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Conserved domains on  [gi|665407853|ref|NP_001285889|]
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NADH dehydrogenase (ubiquinone) B22 subunit, isoform B [Drosophila melanogaster]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9( domain architecture ID 14448744)

NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis

Gene Ontology:  GO:0006120|GO:0008137|GO:0032981|GO:0005747

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 11-86 6.99e-28

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


:

Pssm-ID: 380758  Cd Length: 77  Bit Score: 98.02  E-value: 6.99e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407853  11 HKRQVCSLYKRALRNLESWYDRRNVYRYRAVQLRARFDENRS-KDLGEGIRLLACGQRELFETRHFQPRNFANSAGG 86
Cdd:cd20263    1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDvKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 11-86 6.99e-28

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 98.02  E-value: 6.99e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407853  11 HKRQVCSLYKRALRNLESWYDRRNVYRYRAVQLRARFDENRS-KDLGEGIRLLACGQRELFETRHFQPRNFANSAGG 86
Cdd:cd20263    1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDvKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 13-69 8.36e-04

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 35.63  E-value: 8.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665407853   13 RQVCSLYKRALRNLESWYDrRNVYRYRAVQLRARFDENRS-KDLGEGIRLLACGQREL 69
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPD-YNFREYFRRRIRDEFRKNKDlTDPEKIEKLLKEGKEEL 57
 
Name Accession Description Interval E-value
Complex1_LYR_NDUFB9_LYRM3 cd20263
LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta ...
 11-86 6.99e-28

LYR (leucine-tyrosine-arginine) motif found in NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 (NDUFB9) and similar proteins; NDUFB9, also called LYR motif-containing protein 3 (LYRM3), or Complex I-B22 (CI-B22), or NADH-ubiquinone oxidoreductase B22 subunit (UQOR22), is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I), and is believed to be not involved in catalysis. In general, accessory subunits are integral for assembly and function of Complex I, which functions in the transfer of electrons from NADH to the respiratory chain. NDUFB9 belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus.


Pssm-ID: 380758  Cd Length: 77  Bit Score: 98.02  E-value: 6.99e-28
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407853  11 HKRQVCSLYKRALRNLESWYDRRNVYRYRAVQLRARFDENRS-KDLGEGIRLLACGQRELFETRHFQPRNFANSAGG 86
Cdd:cd20263    1 HKQRVLRLYRRALKTLLSWCVDRDIFRYEAVLLRARFDANKDvKDPRKAEKLLEEGEAELWENQHPDPYIFPTSPGG 77
Complex1_LYR pfam05347
Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the ...
 13-69 8.36e-04

Complex 1 protein (LYR family); Proteins in this family include an accessory subunit of the higher eukaryotic NADH dehydrogenase complex. In Saccharomyces cerevisiae, the Isd11 protein has been shown to play a role in Fe/S cluster biogenesis in mitochondria. We have named this family LYR after a highly conserved tripeptide motif close to the N-terminus of these proteins.


Pssm-ID: 428432  Cd Length: 59  Bit Score: 35.63  E-value: 8.36e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665407853   13 RQVCSLYKRALRNLESWYDrRNVYRYRAVQLRARFDENRS-KDLGEGIRLLACGQREL 69
Cdd:pfam05347   1 RQVLSLYRALLRAARKFPD-YNFREYFRRRIRDEFRKNKDlTDPEKIEKLLKEGKEEL 57
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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