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Conserved domains on  [gi|665391943|ref|NP_001285351|]
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uncharacterized protein Dmel_CG32568, isoform C [Drosophila melanogaster]

Protein Classification

phosphatase 2A regulatory subunit B56 family protein( domain architecture ID 706874)

phosphatase 2A regulatory subunit B56 family protein may function as the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulating substrate specificity, subcellular localization, and responsiveness to phosphorylation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
B56 super family cl27532
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
33-297 1.29e-63

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


The actual alignment was detected with superfamily member pfam01603:

Pssm-ID: 474937  Cd Length: 404  Bit Score: 206.70  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943   33 DLFSSFVNTHHFRPNPDGQRIDKIIVIKLVERLETTDVNDRKFMQSILRRVYLKCTDLRLFIRNQLNDVFFRLIFEGTDF 112
Cdd:pfam01603 106 EILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKFLGLRPFIRKAINNIFYRFIYETERH 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  113 HCIPEILEIYYDIIKGFTQPYETEHEQLLFKILLPLHKPPSLTKYFHQLIKCIIAFLNQYPSFIEKYVKGLLRLWPKTSF 192
Cdd:pfam01603 186 NGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQFIEKDPSLAEPVIRGLLKHWPKTNS 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  193 TKVTLFLSEIARILVIKNEQEVKKVMLTIFNHIAKCLCDESNKIAEHTLLLWKNNAVLEVIHRNHALIMPIVYPHVLRVL 272
Cdd:pfam01603 266 QKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNEYIVNLISDNSKVILPIIFPALEKNS 345
                         250       260
                  ....*....|....*....|....*
gi 665391943  273 IRHYmRKPMQTNASIALCTLLKMNN 297
Cdd:pfam01603 346 KNHW-NQTVRNLALNVLKLLMEMDP 369
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
33-297 1.29e-63

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 206.70  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943   33 DLFSSFVNTHHFRPNPDGQRIDKIIVIKLVERLETTDVNDRKFMQSILRRVYLKCTDLRLFIRNQLNDVFFRLIFEGTDF 112
Cdd:pfam01603 106 EILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKFLGLRPFIRKAINNIFYRFIYETERH 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  113 HCIPEILEIYYDIIKGFTQPYETEHEQLLFKILLPLHKPPSLTKYFHQLIKCIIAFLNQYPSFIEKYVKGLLRLWPKTSF 192
Cdd:pfam01603 186 NGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQFIEKDPSLAEPVIRGLLKHWPKTNS 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  193 TKVTLFLSEIARILVIKNEQEVKKVMLTIFNHIAKCLCDESNKIAEHTLLLWKNNAVLEVIHRNHALIMPIVYPHVLRVL 272
Cdd:pfam01603 266 QKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNEYIVNLISDNSKVILPIIFPALEKNS 345
                         250       260
                  ....*....|....*....|....*
gi 665391943  273 IRHYmRKPMQTNASIALCTLLKMNN 297
Cdd:pfam01603 346 KNHW-NQTVRNLALNVLKLLMEMDP 369
 
Name Accession Description Interval E-value
B56 pfam01603
Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a ...
33-297 1.29e-63

Protein phosphatase 2A regulatory B subunit (B56 family); Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also pfam01240), this family is called the B56 family.


Pssm-ID: 460264  Cd Length: 404  Bit Score: 206.70  E-value: 1.29e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943   33 DLFSSFVNTHHFRPNPDGQRIDKIIVIKLVERLETTDVNDRKFMQSILRRVYLKCTDLRLFIRNQLNDVFFRLIFEGTDF 112
Cdd:pfam01603 106 EILLRFVESPDFDPKVAKKYIDHSFVLRLLDLFDSEDPRERDYLKTFLHRIYGKFLGLRPFIRKAINNIFYRFIYETERH 185
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  113 HCIPEILEIYYDIIKGFTQPYETEHEQLLFKILLPLHKPPSLTKYFHQLIKCIIAFLNQYPSFIEKYVKGLLRLWPKTSF 192
Cdd:pfam01603 186 NGIAELLEILGSIINGFALPLKEEHKIFLLRVLLPLHKPKHLSLYHQQLAYCVVQFIEKDPSLAEPVIRGLLKHWPKTNS 265
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665391943  193 TKVTLFLSEIARILVIKNEQEVKKVMLTIFNHIAKCLCDESNKIAEHTLLLWKNNAVLEVIHRNHALIMPIVYPHVLRVL 272
Cdd:pfam01603 266 QKEVMFLNELEEILEVIPPEEFQKIMVPLFKQLARCINSPHFQVAERALYLWNNEYIVNLISDNSKVILPIIFPALEKNS 345
                         250       260
                  ....*....|....*....|....*
gi 665391943  273 IRHYmRKPMQTNASIALCTLLKMNN 297
Cdd:pfam01603 346 KNHW-NQTVRNLALNVLKLLMEMDP 369
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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