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Conserved domains on  [gi|665400511|ref|NP_001286359|]
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no extended memory, isoform L [Drosophila melanogaster]

Protein Classification

cytochrome b family protein( domain architecture ID 581032)

cytochrome b family protein such as formate dehydrogenase subunit gamma or cytochrome b, a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.

Gene Ontology:  GO:0046872|GO:0016491

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cytochrome_b_N super family cl23723
Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit ...
 46-243 1.82e-44

Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria, cytochrome b6 is analogous to eukaryote cytochrome b, containing two chains: helices A-D are encoded by the petB gene and helices E-H are encoded by the petD gene in these organisms. Cytochrome b/b6 contains two bound hemes and two ubiquinol/ubiquinone binding sites. The C-terminal portion of cytochrome b is described in a separate CD.


The actual alignment was detected with superfamily member cd08764:

Pssm-ID: 474033  Cd Length: 214  Bit Score: 149.02  E-value: 1.82e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  46 WVMFYRDGFAWSeSPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDA 125
Cdd:cd08764    7 WLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAVFDSHNL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 126 LH--KVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENktysCRSAMVPIHASLGLANFWLAIATSVTGLIEKere 203
Cdd:cd08764   86 AKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPET----LRAAYLPLHVFFGLFIFVLAVATALLGITEK--- 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665400511 204 TVNEAGVSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSN 243
Cdd:cd08764  159 AFFSLNKYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPD 198
 
Name Accession Description Interval E-value
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 46-243 1.82e-44

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 149.02  E-value: 1.82e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  46 WVMFYRDGFAWSeSPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDA 125
Cdd:cd08764    7 WLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAVFDSHNL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 126 LH--KVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENktysCRSAMVPIHASLGLANFWLAIATSVTGLIEKere 203
Cdd:cd08764   86 AKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPET----LRAAYLPLHVFFGLFIFVLAVATALLGITEK--- 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665400511 204 TVNEAGVSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSN 243
Cdd:cd08764  159 AFFSLNKYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPD 198
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 66-197 4.97e-36

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 124.65  E-value: 4.97e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511    66 LHPILMIAGFVTLSGFSILIYR-LCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTMG 144
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 665400511   145 MFVLQFVIGFFSFLVMLCcenkTYSCRSAMVPIHASLGLANFWLAIATSVTGL 197
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGL----PSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 66-200 2.19e-35

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 123.10  E-value: 2.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511   66 LHPILMIAGFVTLSGFSILIYRLC--RCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTM 143
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNstRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665400511  144 GMFVLQFVIGFFSFLvmlcCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:pfam03188  81 ILYALQWVGGFVTFL----FPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEK 133
PLN02680 PLN02680
carbon-monoxide oxygenase
 45-249 5.95e-24

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 96.02  E-value: 5.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  45 FWVMFYRDGFAWSESPKQQ-FNLHPILMIAGFVTLSGFSILIYRLCRCVKQiYVKLIHMFFHAVAIPCIALGFISVFASH 123
Cdd:PLN02680  27 TWTVHYRGGLALSSDNKDLiFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKN-LKKLVHLTLQFLAFCLSLIGVWAALKFH 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 124 DALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVmlccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKere 203
Cdd:PLN02680 106 NEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWY----PGGSRNSRASLLPWHVFFGIYIYALAVATATTGILEK--- 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 665400511 204 tvnEAGVSENKLVEHYITSAIGVTLIFIGIIVT--FAVRRSNAPASAK 249
Cdd:PLN02680 179 ---ATFLQSNKVISRYSTEAMLVNSLGILIVVLggFVILAIVTPLNGK 223
 
Name Accession Description Interval E-value
Cyt_b561_CG1275_like cd08764
Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate ...
 46-243 1.82e-44

Non-vertebrate eumetazoan cytochrome b(561); Cytochrome b(561), as found in non-vertebrate eumetazoans, similar to the Drosophila melanogaster CG1275 gene product. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176494  Cd Length: 214  Bit Score: 149.02  E-value: 1.82e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  46 WVMFYRDGFAWSeSPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDA 125
Cdd:cd08764    7 WLGKFRGGFSWT-GPGLQFNWHPLLMVLGLIFLYGNSILVYRVFRNTRKKRLKLLHAVLHLLAFILAVIGLKAVFDSHNL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 126 LH--KVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCCENktysCRSAMVPIHASLGLANFWLAIATSVTGLIEKere 203
Cdd:cd08764   86 AKppIPNMYSLHSWLGLTAVILFSLQWVGGFVSFLFPGLPET----LRAAYLPLHVFFGLFIFVLAVATALLGITEK--- 158

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 665400511 204 TVNEAGVSENKLVEHYITSAIGVTLIFIGIIVTFAVRRSN 243
Cdd:cd08764  159 AFFSLNKYSNLPAEGVLGNFIGIVLVIFGGLVVYLVTEPD 198
Cyt_b561 cd08554
Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory ...
 63-197 3.02e-37

Eukaryotic cytochrome b(561); Cytochrome b(561) is a family of endosomal or secretory vesicle-specific electron transport proteins. They are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments. This is an exclusively eukaryotic family. Members of the prokaryotic cytochrome b561 family are not deemed homologous.


Pssm-ID: 176489  Cd Length: 131  Bit Score: 127.78  E-value: 3.02e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  63 QFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVT 142
Cdd:cd08554    1 EFNWHPLLMVIGFVFLMGEALLVYRVFRLLTKRALKLLHAILHLLAFVLGLVGLLAVFLFHNAGGIANLYSLHSWLGLAT 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 665400511 143 MGMFVLQFVIGFFSFLVMLCCEnktySCRSAMVPIHASLGLANFWLAIATSVTGL 197
Cdd:cd08554   81 VLLFLLQFLSGFVLFLLPLLRL----SYRSSLLPFHRFFGLAIFVLAIATILLGI 131
B561 smart00665
Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate ...
 66-197 4.97e-36

Cytochrome b-561 / ferric reductase transmembrane domain; Cytochrome b-561 recycles ascorbate for the generation of norepinephrine by dopamine-beta-hydroxylase in the chromaffin vesicles of the adrenal gland. It is a transmembrane heme protein with the two heme groups being bound to conserved histidine residues. A cytochrome b-561 homologue, termed Dcytb, is an iron-regulated ferric reductase in the duodenal mucosa. Other homologues of these are also likely to be ferric reductases. SDR2 is proposed to be important in regulating the metabolism of iron in the onset of neurodegenerative disorders.


Pssm-ID: 214769  Cd Length: 129  Bit Score: 124.65  E-value: 4.97e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511    66 LHPILMIAGFVTLSGFSILIYR-LCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTMG 144
Cdd:smart00665   1 LHPVLMILGFGFLMGEAILVARpLTRFLSKPTWFLLHVVLQILALVLGVIGLLAIFISHNESGIANFYSLHSWLGLAAFV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 665400511   145 MFVLQFVIGFFSFLVMLCcenkTYSCRSAMVPIHASLGLANFWLAIATSVTGL 197
Cdd:smart00665  81 LAGLQWLSGFLRPLPPGL----PSKYRSYLNPYHRFVGLAAFILAIVTIFLGL 129
Cytochrom_B561 pfam03188
Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport ...
 66-200 2.19e-35

Eukaryotic cytochrome b561; Cytochrome b561 is a secretory vesicle-specific electron transport protein. It is an integral membrane protein, that binds two heme groups non-covalently. This is a eukaryotic family. Members of the 'prokaryotic cytochrome b561' family can be found in Pfam: PF01292.


Pssm-ID: 427188  Cd Length: 137  Bit Score: 123.10  E-value: 2.19e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511   66 LHPILMIAGFVTLSGFSILIYRLC--RCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVTM 143
Cdd:pfam03188   1 WHPVLMVIGFIFLMGEAILVYRVNstRRLSKKTKKLLHWILQALALILAVIGLVAVFKFHNLSGIPHFYSLHSWLGLLTV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665400511  144 GMFVLQFVIGFFSFLvmlcCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:pfam03188  81 ILYALQWVGGFVTFL----FPGLSKRIRPLLLPLHVFFGLVIFVLAIVTALLGLLEK 133
Cyt_b561_ACYB-1_like cd08766
Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as ...
 57-200 9.95e-33

Plant cytochrome b(561), including the carbon monoxide oxygenase ACYB-1; Cytochrome b(561), as found in plants, similar to the Arabidopsis thaliana ACYB-1 gene product, a cytochrome b561 isoform localized to the tonoplast. This protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), and might be capable of trans-membrane electron transport from intracellular ascorbate to extracellular ferric chelates. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176496  Cd Length: 144  Bit Score: 116.64  E-value: 9.95e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  57 SESPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQiYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHS 136
Cdd:cd08766    1 SDNKGLIFNVHPVLMVIGFIFLAGEAILAYKTVPGSRE-VQKAVHLTLHLVALVLGIVGIYAAFKFHNEVGIPNLYSLHS 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665400511 137 WLGFVTMGMFVLQFVIGFFSFLVmlccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:cd08766   80 WLGIGTISLFGLQWLFGFVTFWF----PGASRNTRAALLPWHVFLGLAIYYLAIATAETGLLEK 139
PLN02680 PLN02680
carbon-monoxide oxygenase
 45-249 5.95e-24

carbon-monoxide oxygenase


Pssm-ID: 215365  Cd Length: 232  Bit Score: 96.02  E-value: 5.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  45 FWVMFYRDGFAWSESPKQQ-FNLHPILMIAGFVTLSGFSILIYRLCRCVKQiYVKLIHMFFHAVAIPCIALGFISVFASH 123
Cdd:PLN02680  27 TWTVHYRGGLALSSDNKDLiFNVHPVLMVIGLVLLNGEAMLAYKTVPGTKN-LKKLVHLTLQFLAFCLSLIGVWAALKFH 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 124 DALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVmlccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKere 203
Cdd:PLN02680 106 NEKGIDNFYSLHSWLGLACLFLFSLQWAAGFVTFWY----PGGSRNSRASLLPWHVFFGIYIYALAVATATTGILEK--- 178

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 665400511 204 tvnEAGVSENKLVEHYITSAIGVTLIFIGIIVT--FAVRRSNAPASAK 249
Cdd:PLN02680 179 ---ATFLQSNKVISRYSTEAMLVNSLGILIVVLggFVILAIVTPLNGK 223
PLN02810 PLN02810
carbon-monoxide oxygenase
 46-200 9.57e-24

carbon-monoxide oxygenase


Pssm-ID: 178406  Cd Length: 231  Bit Score: 95.66  E-value: 9.57e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  46 WVMFYRDGFAWSESPKQQ-FNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYvKLIHMFFHAVAIPCIALGFISVFASHD 124
Cdd:PLN02810  28 WSIYYRGGLAWEATNKNLiFNLHPVLMLIGLIIIGGEAIMSYKSLPLKKEVK-KLIHLVLHAIALILGIFGICAAFKNHN 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665400511 125 ALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVmlccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:PLN02810 107 ESGIANLYSLHSWLGIGIISLYGIQWIYGFIVFFF----PGGSTNLRSGSLPWHVLFGLFVYILAVGNAALGFLEK 178
Cyt_b561_CYBASC3 cd08762
Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as ...
 45-200 2.52e-23

Vertebrate cytochrome b(561), CYBASC3 gene product; Cytochrome b ascorbate-dependent 3, as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176492  Cd Length: 179  Bit Score: 93.01  E-value: 2.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  45 FWVMFYRDGFAWSESPKQqFNLHPILMIAGFVTLSGFSILIYRLCRCV--KQIYVKLIHMFFHAVAIPCIALGFISVFAS 122
Cdd:cd08762   17 HWNQMWRGGFAWDGSSKN-FNWHPVLMVTGMVVLYGNAALVYRIPLTWggPKLPWKLLHAGLLLLAFILTVIGLCAVFNF 95

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400511 123 HDALHKVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCcenkTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:cd08762   96 HNVHHTANLYSLHSWVGICTVALFTCQWVMGFTSFLLPWA----PMWLRALVKPIHVFFGAMILVLSIASCISGINEK 169
Cyt_b561_CYBRD1 cd08765
Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate ...
 52-200 3.46e-23

Vertebrate cytochrome b(561), CYBRD1 gene product; Duodenal cytochrome b or ferric-chelate reductase 3, a cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. This protein is expressed at the brush border of duodenal enterocytes and may play a role in the uptake of dietary Fe(3+), facilitating its transport into the mucosal cells. It may also be involved in the recycling of extracellular ascorbate in erythrocyte membranes, and act as a ferrireductase in epithelial cells of the respiratory system. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176495  Cd Length: 153  Bit Score: 91.88  E-value: 3.46e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  52 DGFAWSESpKQQFNLHPILMIAGFVTLSGFSILIYRL---CRCVKQIyVKLIHMFFHAVAIPCIALGFISVFASHDALHK 128
Cdd:cd08765    1 EGLGWDGG-AAEFNWHPVLMVIGFIFIQGIAIIVYRLpwtWKCSKLL-MKLIHAGLHILAFILAIISVVAVFVFHNAKNI 78

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400511 129 VNFYSLHSWLGFVTMGMFVLQFVIGFFSFLVMLCcenkTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:cd08765   79 PNMYSLHSWVGLAAVILYPLQLVLGISVYLLPVA----PVRLRAALMPLHVYSGLFIFGTVIATALMGITEK 146
PLN02351 PLN02351
cytochromes b561 family protein
 45-239 3.73e-23

cytochromes b561 family protein


Pssm-ID: 215201  Cd Length: 242  Bit Score: 94.20  E-value: 3.73e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  45 FWVMFYRDGFAWSESPKQQFN---LHPILMIAGFVTLSGFSILIYRLCRCVKQiYVKLIHMFFHAVAIPCIALGFISVFA 121
Cdd:PLN02351  29 YWALFFKSSFLPQSTSQEDLVyavLHPLLMVIGFILISGEAILVHRWLPGSRK-TKKSVHLWLQGLALASGVFGIWTKFH 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511 122 SHDALHkVNFYSLHSWLGFVTMGMFVLQFVIGFFSFLvmlcCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEKE 201
Cdd:PLN02351 108 GQDGIV-ANFYSLHSWMGLICVSLFGAQWLTGFMSFW----HRGEMRTTRTTVLPWHVFLGLYTYGLAVATAETGLLEKL 182

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665400511 202 RETVNEAGVSENKlVEHYITSAIGVTLIFI-GIIVTFAV 239
Cdd:PLN02351 183 TFLQTKRNVSKHG-SESMVVNGLGLGLALLsGIVILAAV 220
Cyt_b561_CYB561 cd08763
Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, ...
 63-200 8.42e-21

Vertebrate cytochrome b(561), CYB561 gene product; Cytochrome b(561), as found in vertebrates, which might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176493  Cd Length: 143  Bit Score: 85.25  E-value: 8.42e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  63 QFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLIHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLGFVT 142
Cdd:cd08763    6 QFNVHPLCMVLGLVFLCGEALLVYRVFRNETKRSTKILHGLLHIMALVISLVGLVAVFDYHQANGYPDMYSLHSWCGILT 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665400511 143 MGMFVLQFVIGFFSFLVmlccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGLIEK 200
Cdd:cd08763   86 FVLYFLQWLIGFSFFLF----PGASFTLRSQYKPLHEFFGRALFLSSVGTSLLGLTEK 139
Cyt_b561_CYB561D2_like cd08761
Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found ...
 64-197 6.16e-13

Eukaryotic cytochrome b(561), including the CYB561D2 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human CYB561D2 gene product. CYB561D2 is a candidate tumor suppressor. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176491  Cd Length: 183  Bit Score: 65.39  E-value: 6.16e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  64 FNLHPILMIAGFVTLSGFSILIYR----LCRCVKQIYVKLiHMFFHAVAIPCIALGFISVFASHDALHKVNFYSLHSWLG 139
Cdd:cd08761   21 FSWHPLLMSLGFLLLMTEALLLLQptssLTKLARKTKVRL-HWILQLLALLCILAGLVAIYYNKERNGKPHFTSWHGILG 99

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 665400511 140 FVTMGMFVLQFVIGFFSFLVMLccENKTYSCRSAMVPIHASLGLANFWLAIATSVTGL 197
Cdd:cd08761  100 LVTVILIVLQALGGLALLYPPG--LRRGESKAKKLKKYHRLSGYVAYLLGLATLVLGL 155
Cyt_b561_FRRS1_like cd08760
Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in ...
 57-197 3.76e-08

Eukaryotic cytochrome b(561), including the FRRS1 gene product; Cytochrome b(561), as found in eukaryotes, similar to and including the human FRRS1 gene product (ferric-chelate reductase 1), also called SDR-2 (stromal cell-derived receptor 2). This family comprises a variety of domain architectures, many of which contain dopamine beta-monooxygenase (DOMON) domains. The protein might act as a ferric-chelate reductase, catalyzing the reduction of Fe(3+) to Fe(2+), such as associated with the transport of iron from the endosome to the cytoplasm. It is assumed that this protein uses ascorbate as the electron donor. Belongs to the cytochrome b(561) family, which are secretory vesicle-specific electron transport proteins. Cytochromes b(561) are integral membrane proteins that bind two heme groups non-covalently, and may have six alpha-helical trans-membrane segments.


Pssm-ID: 176490  Cd Length: 191  Bit Score: 51.96  E-value: 3.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400511  57 SESPKQQFNLHPILMIAGFVTLSGFSILIYRLCRCVKQIYVKLiHMFFHAVAIPCIALGFISVFAsHDALHKVNFYSLHS 136
Cdd:cd08760   29 VGSSDTLIKAHGVLMAIAWGILMPIGALLARYFLLGDPVWFYL-HAGLQLLAVLLAIAGFVLGIV-LVQGGGGSLNNAHA 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665400511 137 WLGFVTMGMFVLQFVIGFFsflvmlcCENKTYSCRSAMVPIHASLGLANFWLAIATSVTGL 197
Cdd:cd08760  107 ILGIIVLALAILQPLLGLL-------RPHPGSKKRSIWNWAHRWLGRAALILAIVNIFLGL 160
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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