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Conserved domains on  [gi|665407881|ref|NP_001285897|]
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uncharacterized protein Dmel_CG16957, isoform B [Drosophila melanogaster]

Protein Classification

cytochrome b5-like heme/steroid binding domain-containing protein( domain architecture ID 1903536)

cytochrome b5-like heme/steroid binding domain-containing protein similar to Xenopus laevis cytochrome b5 domain-containing protein 1

CATH:  3.10.120.10
Gene Ontology:  GO:0097159
PubMed:  12537557
SCOP:  3000073

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cyt-b5 super family cl44470
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-127 1.49e-07

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


The actual alignment was detected with superfamily member pfam00173:

Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 46.85  E-value: 1.49e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665407881   74 TVRELREYDGtraDGRILVAILFNIYDVSRSVHYY-GRNGVNPNYAGRDISRILI 127
Cdd:pfam00173   1 TLEELSKHNG---DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFE 52
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-127 1.49e-07

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 46.85  E-value: 1.49e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665407881   74 TVRELREYDGtraDGRILVAILFNIYDVSRSVHYY-GRNGVNPNYAGRDISRILI 127
Cdd:pfam00173   1 TLEELSKHNG---DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFE 52
 
Name Accession Description Interval E-value
Cyt-b5 pfam00173
Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from ...
 74-127 1.49e-07

Cytochrome b5-like Heme/Steroid binding domain; This family includes heme binding domains from a diverse range of proteins. This family also includes proteins that bind to steroids. The family includes progesterone receptors. Many members of this subfamily are membrane anchored by an N-terminal transmembrane alpha helix. This family also includes a domain in some chitin synthases. There is no known ligand for this domain in the chitin synthases.


Pssm-ID: 459698 [Multi-domain]  Cd Length: 74  Bit Score: 46.85  E-value: 1.49e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 665407881   74 TVRELREYDGtraDGRILVAILFNIYDVSRSVHYY-GRNGVNPNYAGRDISRILI 127
Cdd:pfam00173   1 TLEELSKHNG---DGDCWVAINGKVYDVTKFLKEHpGGEDVILSAAGKDATDAFE 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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