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Conserved domains on  [gi|665400952|ref|NP_001286425|]
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tarag, isoform D [Drosophila melanogaster]

Protein Classification

MCT family MFS transporter( domain architecture ID 13023897)

monocarboxylate transporter (MCT) family major facilitator superfamily (MFS) transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 304-842 3.15e-83

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 270.96  E-value: 3.15e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVL---GGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 464 NMLRTQAGLIMLILLMVVAyvevaptqvgmyhlpgssdtssdeyygnfyvhdylrqsamtaksrsilstyeprpkkkgca 543
Cdd:cd17352  158 GALLILGGLCLNLCVCGLL------------------------------------------------------------- 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 544 kfcpscsnccwrrrkksqnadeqnllirpapleredlfytgpaeyekphskenvdgkefllmgsdkntqqvnygiknirv 623
Cdd:cd17352      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 624 ddepdrisrvhrerrwsnenqkkqnscrnsrfmltvlklfdYRLLKQFEFKILVASAFLFPMGFNIPFVYSSARTT---I 700
Cdd:cd17352  177 -----------------------------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKslgI 215

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 701 PVEYARMIGPIIGISNLVMRNILGILAYKRRSWTLGLCGCGLIFGGVSVLISAFYGEnlIWFQFLYGFSYAVAPAVYSTL 780
Cdd:cd17352  216 DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSL 293

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952 781 RGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17352  294 TPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 304-842 3.15e-83

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 270.96  E-value: 3.15e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVL---GGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 464 NMLRTQAGLIMLILLMVVAyvevaptqvgmyhlpgssdtssdeyygnfyvhdylrqsamtaksrsilstyeprpkkkgca 543
Cdd:cd17352  158 GALLILGGLCLNLCVCGLL------------------------------------------------------------- 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 544 kfcpscsnccwrrrkksqnadeqnllirpapleredlfytgpaeyekphskenvdgkefllmgsdkntqqvnygiknirv 623
Cdd:cd17352      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 624 ddepdrisrvhrerrwsnenqkkqnscrnsrfmltvlklfdYRLLKQFEFKILVASAFLFPMGFNIPFVYSSARTT---I 700
Cdd:cd17352  177 -----------------------------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKslgI 215

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 701 PVEYARMIGPIIGISNLVMRNILGILAYKRRSWTLGLCGCGLIFGGVSVLISAFYGEnlIWFQFLYGFSYAVAPAVYSTL 780
Cdd:cd17352  216 DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSL 293

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952 781 RGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17352  294 TPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
301-481 4.40e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 110.73  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 301 GGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLC 380
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPI 459
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLL----GLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180
                 ....*....|....*....|..
gi 665400952 460 IGWRNMLRTQAGLIMLILLMVV 481
Cdd:COG2271  161 FGWRAAFLILGLPGLLLALLRF 182
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 298-841 5.70e-25

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 109.06  E-value: 5.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAG 377
Cdd:TIGR00892  11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  378 VLCSAVSILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLV 457
Cdd:TIGR00892  91 GLLASLGMILASFSSNVIELYLTAGFI---TGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  458 PIIGWRNMLrtqagLIMLILLMvvayvevaptqvgmyhlpgssdtssdeyygnfyvhdylrqsamtaksrsilstyeprp 537
Cdd:TIGR00892 168 ESFGWRGSF-----LILGGLLL---------------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  538 kkkgcakfcpscsNCCwrrrkksqnadEQNLLIRPAPleredlfyTGPAEyEKPHSKEnvdgkefllmgsdkntqqvnyg 617
Cdd:TIGR00892 185 -------------HCC-----------VCGALMRPVG--------PSQRV-SKSKSKE---------------------- 209

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  618 ikNIRVDDEPDRISRVHRERrwsnenqkkqnscrnsrfmlTVLKLFDYRLLKQFEFKILVASAFLFPMGFNIPFVYSS-- 695
Cdd:TIGR00892 210 --GLPPDGSTKKLSKKSTAE--------------------KINRFLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVpy 267

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  696 -ARTTIPVEYARMIGPIIGISNLVMRNILGILAYKR--RSWTLGLCGCGLIFGGVSVLISAFYGE--NLIWFQFLYGFSY 770
Cdd:TIGR00892 268 aKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKwiRPHVQYLFSFALLFNGLTHLLCALAGDytGLVIYCIFFGLSF 347

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952  771 AVAPAV-YSTLRGLIyvkylGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSG 841
Cdd:TIGR00892 348 GSVGALlFEVLMDLV-----GAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAG 414
MFS_1 pfam07690
Major Facilitator Superfamily;
312-488 1.24e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.24  E-value: 1.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  312 FLAQLIIDGLIFTIGVLLPS-IAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSW 390
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  391 SVSLTMLIffysVLACAGGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQ 469
Cdd:pfam07690  82 ASSLWLLL----VLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170
                  ....*....|....*....
gi 665400952  470 AGLIMLILLMVVAYVEVAP 488
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPE 176
PRK03699 PRK03699
putative transporter; Provisional
 310-456 2.33e-08

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 57.24  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 310 LSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASS 389
Cdd:PRK03699  11 ISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLM 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952 390 WSVSLTMLIFFYSVLACAGGITLSMiwaSSQLIVGYYFERYRPMA-----NGFSCSGggagiVLFTFLNSWL 456
Cdd:PRK03699  91 FSHSLALFSIAMFVLGVVSGITMSI---GTFLITHVYEGKQRGSRllftdSFFSMAG-----MIFPIIAAYL 154
 
Name Accession Description Interval E-value
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 304-842 3.15e-83

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 270.96  E-value: 3.15e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17352    1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17352   81 GLLLSSFATSLWQLYLTYGVL---GGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWR 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 464 NMLRTQAGLIMLILLMVVAyvevaptqvgmyhlpgssdtssdeyygnfyvhdylrqsamtaksrsilstyeprpkkkgca 543
Cdd:cd17352  158 GALLILGGLCLNLCVCGLL------------------------------------------------------------- 176

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 544 kfcpscsnccwrrrkksqnadeqnllirpapleredlfytgpaeyekphskenvdgkefllmgsdkntqqvnygiknirv 623
Cdd:cd17352      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 624 ddepdrisrvhrerrwsnenqkkqnscrnsrfmltvlklfdYRLLKQFEFKILVASAFLFPMGFNIPFVYSSARTT---I 700
Cdd:cd17352  177 -----------------------------------------LRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKslgI 215

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 701 PVEYARMIGPIIGISNLVMRNILGILAYKRRSWTLGLCGCGLIFGGVSVLISAFYGEnlIWFQFLYGFSYAVAPAVYSTL 780
Cdd:cd17352  216 DESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIFTLLILGLSLLAFPLATT--YVGLIVFSVLFGFCSGSYSSL 293

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952 781 RGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17352  294 TPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAFYFCGACLLLSGV 355
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
301-481 4.40e-26

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 110.73  E-value: 4.40e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 301 GGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLC 380
Cdd:COG2271    5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPI 459
Cdd:COG2271   85 WGLATLLFGFATSFWQLLLLRFLL----GLGEAGFFPAALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180
                 ....*....|....*....|..
gi 665400952 460 IGWRNMLRTQAGLIMLILLMVV 481
Cdd:COG2271  161 FGWRAAFLILGLPGLLLALLRF 182
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 304-483 1.13e-25

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 110.05  E-value: 1.13e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17355    1 GWVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLACAGGITLSMIWAssQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17355   81 GLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAF--ATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWR 158

                        170       180
                 ....*....|....*....|
gi 665400952 464 NMLRTQAGLIMLILLMVVAY 483
Cdd:cd17355  159 TALLVLALLALLVLVPVLLL 178
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
305-488 4.89e-25

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 108.43  E-value: 4.89e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVS 384
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 385 ILASSWSVSLTMLIFFysvlACAGGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:COG2223   84 LLLLALAVSYWLLLLL----GLLLGIGGGGSFAVGIALVSKWFpPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWR 159

                        170       180
                 ....*....|....*....|....*
gi 665400952 464 NMLRTQAGLIMLILLMVVAYVEVAP 488
Cdd:COG2223  160 NAFLILGILLLVVAVLAWLFLRDPP 184
2A0113 TIGR00892
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ...
 298-841 5.70e-25

monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273325 [Multi-domain]  Cd Length: 455  Bit Score: 109.06  E-value: 5.70e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAG 377
Cdd:TIGR00892  11 PPDGGWGWVVLGATFVSIGFSYAFPKAVTVFFKELQQIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVIAG 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  378 VLCSAVSILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLV 457
Cdd:TIGR00892  91 GLLASLGMILASFSSNVIELYLTAGFI---TGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLF 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  458 PIIGWRNMLrtqagLIMLILLMvvayvevaptqvgmyhlpgssdtssdeyygnfyvhdylrqsamtaksrsilstyeprp 537
Cdd:TIGR00892 168 ESFGWRGSF-----LILGGLLL---------------------------------------------------------- 184

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  538 kkkgcakfcpscsNCCwrrrkksqnadEQNLLIRPAPleredlfyTGPAEyEKPHSKEnvdgkefllmgsdkntqqvnyg 617
Cdd:TIGR00892 185 -------------HCC-----------VCGALMRPVG--------PSQRV-SKSKSKE---------------------- 209

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  618 ikNIRVDDEPDRISRVHRERrwsnenqkkqnscrnsrfmlTVLKLFDYRLLKQFEFKILVASAFLFPMGFNIPFVYSS-- 695
Cdd:TIGR00892 210 --GLPPDGSTKKLSKKSTAE--------------------KINRFLDFSLFTHRGFLVYLSGNVIMFLGFFAPIIFLVpy 267

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  696 -ARTTIPVEYARMIGPIIGISNLVMRNILGILAYKR--RSWTLGLCGCGLIFGGVSVLISAFYGE--NLIWFQFLYGFSY 770
Cdd:TIGR00892 268 aKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGLKwiRPHVQYLFSFALLFNGLTHLLCALAGDytGLVIYCIFFGLSF 347

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952  771 AVAPAV-YSTLRGLIyvkylGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSG 841
Cdd:TIGR00892 348 GSVGALlFEVLMDLV-----GAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDATKNYKYIFYASGSIVVSAG 414
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
298-484 6.62e-23

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 101.20  E-value: 6.62e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 298 PPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAG 377
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 378 VLCSAVSILASSWSVSLTMLIffysVLACAGGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWL 456
Cdd:COG2814   82 LLLFALGSLLCALAPSLWLLL----AARFLQGLGAGALFPAALALIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLL 157

                        170       180
                 ....*....|....*....|....*...
gi 665400952 457 VPIIGWRNMLRTQAGLIMLILLMVVAYV 484
Cdd:COG2814  158 ADLFGWRWVFLVNAVLALLALLLLLRLL 185
MFS_1 pfam07690
Major Facilitator Superfamily;
312-488 1.24e-18

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 88.24  E-value: 1.24e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  312 FLAQLIIDGLIFTIGVLLPS-IAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSW 390
Cdd:pfam07690   2 FLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  391 SVSLTMLIffysVLACAGGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQ 469
Cdd:pfam07690  82 ASSLWLLL----VLRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157

                         170
                  ....*....|....*....
gi 665400952  470 AGLIMLILLMVVAYVEVAP 488
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPE 176
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 305-484 3.50e-17

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 82.94  E-value: 3.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIiDGLIFTI-GVLLPSIAQDLDVSISSVSFVASVqigcYFTSGAFSAVLI----NRFGFRKVAIAGVL 379
Cdd:COG0477   13 RRALLALALGTFL-EGLDFTIvNVALPSIAADLGASSAQLGWIVSA----YLLGRAIGLLLFgrlgDRYGRKRVLLIGLL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 380 CSAVSILASSWSVSLTMLIFFYSVLACAGGitlsMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVP 458
Cdd:COG0477   88 LFGLASLLCGLAPSPELLIAARALQGIGAG----GLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLLGGLLVA 163

                        170       180
                 ....*....|....*....|....*.
gi 665400952 459 IIGWRNMLrtqagLIMLILLMVVAYV 484
Cdd:COG0477  164 ALGWRWIF-----LINAPLGLLALVL 184
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 305-484 1.72e-16

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 82.27  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVS 384
Cdd:cd17353    2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 385 ILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRN 464
Cdd:cd17353   82 FILSAFAISLPLLFLGYGVL---GGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPT 158

                        170       180
                 ....*....|....*....|
gi 665400952 465 MLRTQaGLIMLILLMVVAYV 484
Cdd:cd17353  159 TFLIL-GIIFLIIIVIGAFL 177
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
304-478 1.85e-16

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 82.23  E-value: 1.85e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:COG2807   16 RWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAA 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFySVLACAgGITLSMIWASSqlIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:COG2807   96 GLLLRSLAPSVALLLAG-TALIGA-GIAVGNVLLPG--LIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWR 171

                        170
                 ....*....|....*
gi 665400952 464 NMLRTQAGLIMLILL 478
Cdd:COG2807  172 GALAVWALLALLALL 186
MFS_MCT14 cd17429
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ...
 304-472 8.53e-16

Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340987 [Multi-domain]  Cd Length: 361  Bit Score: 79.88  E-value: 8.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17429    1 AWMVVLSSFIVHILVMGSQMALGILNMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILTSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLAcagGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17429   81 GWVLSAYATNVHYLFISFGVTA---GIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAEFGWR 157


                 ....*....
gi 665400952 464 NMLRTQAGL 472
Cdd:cd17429  158 NAMFIQGAV 166
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 304-472 1.85e-15

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 79.36  E-value: 1.85e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGC-YFTSGAFSAvLINRFGFRKVAIAGVLCSA 382
Cdd:cd17423    1 GWVVVLAAFLQNALVFGVLRSFGVFFVEFVEYFEESAQRVSWITSIGLAVqQLASPVGSA-LSTRYGARPVVMLGGLLSS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 383 VSILASSWSVSLTMLiffYSVLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGW 462
Cdd:cd17423   80 LGFLLASFATSLLHL---YLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLDTYAW 156

                        170
                 ....*....|
gi 665400952 463 RNMLRTQAGL 472
Cdd:cd17423  157 RGALLLLSAL 166
MFS_MCT6 cd17425
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ...
 304-464 6.56e-15

Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340983 [Multi-domain]  Cd Length: 364  Bit Score: 77.12  E-value: 6.56e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17425    1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETSWFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLSGV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17425   81 GMVASSFSHSIVQLYFTAGFI---TGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQYLLEEMGWR 157


                 .
gi 665400952 464 N 464
Cdd:cd17425  158 G 158
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
305-484 7.18e-15

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 77.59  E-value: 7.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAqLIIDGLIFTI-GVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:COG0738    7 RRALIAIYLL-FFLWGFATALwGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLACAGGITLSmiwASSQLIVGYYFERYR---PMANGFSCSGGGAGIVLFTFLNSWLVPiI 460
Cdd:COG0738   86 GLLLFALAPSYPLLLLALFLLGLGLGLLDV---AANPYVAALGPETAAsrlNLLHAFFSLGALLGPLLGGLLILLGLS-L 161

                        170       180
                 ....*....|....*....|....
gi 665400952 461 GWRNMLRTqAGLIMLILLMVVAYV 484
Cdd:COG0738  162 SWHLPYLI-LAVLLLLLALLFLRS 184
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 307-484 1.35e-14

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 76.43  E-value: 1.35e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 307 IMVLSFLAQLIIDGLIFTIGvLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSIL 386
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQG-LLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 387 ASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNM 465
Cdd:cd17324   80 LAALAPSFALLLLARALA----GLAHGGFWAIAAAYAADLVpPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAA 155

                        170
                 ....*....|....*....
gi 665400952 466 LRTqAGLIMLILLMVVAYV 484
Cdd:cd17324  156 FLA-IAVLALLAALLLWRL 173
MFS_MCT8_10 cd17420
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ...
 304-489 1.37e-14

Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340978 [Multi-domain]  Cd Length: 400  Bit Score: 76.80  E-value: 1.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDL-----DVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGV 378
Cdd:cd17420    1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLtklgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 379 LCSAVSILASSWSVSLTMLIFFYSVLACAGGitlSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVP 458
Cdd:cd17420   81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGC---SFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLD 157

                        170       180       190
                 ....*....|....*....|....*....|.
gi 665400952 459 IIGWRNMLRTQAGLIMLILLMVVAYVEVAPT 489
Cdd:cd17420  158 SYGLEGTLRVLSLFMFVLILCSFTYRPLHPS 188
MFS_MCT7 cd17422
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ...
 304-478 1.52e-14

Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340980 [Multi-domain]  Cd Length: 363  Bit Score: 76.33  E-value: 1.52e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17422    1 GWAVAVAFFFVEVFTYGVIKSFGVFFNDLMSYFNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLISL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLiffYSVLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17422   81 GMITASFASSIVEM---YLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFAPAFTALKESIGWR 157

                        170
                 ....*....|....*
gi 665400952 464 NMLRTQAGLIMLILL 478
Cdd:cd17422  158 YCLLVVGALQLNIVV 172
MFS_MCT1 cd17426
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ...
 304-474 2.42e-14

Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340984 [Multi-domain]  Cd Length: 374  Bit Score: 75.68  E-value: 2.42e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17426    1 GWAVVLGAFISIGFSYAFPKSITVFFKEIEVIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17426   81 GLIAASFCNTVEGLYFCVGVV---GGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPVFLSTLAPLNQWFFDIFGWR 157

                        170
                 ....*....|.
gi 665400952 464 NMLRTQAGLIM 474
Cdd:cd17426  158 GSFLILGGLLL 168
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 303-501 3.23e-14

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 75.47  E-value: 3.23e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  303 FGWVIMVLSFLAqLIIDGL-IFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCS 381
Cdd:TIGR00895  14 YQWRAIILSFLI-MLMDGYdLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLF 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  382 AVSILASSWSVSLTMLIFFySVLAcagGITL-SMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPII 460
Cdd:TIGR00895  93 SVFTLLCALATNVTQLLIL-RFLA---GLGLgGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVF 168

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 665400952  461 GWRNMLRTqAGLIMLILLMVVayvevaptqvgMYHLPGSSD 501
Cdd:TIGR00895 169 GWRSLFYV-GGIAPLLLLLLL-----------MRFLPESID 197
MFS_MCT2 cd17427
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ...
 304-474 8.68e-14

Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340985 [Multi-domain]  Cd Length: 367  Bit Score: 73.69  E-value: 8.68e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17427    1 GWAVVFGAFISIGFSYAFPKAITVFFKEIQEIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLiffYSVLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17427   81 GMISASFCNSVMQL---YLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGSPVFLSTLAPLNQFLFNQFGWR 157

                        170
                 ....*....|.
gi 665400952 464 NMLRTQAGLIM 474
Cdd:cd17427  158 GSFLILGGLLL 168
MFS_MCT3_4 cd17430
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ...
 304-474 1.35e-13

Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340988 [Multi-domain]  Cd Length: 368  Bit Score: 73.22  E-value: 1.35e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFlaqlIIDGLIF----TIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVL 379
Cdd:cd17430    1 GWAVLFGCF----VITGFSYafpkAVSVFFKELMREFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 380 CSAVSILASSWSVSLTMLIFFYSVLAcagGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPI 459
Cdd:cd17430   77 LASLGMILASFCTSIIQLYLTAGVIT---GLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPVFLSALSPLGQILLEE 153

                        170
                 ....*....|....*
gi 665400952 460 IGWRNMLRTQAGLIM 474
Cdd:cd17430  154 YGWRGGFLILGGLLL 168
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
290-481 1.98e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 72.60  E-value: 1.98e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 290 MVFIYMVIPPdGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQD-LDVSISSVSFVASVQIGCYFTSGAFSAVLINRF 368
Cdd:COG2271  165 AAFLILGLPG-LLLALLRFWLLALAYFLVYFALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRL 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 369 G--FRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGyyfERYRPMANGFSCSGGGAGI 446
Cdd:COG2271  244 GrrRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFP---KKARGTASGLVNTFGFLGG 320

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 665400952 447 VLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVV 481
Cdd:COG2271  321 ALGPLLVGYLLDATGYQAAFLLLAALALLAALLAL 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 312-485 1.28e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 70.53  E-value: 1.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 312 FLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSWS 391
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 392 VSLTMLIFFYSVLACAGGItlsMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPII--GWRNMLRTQ 469
Cdd:cd06174   82 PSFWLLLLGRFLLGLGSGL---IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIA 158

                        170
                 ....*....|....*.
gi 665400952 470 AGLIMLILLMVVAYVE 485
Cdd:cd06174  159 AALALLAAILLLLVVP 174
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 307-463 2.98e-11

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 66.04  E-value: 2.98e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 307 IMVLSFLAQLiiDGLIftIGVLLPSIAQDLDVSISSVSFVASVqigcYF-TSGAFSAV---LINRFGFRKVAIAGVLCSA 382
Cdd:cd17321    1 LLLAVFLAAL--DVTI--VNVALPTIARDLGASPSQLQWVVNA----YLlAFAALLLLagrLGDRFGRKRVFLIGLALFG 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 383 VSILASSWSVSLTMLIFFYSVLACAGGITLSmiwASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGW 462
Cdd:cd17321   73 LASLLCALAPSLAFLIAARALQGIGAAAIMP---ASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW 149


                 .
gi 665400952 463 R 463
Cdd:cd17321  150 R 150
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 311-485 4.38e-11

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 65.72  E-value: 4.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 311 SFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVAS-VQIGCYFTSgAFSAVLINRFGFRKVAIAGVLCSAVSILASS 389
Cdd:cd17475    1 ATLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSaLNLGVAVSM-LPAGWLLDRFGERRVLAVGLLLMGAAALLMA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 390 WSVSLTMLIFFysvLACAGGITLSMIWASSQLIVGYYFERYRPMANGFScsggGAGIVLFTFLNSWLVPII----GWRNM 465
Cdd:cd17475   80 LVGSYPVLLVL---LFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIR----QTGVPLGGALAAALLPPLalhyGWRAA 152

                        170       180
                 ....*....|....*....|.
gi 665400952 466 LRTQAGLIMLILLMVVA-YVE 485
Cdd:cd17475  153 FVVAGLVSILAAVLFWLfYRE 173
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 304-497 7.31e-11

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 65.13  E-value: 7.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17314    1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLACAGGitlSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWr 463
Cdd:cd17314   81 GYTYLSYVFNSFPLSYACFVFIGAGT---GILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFYGL- 156

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665400952 464 nmlrtqaGLIMLILLMVVAYVEVAPTQVGMYHLP 497
Cdd:cd17314  157 -------ALVYTILGILAAIVLSVVSLLGFKEPP 183
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 309-482 2.88e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 62.99  E-value: 2.88e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 309 VLSFLAqLIIDGL-IFTIGVLLPSIAQDLDVSISSVSFVASVQ-IGcyFTSGA-FSAVLINRFGFRKVAIAGVLCSAVSI 385
Cdd:cd17365    2 ALCFLI-IVLDGFdLAVMGFVAPALAQDWGLSPAQLGPVGSAAlFG--MAIGAlLAGPLADRFGRKRVLLVSVALFGLFT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSWSVSLTMLIFFySVLACAGgitLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRN 464
Cdd:cd17365   79 LLTAFAQSVLQLALL-RFLTGLG---LGAAMPNAITLVSEYApARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154

                        170
                 ....*....|....*...
gi 665400952 465 MLRTQAGLIMLILLMVVA 482
Cdd:cd17365  155 VFLLGGVPPLILLPLLRG 172
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 304-461 4.21e-10

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 62.53  E-value: 4.21e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17428    1 GWVIVFVSFLAQFLCYGSPLAVGVLYPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVAG 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400952 384 SILASSWSVSLTMLIFFYSVLAcagGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIG 461
Cdd:cd17428   81 GLMLSAFAPNIYFLIFSYGIVV---GLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIELYG 155
MFS_MCT10 cd17464
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ...
 304-488 1.26e-09

Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341022 [Multi-domain]  Cd Length: 395  Bit Score: 60.96  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSI-----AQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGV 378
Cdd:cd17464    1 GWVVMLAAMWCNGSVFGIQNAFGVLFVSLleefgSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 379 LCSAVSILASSWSVSLTMLIFFYSVLACAGgitLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVP 458
Cdd:cd17464   81 AVGFVGLLASSFVSSIEPLYFTYGIIFACG---CSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLRVLLD 157

                        170       180       190
                 ....*....|....*....|....*....|
gi 665400952 459 IIGWRNMLRTQAGLIMLILLMVVAYVEVAP 488
Cdd:cd17464  158 SVGLFNTLRVLCIFMFVLFLAGFTYKPLVP 187
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
303-448 2.67e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 59.99  E-value: 2.67e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 303 FGWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQD-LDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCS 381
Cdd:COG2814  204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLL 283

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665400952 382 AVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWAssqLIVGYYFERYRPMANGFSCSGGGAGIVL 448
Cdd:COG2814  284 ALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQA---LVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 316-485 4.00e-09

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 59.51  E-value: 4.00e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 316 LIIDGLIFTIGV-LLPSIAQDLDVSISSVSFVasvqIGCYFTSGA----FSAVLINRFGFRKVAIAGVLCSAVSILASSW 390
Cdd:cd17325    5 LFLDMLGYGIIIpILPLYAESLGASVAQIGLI----VAAYALAQLlfspPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 391 SVSLTMLIffysVLACAGGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQ 469
Cdd:cd17325   81 ATSYWQLL----LARFLQGLASAAVWPAAMALIADIApPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156

                        170
                 ....*....|....*.
gi 665400952 470 AGLIMLILLMVVAYVE 485
Cdd:cd17325  157 AALALLALVLALLLLP 172
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 290-484 4.21e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 59.15  E-value: 4.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 290 MVFIYMVIPPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLLPSI-AQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRF 368
Cdd:cd17316  161 LFLIGALPALLALLLRRRTLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI 240

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 369 GFRKVAIAGVLCSAVS--ILASSWSVSLTMLIFFYSVLAcaggITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAG 445
Cdd:cd17316  241 GRKKTLVIGLILSGILalPLFYLLSGSPTLLLLLLFILS----FFVGGVWGALYAYLAELFpTEVRATGVGLSYNLGRLG 316

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 665400952 446 IVLFTFLNSWLVPiigwrNMLRTQAGLIMLILLMVVAYV 484
Cdd:cd17316  317 GGGAPPLIALLLA-----STGGTGVPALILALLAIVALI 350
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 305-484 4.70e-09

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 59.12  E-value: 4.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLI--IDGLifTIGVLLPSIAQDLDVSISSVSFVASV-QIGcYFTSGAFSAVLINRFGFRKV-AIAGVLC 380
Cdd:cd17319    2 WRIIPLLFLAYVInyLDRV--NISVAAPTIMKDLGLSPTQYGLIASAfFLG-YALFQVPGGWLLDRFGARKVlAVSMLLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILaSSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPI 459
Cdd:cd17319   79 SLFTAL-TGFATSLTSLYVLRFLL----GVAEAGFFPGAIKALAEWFpARERGRATGLFNSGAPLGAAIGPPLSGWLLLL 153

                        170       180
                 ....*....|....*....|....*
gi 665400952 460 IGWRNMLRTQAGLIMLILLMVVAYV 484
Cdd:cd17319  154 FGWRWAFIIEGLLGLLLAVLWWFYL 178
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 308-484 6.69e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.77  E-value: 6.69e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 308 MVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISS--VSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSI 385
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLlqTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVG-YYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPII---- 460
Cdd:cd17316   81 LLIGLLPTPILLLVLRFLQ----GIGIGGEYPGASTYVAeFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLsgdw 156

                        170       180
                 ....*....|....*....|....
gi 665400952 461 GWRNMLrtqagLIMLILLMVVAYV 484
Cdd:cd17316  157 GWRILF-----LIGALPALLALLL 175
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 305-484 1.02e-08

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 58.35  E-value: 1.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIdGLIFTIgvlLPSIAQDLDVSISSVSFVasvqIGCYFTSGAFSA----VLINRFGFRKVAIAGVLC 380
Cdd:cd17474    2 YAVFFATLLAVLGV-SIVDPI---LPAIAEALGASPAQVGLL----ITAFTLPAAVLMpvagVLADRFGRKKVLLPGLLL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSV--LACAGGITLSMIwassqLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVp 458
Cdd:cd17474   74 FGIGGLLCGLSDSFALLLAGRALqgIGAAGLGPLALT-----LIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA- 147

                        170       180
                 ....*....|....*....|....*.
gi 665400952 459 IIGWRnmlrtqAGLIMLILLMVVAYV 484
Cdd:cd17474  148 AISWR------YPFFLLAALIPVAFL 167
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 305-483 1.08e-08

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 57.97  E-value: 1.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIDglIFTIGvlLPSIAQDLDVSISSVSFVasvqIGCYFTSGAFSAVLI----NRFGFRKVAIAGVLC 380
Cdd:cd17320    2 LLLALLVALGPLAID--MYLPA--LPAIARDLGASASAVQLT----LSAYLLGFALGQLLYgplsDRFGRRPVLLAGLLL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSVLACAGGITLSMiwasSQLIVGYYFERyRPMANGFSCSGGGAGI--VLFTFLNSWLVP 458
Cdd:cd17320   74 FILASLLCALASSIEQLLIARFLQGLGAAAGSVV----ARAIVRDLYSG-AELAKIFSLLMMILAIapALAPLLGGLLLL 148

                        170       180
                 ....*....|....*....|....*
gi 665400952 459 IIGWRNMLRTQAGLIMLILLMVVAY 483
Cdd:cd17320  149 FFGWRAIFVFLALLGLLLLLLVLLF 173
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 310-481 1.09e-08

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 58.10  E-value: 1.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 310 LSFLAQLIIDGLIftiGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLC--SAVSILA 387
Cdd:cd17333    3 ISFFSNGLTDALL---GILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLisLALALIF 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 388 SSWsvSLTMLIFFYSVLACAGGITLSMIWAssqlIVGYYFERYRP----MANGFSCSGGGAGIVLFTFL----NSWLVPI 459
Cdd:cd17333   80 ATP--SIYLFVVLMFLAGLGAGILDTGANT----FVGALFEESSAtrlnVLHGFFGLGALIGPLIATSLltseLSWSWAY 153

                        170       180
                 ....*....|....*....|..
gi 665400952 460 IGwrnmlrtqAGLIMLILLMVV 481
Cdd:cd17333  154 LI--------IGLIYLLLAILI 167
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 307-484 1.27e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 57.97  E-value: 1.27e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 307 IMVLSFLAQLIIdglifTI-GVLLPSIAQDLDVSISSVSFVASVqigcYFTSGA----FSAVLINRFGFRKVAIAGVLCS 381
Cdd:cd17503    1 LLLGAFMAILDT-----TIvNVALPTIMGDLGASLDTVQWVITS----YLLALAimipLSGWLADRFGTRRLFLTALALF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 382 AVSILASSWSVSLTMLIFFYSVLACAGGITLSMiwaSSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIG 461
Cdd:cd17503   72 TLGSLLCGLAPNLASLIIFRILQGFGGGVLIPL---AQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS 148

                        170       180
                 ....*....|....*....|...
gi 665400952 462 WRnmlrtqagLIMLILLMVVAYV 484
Cdd:cd17503  149 WR--------WIFYINLPIGILA 163
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 305-484 1.70e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 57.59  E-value: 1.70e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIdGLIFTIgvlLPSIAQDL-DVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17325  202 LALFLAIFVLAFAF-GALEPF---LPLYAAELgGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGW 462
Cdd:cd17325  278 ALLLLPLATSFWLLLLLLALL----GLGLGLVFPATLALLADIVpPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353

                        170       180
                 ....*....|....*....|..
gi 665400952 463 RNMLRTQAGLIMLILLMVVAYV 484
Cdd:cd17325  354 ATPFLAAAALLLLAAVLFLLLR 375
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 305-484 1.85e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.44  E-value: 1.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIDGLIFTIGVLLpsiAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRK-VAIAGVLCSAV 383
Cdd:cd06174  206 WLLLLAIFLVNLAYYSFSTLLPLFL---LDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMAL 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGyyfERYRPMANGF-SCSGGGAGIVLFTFLNSWLVPIIGW 462
Cdd:cd06174  283 GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP---PEIRGTAFGLlNTFGFLGGAIGPLLAGFLLAATFGL 359

                        170       180
                 ....*....|....*....|..
gi 665400952 463 RNMlrtqagLIMLILLMVVAYV 484
Cdd:cd06174  360 TGA------FLVLAVLLLLAAI 375
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 303-482 2.09e-08

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 57.26  E-value: 2.09e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 303 FGWVIMVLSFLAQLIIdgliftiGVLLPSIAQDLDVSISSVSFVASVQIGcyftSGAFSAV----LINRFGFRKVAIAGV 378
Cdd:cd17341    3 LSWLSFFLGFMVWFLF-------APLGPVIRDDLGLSTSQIGLLVAIPVL----AGALLRLpygfLCDRFGGRRVFIASL 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 379 LCSAVSILASSWSV-SLTMLIFFYSVLACAGGitlsmIWASSQLIVGYYFERYRP-MANGFSCSGGGAGIVLFTFLNSWL 456
Cdd:cd17341   72 LLLLIPLLALALAVsSYWGLLVLGFLLGFAGA-----NFASGQPWASFWFPKEKIgGAAGGIAGAGNMGVAVSQLLAPLI 146

                        170       180       190
                 ....*....|....*....|....*....|...
gi 665400952 457 V-------PIIGWRNmlrtqAGLIMLILLMVVA 482
Cdd:cd17341  147 AgaivfdgGFVGWRN-----AFFVPGILLAIAA 174
PRK03699 PRK03699
putative transporter; Provisional
 310-456 2.33e-08

putative transporter; Provisional


Pssm-ID: 235151 [Multi-domain]  Cd Length: 394  Bit Score: 57.24  E-value: 2.33e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 310 LSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASS 389
Cdd:PRK03699  11 ISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSMSNTFTFLNAGILISIFLNAWLMEIIPLKRQLIFGFALMILAVAGLM 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665400952 390 WSVSLTMLIFFYSVLACAGGITLSMiwaSSQLIVGYYFERYRPMA-----NGFSCSGggagiVLFTFLNSWL 456
Cdd:PRK03699  91 FSHSLALFSIAMFVLGVVSGITMSI---GTFLITHVYEGKQRGSRllftdSFFSMAG-----MIFPIIAAYL 154
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 329-480 3.24e-08

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 56.43  E-value: 3.24e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 329 LPSIAQDLDVSISSVSFVASVqigcYFTSGAFSAVLINR----FGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVL 404
Cdd:cd17504   19 LPTIQREFGTSAAAVSWVLTA----YLLVGAVSTPILGRlgdlYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQ 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 405 ACAGGIT-LSMIwassqlIVGYYFERYR-PMANGF--SCSGGGAGIVLFtfLNSWLVPIIGWRNMLRTQAGLIMLILLMV 480
Cdd:cd17504   95 GIGGAVFpLAFA------LVREEFPPERvPVAQGIlsATFGIGAGIGLP--LGGWIVQHLGWRWIFWTAAPVAVLLAALV 166
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 290-482 4.30e-08

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 56.04  E-value: 4.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 290 MVFIYMVIPpdgGFGWVIMVLSF--------LAQLIIDGLIFTIGVLLPSI-AQDLDVSISSVSFVASVQIGCYFTSGAF 360
Cdd:cd17319  158 WAFIIEGLL---GLLLAVLWWFYlrqvwglaLGYFGINYALYGLLTWLPTYlKQARGFSLKQVGLLAAIPFLAGAIGMIL 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 361 SAVLINRFGF---RKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGyyfERYRPMANGF 437
Cdd:cd17319  235 GGRLSDRLLRgarRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLP---GEAAATAGGL 311

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 665400952 438 SCSGGGAGIVLFTFLNSWLVPIIGwrnmlRTQAGLIMLILLMVVA 482
Cdd:cd17319  312 INSGGNLGGFVAPLLIGYLVDATG-----SYTAAFLFLAAVALLA 351
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 323-491 5.13e-08

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 55.77  E-value: 5.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 323 FTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYS 402
Cdd:cd06180   16 FAYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLALRF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 403 VLACAGGITLSMIwasSQLIVGYYFERYRPMANGFSCSGGGAGIvlftFLNSWLVPII-----GWRNMLRTQAGL--IML 475
Cdd:cd06180   96 LAGAASAFVFVFG---SNLVLHHATAAGRGHLIGLLFAGVGLGI----ALSGLLVPAGlggglSWRAGWLALALLsaVLL 168

                        170
                 ....*....|....*..
gi 665400952 476 ILLMVVAY-VEVAPTQV 491
Cdd:cd06180  169 LLSFLLLRrGPSAPTEA 185
MFS_MCT9 cd17428
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ...
 666-842 1.82e-07

Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340986 [Multi-domain]  Cd Length: 361  Bit Score: 54.05  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 666 RLLKQFEFKILVASAFLFPMGFNIP--FVYSSARTT--IPVEYARMIGPIIGISNLVMRNILGILAYKRRSWTLGLCGCG 741
Cdd:cd17428  178 RLFKNRVFSALFIAILLFDIGAFPPslLMEDVARSEniIEEIALIPLVSIIGITTAIGKLILGVLADFKWVNSLYLYVLT 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 742 LIFGGVSVLisafygenLIWFQFLYgFSYAVAPAVYSTLRG------LIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTI 815
Cdd:cd17428  258 LIGMGAALL--------AIPFAKSY-LTLAVLSAILGFLSGnwsifpYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPI 328

                        170       180
                 ....*....|....*....|....*..
gi 665400952 816 AGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17428  329 VGWFYDWTQTYDIAFYFSGFCVLLGGF 355
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 305-476 2.84e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 53.43  E-value: 2.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCY----FTSGAFSavliNRFGFRKVAIAGVLC 380
Cdd:cd17312    2 WRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYavgkFISGFLS----DRSNIRRFMSAGLLL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLtmliFFYSVLACAGGITLSMIWASSQLIVGYYFERY-RPMANGFSCSGGGAGIVLFTFLNSWLVPI 459
Cdd:cd17312   78 SALANIFMGFSTSL----WFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKeRGTVYGIWSTSHNFGGILAPILAASLASY 153

                        170
                 ....*....|....*..
gi 665400952 460 IGWRNMLRTqAGLIMLI 476
Cdd:cd17312  154 YGWRAAFLV-PGIVGLV 169
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 305-484 8.10e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.21  E-value: 8.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIdgliFTIGVLLPSIAQDLdvSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVS 384
Cdd:cd17489  197 LPPALILFLASIAY----GAISTFLPLYAAER--GISNAGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALG 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 385 ILASSWSVSLTMLIFFYSVLACAGGITLSMIWAssqLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRN 464
Cdd:cd17489  271 LLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQA---LAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRA 347

                        170       180
                 ....*....|....*....|
gi 665400952 465 MLRTQAGLIMLILLMVVAYV 484
Cdd:cd17489  348 MFLLAAVVVLLALVLYIFLL 367
MFS_MCT8 cd17465
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ...
 304-483 1.66e-06

Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341023 [Multi-domain]  Cd Length: 367  Bit Score: 51.34  E-value: 1.66e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISS-----VSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGV 378
Cdd:cd17465    1 GWVVVFAATWCNGSIFGIQNSFGILYVMLLNEQEDQKDQavqfkTAWVGALAMGMIFFCSPVVSIFTDRFGCRKTAMGGA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 379 LCSAVSILASSWSVSLTMLIFFYSVLACAGGitlSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVP 458
Cdd:cd17465   81 AVAFIGLLSSSFTKSLGLRYFTYGILFGCGS---SFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLKMVGD 157

                        170       180
                 ....*....|....*....|....*
gi 665400952 459 IIGWRNMLRTQAGLIMLILLMVVAY 483
Cdd:cd17465  158 AIGLAHTFQVLSLFMFIQIFLSLTY 182
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 304-463 3.30e-06

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 50.26  E-value: 3.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIdgliFTIGVLLPSIAQD-LDVSISSVSFVASV-QIGCYFTSGaFSAVLINRFGFRKVAIAGVLCS 381
Cdd:cd17473    1 LITLLLASTLTVMAG----AAIAPALPAIAQHfVPNSELLVPLLLTLpALFIALFAP-LAGWLADRFGRKRLLIAGLLLY 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 382 AVSILASSWSVSLTMLIFFYSVLacagGITLSMIWASSQLIVGYYF---ERYRPMANGFSCSGGGAgiVLFTFLNSWLVP 458
Cdd:cd17473   76 GIGGVAGLFLDSLYALLASRALL----GIGVAGIMTLATALIGDYFegeERAKMLGLQSAAMSLGG--VVFLLLGGALAE 149


                 ....*
gi 665400952 459 iIGWR 463
Cdd:cd17473  150 -IGWR 153
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
305-417 4.93e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 49.90  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIidGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVS 384
Cdd:COG2211  230 FLLLLLAYLLFFL--ALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665400952 385 ILASSWSV--SLTMLIFFYSVLACAGGITLSMIWA 417
Cdd:COG2211  308 LLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWA 342
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 304-478 6.17e-06

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 49.44  E-value: 6.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17421    1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEFGGSSEQISWIGSIMSSLRLSAGPLASVACGRLGERWTSILGAFLVSA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTmliFFYSVLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFlNSWLVPIIGWR 463
Cdd:cd17421   81 GFLISIFATSVP---FLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSGMGLTFALAPF-TQLLLDEYDWQ 156

                        170
                 ....*....|....*
gi 665400952 464 NMLRTQAGlIMLILL 478
Cdd:cd17421  157 GALLIFGG-IMLNLV 170
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
290-482 6.79e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 49.49  E-value: 6.79e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 290 MVFIYMvippdGGFGWVIMVLSFLAQLIIDGLIFTIGVLLpSIAqdldvsiSSVSFVASVqigcyftSGAFSAVLINRFG 369
Cdd:COG2223  210 LSLLYF-----GTFGSFIGFSSWLPPYLVDQFGLSAATAG-LLA-------ALFALLGAL-------GRPLGGWLSDRIG 269

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 370 FRKVAIAGVLCSAVSILASSWSV-SLTMLIFFYSVLACAGGITLSMIWAssqLIVGYYFERYRPMANGFSCSGGGAGIVL 448
Cdd:COG2223  270 GRRVLLIVFALMALGLLLLALALgSLWLFLVLFLLLGLALGGGNGAVFA---LVPDIFPTKNAGAVYGLVGAAGGLGGFL 346

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665400952 449 FTFLNSWLVPIIGWRnmlrtQAGLIMLILLMVVA 482
Cdd:COG2223  347 GPLLFGALLDATGSY-----TAAFLVFAVLALVA 375
MFS_1 pfam07690
Major Facilitator Superfamily;
308-450 8.00e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 48.95  E-value: 8.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  308 MVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILA 387
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665400952  388 SSWSVSLTMLIFFYSVLACAgGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFT 450
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALLLL-GFGFGLVFPALNALVSDLApKEERGTASGLYNTAGSLGGALGP 344
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 675-840 1.04e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.74  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 675 ILVASAFLFpMGFNIPFvyssarTTIPVeYARMIGP---IIG-------ISNLVMRNILG-ILAYKRRSWTLGlcgCGLI 743
Cdd:cd17489    1 ILLANFFFF-LSFYLLL------PVLPL-YAHDLGGseaVAGlvvglftLAALLARPFAGrLLDRFGRKRLLL---IGLL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 744 FGGVSVLISAFyGENLIWFQ---FLYGFSYAVAPAVYSTlrglIYVKYLGLSKLTNAFGITSLAMGMGAFIGtTIAGKLI 820
Cdd:cd17489   70 IFALATLLYLL-ATSVALLLvlrLIHGIGWGAFTTAAAT----LVADIIPPSRRGEGIGYYGLATTLAMALG-PALGLFL 143

                        170       180
                 ....*....|....*....|
gi 665400952 821 GITGNYSAAFCFAGLCLIVS 840
Cdd:cd17489  144 YQHLGFAVLFIVAAVLALLA 163
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 306-465 1.16e-05

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 48.91  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  306 VIMVLSFLAqlIIDGLIftIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSI 385
Cdd:TIGR00711   6 VLMLGTFMA--VLDSTI--VNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  386 LASSWSVSLTMLIFFYSVLACAGGItlsMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNM 465
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGP---LIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWI 158
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 306-497 2.67e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 47.62  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 306 VIMVLSFLAQLIidGLIFTiGVLLPSIAQDLDVSISSVsFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSI 385
Cdd:cd06179    1 AALCLAYFAQLF--GVTLP-AAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGS 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGyyfeRYRPMANGfscsgggaGIVLFTFLNSWLVPII----- 460
Cdd:cd06179   77 IVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVPN----KYRGLVQG--------VVNLVASPGSALGPLIagalv 144

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 665400952 461 -----GWRNMLRTQAGL--IMLILLMVVayvevaptqvgmYHLP 497
Cdd:cd06179  145 eanaaGWRWIFYINAIFnaLALILLFFF------------YHPP 176
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 680-842 5.75e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.42  E-value: 5.75e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 680 AFLFPMGFNIPFVYSSARTTIPVEYARMIGP----------IIGISNLVMRNILGILAYK--RRSW-TLGLCGCGLIFGG 746
Cdd:cd17325  202 LALFLAIFVLAFAFGALEPFLPLYAAELGGLspaqigllfgAQGLASALSQPPAGKLSDRigRKPLiLIGLLLSAVALLL 281

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 747 VSVLISAFYgenLIWFQFLYGFSYAVAPAVYSTLRGLIYVKylglSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGnY 826
Cdd:cd17325  282 LPLATSFWL---LLLLLALLGLGLGLVFPATLALLADIVPP----EGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-F 353

                        170
                 ....*....|....*.
gi 665400952 827 SAAFCFAGLCLIVSGF 842
Cdd:cd17325  354 ATPFLAAAALLLLAAV 369
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 317-488 6.54e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 46.14  E-value: 6.54e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 317 IIDGLIFtiGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSWSVSLTM 396
Cdd:cd17371   12 GFDLLLL--GLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQ 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 397 LIFFYSVLacagGITLSMIWASSQLIVGYYF-ERYRPMANGFSCSGGGAGIVLFTFLNSWLVPI----IGWRNMLRTqAG 471
Cdd:cd17371   90 LLILRALA----GLGFGGEWAAGAALMAEYVpARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLL-GA 164

                        170
                 ....*....|....*..
gi 665400952 472 LIMLILLMVVAYVEVAP 488
Cdd:cd17371  165 LPALLVLFIRRFVKEPP 181
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 729-842 6.99e-05

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 46.02  E-value: 6.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 729 KRRSWtlgLCGCGLIFGGVSVLISAFyGENL----IWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLskltnAFGITSLA 804
Cdd:cd17319  245 GARRL---VIIIGLLLAAVGLLLAYL-TTSPvvavILLSLAGFGIGAASPVFWSLPADLLPGEAAAT-----AGGLINSG 315

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665400952 805 MGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17319  316 GNLGGFVAPLLIGYLVDATGSYTAAFLFLAAVALLAAL 353
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
675-842 8.85e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.64  E-value: 8.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 675 ILVASAFLFPMGFNIPFVYSSARTTIPVEY---ARMIGPIIGISNLV---MRNILGILA--YKRRSWTLGlcgcGLIFGG 746
Cdd:COG2223    6 VLLLATLAFFLAFGVWYLWSVLAPPLAEEFglsAAQLGLLFAIPVLVgalLRIPLGFLVdrFGPRRVLLI----GLLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 747 VSVLISAF---YGEnLIWFQFLYGF----SYAVAPAVYST-----LRGLiyvkylglskltnAFGITSLAMGMGAFIGTT 814
Cdd:COG2223   82 IGLLLLALavsYWL-LLLLGLLLGIggggSFAVGIALVSKwfppdRRGL-------------ALGLAAGGGNLGAAVAAF 147

                        170       180
                 ....*....|....*....|....*...
gi 665400952 815 IAGKLIGITGnYSAAFCFAGLCLIVSGF 842
Cdd:COG2223  148 LAPLLIAAFG-WRNAFLILGILLLVVAV 174
MFS_MCT5 cd17421
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ...
 659-840 1.20e-04

Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340979 [Multi-domain]  Cd Length: 369  Bit Score: 45.20  E-value: 1.20e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 659 VLKLFDYRLLKQFEFKILVASAFLFPMGFNIPFVYSSARTT---IPVEYARMIGPIIGISNLVMRNILGILAYKRRSWTL 735
Cdd:cd17421  175 LLRPIDFSLLKDPFFCIYTWSFVFSQLAYFIPYFHLVARARtlgIDPMDASFIISVAGITETVAQLASGWIADQNWIKKY 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 736 GLCGCGLIFGGVSVLISAFygenLIWFQFL--YGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGT 813
Cdd:cd17421  255 HYHKAYLILCGVTNLLAPL----ATTYPLLmtYAVFFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFFAGIGCLTGP 330

                        170       180
                 ....*....|....*....|....*..
gi 665400952 814 TIAGKLIGITGNYSAAFCFAGLCLIVS 840
Cdd:cd17421  331 PLAGWLYDYTQTYDCSFYLAGGCYLLS 357
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
303-484 1.24e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.23  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 303 FGWVIMVLSFLAQliidgliFTIGVLLPSIAQD-LDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKV----AIAG 377
Cdd:COG0738  214 LGGLAIFLYVGAE-------GAIGDWLPLYLKDvLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLlrlsALLA 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 378 VLCSAVSILASSWSVSLTMLIFFysvlacagGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLV 457
Cdd:COG0738  287 AVGLLLALLAPGPWLALIGLALV--------GLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLA 358

                        170       180
                 ....*....|....*....|....*..
gi 665400952 458 PIIGWRNMLrtqagLIMLILLMVVAYV 484
Cdd:COG0738  359 DAFGLRAAF-----LVPLVCYLLILLL 380
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 266-478 1.40e-04

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 45.27  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 266 FDMESKNSKESFDFSRGGRRLGSGMVFIYMVIPPDGGFGWvIMVLSFLAQLIID--------GLIFTIGVllpsiaqdld 337
Cdd:cd17335  175 FPFRPKHPEPNENTGGLLALLRNPRVLAFLLVAFLMGFGH-GLIYSFLFWHLQDlggsktliGLLWTVGV---------- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 338 vsISSVSFvasvqigcYFtsgaFSAVLINRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFySVLAcagGITLSMIW- 416
Cdd:cd17335  244 --VSEIPF--------FF----FSSRLIQRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPI-ELLH---GLTFALVWa 305

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665400952 417 ASSQLIVGYYFERYRPMANG-FSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILL 478
Cdd:cd17335  306 AAVSYASAAAPPGLRATAQGlLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRFFAIAALAGLL 368
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 666-840 2.24e-04

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 44.42  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 666 RLLKQFEFKILVASAFLFPMGFNIPFVY---SSARTTIPVEYARMIGPIIGISNLVMRNILGILAYKRRSWTLGLCgCGL 742
Cdd:cd17424  178 RFLLMPDFLVLAVSVLFLAYGCSPPFVYlvpYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDRRCLKKYRYF-CYL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 743 IFGGVSVLISAFYgENLIWFQFL--YGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLI 820
Cdd:cd17424  257 FAVGMDGLCCLFL-PILKTFPLLvpFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLV 335

                        170       180
                 ....*....|....*....|
gi 665400952 821 GITGNYSAAFCFAGLCLIVS 840
Cdd:cd17424  336 DTTGTYTAAFLLSGFSMIFS 355
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
675-839 2.92e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 675 ILVASAFLFPMGFnipFVYSSARTTIPVEY---ARMIGPIIGISNLVMrnILGILAYKRRSWTLG----LCGCGLIFGgV 747
Cdd:COG2814   14 ALALGAFLSGLGI---GIVLPALPLIAADLgasPAQAGLVVTAYLLGA--ALGAPLAGRLADRFGrrrvLLLGLLLFA-L 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 748 SVLISAF---YGEnLIWFQFLYGFSYAVA-PAVYSTLRGLIyvkylGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGIT 823
Cdd:COG2814   88 GSLLCALapsLWL-LLAARFLQGLGAGALfPAALALIADLV-----PPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161

                        170
                 ....*....|....*.
gi 665400952 824 GNYSAAFCFAGLCLIV 839
Cdd:COG2814  162 GWRWVFLVNAVLALLA 177
MFS_MCT12 cd17424
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ...
 304-474 5.04e-04

Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340982 [Multi-domain]  Cd Length: 363  Bit Score: 43.26  E-value: 5.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 304 GWVIMVLSFLAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAV 383
Cdd:cd17424    1 GWMIVAGCFLVTVCTRAVTRCISIFFVEFQNYFAQDYARTAWIHSIVDCTTMLCAPLGSLISNHLSCQVGIILGGLLAST 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILASSWSVSLTMLiffYSVLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWR 463
Cdd:cd17424   81 GLILSSFATSLEYL---YLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILAPVVQLLIEQFSWR 157

                        170
                 ....*....|.
gi 665400952 464 NMLRTQAGLIM 474
Cdd:cd17424  158 GALLILGGFVL 168
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 305-409 5.25e-04

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 43.34  E-value: 5.25e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQliidGLIFTIgvlLPSIAQDLdVSISSVSFVASVQIGCYFTSGAFSAVLI----NRFGFRKVAIAGVLC 380
Cdd:cd17330    2 FLVVFLDALGF----GIVFPV---LPFYVREF-NKLGASGYYVGLLQSSYSLGQFLASPLWgrlsDRYGRKPVLLLSLAG 73

                         90       100
                 ....*....|....*....|....*....
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSVLACAGG 409
Cdd:cd17330   74 SAVSYVLLGLSRNLWLLFLARFLDGLTGG 102
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 673-840 6.80e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.92  E-value: 6.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 673 FKILVASAFLFPMG-FNIPF-VYSSARTTIPVEYARMIGPIIGISNLVMRNILGILAYKR-RSWTLGLcgcGLIFGGVSV 749
Cdd:cd17370  202 FWLYLLAVALFALGnFSFAFlILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIgRKKLLIL---GYLSLALAY 278

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 750 LISAFyGENLIWFQFLYGFsYAVAPAVYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLIGITGnYSAA 829
Cdd:cd17370  279 LGFAL-GSSLWLLLLGFIL-WGLYMGAQESIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDLIS-PSAA 355

                        170
                 ....*....|.
gi 665400952 830 FCFAGLCLIVS 840
Cdd:cd17370  356 FLFSAVLALIA 366
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 320-399 6.80e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 42.95  E-value: 6.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 320 GLIF-----TIGVLLPSIAQDLDVSISSV---SFVASVQIGCyFTSGAFSAVLINRFGFRKV-AIAGVLcSAVSILASSW 390
Cdd:cd17315    6 GLLFgydlgVINGALLYIAKDLGFGLSTSlqgLVVSSLLLGA-AIGSLFGGPLADRFGRRKSlLIAAVL-YVIGALLSAL 83


                 ....*....
gi 665400952 391 SVSLTMLIF 399
Cdd:cd17315   84 APNVWVLIV 92
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 722-842 7.48e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.60  E-value: 7.48e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 722 ILGILA--YKRRsWTLGLCGCGLIFGGVSVLISAFYGENLIWFQFLYGFSYAVAPAVYSTLRGLIYVKYLGLSKLTNAFG 799
Cdd:cd06173   53 FAGVLAdrFDRR-RLLILADLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANA 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 665400952 800 ITSLAMGMGAFIGTTIAGKLIGITGNySAAFCFAGLCLIVSGF 842
Cdd:cd06173  132 LNSLATQLARIIGPALGGLLVALLGP-GGAFAINALSFLLSAL 173
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 313-484 8.94e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 8.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 313 LAQLIIDGLIFTIGVLLPSIAQDLDVSISSVSFVASVqigcyftSGAFSAVL-------INRFGFRKVAIAGVLCSAVSI 385
Cdd:cd17478    3 LGHFLNDFYQGFLPALLPLLIAKLGLSYAQAGLLVSV-------FSITSSLLqplfgylADRKPRRYLLPLGPLLTGLGL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSWSVSLTMLIFfysvLACAGGITLSMIWASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNM 465
Cdd:cd17478   76 SLLGFAPNYWLLLL----LVALAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGL 151

                        170
                 ....*....|....*....
gi 665400952 466 LrtqagLIMLILLMVVAYV 484
Cdd:cd17478  152 L-----ILLIIPGLAVALL 165
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 681-842 1.10e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 42.21  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 681 FLFPMGFNIPFVYSSARTTIpvEYARMIGPII---GISNLVMRNILGILAYKRRSWTLgLCGCGLIFGGVSVLISAFY-- 755
Cdd:cd17490    8 FWFSQYVYVPFLSPYAESLG--ASLSMIGIILgayGISQMLLRIPLGILSDRIGKRKL-FIIIGLLFTVLASLIMILFps 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 756 GENLIWFQFLYGFSYA--VAPAVYstlrgliYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGkLIGITGNYSAAFCFA 833
Cdd:cd17490   85 PWGLLIARFLSGIAAAtwVSFTVL-------YASYFPPDEAAKAMGLINLVNNLGQLIAFLIGG-LIAEHFGMRAPFLLA 156


                 ....*....
gi 665400952 834 gLCLIVSGF 842
Cdd:cd17490  157 -ALAGVLGF 164
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 307-489 1.10e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 42.16  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 307 IMVLSFLAQLIIdGLIFTigvLLPSIAQDLDVSISSVSFVASVQ-----IGCYFTSGafsavLINRFGFRKVAIAGVLCS 381
Cdd:cd17477    1 LLLSVALLGLGS-GLLLP---LLSLRLEREGVSTALIGLVASAYylgilLGSPLVPR-----LIRRVGHIRAFAAGAAIT 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 382 AVSILASswsvSLTMLIFFYSVLACAGGITLSMIWASSQ-LIVGYYFERYRPMANG----FSCSGGGAGIVLFTFL--NS 454
Cdd:cd17477   72 AVSVLLL----ALTDSPWVWFLLRFVMGIGLAGLFVVSEsWLNALATNENRGRVLGlystVLGLGFALGPLLLALVgtAG 147

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 665400952 455 WLVPIIGwrnmlrtqAGLIMLILLMVVAYVEVAPT 489
Cdd:cd17477  148 ALPFLIA--------AVLLLLALVPLLLTRRAAPE 174
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 311-465 1.62e-03

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 41.99  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 311 SFLAQLI---IDGLIFT-IGVLLPSIAQDLDVS-ISSVSFVASVQIGCYFTSGAFSAVLiNRFGFRKVAIAGVLCSAVSI 385
Cdd:PRK03893  21 AFSAAWLgylLDGFDFVlITLVLTEVQGEFGLTtVQAASLISAAFISRWFGGLLLGAMG-DRYGRRLAMVISIVLFSVGT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSWSVSLTMLIFFYSVLacagGITLSMIWASSqliVGYYFE----RYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIG 461
Cdd:PRK03893 100 LACGFAPGYWTLFIARLVI----GMGMAGEYGSS---ATYVIEswpkHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWG 172


                 ....
gi 665400952 462 WRNM 465
Cdd:PRK03893 173 WRAL 176
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 307-489 2.00e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.43  E-value: 2.00e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 307 IMVLSFLaqliidgLIFTIGVLLPSI---AQDLDVSISSVSFVASVQigcYFTSGA---FSAVLINRFGFRKVAIAGVLC 380
Cdd:cd17489    1 ILLANFF-------FFLSFYLLLPVLplyAHDLGGSEAVAGLVVGLF---TLAALLarpFAGRLLDRFGRKRLLLIGLLI 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 381 SAVSILASSWSVSLTMLIFFYSVLACAGGITLSmiwASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPII 460
Cdd:cd17489   71 FALATLLYLLATSVALLLVLRLIHGIGWGAFTT---AAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHL 147

                        170       180
                 ....*....|....*....|....*....
gi 665400952 461 GWrNMLRTQAGLIMLILLMVVAYVEVAPT 489
Cdd:cd17489  148 GF-AVLFIVAAVLALLALLLVFLVKDPPP 175
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 305-462 2.24e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 41.41  E-value: 2.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 305 WVIMVLSFLAQLIIdgliFTIGVLLPSIAQD-------LDVSISSVSFVASVQIGcyFTSGAFSAVLINRFGFRKVAIAG 377
Cdd:cd17504  180 LLANITALLAGFGM----FMVFQLLPQLLQLptptgfgLGITEAGLLLLPGALVM--LIAGPLAGRLIARVGPRRVLLIG 253

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 378 VLCSAVSILASSWSVSLTMLIFFYSVLacaGGITLSMIWASSQLIVGYYFERYRP-----MANGFSCSGGGAG-IVLFTF 451
Cdd:cd17504  254 LVISAVGLLLLALLHSSLWALVVALLL---IGIGLGLAFASLPNIVVESVPPDRTgiatgMNTVLRTIGSAIGpAIAGAI 330

                        170
                 ....*....|.
gi 665400952 452 LNSWLVPIIGW 462
Cdd:cd17504  331 LTTYTVSITSG 341
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 671-842 2.32e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.04  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 671 FEFKILVASAFLFPMGFnipfVYSSARTTIPVeYARMIGP--------IIGISNLVMRNILGILA-YKRRSWTLGLCgcg 741
Cdd:cd17489  192 VEKKVLPPALILFLASI----AYGAISTFLPL-YAAERGIsnaglfftVYAIALLLSRPFSGKLSdRKGPKTVIIPG--- 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 742 LIFGGVSVLISAFYGEN--LIWFQFLYGFSYAvapAVYSTLRGLIyVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKL 819
Cdd:cd17489  264 LLLLALGLLLLSFAGSPwmLLLAAVLYGLGFG---LLFPALQALA-VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLV 339

                        170       180
                 ....*....|....*....|...
gi 665400952 820 IGITGnYSAAFCFAGLCLIVSGF 842
Cdd:cd17489  340 AELFG-YRAMFLLAAVVVLLALV 361
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 675-841 2.45e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 41.02  E-value: 2.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 675 ILVASAFLFPMGFNIPFVYSSarttIPVEYARMIGPIIGISNLVMrnILGILAYKRRS----------WTLGLCGCGLIF 744
Cdd:cd17473  206 AFLAMLLFYVIPIQLPFLLQE----RGGGSAALIGLALAIASLAG--AIGALLFGRLKrrlgkrrllaIGFALMALGFLL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 745 GGVSVLISAFYGENLIwFQFLYGFSYavaPAVYSTLRGLIYVKYLGLskltnAFGITSLAMGMGAFIGTTIAGKLIGITG 824
Cdd:cd17473  280 LALASGLWVVLLGAIL-AGLGFGLLL---PTLNSWAMSLVPPELRGR-----AMGIVTSAFFLGQFLSPLVLGPLVNLTG 350

                        170
                 ....*....|....*..
gi 665400952 825 NYSAAFCFAGLCLIVSG 841
Cdd:cd17473  351 GLSGAFLILGVLALVLA 367
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 673-842 2.93e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 40.87  E-value: 2.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 673 FKILVASAFLFPMGFNIPFVYSSARTTIPVEYARMIGPIIGISNLVMRNILGILA-YKRRSWTLGLCGCGLIFGGVsVLI 751
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAdRFGRRPVLLLGLLLFALGAL-LFA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 752 SAFYGENLIWFQFLYGFSYAVapavYSTLRGLIYVKYLGLSKLTNAFGITSLAMGMGAFIGTTIAGKLI-GITGNYSAAF 830
Cdd:cd06174   80 FAPSFWLLLLGRFLLGLGSGL----IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVF 155

                        170
                 ....*....|..
gi 665400952 831 CFAGLCLIVSGF 842
Cdd:cd06174  156 LIAAALALLAAI 167
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 666-842 3.10e-03

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 40.86  E-value: 3.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 666 RLLKQFEFKILVASAFL-----FPMGFNIPFVYSSARTTIPVEYARMIGpIIGISNLVMRNILGILA------YKRRSWT 734
Cdd:cd17314  201 EIFRDKVFWILFIAIFLvliggFLFIANMASLVRSLQLDAPSFVTKLMS-IYGLFNAFGRLLWGIVAdffggrLSTLSIL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 735 LGLCGCGLIfggvSVLISAFYGE-NLIWFQFLYGFSYAVAPAVYSTLRGLIYvkylGLSKLTNAFGITSLAMGMGAFIGT 813
Cdd:cd17314  280 LTILGLGLC----AFLFLLKMTPvGLVLTGSLLGFSYGGLFTVYPATVSTVF----GTESFATLYGILLFAPAIGSILGP 351

                        170       180
                 ....*....|....*....|....*....
gi 665400952 814 TIAGKLIGITGNYSAAFCFAGLCLIVSGF 842
Cdd:cd17314  352 MLGAKFYDRTPSYISAVYIYAVIVFLASA 380
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 302-480 3.37e-03

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 40.60  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 302 GFGWV-----IMVLSFLAqliidgliftigvllPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIA 376
Cdd:cd17372    5 GMGWVaeameMMLLSFVG---------------PAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLII 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 377 GVLCSAVSILASSWSVSLTMLIFFYSVLACA-GGITLSMIWaSSQLIVGYYFERYRPMANGFSCsgggAGIVLFTFLNSW 455
Cdd:cd17372   70 SALWTFYAGFLSAFAPNYMWLIILRCLVGLGlGGGPQLASW-YLEFLPAKSRGTWMVLFSVFWT----VGTIFEASLAWL 144

                        170       180
                 ....*....|....*....|....*
gi 665400952 456 LVPIIGWRNMLRTQAglIMLILLMV 480
Cdd:cd17372  145 VMPRLGWRWLLAFSS--VPSSLLLV 167
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 286-484 3.50e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 286 LGSGMVFIYmvippdgGFGWVIMVLSFLAQLIIDGLIFTIGVLLpsiaqdldvSISSVSFVAsvqigcyfTSGAFSAVLI 365
Cdd:cd17474  204 LVSAFLYFF-------LYFAFLTYLPFLLELLYGISPIIIGLLF---------AGWSVLLAL--------GSLFVGRLLK 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 366 NRFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIwasSQLIVGYYFERYRPMA---NGFSCSGG 442
Cdd:cd17474  260 KRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL---TTLVTELAPEEERGTAsslYNFVRFLG 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 665400952 443 GA-GIVLFtflnSWLVPIIGWRNMLRTqAGLIMLILLMVVAYV 484
Cdd:cd17474  337 QAvGPLLF----GLLLEIFGLSAPFLV-GAAIALAAAVLLALL 374
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 316-490 4.09e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 40.29  E-value: 4.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 316 LIIDGLIFTIG--VLLPSIA----QDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASS 389
Cdd:cd17329    4 LLIGSFLNRLGffMVWPFMAiylhQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 390 WSVSLTMLIFFYSVLACAGGItlsMIWASSQLIVGYYFERYRPMAngFSCS--GGGAGIVLFTFLNSWLVpIIGWRnmLR 467
Cdd:cd17329   84 FAHSPWLFAIALVLTGFGGGL---FEPASEAMIADVTTPENRTRA--FSLLywAINLGVAIGPLLGGLLL-LYSFR--LL 155

                        170       180
                 ....*....|....*....|...
gi 665400952 468 TQAGLIMLILLMVVAYVEVAPTQ 490
Cdd:cd17329  156 FLAAAVLFLLAALVLLFLLPETR 178
MFS_CsbX cd17337
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ...
 703-838 4.32e-03

CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340895 [Multi-domain]  Cd Length: 388  Bit Score: 40.18  E-value: 4.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 703 EYARMIGpIIGISNLVMRNILGILAYK---RRswTLGLCGCglIFGGVSVLisAFYgenliWFQFLYGFSYAVApAVYST 779
Cdd:cd17337  245 QWLQIWG-IIFLVNIFFNLIFGILGDKigwRR--TVRWFGG--VGCAISTL--LFY-----YVPQLFGHNYWAA-LIAAI 311

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400952 780 LRGLIYVKYLGLSKLT---------NAFGITSLAMGMGAFIGTTIAGKLIGITGNYSAAFCFAGLCLI 838
Cdd:cd17337  312 LFGIGLAGFVPLSALMpslapehkgAAMSILNLGAGLSNFVGPAIVTLFLGSFGAGGVVWIFAGLYLL 379
MFS_NIMT_CynX_like cd17339
2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator ...
 322-484 5.33e-03

2-nitroimidazole and cyanate transporters and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli 2-nitroimidazole transporter (NIMT) and cyanate transport protein CynX, and similar proteins. NIMT, also called YeaN, confers resistance to 2-nitroimidazole, the antibacterial and antifungal antibiotic, by mediating the active efflux of this compound. CynX is part of an active transport system that transports exogenous cyanate into E. coli cells. The NIMT/CynX-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340897 [Multi-domain]  Cd Length: 374  Bit Score: 39.87  E-value: 5.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 322 IFTIGVLLPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSILASSWSVslTMLIFFY 401
Cdd:cd17339   15 ITSVGPLLPEIRDDLGLSASQAGLLTTLPLLCFAVFSPLAPRLARRFGLERTLLLALLLLAAGILLRSLGG--IALLFLG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 402 SVLACAgGITLSMIWASSqlIVGYYFERYRPMANG---FSCSGGGA---GI-VLFTFLNSWlvpiiGWRNmlrtqaGLIM 474
Cdd:cd17339   93 TALAGA-GIAVGNVLLPS--LIKRDFPRRVGLMTGlytTSMNLGAAlasGLsVPLAQALGG-----GWRG------ALAI 158

                        170
                 ....*....|
gi 665400952 475 LILLMVVAYV 484
Cdd:cd17339  159 WALPALLALL 168
MFS_1 pfam07690
Major Facilitator Superfamily;
740-839 6.03e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 6.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952  740 CGLIFGGVSVLISAFYGEN--LIWFQFLYGFSYAVAPAVYSTLRGLIYVKylglSKLTNAFGITSLAMGMGAFIGTTIAG 817
Cdd:pfam07690  67 IGLLLFALGLLLLLFASSLwlLLVLRVLQGLGAGALFPAALALIADWFPP----EERGRALGLVSAGFGLGAALGPLLGG 142

                          90       100
                  ....*....|....*....|..
gi 665400952  818 KLIGITGNYSAAFCFAGLCLIV 839
Cdd:pfam07690 143 LLASLFGWRAAFLILAILSLLA 164
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 308-484 6.29e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 39.85  E-value: 6.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 308 MVLSFLAQLI--IDGLIFTIGVllPSIAQDLDVSISSVSFVASVQIGCYFTSGAFSAVLINRFGFRKVAIAGVLCSAVSI 385
Cdd:cd17380    1 VILLFLATCIcyADRVNMPIAI--VPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLAT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 386 LASSW--SVSLTMLIFFYSVLACAGGITL-SMIWASSQLIVgyYFERYRPManGFSCSGGGAGIVLFTFLNSWLVPIIGW 462
Cdd:cd17380   79 LLTPLlaYSSLPLLILSRILLGLGEGVHFpSMTSLFSRWVP--VSERSRAV--SIVTAGSYLGTLLGGLIGPLLLEYYGW 154

                        170       180
                 ....*....|....*....|..
gi 665400952 463 RNMLRTQAGLIMLILLMVVAYV 484
Cdd:cd17380  155 PSVFYFFGLLGLLWALVWLIYL 176
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 346-503 6.38e-03

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 39.84  E-value: 6.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 346 VASVQIGCYFTSGAFSAVLIN---------RFGFRKVAIAGVLCSAVSILASSWSVSLTMLIFFYSVLACAGGITLSMIW 416
Cdd:cd17471   29 ASPLQIGIFMTLSALSGIVVSqwlgrlsdrGGDRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVVLLSLGAAAFPQLF 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 417 ASSQLIVGYYFERYRPMANGFSCSGGGAGIVLFTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQVGMYHL 496
Cdd:cd17471  109 ALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATP 188


                 ....*..
gi 665400952 497 PGSSDTS 503
Cdd:cd17471  189 ASSLVKA 195
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
310-491 8.83e-03

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 39.49  E-value: 8.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 310 LSFLAQLIIDGLIFTiGVLLP---SIAQDLDVSISSVSfvASVQIgcyFTSG-AFSAV----LINRFGFRKVAIAGVLCS 381
Cdd:PRK11043   8 LVYLAGLSMLGFLAT-DMYLPafkAIQADLQTSASAVS--ASLSL---FLAGfALGQLlwgpLSDRYGRKPVLLAGLSLF 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 382 AVSILASSWSVSLTMLI---FFYSVLACAGGItlsmIWassQLIVgyyFERYRP-MANG-FscsgggAGIV--------L 448
Cdd:PRK11043  82 ALGSLGMLWVESAAQLLvlrFVQAVGVCSAAV----IW---QALV---IDRYPAqKANRvF------ATIMplvalspaL 145

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 665400952 449 FTFLNSWLVPIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQV 491
Cdd:PRK11043 146 APLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARK 188
MFS_MFSD3 cd17485
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ...
 312-491 9.08e-03

Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341038 [Multi-domain]  Cd Length: 386  Bit Score: 39.52  E-value: 9.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 312 FLAQLIIDGLIFTigvLLPSIAQDLDVSISSVSFVASVQI--GCYFtsgaFSAVLINRFGFRKVA------IAGVLCSAV 383
Cdd:cd17485    6 YLAQGLPYGFQSQ---ALPVLLRSAGVSLTAIGLLKLLYLpwVLKF----LWAPLVDRYGLPRLGrrrswlLPTQLGLAL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 384 SILAsswsVSLTMliFFYSVLACAGGITLSMIWASSQLIV--GYYFE----RYRPMANGFSCSGGGAGIVLFTFLNSWLV 457
Cdd:cd17485   79 LLLA----LAFLP--PTTNLLAFLGLLFLLNLFSATQDIAtdGLAVElltpEERGLGNAAQVVGYKLGSLLGGGGLLWLY 152

                        170       180       190
                 ....*....|....*....|....*....|....
gi 665400952 458 PIIGWRNMLRTQAGLIMLILLMVVAYVEVAPTQV 491
Cdd:cd17485  153 DLIGWQSLLLSLAALYLLLLLPVLFLRELELPQQ 186
RfbX COG2244
Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane ...
 286-427 9.23e-03

Membrane protein involved in the export of O-antigen and teichoic acid [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441845 [Multi-domain]  Cd Length: 366  Bit Score: 39.16  E-value: 9.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665400952 286 LGSGMVFIYMVIPPDGGFGWVIMVLSFLAQLIIDGLIFTIGVLL-PSIAQDLDVS-ISSVSFVASVQIGCYFTSGAFSAV 363
Cdd:COG2244   57 LGLSTALVRFIAEYREEELRRLLSTALLLRLLLSLLLALLLLLLaPFIAALLGEPeLALLLLLLALALLLSALSAVLLAL 136

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665400952 364 LINRFGFRKVAIAGVLCSAVSILAS----SWSVSLTMLIFFYSVLACAGGITLSMIWASSQLIVGYYF 427
Cdd:COG2244  137 LRGLERFKLLALINILSSLLSLLLAlllaLLGLGLWGLVLKYSLPLLLSGLLGLLLTNLDRLLLGALL 204
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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