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Conserved domains on  [gi|665407118|ref|NP_001285741|]
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phosphatidic acid phospholipase A1, isoform D [Drosophila melanogaster]

Protein Classification

DDHD family phospholipase( domain architecture ID 13590144)

DDHD family phospholipase similar to Homo sapiens phospholipase DDHD1 that hydrolyzes phosphatidic acid, including 1,2-dioleoyl-sn-phosphatidic acid

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 1753-1980 4.04e-71

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


:

Pssm-ID: 460725  Cd Length: 241  Bit Score: 238.49  E-value: 4.04e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1753 LIFHPKKFFALGSPIGMFVTIRGIDKLGLDFH-----LPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGR 1827
Cdd:pfam02862    1 LDFEVENFFLLGSPLGLFLALRGAQIAGRSRSdhiygSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1828 KRMHLELKETMTRVGADIKQRFMDTFKT-----TLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVA 1902
Cdd:pfam02862   81 GLRHLELGEGLTRIGAAVGQSVSGLWSSlssgaSLNRSLGLSDESSASSADSEQSHERSSEASSASESSLQAQSSSAPSS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1903 SSSCKLRNRTDSNSTTASDPEF-----IELDFPLGKLNDSKRVDYVLQEAPLEFinEYIFALSSHVCYWGSEDTILFVMK 1977
Cdd:pfam02862  161 TSSSNGIKEIEETELDWSESERkadklEREEAKVRALNPNGRIDYVLQEGALES--QYLSALTSHLSYWESEDVALFLLR 238


                   ...
gi 665407118  1978 EIY 1980
Cdd:pfam02862  239 QLL 241
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 375-1012 9.60e-18

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.77  E-value: 9.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  375 GGPNSTFPPGGNYFVP--GAPPSLPSTGVVGPPSVGNFFAPAAPlpvAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPL 452
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  453 APQPFQSATVNQ-------SALPPNNPPTASAVGELFVP----APTTIAQGTSPAVPFVDTQAVPTI-PLTVPPGNPPPT 520
Cdd:PHA03247 2626 PPPPSPSPAANEpdphpppTVPPPERPRDDPAPGRVSRPrrarRLGRAAQASSPPQRPRRRAARPTVgSLTSLADPPPPP 2705

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  521 STlggffttGEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNPN 600
Cdd:PHA03247 2706 PT-------PEPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  601 plpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqGV 680
Cdd:PHA03247 2776 ----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------AP 2814

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  681 PFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISST 749
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  750 PIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISNQ 829
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLGA 2966

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  830 GIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSVP 908
Cdd:PHA03247 2967 LVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLWP 3030

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  909 PASKVDQEDIvypepsapveqeiPLFVPVPGLPGLSQDIPLYPPPptgsttassifaappvaSSAPLFVPVPGPPSVSSL 988
Cdd:PHA03247 3031 PDDTEDSDAD-------------SLFDSDSERSDLEALDPLPPEP-----------------HDPFAHEPDPATPEAGAR 3080

                         650       660
                  ....*....|....*....|....
gi 665407118  989 FSPSqvdstsSLFAPPPTSANTTI 1012
Cdd:PHA03247 3081 ESPS------SQFGPPPLSANAAL 3098
WWE pfam02825
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ...
 1379-1446 6.24e-07

WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.


:

Pssm-ID: 460715 [Multi-domain]  Cd Length: 66  Bit Score: 48.45  E-value: 6.24e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1379 HWFYKrsvDTKFIWTPFSHYDSALLETS--LNLDDSTLIIPVEGGRYDVNIKERTKTPVYwEGKAIEVRR 1446
Cdd:pfam02825    1 VWEWE---DDNGGWHPYDPEVSSLIEEAyqKGKPSVDLSITTAGFPYTIDFKSMTQTNKD-TGTTRPVRR 66
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 888-1179 1.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   888 PPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPV-----------PGLPGLSQDI-PLYPPPPT 955
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpQRLPSPHPPLqPMTQPPPP 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   956 GSTTASSIFAA------PPVA---SSAPLFVPVPGPPS---VSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTL 1023
Cdd:pfam03154  259 SQVSPQPLPQPslhgqmPPMPhslQTGPSHMQHPVPPQpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1024 FANN--IPTTTPSIPDIVP--TTSAELVDAPPGFQGSSDDTATNLFQGNTETQtvfSPFAQTKATPLVQETKPELVPPPI 1099
Cdd:pfam03154  339 PPREqpLPPAPLSMPHIKPppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPL 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1100 GFFapkSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGiAPPPLALESPPQNSVSNIATS 1179
Cdd:pfam03154  416 QLM---PQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPG-GPPPITPPSGPPTSTSSAMPG 491
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 38-590 1.86e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   38 DDFPNKPQLLPAaPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNT-SSEDSVGAGGSSPylgag 116
Cdd:PHA03247 2606 GDPRGPAPPSPL-PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP----- 2679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  117 DQNANPLLEPPTEAGNDSLLSQAASSFTALPAvasnvfstfskriyagSRETSEEPKLDIQPSYIQQASYVQPVAPVPAP 196
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------------PHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  197 FYAAPPAAANEVVAPEPPkfyapTEVPPPNVGVPAPPPTSGNPNTYRfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQA 276
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  277 APSFQTPPYPPQLTYAANPAPfdiSAQPAAIPAEERKSGGglfsltSLVPTGVLQNiTGIVQSATGRSSEPEHTNVQQag 356
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTA---PPPPPGPPPPSLPLGG------SVAPGGDVRR-RPPSRSPAAKPAAPARPPVRR-- 2885

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  357 gyldiTTASAPAPSTNLFGGPnstfppggnyfvPGAPPSLPStgvvgppsvgnffaPAAPLPVAQTAAPPavgafftsAA 436
Cdd:PHA03247 2886 -----LARPAVSRSTESFALP------------PDQPERPPQ--------------PQAPPPPQPQPQPP--------PP 2926

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  437 PSVTPSVFTPG-TVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTtiaqgTSPAVPFVDTQAVPTIPLTVPP- 514
Cdd:PHA03247 2927 PQPQPPPPPPPrPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFR-----VPQPAPSREAPASSTPPLTGHSl 3001

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  515 ---------------GNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLA-EPVPTIPITSSGV 578
Cdd:PHA03247 3002 srvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAhEPDPATPEAGARE 3081

                         570
                  ....*....|..
gi 665407118  579 PPIGLFPPAPAQ 590
Cdd:PHA03247 3082 SPSSQFGPPPLS 3093
 
Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 1753-1980 4.04e-71

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


Pssm-ID: 460725  Cd Length: 241  Bit Score: 238.49  E-value: 4.04e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1753 LIFHPKKFFALGSPIGMFVTIRGIDKLGLDFH-----LPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGR 1827
Cdd:pfam02862    1 LDFEVENFFLLGSPLGLFLALRGAQIAGRSRSdhiygSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1828 KRMHLELKETMTRVGADIKQRFMDTFKT-----TLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVA 1902
Cdd:pfam02862   81 GLRHLELGEGLTRIGAAVGQSVSGLWSSlssgaSLNRSLGLSDESSASSADSEQSHERSSEASSASESSLQAQSSSAPSS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1903 SSSCKLRNRTDSNSTTASDPEF-----IELDFPLGKLNDSKRVDYVLQEAPLEFinEYIFALSSHVCYWGSEDTILFVMK 1977
Cdd:pfam02862  161 TSSSNGIKEIEETELDWSESERkadklEREEAKVRALNPNGRIDYVLQEGALES--QYLSALTSHLSYWESEDVALFLLR 238


                   ...
gi 665407118  1978 EIY 1980
Cdd:pfam02862  239 QLL 241
PHA03247 PHA03247
large tegument protein UL36; Provisional
 375-1012 9.60e-18

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.77  E-value: 9.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  375 GGPNSTFPPGGNYFVP--GAPPSLPSTGVVGPPSVGNFFAPAAPlpvAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPL 452
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  453 APQPFQSATVNQ-------SALPPNNPPTASAVGELFVP----APTTIAQGTSPAVPFVDTQAVPTI-PLTVPPGNPPPT 520
Cdd:PHA03247 2626 PPPPSPSPAANEpdphpppTVPPPERPRDDPAPGRVSRPrrarRLGRAAQASSPPQRPRRRAARPTVgSLTSLADPPPPP 2705

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  521 STlggffttGEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNPN 600
Cdd:PHA03247 2706 PT-------PEPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  601 plpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqGV 680
Cdd:PHA03247 2776 ----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------AP 2814

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  681 PFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISST 749
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  750 PIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISNQ 829
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLGA 2966

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  830 GIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSVP 908
Cdd:PHA03247 2967 LVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLWP 3030

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  909 PASKVDQEDIvypepsapveqeiPLFVPVPGLPGLSQDIPLYPPPptgsttassifaappvaSSAPLFVPVPGPPSVSSL 988
Cdd:PHA03247 3031 PDDTEDSDAD-------------SLFDSDSERSDLEALDPLPPEP-----------------HDPFAHEPDPATPEAGAR 3080

                         650       660
                  ....*....|....*....|....
gi 665407118  989 FSPSqvdstsSLFAPPPTSANTTI 1012
Cdd:PHA03247 3081 ESPS------SQFGPPPLSANAAL 3098
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 693-1098 9.81e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.55  E-value: 9.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   693 QVAAPTVAVPQSAPIAPPPGtsstsvaPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQEN 772
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPSPP-------PPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   773 E-ATASTTLEGLVQGPAPTLSASQffDTPLPTGTQPENQVASVSSERENLVQEPIsnqgipffaPPQTNIFTPQLQQEFI 851
Cdd:pfam03154  241 RlPSPHPPLQPMTQPPPPSQVSPQ--PLPQPSLHGQMPPMPHSLQTGPSHMQHPV---------PPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   852 APAEDSKRSEIQEEFLSAPPQESNLSTElredthtGPPVIEPvLEETPASSSESSVPPASKVdqedivyPEPSAPVEQEI 931
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQ-------QPPREQP-LPPAPLSMPHIKPPPTTPI-------PQLPNPQSHKH 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   932 PLFVPVPGLPGLSQDIPlypPPPTGSTTASSIFAAPPVASSAPLFV-----PVPGPPSVSSLFSPSQVDSTSSLFAPPPT 1006
Cdd:pfam03154  375 PPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPLQLmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1007 SANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNlfqgnteTQTVFSPFAQTKATPL 1086
Cdd:pfam03154  452 GLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA-------AVSCPLPPVQIKEEAL 524

                          410
                   ....*....|..
gi 665407118  1087 VQETKPELVPPP 1098
Cdd:pfam03154  525 DEAEEPESPPPP 536
WWE pfam02825
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ...
 1379-1446 6.24e-07

WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.


Pssm-ID: 460715 [Multi-domain]  Cd Length: 66  Bit Score: 48.45  E-value: 6.24e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1379 HWFYKrsvDTKFIWTPFSHYDSALLETS--LNLDDSTLIIPVEGGRYDVNIKERTKTPVYwEGKAIEVRR 1446
Cdd:pfam02825    1 VWEWE---DDNGGWHPYDPEVSSLIEEAyqKGKPSVDLSITTAGFPYTIDFKSMTQTNKD-TGTTRPVRR 66
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 888-1179 1.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   888 PPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPV-----------PGLPGLSQDI-PLYPPPPT 955
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpQRLPSPHPPLqPMTQPPPP 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   956 GSTTASSIFAA------PPVA---SSAPLFVPVPGPPS---VSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTL 1023
Cdd:pfam03154  259 SQVSPQPLPQPslhgqmPPMPhslQTGPSHMQHPVPPQpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1024 FANN--IPTTTPSIPDIVP--TTSAELVDAPPGFQGSSDDTATNLFQGNTETQtvfSPFAQTKATPLVQETKPELVPPPI 1099
Cdd:pfam03154  339 PPREqpLPPAPLSMPHIKPppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPL 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1100 GFFapkSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGiAPPPLALESPPQNSVSNIATS 1179
Cdd:pfam03154  416 QLM---PQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPG-GPPPITPPSGPPTSTSSAMPG 491
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
362-526 3.76e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.51  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTP 441
Cdd:COG3469    55 GSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGeLFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTV--PPGNPPP 519
Cdd:COG3469   135 TSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTT-TSASTTPSATTTATATTASGATTPSATTTATTtgPPTPGLP 213


                  ....*..
gi 665407118  520 TSTLGGF 526
Cdd:COG3469   214 KHVLVGY 220
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-590 1.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   38 DDFPNKPQLLPAaPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNT-SSEDSVGAGGSSPylgag 116
Cdd:PHA03247 2606 GDPRGPAPPSPL-PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP----- 2679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  117 DQNANPLLEPPTEAGNDSLLSQAASSFTALPAvasnvfstfskriyagSRETSEEPKLDIQPSYIQQASYVQPVAPVPAP 196
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------------PHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  197 FYAAPPAAANEVVAPEPPkfyapTEVPPPNVGVPAPPPTSGNPNTYRfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQA 276
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  277 APSFQTPPYPPQLTYAANPAPfdiSAQPAAIPAEERKSGGglfsltSLVPTGVLQNiTGIVQSATGRSSEPEHTNVQQag 356
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTA---PPPPPGPPPPSLPLGG------SVAPGGDVRR-RPPSRSPAAKPAAPARPPVRR-- 2885

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  357 gyldiTTASAPAPSTNLFGGPnstfppggnyfvPGAPPSLPStgvvgppsvgnffaPAAPLPVAQTAAPPavgafftsAA 436
Cdd:PHA03247 2886 -----LARPAVSRSTESFALP------------PDQPERPPQ--------------PQAPPPPQPQPQPP--------PP 2926

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  437 PSVTPSVFTPG-TVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTtiaqgTSPAVPFVDTQAVPTIPLTVPP- 514
Cdd:PHA03247 2927 PQPQPPPPPPPrPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFR-----VPQPAPSREAPASSTPPLTGHSl 3001

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  515 ---------------GNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLA-EPVPTIPITSSGV 578
Cdd:PHA03247 3002 srvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAhEPDPATPEAGARE 3081

                         570
                  ....*....|..
gi 665407118  579 PPIGLFPPAPAQ 590
Cdd:PHA03247 3082 SPSSQFGPPPLS 3093
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 684-824 7.27e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.21  E-value: 7.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   684 TPPVQNPPGQVAAPTVAVPQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:TIGR01645  344 NKAVVSSAKKEAEEVPPLPQAAPAVVKPGpmEIPTPVPPPGLAIPSLVAPPG--LVAPTEINPSFLASPRKKMKREKLPV 421

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665407118   762 EV-----TTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLVQE 824
Cdd:TIGR01645  422 TFgalddTLAWKEPSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEGEELQPKLVMNSEDASLAS 489
 
Name Accession Description Interval E-value
DDHD pfam02862
DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that ...
 1753-1980 4.04e-71

DDHD domain; The DDHD domain is 180 residues long and contains four conserved residues that may form a metal binding site. The domain is named after these four residues. This pattern of conservation of metal binding residues is often seen in phosphoesterase domains. This domain is found in retinal degeneration B proteins, as well as a family of probable phospholipases. It has been shown that this domain is found in a longer C terminal region that binds to PYK2 tyrosine kinase. These proteins have been called N-terminal domain-interacting receptor (Nir1, Nir2 and Nir3). This suggests that this region is involved in functionally important interactions in other members of this family.


Pssm-ID: 460725  Cd Length: 241  Bit Score: 238.49  E-value: 4.04e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1753 LIFHPKKFFALGSPIGMFVTIRGIDKLGLDFH-----LPTCPGFYNIFHPFDPVAYRIEALVNPDMNGIRPVLIPHHKGR 1827
Cdd:pfam02862    1 LDFEVENFFLLGSPLGLFLALRGAQIAGRSRSdhiygSPACKQLYNIFHPYDPVAYRLEPLIDPAYSNLKPVLIPYYKKR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1828 KRMHLELKETMTRVGADIKQRFMDTFKT-----TLDSVNFLTTVTKVKKEAEESLEKETSQTSSQAFQKQTEDQDESSVA 1902
Cdd:pfam02862   81 GLRHLELGEGLTRIGAAVGQSVSGLWSSlssgaSLNRSLGLSDESSASSADSEQSHERSSEASSASESSLQAQSSSAPSS 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1903 SSSCKLRNRTDSNSTTASDPEF-----IELDFPLGKLNDSKRVDYVLQEAPLEFinEYIFALSSHVCYWGSEDTILFVMK 1977
Cdd:pfam02862  161 TSSSNGIKEIEETELDWSESERkadklEREEAKVRALNPNGRIDYVLQEGALES--QYLSALTSHLSYWESEDVALFLLR 238


                   ...
gi 665407118  1978 EIY 1980
Cdd:pfam02862  239 QLL 241
PHA03247 PHA03247
large tegument protein UL36; Provisional
 375-1012 9.60e-18

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 90.77  E-value: 9.60e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  375 GGPNSTFPPGGNYFVP--GAPPSLPSTGVVGPPSVGNFFAPAAPlpvAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPL 452
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrSVPPPRPAPRPSEPAVTSRARRPDAP---PQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPD 2625

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  453 APQPFQSATVNQ-------SALPPNNPPTASAVGELFVP----APTTIAQGTSPAVPFVDTQAVPTI-PLTVPPGNPPPT 520
Cdd:PHA03247 2626 PPPPSPSPAANEpdphpppTVPPPERPRDDPAPGRVSRPrrarRLGRAAQASSPPQRPRRRAARPTVgSLTSLADPPPPP 2705

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  521 STlggffttGEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNPN 600
Cdd:PHA03247 2706 PT-------PEPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAAP 2775

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  601 plpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqGV 680
Cdd:PHA03247 2776 ----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------AP 2814

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  681 PFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISST 749
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSRS 2894

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  750 PIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISNQ 829
Cdd:PHA03247 2895 TESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLGA 2966

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  830 GIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSVP 908
Cdd:PHA03247 2967 LVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLWP 3030

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  909 PASKVDQEDIvypepsapveqeiPLFVPVPGLPGLSQDIPLYPPPptgsttassifaappvaSSAPLFVPVPGPPSVSSL 988
Cdd:PHA03247 3031 PDDTEDSDAD-------------SLFDSDSERSDLEALDPLPPEP-----------------HDPFAHEPDPATPEAGAR 3080

                         650       660
                  ....*....|....*....|....
gi 665407118  989 FSPSqvdstsSLFAPPPTSANTTI 1012
Cdd:PHA03247 3081 ESPS------SQFGPPPLSANAAL 3098
PHA03247 PHA03247
large tegument protein UL36; Provisional
 209-737 3.24e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 3.24e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  209 VAPEPPKFYAPTEVPPPNvgvPAPPPtSGNPNTYRftARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPYPPq 288
Cdd:PHA03247 2555 LPPAAPPAAPDRSVPPPR---PAPRP-SEPAVTSR--ARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPP- 2627

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  289 lTYAANPAPFDI-SAQPAAIPAEERKSGGglfsltSLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASA- 366
Cdd:PHA03247 2628 -PPSPSPAANEPdPHPPPTVPPPERPRDD------PAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLAd 2700

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  367 -PAPSTNLFGGPNSTFP----PGGNYFVPGAPPSLPSTGVvgPPSVGNffAPAAPLPVAQTAAPPAvgaffTSAAPSVTP 441
Cdd:PHA03247 2701 pPPPPPTPEPAPHALVSatplPPGPAAARQASPALPAAPA--PPAVPA--GPATPGGPARPARPPT-----TAGPPAPAP 2771

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  442 SVFTPGTVPPLAPQP-FQSATVNQSALP-PNNPPTASAVGELFVPAPTTIAQGTSPAVPfvDTQAVPTIPLTvPPGNPPP 519
Cdd:PHA03247 2772 PAAPAAGPPRRLTRPaVASLSESRESLPsPWDPADPPAAVLAPAAALPPAASPAGPLPP--PTSAQPTAPPP-PPGPPPP 2848

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  520 TSTLGGFFTTGevAPVVAPFGTQASPATQSAgffnpgEVRPNV-PLAEPVPTIPITSSGVPPIGLFPPAPAQPgvqtasn 598
Cdd:PHA03247 2849 SLPLGGSVAPG--GDVRRRPPSRSPAAKPAA------PARPPVrRLARPAVSRSTESFALPPDQPERPPQPQA------- 2913

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  599 pnplpgaaapppaagqasyrlqkgtrlyKSPLTPQETATSSGFAAPLPPTSVTPaifNPFGAPAPGsfnsvghlegqsSQ 678
Cdd:PHA03247 2914 ----------------------------PPPPQPQPQPPPPPQPQPPPPPPPRP---QPPLAPTTD------------PA 2950

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665407118  679 GVPFFTPPVQNP------PGQVAAPTVAVPQSAPIAPPPGTSStsvaPPLTASIAnpPPTSGFAS 737
Cdd:PHA03247 2951 GAGEPSGAVPQPwlgalvPGRVAVPRFRVPQPAPSREAPASST----PPLTGHSL--SRVSSWAS 3009
PHA03247 PHA03247
large tegument protein UL36; Provisional
 210-975 3.68e-15

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 82.29  E-value: 3.68e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  210 APEPPKFYAPTEVPPPNVGVPAPPptsgnpntyrftarkKLYAPIPGLSEQSGQPAQQPqvpqapqaapsfqTPPYPPql 289
Cdd:PHA03247 2508 APPAPSRLAPAILPDEPVGEPVHP---------------RMLTWIRGLEELASDDAGDP-------------PPPLPP-- 2557

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  290 tyAANPAPFDIS---AQPAAIPAEErksggglfsltslvptgvlqnitgivqSATGRSSEPehtnvqqaggyldittaSA 366
Cdd:PHA03247 2558 --AAPPAAPDRSvppPRPAPRPSEP---------------------------AVTSRARRP-----------------DA 2591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  367 PapstnlfggPNSTFPPggnyfVPGAPPslpstgvvgppsvGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTP 446
Cdd:PHA03247 2592 P---------PQSARPR-----APVDDR-------------GDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPP 2644

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  447 GTVPPlaPQPFQSATVNQSALP-----PNNPPTASAVGELFVP--APTTIAQGTSPAVPfvdtqavptipltvPPGNPPP 519
Cdd:PHA03247 2645 TVPPP--ERPRDDPAPGRVSRPrrarrLGRAAQASSPPQRPRRraARPTVGSLTSLADP--------------PPPPPTP 2708

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  520 tstlggffttgEVAPVVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLfPPAPAQPGVQTASNP 599
Cdd:PHA03247 2709 -----------EPAPHALVSATPLPPGPAAARQASPAL--PAAPAPPAVPAGPATPGGPARPAR-PPTTAGPPAPAPPAA 2774

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  600 NplpgaaapppaagqasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSfnsvghlegqssqG 679
Cdd:PHA03247 2775 P----------------------------AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVL-------------A 2813

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  680 VPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSST----SVAP-------PLTASIANPPPTSGFASVPLFAAPTISS 748
Cdd:PHA03247 2814 PAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLplggSVAPggdvrrrPPSRSPAAKPAAPARPPVRRLARPAVSR 2893

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  749 TPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQffdTPLPTGTQPENQvasvsSERENLVQEPISN 828
Cdd:PHA03247 2894 STESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ---PPLAPTTDPAGA-----GEPSGAVPQPWLG 2965

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  829 QGIPFFAP-PQTNIFTPQLQQEFIAPAEDSKRSeiqeeflSAPPQESNLSTELREDTHTGPPviepvleetPASSSESSV 907
Cdd:PHA03247 2966 ALVPGRVAvPRFRVPQPAPSREAPASSTPPLTG-------HSLSRVSSWASSLALHEETDPP---------PVSLKQTLW 3029

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  908 PPaSKVDQEDIVYPEPSAPVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTAS--SIFAAPPVASSAPL 975
Cdd:PHA03247 3030 PP-DDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESpsSQFGPPPLSANAAL 3098
PHA03247 PHA03247
large tegument protein UL36; Provisional
 642-1165 1.88e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.50  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  642 AAPLPPTSVTPAIF--NPFGAPAPGSF----NSVGHLEGQSSQGVPFFTPPVQNPPG------------QVAAPTV---- 699
Cdd:PHA03247 2507 DAPPAPSRLAPAILpdEPVGEPVHPRMltwiRGLEELASDDAGDPPPPLPPAAPPAApdrsvppprpapRPSEPAVtsra 2586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  700 ----AVPQSA-------PIAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTG-- 766
Cdd:PHA03247 2587 rrpdAPPQSArprapvdDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrr 2666

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  767 LSQQENEATASTTLEGLVQGPA-PTLSASQFFDTPLPTGTQPENQVASVSSErenLVQEPISNQGIPFFAPPQTNIFTPQ 845
Cdd:PHA03247 2667 ARRLGRAAQASSPPQRPRRRAArPTVGSLTSLADPPPPPPTPEPAPHALVSA---TPLPPGPAAARQASPALPAAPAPPA 2743

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  846 LQQEFIAPAEDSKRSeiqeeflsAPPqesnlstelredTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSA 925
Cdd:PHA03247 2744 VPAGPATPGGPARPA--------RPP------------TTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  926 PVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASSIFAAP---------------PVASSAPLFVPVPGP-----PSV 985
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPpppslplggsvapggDVRRRPPSRSPAAKPaaparPPV 2883

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  986 SSLFSPSQVDSTSSLFAPPPTSANTTilTPAPDTTstlfanniPTTTPSIPdivpttSAELVDAPPGFQGSSDdtatnlf 1065
Cdd:PHA03247 2884 RRLARPAVSRSTESFALPPDQPERPP--QPQAPPP--------PQPQPQPP------PPPQPQPPPPPPPRPQ------- 2940

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118 1066 qgntetqtvfSPFAQTKATPLVQETKPELVPPPIGFFAPkseSEVLSQPPLAPSPLQSFFSTAPETATTTDfnfFGSPAP 1145
Cdd:PHA03247 2941 ----------PPLAPTTDPAGAGEPSGAVPQPWLGALVP---GRVAVPRFRVPQPAPSREAPASSTPPLTG---HSLSRV 3004

                         570       580
                  ....*....|....*....|
gi 665407118 1146 GSVFPDLPVQQGIAPPPLAL 1165
Cdd:PHA03247 3005 SSWASSLALHEETDPPPVSL 3024
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 693-1098 9.81e-09

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 60.55  E-value: 9.81e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   693 QVAAPTVAVPQSAPIAPPPGtsstsvaPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQEN 772
Cdd:pfam03154  168 QTQPPVLQAQSGAASPPSPP-------PPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQ 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   773 E-ATASTTLEGLVQGPAPTLSASQffDTPLPTGTQPENQVASVSSERENLVQEPIsnqgipffaPPQTNIFTPQLQQEFI 851
Cdd:pfam03154  241 RlPSPHPPLQPMTQPPPPSQVSPQ--PLPQPSLHGQMPPMPHSLQTGPSHMQHPV---------PPQPFPLTPQSSQSQV 309

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   852 APAEDSKRSEIQEEFLSAPPQESNLSTElredthtGPPVIEPvLEETPASSSESSVPPASKVdqedivyPEPSAPVEQEI 931
Cdd:pfam03154  310 PPGPSPAAPGQSQQRIHTPPSQSQLQSQ-------QPPREQP-LPPAPLSMPHIKPPPTTPI-------PQLPNPQSHKH 374

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   932 PLFVPVPGLPGLSQDIPlypPPPTGSTTASSIFAAPPVASSAPLFV-----PVPGPPSVSSLFSPSQVDSTSSLFAPPPT 1006
Cdd:pfam03154  375 PPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPLQLmpqsqQLPPPPAQPPVLTQSQSLPPPAASHPPTS 451

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1007 SANTTILTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNlfqgnteTQTVFSPFAQTKATPL 1086
Cdd:pfam03154  452 GLHQVPSQSPFPQHPFVPGGPPPITPPSGPPTSTSSAMPGIQPPSSASVSSSGPVPA-------AVSCPLPPVQIKEEAL 524

                          410
                   ....*....|..
gi 665407118  1087 VQETKPELVPPP 1098
Cdd:pfam03154  525 DEAEEPESPPPP 536
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 375-744 1.63e-08

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 60.00  E-value: 1.63e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  375 GGPNSTFPPGGNYFVPGAPPslPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVfTPGTVPPLAP 454
Cdd:PRK07764  390 GAGAPAAAAPSAAAAAPAAA--PAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSP-PPAAAPSAQP 466

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  455 QPFQSATVNQSALPPNNPPTASA-VGELFVPAPTTIAQGTSPAVpfVDTQAVPTIPLTVPPGNPP--------------- 518
Cdd:PRK07764  467 APAPAAAPEPTAAPAPAPPAAPApAAAPAAPAAPAAPAGADDAA--TLRERWPEILAAVPKRSRKtwaillpeatvlgvr 544

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  519 --------PTSTLGGFFTTGEVAPVVAP-----FGTQASPATQSAGffNPGEVRPNVPLAEPvptipitSSGVPPIGLFP 585
Cdd:PRK07764  545 gdtlvlgfSTGGLARRFASPGNAEVLVTalaeeLGGDWQVEAVVGP--APGAAGGEGPPAPA-------SSGPPEEAARP 615

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  586 PAPAQPGVQTASnpnplpgaaapppaagqasyrlqkgtrlyksplTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGS 665
Cdd:PRK07764  616 AAPAAPAAPAAP---------------------------------APAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDA 662

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  666 FNSVGHLEGQSSQGVPFFTPPVQNPPGQVA----APTVAVPQSAPIAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLF 741
Cdd:PRK07764  663 SDGGDGWPAKAGGAAPAAPPPAPAPAAPAApagaAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVPLP 742


                  ...
gi 665407118  742 AAP 744
Cdd:PRK07764  743 PEP 745
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 675-1022 6.47e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 57.85  E-value: 6.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   675 QSSQGVPffTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAPPLTASIAnpPPTSGFASVPLFAAPTISStPIPFF 754
Cdd:pfam03154  175 QAQSGAA--SPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTA--APHTLIQQTPTLHPQRLPS-PHPPL 249

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   755 NPQPTGAEVttglSQQENEATASTTLEGLVQ-GPAPTLSASQFFDTPLPTGTQP-ENQVASVSSERENLVQEPISNQGIP 832
Cdd:pfam03154  250 QPMTQPPPP----SQVSPQPLPQPSLHGQMPpMPHSLQTGPSHMQHPVPPQPFPlTPQSSQSQVPPGPSPAAPGQSQQRI 325

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   833 FFAPPQTNIFTPQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLSTELREDTHTGPPVIE------PVLEETPASSSESS 906
Cdd:pfam03154  326 HTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQmnsnlpPPPALKPLSSLSTH 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   907 VPPASkvdqedivYPEPSAPVEQEIPLFVPVPGLPGLSQDiPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPSVS 986
Cdd:pfam03154  406 HPPSA--------HPPPLQLMPQSQQLPPPPAQPPVLTQS-QSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPPIT 476

                          330       340       350
                   ....*....|....*....|....*....|....*.
gi 665407118   987 SLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTST 1022
Cdd:pfam03154  477 PPSGPPTSTSSAMPGIQPPSSASVSSSGPVPAAVSC 512
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
381-597 1.97e-07

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 56.42  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  381 FPPGGNYfvPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSA 460
Cdd:PRK12323  363 FRPGQSG--GGAGPATAAAAPVAQPAP----AAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAA 436

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  461 TVNQSALPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVP---PGNPPPTSTLGGFFttgevaPVVA 537
Cdd:PRK12323  437 RQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPapaDDDPPPWEELPPEF------ASPA 510

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665407118  538 PFGTQASPA-TQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTAS 597
Cdd:PRK12323  511 PAQPDAAPAgWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASAS 571
WWE pfam02825
WWE domain; The WWE domain is named after three of its conserved residues and is predicted to ...
 1379-1446 6.24e-07

WWE domain; The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein- protein interactions in ubiquitin and ADP ribose conjugation systems.


Pssm-ID: 460715 [Multi-domain]  Cd Length: 66  Bit Score: 48.45  E-value: 6.24e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1379 HWFYKrsvDTKFIWTPFSHYDSALLETS--LNLDDSTLIIPVEGGRYDVNIKERTKTPVYwEGKAIEVRR 1446
Cdd:pfam02825    1 VWEWE---DDNGGWHPYDPEVSSLIEEAyqKGKPSVDLSITTAGFPYTIDFKSMTQTNKD-TGTTRPVRR 66
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 329-765 1.79e-06

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 53.23  E-value: 1.79e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   329 VLQNITGIVQSATGRSSEPEHTNVQQAGgyLDITTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVG 408
Cdd:pfam03154  166 ILQTQPPVLQAQSGAASPPSPPPPGTTQ--AATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLIQQTPTLHPQRLP 243

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   409 NFFAPAAPLPvaQTAAPPAVGA-------FFTSAAPSVTPSVFTPGTVP-PLAPQPF-QSATVNQSALPPNNPPTASAVG 479
Cdd:pfam03154  244 SPHPPLQPMT--QPPPPSQVSPqplpqpsLHGQMPPMPHSLQTGPSHMQhPVPPQPFpLTPQSSQSQVPPGPSPAAPGQS 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   480 ELFVPAPTTIAQGTSPAVPfvDTQAVPTIPLTVPPGNPPPTSTlggffttgeVAPVVAPFGTQASPATQSAGFFNPGEVR 559
Cdd:pfam03154  322 QQRIHTPPSQSQLQSQQPP--REQPLPPAPLSMPHIKPPPTTP---------IPQLPNPQSHKHPPHLSGPSPFQMNSNL 390

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   560 PNVPLAEPVPTIPI---TSSGVPPIGLFP------PAPAQPGVqtasnpnplpgaaapppaagqasyrlqkgtrlykspL 630
Cdd:pfam03154  391 PPPPALKPLSSLSThhpPSAHPPPLQLMPqsqqlpPPPAQPPV------------------------------------L 434

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   631 TPQETATSSGFAAPLPPTSVTPAIFNPFgapAPGSFnsvghlegqssqgVPFFTPPVQNPPGqvaaPTVAVPQSAPIAPP 710
Cdd:pfam03154  435 TQSQSLPPPAASHPPTSGLHQVPSQSPF---PQHPF-------------VPGGPPPITPPSG----PPTSTSSAMPGIQP 494

                          410       420       430       440       450
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 665407118   711 PGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTT 765
Cdd:pfam03154  495 PSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPPPRSPSPEPTVVNT 549
PHA03378 PHA03378
EBNA-3B; Provisional
 393-761 2.25e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.15  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  393 PPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAA-----PPAVGafftsaapsvtpsVFTPGTVPPLAPQPFQSAT--VNQS 465
Cdd:PHA03378  457 PPTQPLEGPTGPLSVQAPLEPWQPLPHPQVTPvilhqPPAQG-------------VQAHGSMLDLLEKDDEDMEqrVMAT 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  466 ALPPNNP-PTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTI---PLTVPPGNPPPTSTLGGFFT--TGEVAPVVAPF 539
Cdd:PHA03378  524 LLPPSPPqPRAGRRAPCVYTEDLDIESDEPASTEPVHDQLLPAPglgPLQIQPLTSPTTSQLASSAPsyAQTPWPVPHPS 603

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  540 GTQASPATQSAGFFNPGEVRPNVPLaEPVPTIPITSSGVPPIGLFPPAPAQPgvqtasnpnplpgaaapppAAGQASYRL 619
Cdd:PHA03378  604 QTPEPPTTQSHIPETSAPRQWPMPL-RPIPMRPLRMQPITFNVLVFPTPHQP-------------------PQVEITPYK 663

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  620 QKGTRLYKSPLTPqetaTSSGFAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTV 699
Cdd:PHA03378  664 PTWTQIGHIPYQP----SPTGANTMLPIQWAPGTMQPPPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAA 739

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665407118  700 AVPQsapiAPPPGTSSTSVAPPLTASIANPPPtsgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:PHA03378  740 APGR----ARPPAAAPGRARPPAAAPGRARPP----AAAPGAPTPQPPPQAPPAPQQRPRGA 793
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
383-577 9.95e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 50.62  E-value: 9.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  383 PGGNYFVPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAFFTSAAP-SVTPSVFTPGTVPPLAPQPFQSAT 461
Cdd:PRK07003  362 VTGGGAPGGGVPARVAGAVPAPGAR----AAAAVGASAVPAVTAVTGAAGAALAPkAAAAAAATRAEAPPAAPAPPATAD 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  462 VNQSALPpnNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGT 541
Cdd:PRK07003  438 RGDDAAD--GDAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAA 515

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 665407118  542 QASPATQSAgffnPGEVRPNVPLAEPVPTIPITSSG 577
Cdd:PRK07003  516 ASREDAPAA----AAPPAPEARPPTPAAAAPAARAG 547
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 362-725 1.24e-05

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 50.34  E-value: 1.24e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGnFFAPAAPLPVAQTAAPPAvgaffTSAAPSVTP 441
Cdd:pfam17823   95 TDLSEPATREGAADGAASRALAAAASSSPSSAAQSLPAAIAALPSEA-FSAPRAAACRANASAAPR-----AAIAAASAP 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTAsavgelfvPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTS 521
Cdd:pfam17823  169 HAASPAPRTAASSTTAASSTTAASSAPTTAASSA--------PATLTPARGISTAATATGHPAAGTALAAVGNSSPAAGT 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   522 TLGGFFTTGEVApvVAPFGTQASPATQSAGFFNPGEvrPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTAS---- 597
Cdd:pfam17823  241 VTAAVGTVTPAA--LATLAAAAGTVASAAGTINMGD--PHARRLSPAKHMPSDTMARNPAAPMGAQAQGPIIQVSTdqpv 316

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   598 -NPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAPLPPTSVTPAI--FNPFGAPAPgsfnsVGHLEG 674
Cdd:pfam17823  317 hNTAGEPTPSPSNTTLEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEVeaTSPTTQPSP-----LLPTQG 391

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|.
gi 665407118   675 QSSQGVPFftppvqnPPGQVAapTVAVPQSAPIAPPPgTSSTSVAPPLTAS 725
Cdd:pfam17823  392 AAGPGILL-------APEQVA--TEATAGTASAGPTP-RSSGDPKTLAMAS 432
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 528-990 3.32e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 49.14  E-value: 3.32e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   528 TTGEVAPVVAPFGTQASPATQSAGFfnpgevrpnvplAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAA 607
Cdd:pfam05109  415 TTHKVIFSKAPESTTTSPTLNTTGF------------AAPNTTTGLPSSTHVPTNLTAPASTGPTVSTADVTSPTPAGTT 482

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   608 PPPAAGQASYRLQKGTRLYKSPltpQETATSSGFAAPLP-PTSVTPAIFNPfgapapgSFNSVGHLEGQSSQgvpffTPP 686
Cdd:pfam05109  483 SGASPVTPSPSPRDNGTESKAP---DMTSPTSAVTTPTPnATSPTPAVTTP-------TPNATSPTLGKTSP-----TSA 547

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   687 VQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAPPLTASIANPPP-----TSGFASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:pfam05109  548 VTTPTPNATSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSptvgeTSPQANTTNHTLGGTSSTPVVTSPPKNATS 627

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   762 EVTTGLSQQENEATASTTL--EGLVQGPAPTLSASQFFDTPLPTGTQPenqvasvsSERENLVQepisnqgipfFAPPQT 839
Cdd:pfam05109  628 AVTTGQHNITSSSTSSMSLrpSSISETLSPSTSDNSTSHMPLLTSAHP--------TGGENITQ----------VTPAST 689

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   840 NIFTPQLQQEFIAPAEDSKRSEIQEEFLSAPPQESNLSTELREDTHTGPPViePVLEETPASSSESSVPPASKVDQEDIV 919
Cdd:pfam05109  690 STHHVSTSSPAPRPGTTSQASGPGNSSTSTKPGEVNVTKGTPPKNATSPQA--PSGQKTAVPTVTSTGGKANSTTGGKHT 767

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665407118   920 YPEPSAPVEQEIPLFVPVPGLPGLSQDIPLYPPPPTGSTTASS-IFAAPPVASSAplfVPVPGPPSVSSLFS 990
Cdd:pfam05109  768 TGHGARTSTEPTTDYGGDSTTPRTRYNATTYLPPSTSSKLRPRwTFTSPPVTTAQ---ATVPVPPTSQPRFS 836
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
445-664 8.22e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.56  E-value: 8.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  445 TPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTStlg 524
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP--- 452

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  525 gffttgevAPVVAPFGTQASPATQSAGffNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGV-QTASNPNPLP 603
Cdd:PRK12323  453 --------APAAAPAAAARPAAAGPRP--VAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPaQPDAAPAGWV 522

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665407118  604 GAAAPPPAAGQasyrlqkgtrlyksPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPG 664
Cdd:PRK12323  523 AESIPDPATAD--------------PDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRAS 569
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 888-1179 1.37e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 47.07  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   888 PPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPV-----------PGLPGLSQDI-PLYPPPPT 955
Cdd:pfam03154  179 GAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHtliqqtptlhpQRLPSPHPPLqPMTQPPPP 258

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   956 GSTTASSIFAA------PPVA---SSAPLFVPVPGPPS---VSSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTTSTL 1023
Cdd:pfam03154  259 SQVSPQPLPQPslhgqmPPMPhslQTGPSHMQHPVPPQpfpLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQ 338

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1024 FANN--IPTTTPSIPDIVP--TTSAELVDAPPGFQGSSDDTATNLFQGNTETQtvfSPFAQTKATPLVQETKPELVPPPI 1099
Cdd:pfam03154  339 PPREqpLPPAPLSMPHIKPppTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLP---PPPALKPLSSLSTHHPPSAHPPPL 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1100 GFFapkSESEVLSQPPLAPSPLQSFFSTAPETATTTDFNFFGSPAPGSVFPDLPVQQGiAPPPLALESPPQNSVSNIATS 1179
Cdd:pfam03154  416 QLM---PQSQQLPPPPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPG-GPPPITPPSGPPTSTSSAMPG 491
PRK12727 PRK12727
flagellar biosynthesis protein FlhF;
412-597 1.39e-04

flagellar biosynthesis protein FlhF;


Pssm-ID: 237182 [Multi-domain]  Cd Length: 559  Bit Score: 46.91  E-value: 1.39e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  412 APAAPLPVAQTAAPPAvGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQ 491
Cdd:PRK12727   65 TAAAPAPAPQAPTKPA-APVHAPLKLSANANMSQRQRVASAAEDMIAAMALRQPVSVPRQAPAAAPVRAASIPSPAAQAL 143

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  492 GTSPAVPFVDTQ--AVPTIP-------LTVPPGNPPPTSTLGGFFTTgEVAPVVAPFGTQASPATQSAGFFNPGEVRPNV 562
Cdd:PRK12727  144 AHAAAVRTAPRQehALSAVPeqlfadfLTTAPVPRAPVQAPVVAAPA-PVPAIAAALAAHAAYAQDDDEQLDDDGFDLDD 222

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 665407118  563 PLAEPVPTIPItssgvPPIGLFPPAPAQPGVQTAS 597
Cdd:PRK12727  223 ALPQILPPAAL-----PPIVVAPAAPAALAAVAAA 252
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 702-981 3.36e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.85  E-value: 3.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  702 PQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSGFASVplfAAPTISSTPIP-FFNPQPTGAEVTTGLSQQENEATAST 778
Cdd:PRK10263  315 PITEPVAVAAAatTATQSWAAPVEPVTQTPPVASVDVPP---AQPTVAWQPVPgPQTGEPVIAPAPEGYPQQSQYAQPAV 391

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  779 TLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLV-QEPISNQGIPFFAPPQTNIFTPQLQQEfiaPAEDS 857
Cdd:PRK10263  392 QYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYApAPEQPVAGNAWQAEEQQSTFAPQSTYQ---TEQTY 468

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  858 KRSEIQEEFLSAPPQEsnlstelrEDTHTGPPviEPVLEETpasssESSVPPA---SKVDQEDIVYPEPSAPVEQEIPLF 934
Cdd:PRK10263  469 QQPAAQEPLYQQPQPV--------EQQPVVEP--EPVVEET-----KPARPPLyyfEEVEEKRAREREQLAAWYQPIPEP 533

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665407118  935 V--PVPGLPGLSQDIPLYPPPPTGSTTASSIFAAPPVASS---------APLFVPVPG 981
Cdd:PRK10263  534 VkePEPIKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLatgaaatvaAPVFSLANS 591
Chi1 COG3469
Chitinase [Carbohydrate transport and metabolism];
362-526 3.76e-04

Chitinase [Carbohydrate transport and metabolism];


Pssm-ID: 442692 [Multi-domain]  Cd Length: 534  Bit Score: 45.51  E-value: 3.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  362 TTASAPAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTP 441
Cdd:COG3469    55 GSAGSGTGTTAASSTAATSSTTSTTATATAAAAAATSTSATLVATSTASGANTGTSTVTTTSTGAGSVTSTTSSTAGSTT 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  442 SVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGeLFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTV--PPGNPPP 519
Cdd:COG3469   135 TSGASATSSAGSTTTTTTVSGTETATGGTTTTSTTTTT-TSASTTPSATTTATATTASGATTPSATTTATTtgPPTPGLP 213


                  ....*..
gi 665407118  520 TSTLGGF 526
Cdd:COG3469   214 KHVLVGY 220
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 335-760 5.50e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 5.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  335 GIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNyfVPGAPPSLPSTGVVGPPSVGNFfAPA 414
Cdd:PHA03307   19 EFFPRPPATPGDAADDLLSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTG--PPPGPGTEAPANESRSTPTWSL-STL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  415 APLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSA-----TVNQSALPPNNPPTASAVGELFVPAPTTI 489
Cdd:PHA03307   96 APASPAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVgspgpPPAASPPAAGASPAAVASDAASSRQAALP 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  490 AQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPA---------TQSAGFFNPGEVRP 560
Cdd:PHA03307  176 LSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAgasssdsssSESSGCGWGPENEC 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  561 NVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKgtrlYKSPLTPQETATSSG 640
Cdd:PHA03307  256 PLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASS----SSSSSRESSSSSTSS 331

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  641 FAAPLPPTSVTPAifnPFGAPAPGSfnsvghlegQSSQGVPFFTPPVQNPPGQVAAPTVAvpQSAPIAPPPGTSSTSVAP 720
Cdd:PHA03307  332 SSESSRGAAVSPG---PSPSRSPSP---------SRPPPPADPSSPRKRPRPSRAPSSPA--ASAGRPTRRRARAAVAGR 397

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 665407118  721 PLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTG 760
Cdd:PHA03307  398 ARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTPSG 437
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 476-1017 6.70e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 6.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  476 SAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIpltvppgnppptstlggffTTGEvaPVVAPFGTQASPATQSAgffnP 555
Cdd:PRK10263  334 AAPVEPVTQTPPVASVDVPPAQPTVAWQPVPGP-------------------QTGE--PVIAPAPEGYPQQSQYA----Q 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  556 GEVRPNVPLAEPVPTIPI----TSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQ-----KGTRLY 626
Cdd:PRK10263  389 PAVQYNEPLQQPVQPQQPyyapAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFApqstyQTEQTY 468

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  627 KSPLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAP-GSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSA 705
Cdd:PRK10263  469 QQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPlYYFEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPS 548

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  706 PIAPPPGTSSTSVApPLTASIANPPptsgfasvplFAAPTISSTPIPFFNPQPTGA---EVTTGLSQQ---ENEATASTT 779
Cdd:PRK10263  549 VAAVPPVEAAAAVS-PLASGVKKAT----------LATGAAATVAAPVFSLANSGGprpQVKEGIGPQlprPKRIRVPTR 617

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  780 LEGLVQG---PAPTLSASQFFDTplpTGTQPENQVASVSSERENLVQEPISNQgipfFAPPQTNIFTPQLQQEFIAPAED 856
Cdd:PRK10263  618 RELASYGiklPSQRAAEEKAREA---QRNQYDSGDQYNDDEIDAMQQDELARQ----FAQTQQQRYGEQYQHDVPVNAED 690

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  857 ---SKRSEIQEEFLSAPPQ------------------ESNLSTELREDTHTGP---PVIEPVLE--ETPASSSESSVPPA 910
Cdd:PRK10263  691 adaAAEAELARQFAQTQQQrysgeqpaganpfslddfEFSPMKALLDDGPHEPlftPIVEPVQQpqQPVAPQQQYQQPQQ 770

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  911 SKVDQEDIVYP-EPSAPVEQEIPLFVPVPGLPGLSQdiPLYPPPPTGSTTASSIFAAPPVASSAPLFVPVPGPPsvSSLF 989
Cdd:PRK10263  771 PVAPQPQYQQPqQPVAPQPQYQQPQQPVAPQPQYQQ--PQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ--DTLL 846

                         570       580       590
                  ....*....|....*....|....*....|
gi 665407118  990 SPSQVDSTSSLFAPPPTS--ANTTILTPAP 1017
Cdd:PRK10263  847 HPLLMRNGDSRPLHKPTTplPSLDLLTPPP 876
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 382-526 7.04e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 44.71  E-value: 7.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  382 PPGGNYFVPGAPPSLPSTGVVGPPSVgnffAPAAPLPVAQTAAPPAVGAF-FTSAAPSVTPSvftPGTVPPLAPQPFQSA 460
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAAAPAA----APVAQAAAAPAPAAAPAAAAsAPAAPPAAAPP---APVAAPAAAAPAAAP 438

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665407118  461 TVNQSALPPNNPPTASAVGElFVPAPTTIAQGTSPAVPfvdtqavPTIPLTVPPGNPPPTSTLGGF 526
Cdd:PRK14951  439 AAAPAAVALAPAPPAQAAPE-TVAIPVRVAPEPAVASA-------APAPAAAPAAARLTPTEEGDV 496
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 871-1174 7.59e-04

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 44.52  E-value: 7.59e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   871 PQESNLSTELREDTHTGPPV-IEPVLEETPASSSESSVP----PASKVDQEDIVYPEPSAPVEQeipLFVPVPG----LP 941
Cdd:pfam05109  449 PSSTHVPTNLTAPASTGPTVsTADVTSPTPAGTTSGASPvtpsPSPRDNGTESKAPDMTSPTSA---VTTPTPNatspTP 525

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   942 GLSQDIPLYPPPPTGSTTASSIFAAP-PVASSAPLFVPVPGPPSvsSLFSPSQVDSTSSLFAPPPTSANTTILTPAPDTT 1020
Cdd:pfam05109  526 AVTTPTPNATSPTLGKTSPTSAVTTPtPNATSPTPAVTTPTPNA--TIPTLGKTSPTSAVTTPTPNATSPTVGETSPQAN 603

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1021 STLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLVQETKPELVPPPIG 1100
Cdd:pfam05109  604 TTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLRPSSISETLSPSTSDNSTSHMPLLTSAHPTGGENITQ 683

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665407118  1101 FFAPKSESEVLSQPPLAPSPLQSFFSTAPETATTT----DFNFF-GSPAPGSVFPDLPVQQGIAPPPLALESPPQNSVS 1174
Cdd:pfam05109  684 VTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTStkpgEVNVTkGTPPKNATSPQAPSGQKTAVPTVTSTGGKANSTT 762
PHA03247 PHA03247
large tegument protein UL36; Provisional
 380-592 8.30e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 8.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  380 TFPPGGNYFVPGAPPsLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAvgafftsAAPSVTPSVFTPGTVPPLAPqpfqs 459
Cdd:PHA03247  245 SHPLRGDIAAPAPPP-VVGEGADRAPETARGATGPPPPPEAAAPNGAA-------APPDGVWGAALAGAPLALPA----- 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  460 atvnqsalPPNNPPTASAVGELFVPAPTTIAQGTSPaVPFVDTQAVPTIPLTVPPGNPPPTSTLGgfFTTGEVAPVVAPF 539
Cdd:PHA03247  312 --------PPDPPPPAPAGDAEEEDDEDGAMEVVSP-LPRPRQHYPLGFPKRRRPTWTPPSSLED--LSAGRHHPKRASL 380

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665407118  540 GTQ--------ASPATQSAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPG 592
Cdd:PHA03247  381 PTRkrrsarhaATPFARGPGGDDQTRPAAPVPASVPTPAPTPVPASAPPPPATPLPSAEPG 441
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
405-646 1.14e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  405 PSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVP 484
Cdd:PRK12323  365 PGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  485 APTTIAQGTSPAVPfvdtqaVPTIPLTVPPGNPPPTSTlggffttgevAPVVAPFGTQASPATQSAGFFNPGEVRPNVPL 564
Cdd:PRK12323  445 GGAPAPAPAPAAAP------AAAARPAAAGPRPVAAAA----------AAAPARAAPAAAPAPADDDPPPWEELPPEFAS 508

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  565 AEPVPTIPiTSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQETATSSGFAAP 644
Cdd:PRK12323  509 PAPAQPDA-APAGWVAESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAAR 587


                  ..
gi 665407118  645 LP 646
Cdd:PRK12323  588 LP 589
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
540-794 1.81e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  540 GTQASPATQSAGffnpgevrpnvPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNP--LPGAAAPPPAAGQASY 617
Cdd:PRK12323  369 GGGAGPATAAAA-----------PVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVaaAPARRSPAPEALAAAR 437

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  618 RLQKGTRLYKSPLTPQetatssgfAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAP 697
Cdd:PRK12323  438 QASARGPGGAPAPAPA--------PAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASP 509

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  698 TVAVPQSAP------------IAPPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEV-- 763
Cdd:PRK12323  510 APAQPDAAPagwvaesipdpaTADPDDAFETLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARlp 589

                         250       260       270
                  ....*....|....*....|....*....|....
gi 665407118  764 TTGLSQQENEATASTTLEG---LVQGPAPTLSAS 794
Cdd:PRK12323  590 VRGLAQQLARQSELAGVEGdtvRLRVPVPALAEA 623
PHA03247 PHA03247
large tegument protein UL36; Provisional
 38-590 1.86e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   38 DDFPNKPQLLPAaPPVVHATPPAAPVLIAGILNREPKSLVTVGQPSSIDDSEALDEINLNT-SSEDSVGAGGSSPylgag 116
Cdd:PHA03247 2606 GDPRGPAPPSPL-PPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRrARRLGRAAQASSP----- 2679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  117 DQNANPLLEPPTEAGNDSLLSQAASSFTALPAvasnvfstfskriyagSRETSEEPKLDIQPSYIQQASYVQPVAPVPAP 196
Cdd:PHA03247 2680 PQRPRRRAARPTVGSLTSLADPPPPPPTPEPA----------------PHALVSATPLPPGPAAARQASPALPAAPAPPA 2743

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  197 FYAAPPAAANEVVAPEPPkfyapTEVPPPNVGVPAPPPTSGNPNTYRfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQA 276
Cdd:PHA03247 2744 VPAGPATPGGPARPARPP-----TTAGPPAPAPPAAPAAGPPRRLTR-PAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  277 APSFQTPPYPPQLTYAANPAPfdiSAQPAAIPAEERKSGGglfsltSLVPTGVLQNiTGIVQSATGRSSEPEHTNVQQag 356
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTA---PPPPPGPPPPSLPLGG------SVAPGGDVRR-RPPSRSPAAKPAAPARPPVRR-- 2885

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  357 gyldiTTASAPAPSTNLFGGPnstfppggnyfvPGAPPSLPStgvvgppsvgnffaPAAPLPVAQTAAPPavgafftsAA 436
Cdd:PHA03247 2886 -----LARPAVSRSTESFALP------------PDQPERPPQ--------------PQAPPPPQPQPQPP--------PP 2926

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  437 PSVTPSVFTPG-TVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTtiaqgTSPAVPFVDTQAVPTIPLTVPP- 514
Cdd:PHA03247 2927 PQPQPPPPPPPrPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFR-----VPQPAPSREAPASSTPPLTGHSl 3001

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  515 ---------------GNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLA-EPVPTIPITSSGV 578
Cdd:PHA03247 3002 srvsswasslalheeTDPPPVSLKQTLWPPDDTEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAhEPDPATPEAGARE 3081

                         570
                  ....*....|..
gi 665407118  579 PPIGLFPPAPAQ 590
Cdd:PHA03247 3082 SPSSQFGPPPLS 3093
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 209-588 2.01e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 43.37  E-value: 2.01e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   209 VAPEPPKFYAPTEVPPPNVGVPAPPPTSGNPNTYrftarkklyAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPyppq 288
Cdd:pfam05109  488 VTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT---------SPTPAVTTPTPNATSPTLGKTSPTSAVTTPTPN---- 554

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   289 ltyAANPAPFDISAQP-AAIPaeerksggglfSLTSLVPTGVLQNITGIVQSATGRSSEPEH--TNVQQAGGYLDITTAS 365
Cdd:pfam05109  555 ---ATSPTPAVTTPTPnATIP-----------TLGKTSPTSAVTTPTPNATSPTVGETSPQAntTNHTLGGTSSTPVVTS 620

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   366 APAPSTNLFGGPNSTFPPGGNYFVPGAPPSLPSTGvvgPPSVGNFFAPAAPLpvaQTAAPPAVGAFFTSAAPSVTPSVFT 445
Cdd:pfam05109  621 PPKNATSAVTTGQHNITSSSTSSMSLRPSSISETL---SPSTSDNSTSHMPL---LTSAHPTGGENITQVTPASTSTHHV 694

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   446 PGTVPplAPQPfqsATVNQSAlPPNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNppptSTLGG 525
Cdd:pfam05109  695 STSSP--APRP---GTTSQAS-GPGNSSTSTKPGEVNVTKGTPPKNATSPQAPSGQKTAVPTVTSTGGKAN----STTGG 764

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665407118   526 FFTTGEVAPvvapfgTQASPATQSAGFFNPGEVRPNVPLAEPvptiPITSSGVPPIGLFPPAP 588
Cdd:pfam05109  765 KHTTGHGAR------TSTEPTTDYGGDSTTPRTRYNATTYLP----PSTSSKLRPRWTFTSPP 817
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 855-1152 2.15e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  855 EDSKRSEIQEEflsappQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLF 934
Cdd:PTZ00449  535 EDSKESDEPKE------GGKPGETKEGEVGKKPGPAKEHKPSKIPTLSKKPEFPKDPKHPKDPEEPKKPKRPRSAQRPTR 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  935 VPVPGLPGLSqDIPLYPPPPTGSTTASSifaappvassaplfvpvpgPPSVSSLFSPSQVDSTSSLFAP-PPTSanttil 1013
Cdd:PTZ00449  609 PKSPKLPELL-DIPKSPKRPESPKSPKR-------------------PPPPQRPSSPERPEGPKIIKSPkPPKS------ 662

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118 1014 tpapdttstlfanniptttPSIPdIVPTTSAELVDAPPGFQGSSDDTATNLFQGNTETQTVFSPFAQTKATPLvqeTKPE 1093
Cdd:PTZ00449  663 -------------------PKPP-FDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPETPGTPF---TTPR 719

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665407118 1094 LVPPPIgffaPKSESEVLSQP--PLAPSPLQSFFSTAPETATTtdfnFFGSPAPGSVFPDL 1152
Cdd:PTZ00449  720 PLPPKL----PRDEEFPFEPIgdPDAEQPDDIEFFTPPEEERT----FFHETPADTPLPDI 772
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 672-1018 2.21e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.05  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  672 LEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIAPPPGTSSTSVAP---PLTASIANPPPTSGFASVPLFAAPTISS 748
Cdd:PRK07764  381 LERRLGVAGGAGAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPqpaPAPAPAPAPPSPAGNAPAGGAPSPPPAA 460

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  749 TPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTP------LPTGTQPENQVASVSSERENLV 822
Cdd:PRK07764  461 APSAQPAPAPAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAGADDAATLrerwpeILAAVPKRSRKTWAILLPEATV 540

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  823 QEPISNQGIPFFAppqtnifTPQLQQEFIAP-AEDSKRSEIQEEF--------------------LSAPPQESNLSTELR 881
Cdd:PRK07764  541 LGVRGDTLVLGFS-------TGGLARRFASPgNAEVLVTALAEELggdwqveavvgpapgaaggeGPPAPASSGPPEEAA 613

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  882 EDTHTGPPViEPVLEETPASSSESSVPPASKVDQEDIVYPEPSAPVEQEIPLFVPvPGLPGLSQDIPLYPPPPTGSTTAS 961
Cdd:PRK07764  614 RPAAPAAPA-APAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGD-GWPAKAGGAAPAAPPPAPAPAAPA 691

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665407118  962 SIFAAPPVASSAPLFVPVPGPPSVSSLFSPSQVDSTSSlfAPPPTSANTTILTPAPD 1018
Cdd:PRK07764  692 APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGAS--APSPAADDPVPLPPEPD 746
COG4935 COG4935
Regulatory P domain of the subtilisin-like proprotein convertases and other proteases ...
 314-816 2.86e-03

Regulatory P domain of the subtilisin-like proprotein convertases and other proteases [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443962 [Multi-domain]  Cd Length: 641  Bit Score: 42.50  E-value: 2.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  314 SGGGLFSLTSLVPTGVLQNITGIVQSATGRSSEPEHTNVQQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNYFVPGAP 393
Cdd:COG4935    40 AAVAGASAAAAAATAVGAGASSLAASAAAAAAAASGAAAGAVDAAPAAATVVGAALGVVAVAGAGLAATASGAAAGAVAA 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  394 PSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPFQSATVNQSALPPNNPP 473
Cdd:COG4935   120 AANGNTGAGPGSGGTGGGSGGAGAAAAAAALSAAGAAVGVAAVAGAAGGGGGVGVAAAVGVVLGAGLVADGGNGGGGAVA 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  474 TASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFF 553
Cdd:COG4935   200 GGAAGGGGGGGGGGGLGGAAGGGGAGLAAAGGGGGGAAAAAAAGVGGLGAAATAAAADGGGGGGAGAAGAGGSAGAAAGG 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  554 NPGEVRPNVPLAEPVPT-----IPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKS 628
Cdd:COG4935   280 AGAGVVGAAAGGGDAALggavgAAGTGNAAAAAAASAGSGGGGGSAAAAGAAAAAAAAAAGAAAGVSGAASVVAGASGGG 359

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  629 PLTPQETATSSGFAAPLPPTSVTPAIFNPFGAPAPGSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAPIA 708
Cdd:COG4935   360 AGTAAAAGGGAAAAAAGGAAAAGAAAGAAAGAAAGAAAAGGVASAAGAVGAGTAAGASATAAVSTGAASGSSTTSSTGTT 439

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  709 PPPGTSSTSVAPPLTASIANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTTLEGLVQGPA 788
Cdd:COG4935   440 ATATGLGGGADAGSTSTGTGSAAGAAGGTTTATSGLASSTTAAAAAAAAGLATTAAVAAGAAGAAAAAATAASVGGATGA 519

                         490       500
                  ....*....|....*....|....*...
gi 665407118  789 PTLSASQFFDTPLPTGTQPENQVASVSS 816
Cdd:COG4935   520 AGTTNSTATFSNTTDVAIPDNGPAGVTS 547
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 319-779 3.12e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 42.60  E-value: 3.12e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   319 FSLTSLVPTGVlQNITGIVqsATGRSSEPEHTNVQQAGGYLDITTASAPAPSTN----LFGGPNSTfppggnyfvpGAPP 394
Cdd:pfam05109  366 WTLTSGTPSGC-ENISGAF--ASNRTFDITVSGLGTAPKTLIITRTATNATTTThkviFSKAPEST----------TTSP 432

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   395 SLPSTGVVGPPSVGNFfaPAAPLPVAQTAAPPAVGAFFTSA-APSVTPSVFTPGTvPPLAPQPFQSATVNQSALPPNNPP 473
Cdd:pfam05109  433 TLNTTGFAAPNTTTGL--PSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGA-SPVTPSPSPRDNGTESKAPDMTSP 509

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   474 TASavgelfVPAPTTIAQGTSPAVPfvdtqavptipltvppgNPPPTSTLGGFFTTGEVAPVVAPFGTQASPAtqsagff 553
Cdd:pfam05109  510 TSA------VTTPTPNATSPTPAVT-----------------TPTPNATSPTLGKTSPTSAVTTPTPNATSPT------- 559

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   554 npgevrPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTRLYKSPLTPQ 633
Cdd:pfam05109  560 ------PAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQ 633

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   634 ETATSSGFAA-PLPPTSVTPAIfnpfgAPAPgSFNSVGHLEGQSSQGVPFFTPPVQNPPGQVAAPTVAVPQSAP------ 706
Cdd:pfam05109  634 HNITSSSTSSmSLRPSSISETL-----SPST-SDNSTSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSPAPrpgtts 707

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665407118   707 IAPPPGTSSTSVAPPLTASIANPPPTSgfASVPlfAAPTISSTPIPFFNPQPTGAEVTTGLSQQENEATASTT 779
Cdd:pfam05109  708 QASGPGNSSTSTKPGEVNVTKGTPPKN--ATSP--QAPSGQKTAVPTVTSTGGKANSTTGGKHTTGHGARTST 776
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 389-592 3.49e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 3.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  389 VPGAPPSLPSTGVVGPPSVGNFFAPAAPLPVAQTAAPPAVGAFFTSAAPSVTPSVFTPGTVPPLAPQPfqsatvnQSALP 468
Cdd:PRK07764  588 VGPAPGAAGGEGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPK-------HVAVP 660

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  469 PNNPPTASAVGELFVPAPTTIAQGTSPAVPFVDTQAVPTIPLTVPPGNPPPtstlggffttgevAPVVAPFGTQASPATQ 548
Cdd:PRK07764  661 DASDGGDGWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPA-------------GQADDPAAQPPQAAQG 727

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 665407118  549 SAGFFNPGEVRPNVPLAEPVPTIPITSSGVPPIGLFPPAPAQPG 592
Cdd:PRK07764  728 ASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPA 771
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 210-570 4.39e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.28  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  210 APEPPKFYAPTEVPPPNVGVPAPPPTSGNPNTyrfTARKKLYAPIPGLSEQSGQPAQQPQVPQAPQAAPSFQTPPYPPql 289
Cdd:PRK07764  411 APAAAAPAAAAAPAPAAAPQPAPAPAPAPAPP---SPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPP-- 485

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  290 tyaANPAPfdisAQPAAIPAEERKSGGGLF---------SLTSLVPTGVLQNITGIVQSAT------------------- 341
Cdd:PRK07764  486 ---AAPAP----AAAPAAPAAPAAPAGADDaatlrerwpEILAAVPKRSRKTWAILLPEATvlgvrgdtlvlgfstggla 558

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  342 GRSSEPEHTNV------QQAGGYLDITTASAPAPSTNLFGGPNSTFPPGGNYFV--PGAPPSLPSTGVVGPPSVGNFFAP 413
Cdd:PRK07764  559 RRFASPGNAEVlvtalaEELGGDWQVEAVVGPAPGAAGGEGPPAPASSGPPEEAarPAAPAAPAAPAAPAPAGAAAAPAE 638

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  414 AAPLPVAQTAAPPAVGAFFTSAAPSVTPSvftPGTVPPLAPQPFQSATVNQSALPPNNPPTASAVGELFVPAPTTIAQGT 493
Cdd:PRK07764  639 ASAAPAPGVAAPEHHPKHVAVPDASDGGD---GWPAKAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQAD 715

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  494 SPA----VPFVDTQAVPTIPLTVPPGNPPPTSTLGGFFTTGEVAPVVAPFGTQASPATQSAGFFNPGEVRPNVPLAEPVP 569
Cdd:PRK07764  716 DPAaqppQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDD 795


                  .
gi 665407118  570 T 570
Cdd:PRK07764  796 E 796
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 711-973 5.32e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  711 PGTSSTSVAPPLTASIANPPPTSGFASVplfAAPTISSTPIPffnpqptGAEVTTGLSQQENEATASttleglVQGPAPT 790
Cdd:PRK10263  309 PLLNGAPITEPVAVAAAATTATQSWAAP---VEPVTQTPPVA-------SVDVPPAQPTVAWQPVPG------PQTGEPV 372

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  791 LSasqffdtPLPTGTQPENQVASVSSERENLVQEPISNQGIPFFAPPQTNIFTPQ--------LQQEFIAPAEDSKRSEI 862
Cdd:PRK10263  373 IA-------PAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYyapapeqpAQQPYYAPAPEQPVAGN 445

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  863 QEEflsAPPQESNLSTELREDTHTgpPVIEPVLEETPASSSEsSVPPASKVDQEDIVypEPSAPVEQEIPLFVPV----- 937
Cdd:PRK10263  446 AWQ---AEEQQSTFAPQSTYQTEQ--TYQQPAAQEPLYQQPQ-PVEQQPVVEPEPVV--EETKPARPPLYYFEEVeekra 517

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 665407118  938 ---PGLPGLSQDIP---LYPPPPTGSTTASSIFAAPPVASSA 973
Cdd:PRK10263  518 rerEQLAAWYQPIPepvKEPEPIKSSLKAPSVAAVPPVEAAA 559
GGN pfam15685
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ...
 501-1022 5.71e-03

Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.


Pssm-ID: 434857 [Multi-domain]  Cd Length: 668  Bit Score: 41.68  E-value: 5.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   501 DTQAVPTIPLTVPPGNPP--PTSTLGGFFTTGEVAP-VVAPFGTQASPATQSAGFFNPgevRPNVPLAEPVPTIPITSSG 577
Cdd:pfam15685   24 DSRRTSLVEPEVTPSSPAmrLAQGLGVWFPGSSAPPgLLVPPEPQASPSPLPLTLELP---LPVTPPPEEAAAAAVSTAP 100

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   578 VPPIGLFPPAPAQ------------PGVQTASNPNPLPGAAAPPPAAGQASYRLQKGTrLYKSPLTPQETATSSGFAAPL 645
Cdd:pfam15685  101 PPAVGSLLPAPSKwrkptgtavariRGLLEASHRGQGDPLSLRPLLPLLPRQLIEKDP-APGAPAPPPPTPLEPRKPPPL 179

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   646 PPTS-------VTPAIFNPFGAPAPGSFNSVGhlEGQSSQGVPFFTPPvQNPPGQVAAPTVAVPQSAPIAPPPGTSstsv 718
Cdd:pfam15685  180 PPSDrqppnrgITPALATSATSPTDSQAKHIA--EGKTAGGACGGAPP-QAGEGEMARFAASESGLSLLCKVTFKS---- 252

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   719 APPLTASIANPPPTS-----GFASVPLFAAPT-ISSTPIPFFNPQPTGAEVTTG---LSQQENEATASTTlEGLVQGPAP 789
Cdd:pfam15685  253 AAPLCPAAASGPLAAkaslgGGGGGGLFAASGaISCAEVLKQGPLAPGAARPLGevpRAALETEGGEGDG-EGCSGGPAA 331

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   790 TLSASQFFDTPLPT---GTQPENQVASVSSERENLVQEPISNQGI------------PFFAPPqtnifTPQLQQEfiaPA 854
Cdd:pfam15685  332 PASHARALPPPAYTtfpGSKPKFDWVSPPDGPERHFRFNGAGGGIgaprrraaalsgPWGSPP-----PPPGKAH---PI 403

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   855 EDSKRSEiqeEFLSAPPQESNLSTELREDTHTGPPVIEPVLEETPASSSESSVPPASKvdqedivyPEPSAPVEQEIPLF 934
Cdd:pfam15685  404 PGPRRPA---PALLAPPMFIFPAPTNGEPVRPGPPAPQALLPRPPPPTPPATPPPVPP--------PIPQLPALQPMPLA 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   935 VPVPglpglsqdiplyPPPPTGSTTASSIFAAPPVAssaplfvpvPGPPSVSSLFSPSQVDSTSSLFAPPPTSANTTILT 1014
Cdd:pfam15685  473 AARP------------PTPRPCPGHGESALAPAPTA---------PLPPALAADQAPAPALAAAPAPSPAPAPATADPLP 531


                   ....*...
gi 665407118  1015 PAPDTTST 1022
Cdd:pfam15685  532 PAPAPIKA 539
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 632-762 6.16e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 41.62  E-value: 6.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  632 PQETATSSGFAAPLPPTSVTPAifnpfgAPAPgsfnsvghlegqssqgvpffTPPVQNPPGQVAAPTVAVPQSAPIAPPP 711
Cdd:PRK14951  366 PAAAAEAAAPAEKKTPARPEAA------APAA--------------------APVAQAAAAPAPAAAPAAAASAPAAPPA 419

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 665407118  712 GTSSTSVAPPLTASiANPPPTSGFASVPLFAAPTISSTPIPFFNPQPTGAE 762
Cdd:PRK14951  420 AAPPAPVAAPAAAA-PAAAPAAAPAAVALAPAPPAQAAPETVAIPVRVAPE 469
half-pint TIGR01645
poly-U binding splicing factor, half-pint family; The proteins represented by this model ...
 684-824 7.27e-03

poly-U binding splicing factor, half-pint family; The proteins represented by this model contain three RNA recognition motifs (rrm: pfam00076) and have been characterized as poly-pyrimidine tract binding proteins associated with RNA splicing factors. In the case of PUF60 (GP|6176532), in complex with p54, and in the presence of U2AF, facilitates association of U2 snRNP with pre-mRNA.


Pssm-ID: 130706 [Multi-domain]  Cd Length: 612  Bit Score: 41.21  E-value: 7.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   684 TPPVQNPPGQVAAPTVAVPQSAPIAPPPG--TSSTSVAPPLTASIANPPPTSgfASVPLFAAPTISSTPIPFFNPQPTGA 761
Cdd:TIGR01645  344 NKAVVSSAKKEAEEVPPLPQAAPAVVKPGpmEIPTPVPPPGLAIPSLVAPPG--LVAPTEINPSFLASPRKKMKREKLPV 421

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665407118   762 EV-----TTGLSQQENEATASTTLEGLVQGPAPTLSASQFFDTPLPTGTQPENQVASVSSERENLVQE 824
Cdd:TIGR01645  422 TFgalddTLAWKEPSKEDQTSEDGKMLAIMGEAAAALALEPKKKKKEKEGEELQPKLVMNSEDASLAS 489
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 949-1178 7.51e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 41.44  E-value: 7.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118   949 LYPPPPTGSTTASSI----FAAPPVASSAP--------LFVPVPGPPSVSS--LFSPSQVDSTS--SLFAPPPTSANTTI 1012
Cdd:pfam05109  420 IFSKAPESTTTSPTLnttgFAAPNTTTGLPssthvptnLTAPASTGPTVSTadVTSPTPAGTTSgaSPVTPSPSPRDNGT 499

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1013 LTPAPDTTSTLFANNIPTTTPSIPDIVPTTSAELVDAPPGFQGSSDDTATnlfqgnTETQTVFSPfaqtkaTPLVQETKP 1092
Cdd:pfam05109  500 ESKAPDMTSPTSAVTTPTPNATSPTPAVTTPTPNATSPTLGKTSPTSAVT------TPTPNATSP------TPAVTTPTP 567

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  1093 ELVPPPIGFFAPKseSEVLSQPPLAPSPlqSFFSTAPEtATTTDFNFFGSPAPgsvfpdlPVqqgiappplaLESPPQNS 1172
Cdd:pfam05109  568 NATIPTLGKTSPT--SAVTTPTPNATSP--TVGETSPQ-ANTTNHTLGGTSST-------PV----------VTSPPKNA 625


                   ....*.
gi 665407118  1173 VSNIAT 1178
Cdd:pfam05109  626 TSAVTT 631
PRK14971 PRK14971
DNA polymerase III subunit gamma/tau;
616-781 7.66e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237874 [Multi-domain]  Cd Length: 614  Bit Score: 41.30  E-value: 7.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  616 SYRLQKGTRLY------KSPLTPQETATSSGFAAPLPPTSvtPAIFNPFGAPAPGSFNSVGHLEGQSSQGV-PFFTPPVQ 688
Cdd:PRK14971  341 NYRASKNKRLLveltliQLAQLTQKGDDASGGRGPKQHIK--PVFTQPAAAPQPSAAAAASPSPSQSSAAAqPSAPQSAT 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407118  689 NPpgQVAAPTVAVPQSAPI-APPPGTSSTSVAPPLTASiANPPPTSgfasvplfaapTISSTPIPFFNPQPTGAEvttGL 767
Cdd:PRK14971  419 QP--AGTPPTVSVDPPAAVpVNPPSTAPQAVRPAQFKE-EKKIPVS-----------KVSSLGPSTLRPIQEKAE---QA 481

                         170
                  ....*....|....
gi 665407118  768 SQQENEATASTTLE 781
Cdd:PRK14971  482 TGNIKEAPTGTQKE 495
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 684-752 9.03e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.95  E-value: 9.03e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665407118  684 TPPVQNPPGQVAAPTVAVPQSAP-------IAPPPGTSSTSVAPPLTASIANPPPTSGfASVPLFAAPTISSTPIP 752
Cdd:PRK14950  376 PSPVRPTPAPSTRPKAAAAANIPpkepvreTATPPPVPPRPVAPPVPHTPESAPKLTR-AAIPVDEKPKYTPPAPP 450
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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