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Conserved domains on  [gi|665399511|ref|NP_001286193|]
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pou domain motif 3, isoform E [Drosophila melanogaster]

Protein Classification

POU family transcription factor( domain architecture ID 11036637)

POU (Pit-Oct-Unc) family transcription factor binds specific DNA sequences to direct gene expression programs, playing a role in orchestrating embryonic development and directing cellular fate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pou super family cl22952
Pou domain - N-terminal to homeobox domain;
1108-1181 2.31e-34

Pou domain - N-terminal to homeobox domain;


The actual alignment was detected with superfamily member smart00352:

Pssm-ID: 473999  Cd Length: 75  Bit Score: 126.01  E-value: 2.31e-34
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665399511   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAE 1181
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Homeodomain pfam00046
Homeodomain;
1207-1263 2.79e-18

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.79e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399511  1207 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1263
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1181 2.31e-34

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 126.01  E-value: 2.31e-34
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665399511   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAE 1181
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1181 7.47e-34

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 124.70  E-value: 7.47e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665399511  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAE 1181
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1207-1263 2.79e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.79e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399511  1207 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1263
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1206-1262 8.92e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 8.92e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399511   1206 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1262
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1207-1264 2.12e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.12e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399511 1207 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1264
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1203-1262 2.59e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399511 1203 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1262
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Name Accession Description Interval E-value
POU smart00352
Found in Pit-Oct-Unc transcription factors;
1108-1181 2.31e-34

Found in Pit-Oct-Unc transcription factors;


Pssm-ID: 197673  Cd Length: 75  Bit Score: 126.01  E-value: 2.31e-34
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665399511   1108 DGIDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAE 1181
Cdd:smart00352    2 DDTDPRELEAFAKQFKQRRIKLGFTQADVGLALGALYGPAFSQTTICRFEALQLSFKNMCKLKPLLQKWLEEAE 75
Pou pfam00157
Pou domain - N-terminal to homeobox domain;
1110-1181 7.47e-34

Pou domain - N-terminal to homeobox domain;


Pssm-ID: 459692  Cd Length: 72  Bit Score: 124.70  E-value: 7.47e-34
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665399511  1110 IDLDEIKEFAKAFKLRRLSLGLTQTQVGQALSVTEGPAYSQSAICRFEKLDITPKSAQKIKPVLERWMKEAE 1181
Cdd:pfam00157    1 LNLEELEEFAKEFKQRRIKLGYTQADVGSALGALYGPVFSQSTICRFEKLDLSLKNMCKLKPLLEKWLEEAE 72
Homeodomain pfam00046
Homeodomain;
1207-1263 2.79e-18

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 79.85  E-value: 2.79e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399511  1207 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKN 1263
Cdd:pfam00046    1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 1206-1262 8.92e-16

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 72.67  E-value: 8.92e-16
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 665399511   1206 KRKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1262
Cdd:smart00389    1 KRRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 1207-1264 2.12e-15

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 71.51  E-value: 2.12e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 665399511 1207 RKRRTSFTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALKNT 1264
Cdd:cd00086     1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRS 58
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
1203-1262 2.59e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 51.67  E-value: 2.59e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665399511 1203 PSKKRKRRTsfTPQALELLNAHFERNTHPSGTEITGLAHQLGYEREVIRIWFCNKRQALK 1262
Cdd:COG5576    50 PPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEK 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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