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Conserved domains on  [gi|665400277|ref|NP_001286320|]
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sine oculis-binding protein, isoform B [Drosophila melanogaster]

Protein Classification

SOBP domain-containing protein( domain architecture ID 12172870)

SOBP domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
278-587 1.83e-98

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


:

Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 309.05  E-value: 1.83e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  278 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHL-DMHPHLRDQAMDAGSEAGLITPDLWLRNCRS 356
Cdd:pfam15279   1 VCDWCKHVRHTVSYVDFQDGERQLQFCSAKCLNQYKMDIFCKETQAHLpCMHPHLKGKSKSAGSSAQLITPDLWLSDCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  357 RSASPASTLSVSPGPPPAPAVSRCPdSPPSHHPSKPLISVAPVSKLLAQKSPGPGPGAPPPPPPPVQRHLAGKLGRRKRR 436
Cdd:pfam15279  81 KSASPASTRSESVSPGPSSSASPSS-SPTSSNSSKPLISVASSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLGR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  437 GISSSLGSETVASLLqkqqqqQAPQQHQAPPTLTADFGGSSVPLPPLSPMPSMQEAPQQQQAPQVPptqalPRGPTAIPA 516
Cdd:pfam15279 160 PPGSPPMSMTPRGLL------GKPQQHPPPSPLPAFMEPSSMPPPFLRPPPSIPQPNSPLSNPMLP-----GIGPPPKPP 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  517 SYFATPSNGVpMGHPFAGRPPPPPHHFMHP--PPHGMMPRGFGPHFGPPLPPQ---------MPELGSLLGAVPPVTVMV 585
Cdd:pfam15279 229 RNLGPPSNPM-HRPPFSPHHPPPPPTPPGPppGLPPPPPRGFTPPFGPPFPPVnmmpnppemNFGLPSLAPLVPPVTVLV 307

                  ..
gi 665400277  586 PY 587
Cdd:pfam15279 308 PY 309
 
Name Accession Description Interval E-value
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
278-587 1.83e-98

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 309.05  E-value: 1.83e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  278 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHL-DMHPHLRDQAMDAGSEAGLITPDLWLRNCRS 356
Cdd:pfam15279   1 VCDWCKHVRHTVSYVDFQDGERQLQFCSAKCLNQYKMDIFCKETQAHLpCMHPHLKGKSKSAGSSAQLITPDLWLSDCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  357 RSASPASTLSVSPGPPPAPAVSRCPdSPPSHHPSKPLISVAPVSKLLAQKSPGPGPGAPPPPPPPVQRHLAGKLGRRKRR 436
Cdd:pfam15279  81 KSASPASTRSESVSPGPSSSASPSS-SPTSSNSSKPLISVASSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLGR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  437 GISSSLGSETVASLLqkqqqqQAPQQHQAPPTLTADFGGSSVPLPPLSPMPSMQEAPQQQQAPQVPptqalPRGPTAIPA 516
Cdd:pfam15279 160 PPGSPPMSMTPRGLL------GKPQQHPPPSPLPAFMEPSSMPPPFLRPPPSIPQPNSPLSNPMLP-----GIGPPPKPP 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  517 SYFATPSNGVpMGHPFAGRPPPPPHHFMHP--PPHGMMPRGFGPHFGPPLPPQ---------MPELGSLLGAVPPVTVMV 585
Cdd:pfam15279 229 RNLGPPSNPM-HRPPFSPHHPPPPPTPPGPppGLPPPPPRGFTPPFGPPFPPVnmmpnppemNFGLPSLAPLVPPVTVLV 307

                  ..
gi 665400277  586 PY 587
Cdd:pfam15279 308 PY 309
 
Name Accession Description Interval E-value
SOBP pfam15279
Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual ...
278-587 1.83e-98

Sine oculis-binding protein; SOBP is associated with syndromic and nonsyndromic intellectual disability. It carries a zinc-finger of the zf-C2H2 type at the N-terminus, and a highly characteriztic C-terminal PhPhPhPhPhPh motif. The deduced 873-amino acid protein contains an N-terminal nuclear localization signal (NLS), followed by 2 FCS-type zinc finger motifs, a proline-rich region (PR1), a putative RNA-binding motif region, and a C-terminal NLS embedded in a second proline-rich motif. SOBP is expressed in various human tissues, including developing mouse brain at embryonic day 14. In postnatal and adult mouse brain SOBP is expressed in all neurons, with intense staining in the limbic system. Highest expression is in layer V cortical neurons, hippocampus, pyriform cortex, dorsomedial nucleus of thalamus, amygdala, and hypothalamus. Postnatal expression of SOBP in the limbic system corresponds to a time of active synaptogenesis. the family is also referred to as Jackson circler, JXC1. In seven affected siblings from a consanguineous Israeli Arab family with mental retardation, anterior maxillary protrusion, and strabismus mutations were found in this protein.


Pssm-ID: 464609 [Multi-domain]  Cd Length: 325  Bit Score: 309.05  E-value: 1.83e-98
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  278 TCDWCKHVRHAVSYVDFQDGASQLQFCSEKCLNQYKMQIFCHETQAHL-DMHPHLRDQAMDAGSEAGLITPDLWLRNCRS 356
Cdd:pfam15279   1 VCDWCKHVRHTVSYVDFQDGERQLQFCSAKCLNQYKMDIFCKETQAHLpCMHPHLKGKSKSAGSSAQLITPDLWLSDCRR 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  357 RSASPASTLSVSPGPPPAPAVSRCPdSPPSHHPSKPLISVAPVSKLLAQKSPGPGPGAPPPPPPPVQRHLAGKLGRRKRR 436
Cdd:pfam15279  81 KSASPASTRSESVSPGPSSSASPSS-SPTSSNSSKPLISVASSSKLLAPKPHEPPSLPPPPLPPKKGRRHRPGLHPPLGR 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  437 GISSSLGSETVASLLqkqqqqQAPQQHQAPPTLTADFGGSSVPLPPLSPMPSMQEAPQQQQAPQVPptqalPRGPTAIPA 516
Cdd:pfam15279 160 PPGSPPMSMTPRGLL------GKPQQHPPPSPLPAFMEPSSMPPPFLRPPPSIPQPNSPLSNPMLP-----GIGPPPKPP 228
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400277  517 SYFATPSNGVpMGHPFAGRPPPPPHHFMHP--PPHGMMPRGFGPHFGPPLPPQ---------MPELGSLLGAVPPVTVMV 585
Cdd:pfam15279 229 RNLGPPSNPM-HRPPFSPHHPPPPPTPPGPppGLPPPPPRGFTPPFGPPFPPVnmmpnppemNFGLPSLAPLVPPVTVLV 307

                  ..
gi 665400277  586 PY 587
Cdd:pfam15279 308 PY 309
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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