|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
66-512 |
2.42e-137 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 404.60 E-value: 2.42e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 66 EPAELRQLFDFQLREQGESQDK-LRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 144
Cdd:COG0076 28 SPEELRAALDEPLPEEGLPPEEaLAELEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 145 MEEQVLAEMRRIVGFPNGGqgDGIFCPGGSIANGYAISCARYRHSPE-SKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMG 223
Cdd:COG0076 108 LEREVVRWLADLLGLPEGA--GGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 224 FGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALM 303
Cdd:COG0076 186 LGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 304 SKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDkfyDTSFDTGDKHIQCGRRADVF 383
Cdd:COG0076 266 SPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 384 KFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYVPPGLREM-ERNREFYDRLHkvapkv 462
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP-PELNIVCFRYKPAGLDEEdALNYALRDRLR------ 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 665407938 463 kegmiKKGSMMITYQPLRQLPNfFRLVLQNSCLEESDMVYFLDEIESLAQ 512
Cdd:COG0076 416 -----ARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
67-438 |
1.12e-116 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 348.64 E-value: 1.12e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 67 PAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLM 145
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 146 EEQVLAEMRRIVGFP---NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNG------LFNAKpLIIFTSEDAHYSVE 216
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaefLGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadssGILAK-LVAYTSDQAHSSIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 217 KLAMFMGFGsdhVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 296
Cdd:pfam00282 160 KAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 297 WGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYdtsfDTGDKHIQC 376
Cdd:pfam00282 237 YGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665407938 377 GRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYV 438
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE-VGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
107-510 |
1.37e-114 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 342.26 E-value: 1.37e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 107 FINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGgQGDGIFCPGGSIANGYAISCARY 186
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSE-DADGVFTSGGSESNLLALLAARD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 187 RHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGfgsDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATA 266
Cdd:cd06450 80 RARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 267 GTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRhqqvla 346
Cdd:cd06450 157 GTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 347 qchstnatylfqkdkfydtsfdtgdkhiqcgrradVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlE 426
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 427 SPECTNISFWYVPPglremernrefyDRLHKVAPKVKEGMIKKGSMMITYQPLRQlPNFFRLVLQNSCLEESDMVYFLDE 506
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGG-PNVLRFVVTNPLTTRDDADALLED 341
|
....
gi 665407938 507 IESL 510
Cdd:cd06450 342 IERA 345
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
66-458 |
1.71e-38 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 146.98 E-value: 1.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 66 EPAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 144
Cdd:PLN02880 43 QPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 145 MEEQVLAEMRRIVGFP----NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLfnaKPLIIFTSEDAHYSVEKLAM 220
Cdd:PLN02880 123 LEMIVLDWLAKLLNLPeqflSTGNGGGVIQGTASEAVLVVLLAARDRVLRKVGKNAL---EKLVVYASDQTHSALQKACQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 221 FMGFGSDHVRKIATNEVGKMRLSD--LEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWG 298
Cdd:PLN02880 200 IAGIHPENCRLLKTDSSTNYALAPelLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 299 GGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGR 378
Cdd:PLN02880 280 GSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 379 RADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlESPECTNISFWYVPPGLREMERNREFYDRLHKV 458
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV-TPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAV 438
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| GadA |
COG0076 |
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport ... |
66-512 |
2.42e-137 |
|
Glutamate or tyrosine decarboxylase or a related PLP-dependent protein [Amino acid transport and metabolism]; Glutamate or tyrosine decarboxylase or a related PLP-dependent protein is part of the Pathway/BioSystem: Pantothenate/CoA biosynthesis
Pssm-ID: 439846 [Multi-domain] Cd Length: 460 Bit Score: 404.60 E-value: 2.42e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 66 EPAELRQLFDFQLREQGESQDK-LRELLRETIRFSVKTGHPYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 144
Cdd:COG0076 28 SPEELRAALDEPLPEEGLPPEEaLAELEDLVLPGSVDWNHPRFLAFVTGGTTPAALAADLLASALNQNMGDWDTSPAATE 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 145 MEEQVLAEMRRIVGFPNGGqgDGIFCPGGSIANGYAISCARYRHSPE-SKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMG 223
Cdd:COG0076 108 LEREVVRWLADLLGLPEGA--GGVFTSGGTEANLLALLAARDRALARrVRAEGLPGAPRPRIVVSEEAHSSVDKAARLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 224 FGSDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALM 303
Cdd:COG0076 186 LGRDALRKVPVDEDGRMDPDALEAAIDEDRAAGLNPIAVVATAGTTNTGAIDPLAEIADIAREHGLWLHVDAAYGGFALP 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 304 SKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDkfyDTSFDTGDKHIQCGRRADVF 383
Cdd:COG0076 266 SPELRHLLDGIERADSITVDPHKWLYVPYGCGAVLVRDPELLREAFSFHASYLGPAD---DGVPNLGDYTLELSRRFRAL 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 384 KFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYVPPGLREM-ERNREFYDRLHkvapkv 462
Cdd:COG0076 343 KLWATLRALGREGYRELIERCIDLARYLAEGIAALPGFELLAP-PELNIVCFRYKPAGLDEEdALNYALRDRLR------ 415
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 665407938 463 kegmiKKGSMMITYQPLRQLPNfFRLVLQNSCLEESDMVYFLDEIESLAQ 512
Cdd:COG0076 416 -----ARGRAFLSPTKLDGRVV-LRLVVLNPRTTEDDVDALLDDLREAAA 459
|
|
| Pyridoxal_deC |
pfam00282 |
Pyridoxal-dependent decarboxylase conserved domain; |
67-438 |
1.12e-116 |
|
Pyridoxal-dependent decarboxylase conserved domain;
Pssm-ID: 395219 Cd Length: 373 Bit Score: 348.64 E-value: 1.12e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 67 PAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLM 145
Cdd:pfam00282 1 PGYLKPLLPLAAPIIPEPELQIDGDIRRNLMPGVTTWHsPHFHAYMPTGNSYPSLLGDMLTDAINCNGFTWESSPACTEL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 146 EEQVLAEMRRIVGFP---NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNG------LFNAKpLIIFTSEDAHYSVE 216
Cdd:pfam00282 81 ENVVMNWLGEMLGLPaefLGQEGGGVLQPGSSESNLLALLAARTKWIKRMKAAGkpadssGILAK-LVAYTSDQAHSSIE 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 217 KLAMFMGFGsdhVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 296
Cdd:pfam00282 160 KAALYGGVK---LREIPSDDNGKMRGMDLEKAIEEDKENGLIPFFVVATLGTTGSGAFDDLQELGDICAKHNLWLHVDAA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 297 WGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYdtsfDTGDKHIQC 376
Cdd:pfam00282 237 YGGSAFICPEFRHWLFGIERADSITFNPHKWMLVLLDCSAVWVKDKEALQQAFQFNPLYLGHTDSAY----DTGHKQIPL 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665407938 377 GRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVLEsPECTNISFWYV 438
Cdd:pfam00282 313 SRRFRILKLWFVIRSLGVEGLQNQIRRHVELAQYLEALIRKDGRFEICAE-VGLGLVCFRLK 373
|
|
| DOPA_deC_like |
cd06450 |
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
107-510 |
1.37e-114 |
|
DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and glutamate decarboxylase (GDC). DDC is active as a dimer and catalyzes the decarboxylation of tyrosine. GDC catalyzes the decarboxylation of glutamate and HDC catalyzes the decarboxylation of histidine.
Pssm-ID: 99743 [Multi-domain] Cd Length: 345 Bit Score: 342.26 E-value: 1.37e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 107 FINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPNGgQGDGIFCPGGSIANGYAISCARY 186
Cdd:cd06450 1 FLAGFVTTMDPPALLLEMLTSAKNAIDFTWDESPAATEMEAEVVNWLAKLFGLPSE-DADGVFTSGGSESNLLALLAARD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 187 RHSPESKKNGLFNAKPLIIFTSEDAHYSVEKLAMFMGfgsDHVRKIATNEVGKMRLSDLEKQVKLCLENGWQPLMVSATA 266
Cdd:cd06450 80 RARKRLKAGGGRGIDKLVIVCSDQAHVSVEKAAAYLD---VKVRLVPVDEDGRMDPEALEAAIDEDKAEGLNPIMVVATA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 267 GTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRhqqvla 346
Cdd:cd06450 157 GTTDTGAIDPLEEIADLAEKYDLWLHVDAAYGGFLLPFPEPRHLDFGIERVDSISVDPHKYGLVPLGCSAVLVR------ 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 347 qchstnatylfqkdkfydtsfdtgdkhiqcgrradVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlE 426
Cdd:cd06450 231 -----------------------------------ALKLWATLRRFGRDGYGEHIDRIVDLAKYLAELIRADPGFELL-G 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 427 SPECTNISFWYVPPglremernrefyDRLHKVAPKVKEGMIKKGSMMITYQPLRQlPNFFRLVLQNSCLEESDMVYFLDE 506
Cdd:cd06450 275 EPNLSLVCFRLKPS------------VKLDELNYDLSDRLNERGGWHVPATTLGG-PNVLRFVVTNPLTTRDDADALLED 341
|
....
gi 665407938 507 IESL 510
Cdd:cd06450 342 IERA 345
|
|
| PLN02880 |
PLN02880 |
tyrosine decarboxylase |
66-458 |
1.71e-38 |
|
tyrosine decarboxylase
Pssm-ID: 215475 [Multi-domain] Cd Length: 490 Bit Score: 146.98 E-value: 1.71e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 66 EPAELRQLFDFQLREQGESQDKLRELLRETIRFSVKTGH-PYFINQLYSGVDPYALVGQWLTDALNPSVYTYEVAPLFTL 144
Cdd:PLN02880 43 QPGYLRELLPDSAPNQPETLDQVLDDVQAKILPGVTHWQsPNYFAYYPSNSSVAGFLGEMLSAGLNIVGFSWITSPAATE 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 145 MEEQVLAEMRRIVGFP----NGGQGDGIFCPGGSIANGYAISCARYRHSPESKKNGLfnaKPLIIFTSEDAHYSVEKLAM 220
Cdd:PLN02880 123 LEMIVLDWLAKLLNLPeqflSTGNGGGVIQGTASEAVLVVLLAARDRVLRKVGKNAL---EKLVVYASDQTHSALQKACQ 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 221 FMGFGSDHVRKIATNEVGKMRLSD--LEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWG 298
Cdd:PLN02880 200 IAGIHPENCRLLKTDSSTNYALAPelLSEAISTDLSSGLIPFFLCATVGTTSSTAVDPLLELGKIAKSNGMWFHVDAAYA 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 299 GGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKDKFYDTSFDTGDKHIQCGR 378
Cdd:PLN02880 280 GSACICPEYRHYIDGVEEADSFNMNAHKWFLTNFDCSLLWVKDRNALIQSLSTNPEFLKNKASQANSVVDYKDWQIPLGR 359
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 379 RADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFELVlESPECTNISFWYVPPGLREMERNREFYDRLHKV 458
Cdd:PLN02880 360 RFRSLKLWMVLRLYGVENLQSYIRNHIKLAKEFEQLVAQDSRFEVV-TPRIFSLVCFRLVPPKNNEDNGNKLNHDLLDAV 438
|
|
| PLN02590 |
PLN02590 |
probable tyrosine decarboxylase |
52-451 |
8.21e-37 |
|
probable tyrosine decarboxylase
Pssm-ID: 178200 [Multi-domain] Cd Length: 539 Bit Score: 142.93 E-value: 8.21e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 52 FQGTNRSSKVVEWHEPAELRQLFDFQLREQGESqdkLRELLRETIRfSVKTG-----HPYFINQLYSGVDPYALVGQWLT 126
Cdd:PLN02590 77 LQDSPQDFPVLSQVQPGYLRDMLPDSAPERPES---LKELLDDVSK-KIMPGithwqSPSYFAYYASSTSVAGFLGEMLN 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 127 DALNPSVYTYEVAPLFTLMEEQVLAEMRRIVGFPN----GGQGDGIFCPGGSIANGYAISCARYRhspESKKNGLFNAKP 202
Cdd:PLN02590 153 AGLSVVGFTWLTSPAATELEIIVLDWLAKLLQLPDhflsTGNGGGVIQGTGCEAVLVVVLAARDR---ILKKVGKTLLPQ 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 203 LIIFTSEDAHYSVEKLAMFMGFGSDHVRKIATNEVGK--MRLSDLEKQVKLCLENGWQPLMVSATAGTTVLGAFDDLAGI 280
Cdd:PLN02590 230 LVVYGSDQTHSSFRKACLIGGIHEENIRLLKTDSSTNygMPPESLEEAISHDLAKGFIPFFICATVGTTSSAAVDPLVPL 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 281 SEVCKKYNMWMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQCHSTNATYLFQKD 360
Cdd:PLN02590 310 GNIAKKYGIWLHVDAAYAGNACICPEYRKFIDGIENADSFNMNAHKWLFANQTCSPLWVKDRYSLIDALKTNPEYLEFKV 389
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 361 KFYDTSFDTGDKHIQCGRRADVFKFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRERPGFElVLESPECTNISFWYVPP 440
Cdd:PLN02590 390 SKKDTVVNYKDWQISLSRRFRSLKLWMVLRLYGSENLRNFIRDHVNLAKHFEDYVAQDPSFE-VVTTRYFSLVCFRLAPV 468
|
410
....*....|....
gi 665407938 441 GLREM---ERNREF 451
Cdd:PLN02590 469 DGDEDqcnERNREL 482
|
|
| PRK02769 |
PRK02769 |
histidine decarboxylase; Provisional |
196-418 |
5.03e-19 |
|
histidine decarboxylase; Provisional
Pssm-ID: 235068 [Multi-domain] Cd Length: 380 Bit Score: 88.95 E-value: 5.03e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 196 GLFNAKPL----IIFTSEDAHYSVEKLAMFMGFGSdhvRKIATNEVGKMRLSDLEKQVKlclENGWQPLMVSATAGTTVL 271
Cdd:PRK02769 100 GCYLARELfpdgTLYYSKDTHYSVSKIARLLRIKS---RVITSLPNGEIDYDDLISKIK---ENKNQPPIIFANIGTTMT 173
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 272 GAFDDLAGISEVCKKYNM---WMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVlaQC 348
Cdd:PRK02769 174 GAIDNIKEIQEILKKIGIddyYIHADAALSGMILPFVNNPPPFSFADGIDSIAISGHKFIGSPMPCGIVLAKKKYV--ER 251
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665407938 349 HSTNATYLfqkdkfydtsfDTGDKHIQCGRRAdvFKFWFMWKA---KGTQGLEAHVEKVFRMAEFFTAKVRER 418
Cdd:PRK02769 252 ISVDVDYI-----------GSRDQTISGSRNG--HTALLLWAAirsLGSKGLRQRVQHCLDMAQYAVDRLQAN 311
|
|
| PLN02263 |
PLN02263 |
serine decarboxylase |
204-417 |
7.18e-13 |
|
serine decarboxylase
Pssm-ID: 177904 [Multi-domain] Cd Length: 470 Bit Score: 70.62 E-value: 7.18e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 204 IIFTSEDAHYSVEKLAMFMGFGSDhvrKIATNEVGKMRLSDLEKQVklcLENGWQPLMVSATAGTTVLGAFDDLAGISEV 283
Cdd:PLN02263 180 ILYASRESHYSVFKAARMYRMECV---KVDTLVSGEIDCADFKAKL---LANKDKPAIINVNIGTTVKGAVDDLDLVIKT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 284 CKKY-----NMWMHVDAAWGGgaLMskkyrhlLNGIERADSVTWNP---------HKLLAASQQCSTFLTR--HQQVLaq 347
Cdd:PLN02263 254 LEECgfsqdRFYIHCDGALFG--LM-------MPFVKRAPKVTFKKpigsvsvsgHKFVGCPMPCGVQITRmeHINVL-- 322
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 348 chSTNATYLFQKDKfydTSFDTGDKHiqcgrrADVFkFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRE 417
Cdd:PLN02263 323 --SSNVEYLASRDA---TIMGSRNGH------APIF-LWYTLNRKGYRGFQKEVQKCLRNAHYLKDRLRE 380
|
|
| PLN03032 |
PLN03032 |
serine decarboxylase; Provisional |
204-417 |
2.76e-11 |
|
serine decarboxylase; Provisional
Pssm-ID: 166673 [Multi-domain] Cd Length: 374 Bit Score: 65.23 E-value: 2.76e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 204 IIFTSEDAHYSVEKLAMFMGFgsdHVRKIATNEVGKMRLSDLEKQVklcLENGWQPLMVSATAGTTVLGAFDDLAGISEV 283
Cdd:PLN03032 113 ILYASRESHYSVFKAARMYRM---EAVKVPTLPSGEIDYDDLERAL---AKNRDKPAILNVNIGTTVKGAVDDLDRILRI 186
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 284 CKKYNM-----WMHVDAAWGGGALMSKKYRHLLNGIERADSVTWNPHKLLAASQQCSTFLTRHQQVLAQchSTNATYLFQ 358
Cdd:PLN03032 187 LKELGYtedrfYIHCDGALFGLMMPFVSRAPEVTFRKPIGSVSVSGHKFLGCPMPCGVALTRKKHVKAL--SQNVEYLNS 264
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 665407938 359 KDKfydTSFDTGDKHiqcgrrADVFkFWFMWKAKGTQGLEAHVEKVFRMAEFFTAKVRE 417
Cdd:PLN03032 265 RDA---TIMGSRNGH------APLY-LWYTLRRKGYRGIKRDVQHCMRNAHYLKDRLTE 313
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
153-332 |
2.43e-09 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 56.62 E-value: 2.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 153 MRRIVGFPNGGQGDGIFCPGGSIANGYAISCARYRHSPeskknglfnakpliIFTSEDAHYSVE--KLAMFmGFGSDHVR 230
Cdd:cd01494 6 EEKLARLLQPGNDKAVFVPSGTGANEAALLALLGPGDE--------------VIVDANGHGSRYwvAAELA-GAKPVPVP 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 231 KiatNEVGKMRLS--DLEKqvklcLENGWQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYr 308
Cdd:cd01494 71 V---DDAGYGGLDvaILEE-----LKAKPNVALIVITPNTTSGGVLVPLKEIRKIAKEYGILLLVDAASAGGASPAPGV- 141
|
170 180
....*....|....*....|....
gi 665407938 309 hlLNGIERADSVTWNPHKLLAASQ 332
Cdd:cd01494 142 --LIPEGGADVVTFSLHKNLGGEG 163
|
|
| Aminotran_5 |
pfam00266 |
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes ... |
168-296 |
3.03e-06 |
|
Aminotransferase class-V; This domain is found in amino transferases, and other enzymes including cysteine desulphurase EC:4.4.1.-.
Pssm-ID: 425567 [Multi-domain] Cd Length: 368 Bit Score: 49.55 E-value: 3.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 168 IFCPGGSIANGYAISCarYRHSPESKKNglfnakpliIFTSEDAHYSV----EKLAMFMGFgsdHVRKIATNEVGKMRLS 243
Cdd:pfam00266 65 IFTSGTTEAINLVALS--LGRSLKPGDE---------IVITEMEHHANlvpwQELAKRTGA---RVRVLPLDEDGLLDLD 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 665407938 244 DLEK----QVKLclengwqplmVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 296
Cdd:pfam00266 131 ELEKlitpKTKL----------VAITHVSNVTGTIQPVPEIGKLAHQYGALVLVDAA 177
|
|
| Orn_deC_like |
cd00615 |
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
272-358 |
1.32e-04 |
|
Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine decarboxylase (LDC). ODC is a dodecamer composed of six homodimers and catalyzes the decarboxylation of tryptophan. ADC catalyzes the decarboxylation of arginine and LDC catalyzes the decarboxylation of lysine. Members of this family are widely found in all three forms of life.
Pssm-ID: 99739 [Multi-domain] Cd Length: 294 Bit Score: 43.78 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 272 GAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKY--RHLLNGierADSVTWNPHKLLAASQQCSTFLTRHQQVLAQcH 349
Cdd:cd00615 167 GICYNLRKIVEEAHHRGLPVLVDEAHGAHFRFHPILpsSAAMAG---ADIVVQSTHKTLPALTQGSMIHVKGDLVNPD-R 242
|
....*....
gi 665407938 350 STNATYLFQ 358
Cdd:cd00615 243 VNEALNLHQ 251
|
|
| PRK02948 |
PRK02948 |
IscS subfamily cysteine desulfurase; |
147-295 |
3.44e-04 |
|
IscS subfamily cysteine desulfurase;
Pssm-ID: 179511 [Multi-domain] Cd Length: 381 Bit Score: 42.79 E-value: 3.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 147 EQVLAEMRRIVGFPNGGQGDGI-FCPGGSIANGYAIscaryrhspESKKNGLFNAKPLIIfTSEDAHYSVEKLAMFM--- 222
Cdd:PRK02948 42 SSLLQVCRKTFAEMIGGEEQGIyFTSGGTESNYLAI---------QSLLNALPQNKKHII-TTPMEHASIHSYFQSLesq 111
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665407938 223 GFgsdHVRKIATNEVGKMRLSDLEKQVKLclengwQPLMVSATAGTTVLGAFDDLAGISEVCKKYNMWMHVDA 295
Cdd:PRK02948 112 GY---TVTEIPVDKSGLIRLVDLERAITP------DTVLASIQHANSEIGTIQPIAEIGALLKKYNVLFHSDC 175
|
|
| Beta_elim_lyase |
pfam01212 |
Beta-eliminating lyase; |
151-296 |
1.39e-03 |
|
Beta-eliminating lyase;
Pssm-ID: 426128 [Multi-domain] Cd Length: 288 Bit Score: 40.66 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 151 AEMRRIVGFPNGgqgdgIFCPGGSIANGYAIS--CARYrHSpeskknglfnakpliIFTSEDAHYSVEKLAMFMGFGSDH 228
Cdd:pfam01212 39 DRVAELFGKEAA-----LFVPSGTAANQLALMahCQRG-DE---------------VICGEPAHIHFDETGGHAELGGVQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 229 VRKIATNEVGKMRLSDLEKQVK------------LCLENgwqplmVSATAGTTVLgAFDDLAGISEVCKKYNMWMHVDAA 296
Cdd:pfam01212 98 PRPLDGDEAGNMDLEDLEAAIRevgadifpptglISLEN------THNSAGGQVV-SLENLREIAALAREHGIPVHLDGA 170
|
|
| LdcC |
COG1982 |
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism]; |
272-344 |
1.49e-03 |
|
Arginine/lysine/ornithine decarboxylase [Amino acid transport and metabolism];
Pssm-ID: 441585 [Multi-domain] Cd Length: 486 Bit Score: 41.25 E-value: 1.49e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665407938 272 GAFDDLAGISEVCKKYNMWMHVDAAWGGGALMSKKYRH--LLNGierADSVTWNPHKLLAASQQCSTFLTRHQQV 344
Cdd:COG1982 174 GVCYDLKAIAELAHEHGIPVLVDEAHGAHFGFHPDLPRsaMEAG---ADLVVQSTHKTLGALTQSSMLHVKGGRV 245
|
|
| TA_like |
cd06502 |
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP) ... |
167-296 |
2.10e-03 |
|
Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a secondary glycine biosynthetic pathway.
Pssm-ID: 99748 [Multi-domain] Cd Length: 338 Bit Score: 40.39 E-value: 2.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665407938 167 GIFCPGGSIANGYAIS--CARYrHSpeskknglfnakpliIFTSEDAH---YSVEKLAMFMGfgsdHVRKIATNEVGKMR 241
Cdd:cd06502 50 ALFVPSGTAANQLALAahTQPG-GS---------------VICHETAHiytDEAGAPEFLSG----VKLLPVPGENGKLT 109
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665407938 242 LSDLEKQVK------------LCLENgwqplmvsaTAGTTVLGAFDDLAGISEVCKKYNMWMHVDAA 296
Cdd:cd06502 110 PEDLEAAIRprddihfpppslVSLEN---------TTEGGTVYPLDELKAISALAKENGLPLHLDGA 167
|
|
| |
