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Conserved domains on  [gi|665392362|ref|NP_001285433|]
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rapamycin-insensitive companion of Tor, isoform C [Drosophila melanogaster]

Protein Classification

RICTOR_N and RasGEF_N_2 domain-containing protein( domain architecture ID 10630566)

protein containing domains RICTOR_N, RICTOR_M, RasGEF_N_2, and RICTOR_V

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 51-428 3.08e-109

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464246  Cd Length: 372  Bit Score: 353.38  E-value: 3.08e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362    51 LNALASLclgarkGSHHSNIR--FTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 128
Cdd:pfam14664    3 ANDLVDL------LKRHPTLKydLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   129 MLKNDDERVQALKLVRKMLAIAP--EDISPAVVRCLVSLADsgiEENDNLLRACLATLAEFAVLNPALLIVCGGVTSITR 206
Cdd:pfam14664   77 DNKNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLD 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   207 NVLEcHNPRIAESLCGVLLYLLEWPQTRN--ICGVRLDCLAAPYCDFTYRQsivdKNKDARELRYTSCRLALLSVLRSWT 284
Cdd:pfam14664  154 ALLE-GSFELAESLLGALLYLLDSPRTRKylRPGFDLEVLLSPFTDSLDAN----TKGDSNEERLQASAKAISSLLKSWP 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   285 GTLEFCDPSKpSGLKAIVDALYLNQIEVRKAILDLLYELLTLPQPTWTDDYAVALQAVdPSDFQDTWLLSNGFVSAEGRS 364
Cdd:pfam14664  229 GLMYLSMNDF-RPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665392362   365 ILPTLAARA-PSVVEQHLALMLYCFLETGLLNALVEVVV-SSDQFVSVQATVLIGKILQLMHTHLP 428
Cdd:pfam14664  307 ILPSESSFSrENLVNHYLALLLLVFIEAGLLEALVEVIEeSSDSSLSRKATLLLGELLHLANRLLP 372
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 683-786 7.44e-37

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464248  Cd Length: 104  Bit Score: 134.90  E-value: 7.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   683 TSNRAHDCLFSPQHMNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQV 762
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 665392362   763 LEKALTSAKTRGRLYSTQFMAVLL 786
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 793-896 3.40e-31

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


:

Pssm-ID: 464245  Cd Length: 107  Bit Score: 118.85  E-value: 3.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   793 FEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLN--STMARIED 870
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKylNELGFVEN 80

                           90       100
                   ....*....|....*....|....*.
gi 665392362   871 EIRYWRNGYNKRYVLLVEADTHSSLT 896
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALT 106
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 965-1036 3.46e-20

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


:

Pssm-ID: 464249  Cd Length: 71  Bit Score: 85.97  E-value: 3.46e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665392362   965 LELKAAIWALAHASTHSNGIEYFVELNarLYEKLIVLVTKCEVYSVRATCFSALGLIAGTQAGANILFKLNW 1036
Cdd:pfam14668    1 LKLKAALWAIGHIGSSPLGIQLLEEYD--IVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGW 70
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 51-428 3.08e-109

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 353.38  E-value: 3.08e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362    51 LNALASLclgarkGSHHSNIR--FTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 128
Cdd:pfam14664    3 ANDLVDL------LKRHPTLKydLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   129 MLKNDDERVQALKLVRKMLAIAP--EDISPAVVRCLVSLADsgiEENDNLLRACLATLAEFAVLNPALLIVCGGVTSITR 206
Cdd:pfam14664   77 DNKNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLD 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   207 NVLEcHNPRIAESLCGVLLYLLEWPQTRN--ICGVRLDCLAAPYCDFTYRQsivdKNKDARELRYTSCRLALLSVLRSWT 284
Cdd:pfam14664  154 ALLE-GSFELAESLLGALLYLLDSPRTRKylRPGFDLEVLLSPFTDSLDAN----TKGDSNEERLQASAKAISSLLKSWP 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   285 GTLEFCDPSKpSGLKAIVDALYLNQIEVRKAILDLLYELLTLPQPTWTDDYAVALQAVdPSDFQDTWLLSNGFVSAEGRS 364
Cdd:pfam14664  229 GLMYLSMNDF-RPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665392362   365 ILPTLAARA-PSVVEQHLALMLYCFLETGLLNALVEVVV-SSDQFVSVQATVLIGKILQLMHTHLP 428
Cdd:pfam14664  307 ILPSESSFSrENLVNHYLALLLLVFIEAGLLEALVEVIEeSSDSSLSRKATLLLGELLHLANRLLP 372
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 683-786 7.44e-37

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 134.90  E-value: 7.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   683 TSNRAHDCLFSPQHMNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQV 762
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 665392362   763 LEKALTSAKTRGRLYSTQFMAVLL 786
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 793-896 3.40e-31

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 118.85  E-value: 3.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   793 FEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLN--STMARIED 870
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKylNELGFVEN 80

                           90       100
                   ....*....|....*....|....*.
gi 665392362   871 EIRYWRNGYNKRYVLLVEADTHSSLT 896
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALT 106
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 965-1036 3.46e-20

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 85.97  E-value: 3.46e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665392362   965 LELKAAIWALAHASTHSNGIEYFVELNarLYEKLIVLVTKCEVYSVRATCFSALGLIAGTQAGANILFKLNW 1036
Cdd:pfam14668    1 LKLKAALWAIGHIGSSPLGIQLLEEYD--IVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGW 70
 
Name Accession Description Interval E-value
RICTOR_N pfam14664
Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding ...
 51-428 3.08e-109

Rapamycin-insensitive companion of mTOR, N-term; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the N-terminal conserved section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464246  Cd Length: 372  Bit Score: 353.38  E-value: 3.08e-109
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362    51 LNALASLclgarkGSHHSNIR--FTTEELLYCLSASLVHTFTQVRAAALRTIRYAISTPNDIKTFNALQLQHLLCRSIDL 128
Cdd:pfam14664    3 ANDLVDL------LKRHPTLKydLVLSDFLLRIQPMLLSESKEVRAAGYRILRYLISDEESLQLLRKLHLDIFIIRSLSK 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   129 MLKNDDERVQALKLVRKMLAIAP--EDISPAVVRCLVSLADsgiEENDNLLRACLATLAEFAVLNPALLIVCGGVTSITR 206
Cdd:pfam14664   77 DNKNEVEREQALKLIRAFLEIKDgvSEISRGVVRALVAIAE---HEDDRLRRICLETLCELALLDPELVVRCGGLRVLLD 153

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   207 NVLEcHNPRIAESLCGVLLYLLEWPQTRN--ICGVRLDCLAAPYCDFTYRQsivdKNKDARELRYTSCRLALLSVLRSWT 284
Cdd:pfam14664  154 ALLE-GSFELAESLLGALLYLLDSPRTRKylRPGFDLEVLLSPFTDSLDAN----TKGDSNEERLQASAKAISSLLKSWP 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   285 GTLEFCDPSKpSGLKAIVDALYLNQIEVRKAILDLLYELLTLPQPTWTDDYAVALQAVdPSDFQDTWLLSNGFVSAEGRS 364
Cdd:pfam14664  229 GLMYLSMNDF-RPLRSLVDSLRLPSLEVREAILDLLFDLLRIKPPSWTSSFLALTTYG-RVANLDSWSLSEGFVAAEFKS 306

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665392362   365 ILPTLAARA-PSVVEQHLALMLYCFLETGLLNALVEVVV-SSDQFVSVQATVLIGKILQLMHTHLP 428
Cdd:pfam14664  307 ILPSESSFSrENLVNHYLALLLLVFIEAGLLEALVEVIEeSSDSSLSRKATLLLGELLHLANRLLP 372
RICTOR_M pfam14666
Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a ...
 683-786 7.44e-37

Rapamycin-insensitive companion of mTOR, middle domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464248  Cd Length: 104  Bit Score: 134.90  E-value: 7.44e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   683 TSNRAHDCLFSPQHMNNTMCQQYFLYIGRMCRTVKGIEVLKNTTVFEYLINLVRVTDHVCYVKLIVSGLNYSYEKLPRQV 762
Cdd:pfam14666    1 SGITAGDPLFSKQRLETTLSRGYFLFIGVLSSSKNGLKLLEKWNIFTILYHIVELKSRDDLLKLILSSLDYSLDGHPRII 80

                           90       100
                   ....*....|....*....|....
gi 665392362   763 LEKALTSAKTRGRLYSTQFMAVLL 786
Cdd:pfam14666   81 LSKALTSSSESIRLYATKHLRVLL 104
RasGEF_N_2 pfam14663
Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a ...
 793-896 3.40e-31

Rapamycin-insensitive companion of mTOR RasGEF_N domain; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. This region is the more conserved central section that may include several individual domains. Rictor can be inhibited in the short-term by rapamycin.


Pssm-ID: 464245  Cd Length: 107  Bit Score: 118.85  E-value: 3.40e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665392362   793 FEVWGIPLIINQTRDSDRSVGLAAMDVLEEACHDKYYLEEIVSRWPNLTHRGDAGRLLMARYYSLPRGLN--STMARIED 870
Cdd:pfam14663    1 FEEWGIELLVTQLYDPSPEVVAAAVDVLYEACDDKENLESLVSLRPSLDHLGEIGSPLLLRFLSTPSGFKylNELGFVEN 80

                           90       100
                   ....*....|....*....|....*.
gi 665392362   871 EIRYWRNGYNKRYVLLVEADTHSSLT 896
Cdd:pfam14663   81 ELDKWFEERNLEYVLKVEEFLAEALT 106
RICTOR_V pfam14668
Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding ...
 965-1036 3.46e-20

Rapamycin-insensitive companion of mTOR, domain 5; Rictor appears to serve as a scaffolding protein that is important for maintaining mTORC2 integrity. The mammalian target of rapamycin (mTOR) is a conserved Ser/Thr kinase that forms two functionally distinct complexes, mTROC1 and mTORC2, important for nutrient and growth-factor signalling. These long eukaryotic proteins carry several well-conserved domains, and this is No.5.


Pssm-ID: 464249  Cd Length: 71  Bit Score: 85.97  E-value: 3.46e-20
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665392362   965 LELKAAIWALAHASTHSNGIEYFVELNarLYEKLIVLVTKCEVYSVRATCFSALGLIAGTQAGANILFKLNW 1036
Cdd:pfam14668    1 LKLKAALWAIGHIGSSPLGIQLLEEYD--IVEDIVKIAEESPVLSLRGTAFYVLGLISSTEEGAEILDELGW 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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