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Conserved domains on  [gi|665405974|ref|NP_001285736|]
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uncharacterized protein Dmel_CG12560, isoform C [Drosophila melanogaster]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10552919)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate; similar to the C-terminal region of the D. melanogaster hypothetical protein FR47

CATH:  3.40.630.30
EC:  2.3.1.-
Gene Ontology:  GO:0008080
SCOP:  3000403

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
187-271 2.16e-36

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


:

Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 124.36  E-value: 2.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974  187 NLGAYD-DKGKLVAWCLRLPIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVLAPVVTKNTPSRSMFEKLGFRAI 265
Cdd:pfam08445   1 VLGIYRgDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80

                  ....*.
gi 665405974  266 DNTYWA 271
Cdd:pfam08445  81 DETYWV 86
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
187-271 2.16e-36

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 124.36  E-value: 2.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974  187 NLGAYD-DKGKLVAWCLRLPIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVLAPVVTKNTPSRSMFEKLGFRAI 265
Cdd:pfam08445   1 VLGIYRgDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80

                  ....*.
gi 665405974  266 DNTYWA 271
Cdd:pfam08445  81 DETYWV 86
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
205-266 1.85e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.34  E-value: 1.85e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665405974 205 PIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAG-DQVLAPVVTKNTPSRSMFEKLGFRAID 266
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGaRRLRLEVREDNEAAIALYEKLGFEEVG 74
 
Name Accession Description Interval E-value
FR47 pfam08445
FR47-like protein; The members of this family are similar to the C-terminal region of the D. ...
187-271 2.16e-36

FR47-like protein; The members of this family are similar to the C-terminal region of the D. melanogaster hypothetical protein FR47. This protein has been found to consist of two N-acyltransferase-like domains swapped with the C-terminal strands.


Pssm-ID: 117022 [Multi-domain]  Cd Length: 86  Bit Score: 124.36  E-value: 2.16e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974  187 NLGAYD-DKGKLVAWCLRLPIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVLAPVVTKNTPSRSMFEKLGFRAI 265
Cdd:pfam08445   1 VLGIYRgDTGELAAWCLRLPGGELGALQTLPEHRRRGLGSRLVAALARGIAERGITPFAVVVAGNTPSRRLYEKLGFRKI 80

                  ....*.
gi 665405974  266 DNTYWA 271
Cdd:pfam08445  81 DETYWV 86
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
205-266 1.85e-05

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 42.34  E-value: 1.85e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665405974 205 PIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAG-DQVLAPVVTKNTPSRSMFEKLGFRAID 266
Cdd:COG0456   12 DEAEIEDLAVDPEYRGRGIGRALLEAALERARERGaRRLRLEVREDNEAAIALYEKLGFEEVG 74
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
188-262 4.30e-05

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 42.12  E-value: 4.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974  188 LGAYDDkGKLVAWCL------RLPIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVL-APVVTKNTPSRSMFEKL 260
Cdd:pfam00583  36 FVAEED-GELVGFASlsiiddEPPVGEIEGLAVAPEYRGKGIGTALLQALLEWARERGCERIfLEVAADNLAAIALYEKL 114

                  ..
gi 665405974  261 GF 262
Cdd:pfam00583 115 GF 116
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
149-266 5.59e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 42.67  E-value: 5.59e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974 149 NIHLQHLTIEDA----EIINENWPHN------KPGSIDFVRSLIKYNINLGAY----DDKGKLVAWC------LRLPIGS 208
Cdd:COG1247    1 EMTIRPATPEDApaiaAIYNEAIAEGtatfetEPPSEEEREAWFAAILAPGRPvlvaEEDGEVVGFAslgpfrPRPAYRG 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665405974 209 LGLLQ--VLESHKRLGLGSLLVKSMAKKISAAG-DQVLAPVVTKNTPSRSMFEKLGFRAID 266
Cdd:COG1247   81 TAEESiyVDPDARGRGIGRALLEALIERARARGyRRLVAVVLADNEASIALYEKLGFEEVG 141
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
186-269 2.09e-04

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 40.17  E-value: 2.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974 186 INLGAYDDkGKLVAwCLRL-----PIGSLGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVLapVVTKNTPSRSMFEKL 260
Cdd:COG2153   35 RHLLAYDD-GELVA-TARLlppgdGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGARRI--VLSAQAHAVGFYEKL 110

                 ....*....
gi 665405974 261 GFRAIDNTY 269
Cdd:COG2153  111 GFVPVGEEF 119
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
171-266 3.90e-04

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 39.59  E-value: 3.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974 171 KPGSIDFVRSLIKYNI---NLGAY---DDKGKLVAWC-LRLPIGSLGLLQ---VLESHKRLGLGSLLVKSMAKKISAAGD 240
Cdd:COG1246    7 TPDDVPAILELIRPYAleeEIGEFwvaEEDGEIVGCAaLHPLDEDLAELRslaVHPDYRGRGIGRRLLEALLAEARELGL 86
                         90       100
                 ....*....|....*....|....*.
gi 665405974 241 QVLApVVTkNTPSRSMFEKLGFRAID 266
Cdd:COG1246   87 KRLF-LLT-TSAAIHFYEKLGFEEID 110
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
188-266 4.19e-04

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 39.18  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974  188 LGAYDDkGKLVAWClRLPIGS-LGLLQVLESHKRLGLGSLLVKSMAKKISAAGDQVLAPVVTKNTPSRSMFEKLGFRAID 266
Cdd:pfam13673  34 FVAFEG-GQIVGVI-ALRDRGhISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTVNASPYAVPFYEKLGFRATG 111
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
214-265 2.32e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 36.43  E-value: 2.32e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665405974 214 VLESHKRLGLGSLLVKSMAKKISAAG-DQVLAPVVTKNTPSRSMFEKLGFRAI 265
Cdd:COG3393   23 THPEYRGRGLASALVAALAREALARGaRTPFLYVDADNPAARRLYERLGFRPV 75
RimL COG1670
Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, ...
146-263 4.05e-03

Protein N-acetyltransferase, RimJ/RimL family [Translation, ribosomal structure and biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441276 [Multi-domain]  Cd Length: 173  Bit Score: 37.29  E-value: 4.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665405974 146 DTFNIHLQHLTIEDAEIINE--------NWPHNKPGSIDFVRSLIKYNINLGAYDDKGKLVAWCLR--LPIGSLGLLQVL 215
Cdd:COG1670    4 ETERLRLRPLRPEDAEALAEllndpevaRYLPGPPYSLEEARAWLERLLADWADGGALPFAIEDKEdgELIGVVGLYDID 83
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665405974 216 ESHKRLGLGSLLVKSMAKK--ISAAGDQVL-------------APVVTKNTPSRSMFEKLGFR 263
Cdd:COG1670   84 RANRSAEIGYWLAPAYWGKgyATEALRALLdyafeelglhrveAEVDPDNTASIRVLEKLGFR 146
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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