi 665389490 314 LMivsVIIFVLGRSLYKMKPPA 335
Cdd:COG0738 373 CY---LLILLLALALKRKRRKK 391
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
125-326 |
1.07e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 45.26 E-value: 1.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 125 KKLPYPKSVFFIISNEFCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSWlGKFKTILYL 204
Cdd:cd17325 193 RLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRI-GRKPLILIG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 205 SLVY-ICGSVLLTLGAIGPLnlpmetftMLGLALIALGSGGIKPCVSAFGGDQfkVPEQVKqiTSFFSLFYFSINAGSLI 283
Cdd:cd17325 272 LLLSaVALLLLPLATSFWLL--------LLLLALLGLGLGLVFPATLALLADI--VPPEGR--GTAMGLFNTAFSLGMVL 339
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 665389490 284 STTVTPILREDVScfddincYPLAFGVPAVLMIVSVIIFVLGR 326
Cdd:cd17325 340 GPLLGGFLYDAFG-------FATPFLAAAALLLLAAVLFLLLR 375
|
|
| Rib_recp_KP_reg |
pfam05104 |
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ... |
4-82 |
1.22e-04 |
|
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.
Pssm-ID: 461548 [Multi-domain] Cd Length: 140 Bit Score: 42.80 E-value: 1.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 4 PAEQVPL-LEIQPAA-EPVAEPEPSPAAEIAPASPdgsgPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGESNGTAEAK 81
Cdd:pfam05104 58 ESEEEPReFKTPDEApSAALEPEPVPTPVPAPVEP----EPAPPSESPAPSPKEKKKKEKKSAKVEPAETPEAVQPKPAL 133
|
.
gi 665389490 82 K 82
Cdd:pfam05104 134 E 134
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
147-324 |
1.37e-04 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 45.26 E-value: 1.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 147 YYGMRTVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDsWLGKFKTILYLSLVYICGSVLLtlgAIGPLNLP 226
Cdd:COG2223 221 FIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD-RIGGRRVLLIVFALMALGLLLL---ALALGSLW 296
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 227 MetfTMLGLALIALGSGGIKPCVSAFGGDQFKvpeqVKQITSFFSLFYFSINAGSLISTTVTPILredvscFDDINCYPL 306
Cdd:COG2223 297 L---FLVLFLLLGLALGGGNGAVFALVPDIFP----TKNAGAVYGLVGAAGGLGGFLGPLLFGAL------LDATGSYTA 363
|
170
....*....|....*...
gi 665389490 307 AFGVPAVLMIVSVIIFVL 324
Cdd:COG2223 364 AFLVFAVLALVALVLTLL 381
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
133-285 |
1.91e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 44.33 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 133 VFFIISNEFCERFNYYGMRTVLVLYLSrVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDsWLGKFKTILYLSLVYICGS 212
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD-RLGRRRRLLLALLLLILAA 279
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665389490 213 VLLTLGAIGPLNLpmetFTMLGLALIALGSGGIKPCVSAFGGDQFKVPEQvkqiTSFFSLFYFSINAGSLIST 285
Cdd:pfam07690 280 LGLLLLSLTLSSL----WLLLALLLLGFGFGLVFPALNALVSDLAPKEER----GTASGLYNTAGSLGGALGP 344
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
14-107 |
2.95e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 44.46 E-value: 2.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 14 QPAAEPVAEPEPSPAAEIAP---ASPDGSGPSAAAAEEVTPSVAT-VEDTTPIAAPAESQPSGESNGTAEAKKLPEIAKK 89
Cdd:PRK07003 372 VPARVAGAVPAPGARAAAAVgasAVPAVTAVTGAAGAALAPKAAAaAAATRAEAPPAAPAPPATADRGDDAADGDAPVPA 451
|
90
....*....|....*...
gi 665389490 90 NGKEPDQNDKEPDQNGKE 107
Cdd:PRK07003 452 KANARASADSRCDERDAQ 469
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
141-324 |
4.37e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 43.36 E-value: 4.37e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 141 FCERFNYYGMRTVLVLYLSRVLGYSDDTATVVFhIFTMFVYFL-CVFGAIISDSWlGKFKTILYLSLVYICGSVLLTLGA 219
Cdd:cd17316 187 FFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL-LLISLGALVgALIAGLLSDRI-GRKKTLVIGLILSGILALPLFYLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 220 IGPLNLpmetfTMLGLALIALGSGGIKPCVSAFGGDQFkvPEQVKqitsfFSLFYFSINAGSLISTTVTPILREDVScfd 299
Cdd:cd17316 265 SGSPTL-----LLLLLFILSFFVGGVWGALYAYLAELF--PTEVR-----ATGVGLSYNLGRLGGGGAPPLIALLLA--- 329
|
170 180
....*....|....*....|....*
gi 665389490 300 dincYPLAFGVPAVLMIVSVIIFVL 324
Cdd:cd17316 330 ----STGGTGVPALILALLAIVALI 350
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
152-325 |
4.76e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 43.35 E-value: 4.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 152 TVLVLYLSRVLGYSDDTATVVFHIFTMFVYFLCVFGAIISDSW---LGKFKT-ILYLSLVYICGSVLLtlgAIGPLNLPM 227
Cdd:COG2211 31 AYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTrtrWGRRRPwILIGAIPLALSFVLL---FTAPDLSPT 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 228 ETFTMLGLALIALGSG--GIKPCVSAFGGDQFKVPEQVKQITSFFSLFyfsINAGSLISTTVTPILREDVScFDDINCYP 305
Cdd:COG2211 108 GKLIYALVTYLLLGLAytLVNIPYSALGAELTPDYEERTRLSSWRFAF---AGLGGLLASVLPPPLVAAFG-GDAALGYR 183
|
170 180
....*....|....*....|
gi 665389490 306 LAFGVPAVLMIVSVIIFVLG 325
Cdd:COG2211 184 LTALIFAVLGLLAFLLTFFG 203
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
4-80 |
8.55e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 42.91 E-value: 8.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 4 PAEQVPLLEIQPAAEPVAEPEPSPAA-----EIAPASPDGSGPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGESNGTA 78
Cdd:PRK07003 471 PADSGSASAPASDAPPDAAFEPAPRAaapsaATPAAVPDARAPAAASREDAPAAAAPPAPEARPPTPAAAAPAARAGGAA 550
|
..
gi 665389490 79 EA 80
Cdd:PRK07003 551 AA 552
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
4-102 |
1.02e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.78 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 4 PAEQVPLLEiQPAAEPVAEPEPSPAAEIAPAS-PDGSGPSAAAAEEVTPS-----VATVEDTTPIAAPAESQPSGESNGT 77
Cdd:PRK14951 375 PAEKKTPAR-PEAAAPAAAPVAQAAAAPAPAAaPAAAASAPAAPPAAAPPapvaaPAAAAPAAAPAAAPAAVALAPAPPA 453
|
90 100
....*....|....*....|....*
gi 665389490 78 AEAKKLPEIAKKNGKEPDQNDKEPD 102
Cdd:PRK14951 454 QAAPETVAIPVRVAPEPAVASAAPA 478
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
4-80 |
1.20e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 1.20e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389490 4 PAEQVPLLEIQPAAEPVAEPEPSPAAEIAPASPDGSGPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGESNGTAEA 80
Cdd:PRK07764 418 AAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAP 494
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
5-70 |
1.51e-03 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 42.33 E-value: 1.51e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665389490 5 AEQVPLLEIQPAAEPVAEPEPSPAAEIAPASPDgsgPSAAAAEEVTPSVATVEDTTP--IAAPAESQP 70
Cdd:PRK10811 864 VQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVE---EPVVVAEPQPEEVVVVETTHPevIAAPVTEQP 928
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
14-80 |
1.65e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 1.65e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389490 14 QPAAEPVAEPEPSPAAEIAPASPDGSGPSAAAAEEvTPSVATVEDTTPIAAPAESQPSGESNGTAEA 80
Cdd:PRK07764 430 QPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA-QPAPAPAAAPEPTAAPAPAPPAAPAPAAAPA 495
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
156-328 |
1.82e-03 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 41.47 E-value: 1.82e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 156 LYLSRVLGYSDDTATVVFHIF--TMFVyflcvfGAIISDSWLGKF--KTILYLslvyicGSVLLTLGAIGPLNLPMETFT 231
Cdd:cd17393 224 LYLRDVLGASAALAALGYAVFslAMTV------GRLFGDRLVDRFgdVAVLRA------GALLAALGLLLALLAPSVWVA 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 232 MLGLALIALGSGGIKPCVSAFGGDQFKVPEqVKQITSFFSLFYfsinAGSLISTTVTPILREDVScfddincYPLAFGVP 311
Cdd:cd17393 292 LAGFALMGLGLSVVVPLAFSAAGALPGLAA-GIAVARVATLGY----LGFLVGPPLIGFLADATG-------LRTAFLVV 359
|
170
....*....|....*..
gi 665389490 312 AVLMIVsviIFVLGRSL 328
Cdd:cd17393 360 ALLALL---VALLARAV 373
|
|
| PRK07003 |
PRK07003 |
DNA polymerase III subunit gamma/tau; |
5-85 |
1.95e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 235906 [Multi-domain] Cd Length: 830 Bit Score: 41.76 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 5 AEQVPLLEIQPAAEPVAEPEPSPAAEIAPAspdGSGPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGESNGTAEAKKLP 84
Cdd:PRK07003 452 KANARASADSRCDERDAQPPADSGSASAPA---SDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASREDAPAAAAPP 528
|
.
gi 665389490 85 E 85
Cdd:PRK07003 529 A 529
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
14-80 |
2.06e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 41.90 E-value: 2.06e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665389490 14 QPAAEPVAEPEPSPAAeiaPASPDGSGPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGESNGTAEA 80
Cdd:PRK07764 401 AAAAAPAAAPAPAAAA---PAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSA 464
|
|
| PRK10819 |
PRK10819 |
transport protein TonB; Provisional |
1-94 |
2.20e-03 |
|
transport protein TonB; Provisional
Pssm-ID: 236768 [Multi-domain] Cd Length: 246 Bit Score: 40.44 E-value: 2.20e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 1 MELPAEQVPLLEIQPAAEPVAEPEPSP-------AAEIAPASPDGSGPSAAAAEEVTPSVATVEDTTPIAAPAESQPSGE 73
Cdd:PRK10819 52 MVAPADLEPPQAVQPPPEPVVEPEPEPepipeppKEAPVVIPKPEPKPKPKPKPKPKPVKKVEEQPKREVKPVEPRPASP 131
|
90 100
....*....|....*....|.
gi 665389490 74 SNGTAEAKKLPEIAKKNGKEP 94
Cdd:PRK10819 132 FENTAPARPTSSTATAAASKP 152
|
|
| rne |
PRK10811 |
ribonuclease E; Reviewed |
2-84 |
3.39e-03 |
|
ribonuclease E; Reviewed
Pssm-ID: 236766 [Multi-domain] Cd Length: 1068 Bit Score: 41.18 E-value: 3.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 2 ELPAEQVPLLEIQPAAEPVAEPEPSPAAEIAPASPDGSGPSAAAAEEVTP-SVATVEDTTPIAAPAESQPSGESNGTAEA 80
Cdd:PRK10811 941 EVAEHAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPVVAEVAAEvETVTAVEPEVAPAQVPEATVEHNHATAPM 1020
|
....
gi 665389490 81 KKLP 84
Cdd:PRK10811 1021 TRAP 1024
|
|
| PRK11855 |
PRK11855 |
dihydrolipoamide acetyltransferase; Reviewed |
9-86 |
5.74e-03 |
|
dihydrolipoamide acetyltransferase; Reviewed
Pssm-ID: 237000 [Multi-domain] Cd Length: 547 Bit Score: 40.19 E-value: 5.74e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665389490 9 PLLEIQPAAEPVAEPEPSPAAEIAPASPDGSGPSAAAaeevtpsvatvedttpiAAPAESQPSGesnGTAEAkKLPEI 86
Cdd:PRK11855 71 LLAVIEAAGAAAAAAAPAAAAAPAAAAAAAPAPAAAA-----------------PAAAAAAAGG---GVVEV-KVPDI 127
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
149-324 |
7.06e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.46 E-value: 7.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 149 GMRTVLVLYLSRvLGYSDDTATVvfhIFTMFVyflcvFGAII--------SDsWLGKFKTILylslvyiCGSVLLTLGAI 220
Cdd:cd17477 206 AFYSLLPLYGLR-LGLSVAQAAL---LLAAFV-----LGGLLlqwplgwlAD-RFDRRRVLL-------GCALLGALAAL 268
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665389490 221 GPLNLPMETFTMLGLALIALG-SGGIKPCVSAFGGDQFKvPEQVKQITSFFSLFYfsiNAGSLISTTVTPILREdvscfd 299
Cdd:cd17477 269 LLPLVPGLPLALLVLLFLWGGaAGPLYTLALALAGDRLP-GDELVAANAALLLLY---GLGSVIGPLLAGALMD------ 338
|
170 180
....*....|....*....|....*
gi 665389490 300 dincyplAFGVPAVLMIVSVIIFVL 324
Cdd:cd17477 339 -------AFGPHGLFLFLAAVALLF 356
|
|
| kgd |
PRK12270 |
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ... |
15-89 |
7.76e-03 |
|
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;
Pssm-ID: 237030 [Multi-domain] Cd Length: 1228 Bit Score: 39.87 E-value: 7.76e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665389490 15 PAAEPVAEPEPSPAAEIAPASPDGSGPSAAAAEEVTPSVATVEdtTPIAAPAESQPSGESNGTAEAKKLPEIAKK 89
Cdd:PRK12270 54 AASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAP--AAPPAAAAAAAPAAAAVEDEVTPLRGAAAA 126
|
|
| |
