|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
28-488 |
0e+00 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 591.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 28 YFVTFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEaEEYDDECGDRDIPIDDSQDGEFAWSSALQGYILSSFFYGYV 107
Cdd:TIGR00894 12 YFCSFRLFLSFLLHICNVIIIAQRICLSLTMVAMVNKE-NSTDLACLSAENELDNIKNPNFKWSGALQGLILSSHFYGQI 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 108 ITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMG 187
Cdd:TIGR00894 91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIAL-VVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 188 AAVYAGAQFGTIISMPLSGLLAEYgfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTIDEREKKYINDSLWGTDVV 267
Cdd:TIGR00894 170 GMSTSGFQLGTFIFLPISGWLCES--WGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGS 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 268 KSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISS 347
Cdd:TIGR00894 248 TRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSS 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 348 KRFSHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANL 427
Cdd:TIGR00894 328 KTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFI 407
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665401411 428 AGLLAPIAAGHLISDPSKpmmGQWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQ 488
Cdd:TIGR00894 408 GGLIASTLAGNILSQDSK---NVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
31-473 |
0e+00 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 524.11 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 31 TFMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDdecgdrdIPIDDSQDGEFAWSSALQGYILSSFFYGYVITQ 110
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTD-------KDTLPVEAPEFDWSEKTQGIILSSFFYGYILTQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 111 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGgVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 190
Cdd:cd17318 74 IPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGG-YGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 191 YAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 270
Cdd:cd17318 153 YSGSQFGTVIAMPLSGFLCES---LGWPSIFYIFGGLGLLWCLLWFFLV------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 271 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRF 350
Cdd:cd17318 199 ----------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGIL 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 351 SHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 430
Cdd:cd17318 269 STTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGI 348
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 665401411 431 LAPIAAGHLISDpsKPMMGQWQIVFFIAAFVYIICGTFYNIFG 473
Cdd:cd17318 349 ISPLIVGAIVKN--DQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
32-473 |
8.32e-114 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 342.14 E-value: 8.32e-114
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 32 FMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYDDECGDRDIPIDDSQDGE-FAWSSALQGYILSSFFYGYVITQ 110
Cdd:cd17381 3 LLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHSSSPSVEHNETGKkYDWDAETQGWILGSFFYGYIITQ 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 111 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 190
Cdd:cd17381 83 IPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY-LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTIS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 191 YAGAQFGTIISMPLSGLLAEYGfdgGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 270
Cdd:cd17381 162 YAGAQLGTVVSLPLSGLICYYL---DWTYVFYIFGAVGLLWFFLWIWLV------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 271 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRF 350
Cdd:cd17381 208 ----------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNF 277
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 351 SHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 430
Cdd:cd17381 278 STVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGM 357
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 665401411 431 LAPIAAGHLISDPSkpmMGQWQIVFFIAAFVYIICGTFYNIFG 473
Cdd:cd17381 358 VGPVIAKSLTHNNT---VEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
31-473 |
4.34e-91 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 282.52 E-value: 4.34e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 31 TFMLFLGMANAYVMRTNMSVAIVAMVNhtaiksgeaeeyddecgdrdipiddsqdgEFAWSSALQGYILSSFFYGYVITQ 110
Cdd:cd17380 1 VILLFLATCICYADRVNMPIAIVPMAK-----------------------------EFGWSKTDQGLVLSSFFWGYALTQ 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 111 IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAV 190
Cdd:cd17380 52 VLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAY-SSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIV 130
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 191 YAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedpsshptiderekkyindslwgtdvvksp 270
Cdd:cd17380 131 TAGSYLGTLLGGLIGPLLLEY---YGWPSVFYFFGLLGLLWALVWLIYL------------------------------- 176
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 271 pipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLrFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIsSKRF 350
Cdd:cd17380 177 ----------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWLVMFPSSNVAGWLADHLI-SRGW 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 351 SHTATRKLINSIGQYGPGVALIAASYTgCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGL 430
Cdd:cd17380 245 TVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGI 323
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 665401411 431 LAPIAAGHLISDPskpmmGQWQIVFFIAAFVYIICGTFYNIFG 473
Cdd:cd17380 324 VGVYLTGYILEAT-----GSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
32-473 |
9.96e-83 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 261.51 E-value: 9.96e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 32 FMLFLGMANAYVMRTNMSVAIVAMVNHTAIKSGEAEEYddecgdrdipiddsQDGEFAWSSALQGYILSSFFYGYVITQI 111
Cdd:cd17382 2 IMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIV--------------HKAEFNWTPETVGLIESSFFWGYLVTQI 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 112 PFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWgLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVY 191
Cdd:cd17382 68 PGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGC-VIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 192 AGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIaFLIFVhedpsshptiderekkyindslwgtdvvkspp 271
Cdd:cd17382 147 CGSYAGAVVGMPLSGILVQY---VGWSSPFYVYGVFGIIWYM-FWMLV-------------------------------- 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 272 ipfkaiikSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFS 351
Cdd:cd17382 191 --------SMPVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILS 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 352 HTATRKLINSIGQYGPGVALIAASYTGcDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLL 431
Cdd:cd17382 263 TTAVRKIFNCGGFGMEATFLLVVAFSH-SPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMV 341
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 665401411 432 APIAAGHLISDPSKpmmGQWQIVFFIAAFVYIICGTFYNIFG 473
Cdd:cd17382 342 CPVIVGALTKHKTR---EEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
27-469 |
2.31e-49 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 173.53 E-value: 2.31e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 27 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVnhtaiksgeaeeyddecgdrdipiddsqdGEFAWSSALQGYILSSFFYGY 106
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIM-----------------------------KDLGLSPTQYGLIASAFFLGY 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 107 VITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRM 186
Cdd:cd17319 52 ALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA---TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRA 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 187 GAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEdpsshptiderekkyindslwgtdv 266
Cdd:cd17319 129 TGLFNSGAPLGAAIGPPLSGWLLLL---FGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 267 vksppipfkaiikslpFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIS 346
Cdd:cd17319 181 ----------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLR 244
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 347 SKRFSHTATRKLINSIGqygpgvalIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPR-FAGFLMSITNCSA 425
Cdd:cd17319 245 GARRLVIIIGLLLAAVG--------LLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 665401411 426 NLAGLLAPIAAGHLISDpskpmMGQWQIVFFIAAFVYIICGTFY 469
Cdd:cd17319 317 NLGGFVAPLLIGYLVDA-----TGSYTAAFLFLAAVALLAALLV 355
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
27-469 |
9.26e-42 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 153.10 E-value: 9.26e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 27 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVNhtaiksgeaeeyddecgdrdipiddsqdgEFAWSSALQGYILSSFFYGY 106
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQA-----------------------------DLGLSAAQLGLLASAFFLGY 58
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 107 VITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRM 186
Cdd:COG2271 59 ALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA---TSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRA 135
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 187 GAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIaflifvhedpsshptiderekkyindslwgtdv 266
Cdd:COG2271 136 LGIFNAGGPLGGALAPPLLGWLLAA---FGWRAAFLILGLPGLLLAL--------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 267 vksppipfkaiiksLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADWMIS 346
Cdd:COG2271 180 --------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 347 SkrfshtatRKLINSIGQYGPGVALIAASYTGcDRALTLAILTIGVGLNGGIYSGFKINHLDLTP-RFAGFLMSITNCSA 425
Cdd:COG2271 246 R--------RKLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFG 316
|
410 420 430 440
....*....|....*....|....*....|....*....|....
gi 665401411 426 NLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICGTFY 469
Cdd:COG2271 317 FLGGALGPLLVGYLLD------ATGYQAAFLLLAALALLAALLA 354
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-469 |
4.08e-37 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 140.64 E-value: 4.08e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPI 166
Cdd:cd06174 25 SFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAP---SFWLLLLGRFLLGLGSGLI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 246
Cdd:cd06174 102 DPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASS-LGFGWRAVFLIAAALALLAAILLLLVVPDPPESA 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 326
Cdd:cd06174 181 RAKNEEASS------------KSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADWMISskrfshtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINH 406
Cdd:cd06174 249 GLAGALGSLLLGLLSDRLIG---------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 407 LDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIICGTFY 469
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA-----ATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
87-433 |
1.00e-32 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 127.92 E-value: 1.00e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPI 166
Cdd:pfam07690 26 DLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS---SLWLLLVLRVLQGLGAGAL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhEDPSSH 246
Cdd:pfam07690 103 FPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---FGWRAAFLILAILSLLAAVLLLLPR-PPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKYINDSLWGtdvvksppipfkaIIKSLPFYAILFAHMGHNYGYETLMTELPTYMkQVLRFSLKSNGLLSSLP 326
Cdd:pfam07690 179 RPKPAEEARLSLIVAWK-------------ALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADWMisskrfsHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLnGGIYSGFKINH 406
Cdd:pfam07690 245 GLLGAIGRLLLGRLSDRL-------GRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGF-GLVFPALNALV 316
|
330 340
....*....|....*....|....*...
gi 665401411 407 LDLTP-RFAGFLMSITNCSANLAGLLAP 433
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALGP 344
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
87-465 |
1.84e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 111.13 E-value: 1.84e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:COG2223 34 EFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALA---VSYWLLLLLGLLLGIGGGGS 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 246
Cdd:COG2223 111 FAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIA---AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGA 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTiderekkyindslwgtdVVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 326
Cdd:COG2223 188 AA-----------------AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALF 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQYGPGVALIAASYTGCD-RALTLAILTIGVGLNGGIYSGFKIN 405
Cdd:COG2223 251 ALLGALGRPLGGWLSD------RIG----GRRVLLIVFALMALGLLLLALALGSlWLFLVLFLLLGLALGGGNGAVFALV 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 406 HLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIIC 465
Cdd:COG2223 321 PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD-----ATGSYTAAFLVFAVLALVA 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
87-432 |
1.18e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 107.75 E-value: 1.18e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:COG2814 39 DLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALA---PSLWLLLAARFLQGLGAGAL 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVhedPSSH 246
Cdd:COG2814 116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL---FGWRWVFLVNAVLALLALLLLLRLL---PESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKyindslwgtdvvksppiPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 326
Cdd:COG2814 190 PAARARLRG-----------------SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADWmISSKRFshtatrkLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINH 406
Cdd:COG2814 253 GLGGVLGALLAGRLADR-FGRRRL-------LLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAEL 324
|
330 340
....*....|....*....|....*.
gi 665401411 407 LDltPRFAGFLMSITNCSANLAGLLA 432
Cdd:COG2814 325 AP--PEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
91-472 |
6.92e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 103.04 E-value: 6.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS---YWQLLLARFLQGLASAAVWPAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPTID 250
Cdd:cd17325 106 MALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 251 EREKKyindslwgtdvvksPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAM 330
Cdd:cd17325 183 VSAAR--------------LRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 331 WLFSMFISVVADWMisskrfshtaTRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLngGIYSGFKINHL-DL 409
Cdd:cd17325 249 ALSQPPAGKLSDRI----------GRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGL--GLVFPATLALLaDI 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665401411 410 TPRFA-GFLMSITNCSANLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICGTFYNIF 472
Cdd:cd17325 317 VPPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYD------AFGFATPFLAAAALLLLAAVLFLLL 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
87-351 |
3.86e-16 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 80.11 E-value: 3.86e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSV----FAFlvpvaarGGGVWGLCAVRFIQGLG 162
Cdd:TIGR00881 24 EIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIvnlfFGF-------STSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 163 EGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLsgLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHED 242
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPL--VLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 243 PSShPTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAIL-------FAHMGHNYGYETLmteLPTYMKQVLRFS 315
Cdd:TIGR00881 175 PQS-CGLPPAEEMPNEEPDGDAEKKEEELTKKQIFLQYVLLNKVLwyislgyVFVYVVRTGILDW---SPLYLTQEKGFS 250
|
250 260 270
....*....|....*....|....*....|....*.
gi 665401411 316 LKSNGLLSSLPYLAMWLFSMFISVVADWMISSKRFS 351
Cdd:TIGR00881 251 KEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGP 286
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
97-257 |
2.64e-15 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 77.67 E-value: 2.64e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 97 YILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAK 176
Cdd:cd17327 45 WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLL---TAAVKNFGGLIALRFFLGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 177 WIPPNERSRMGAAVYAGAQFGTIismpLSGLLAeYGF---DG-----GWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHPT 248
Cdd:cd17327 122 WYKREEQAKRIAFFYAAAGLGSI----FGGLLA-YGVfkiLGvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF 196
|
....*....
gi 665401411 249 IDEREKKYI 257
Cdd:cd17327 197 LTEEEKELA 205
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
87-241 |
1.12e-14 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.46 E-value: 1.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:COG0477 43 DLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA---PSPELLIAARALQGIGAGGL 119
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVwSIAFLIFVHE 241
Cdd:COG0477 120 MPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA---LGWRWIFLINAPLGLL-ALVLRLRLPE 190
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
91-469 |
2.26e-14 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 74.96 E-value: 2.26e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:cd17328 32 DDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFA---PNFWQLLLFRALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSHptID 250
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQA--TGGWRWAFRVTGVLGVLLAILLLLFVREPPRGA--AE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 251 EREKKYINDSLWGTDVvksppipfKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSslpyLAM 330
Cdd:cd17328 185 GGVMAKSTATSFLADL--------KALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADVG----LIF 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 331 WLFSMFISVVADWM--ISSKRFSHT--ATRKLINSIGQYGpGVALIAASYTGCDRALTLAILTIGVG-LNGGIYSG--FK 403
Cdd:cd17328 253 GAITCIAGVLGVLLggILADRLRRKtpRADPLVCAVGLLA-AAPFLFLALVLALSNLLLAWVLLFLGeFLLSLNWApvFA 331
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665401411 404 INHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISD-----PSKPMMG--QWQIVFFIAAFVY-IICGTFY 469
Cdd:cd17328 332 ILLYVVIPTRRSTASAIQILLSHLLGDAGSPYLIGLISDllrqnKDSPLAEaaSLQYALLLCSFVLvLGGFFFL 405
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
87-469 |
8.36e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 72.99 E-value: 8.36e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPI 166
Cdd:cd17474 28 ALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDS---FALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSR-MGaaVYAGA-QFGTIISMPLSGLLAEYGfdggWPSIFYVFGIVGTVWSIAFLIFVHEDPS 244
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKaMG--LYEAAlGLGIAVGPLLGGLLAAIS----WRYPFFLLAALIPVAFLAILFLLPEPKE 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 245 SHPTIDEREKKYindslwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSS 324
Cdd:cd17474 179 KAKSSSATKLRD-----------------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 325 LPYLAMWLFSMFISvvadwMISSKRFSHTATRKLINSIgqYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKI 404
Cdd:cd17474 242 GWSVLLALGSLFVG-----RLLKKRFGARRILVIGLLL--YALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVT 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665401411 405 NHLDLTPRfaGFLMSITNCSANLAGLLAPIAAGHLIsdpskpMMGQWQIVFFIAAFVYIICGTFY 469
Cdd:cd17474 315 ELAPEEER--GTASSLYNFVRFLGQAVGPLLFGLLL------EIFGLSAPFLVGAAIALAAAVLL 371
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
87-464 |
3.64e-13 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 71.04 E-value: 3.64e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:cd17324 28 DFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA---PSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 246
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQL---LGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKYIndslwgtDVVKSPPIPFKAIIkslpfYAILFAhmghnyGYETLMTELPTYMKQVLRFSLKSNGLLSSLP 326
Cdd:cd17324 182 PGSLGLLSSLL-------LLLRNPRLRLAYLI-----TFLLFG------GFFALYTYLAPFLTDVPGFSSSAIIGLLLLF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADWmisskrfsHTATRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKinh 406
Cdd:cd17324 244 GVAGVVGSPLAGRLADR--------GGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV--- 312
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 665401411 407 LDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSKPMMGQWQIVFFIAAFVYII 464
Cdd:cd17324 313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
87-466 |
3.76e-13 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 71.18 E-value: 3.76e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 166
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL---CGFAQNYWQLLILRALAGLGFGGE 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDG-GWPSIFYvFGIVGTVWSIAFLIFVHEDPSS 245
Cdd:cd17371 105 WAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPPEiAWRVLFL-LGALPALLVLFIRRFVKEPPQW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 246 hptideREKKYINDSlwgtdvvkSPPIPFKAIIKSLPF-----YAILFAhMGHNYGYETLMTELPTYMKQVLRFSLKSNG 320
Cdd:cd17371 184 ------QAARAARRH--------FADRPSLRELFSPPLlrttlLASLLA-TGALGGYYGITTWLPSYLTGERGLSFEGSA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 321 LlsslpYLAMWLFSMFISVVAdWMISSKRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYS 400
Cdd:cd17371 249 G-----YLVVTILGGFLGYLA-GGFLADRIG----RRNNFALFALGSAISILLYFFLPLSPTLILILGFPLGFFASGPFS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665401411 401 GFKINHLDLTP-RFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICG 466
Cdd:cd17371 319 GMGAYLTELFPtAVRATAQGFCYNVGRIIGALFPFLVGFLAT------SGSLGTAIAVFAAVYYIAG 379
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
96-468 |
1.39e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 69.22 E-value: 1.39e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGML----INSVFAFLVpvaarggGVWGLCAVRFIQGLGEGPIVPCTH 171
Cdd:cd17312 41 GIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLlsalANIFMGFST-------SLWFFAVLWGLNGLFQSMGWPPCV 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 172 AMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPsshPTIde 251
Cdd:cd17312 114 KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASY---YGWRAAFLVPGIVGLVVAIILFFFLRDSP---PYV-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 252 rekkyindslwgtdvvksppipfkaIIKSLpfyAILFAhMGHNYGYETLmteLPTYMKQVLRFSLKSNGLLSSLPYLAMW 331
Cdd:cd17312 186 -------------------------WVLSL---AYAFV-YIVRYACLDW---GPLYLYEVKGYSLIDAGWFSSLYEVGGI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 332 LFSMFISVVADwmissKRFShtATRKLINSIGQYGPGVALIAASYTGCDRALTLAILT-IGVGLNGGIYSGFKINHLDLT 410
Cdd:cd17312 234 AGTILAGLLSD-----KLFG--GRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFlIGFFVGGPINLIGGAAAQDIG 306
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 665401411 411 PRFA-GFLMSITNCSANLAGLLAPIAAGHLISDPSkpmmgqWQIVFFIAAFVYIICGTF 468
Cdd:cd17312 307 RKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYG------WSTVFYFLISAALLSVLL 359
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
27-336 |
4.62e-12 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 67.65 E-value: 4.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 27 RYFVTFMLFLGMANAYVMRTNMSVAIVAMVnhtaiksgeaEEYDdecgdrdipiddsqdgefaWSSALQGYILSSFFYGY 106
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLI----------EQYG-------------------LSKTEIGLIGSALSIAY 51
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 107 VITQIPFGILAKKYGSLRFLGYGM----LINSVFAFlvpVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNE 182
Cdd:cd17345 52 GLSKFVMGNLSDRSNPKRFLAIGLilsaIINILIGF---VPSATSSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKE 128
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 183 RSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH--PTIDEREKKYINDS 260
Cdd:cd17345 129 RGTWTSIWNISHNVGGGLVGPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEA 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 261 LWGTDVVK--SPPIPFKAII--KSLPFYAI--LFAHMGHnYGyetLMTELPTYMKQVLRFSLKSngllsslpylAMWLFS 334
Cdd:cd17345 209 DGEEEEQElsAWEIFVKYVLknKLLWYIAIanVFVYLVR-YG---ILDWAPTYLSEVKGFSKAQ----------AMWAFS 274
|
..
gi 665401411 335 MF 336
Cdd:cd17345 275 LF 276
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
87-239 |
7.23e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.83 E-value: 7.23e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLA---TSFWLLLLLLALLGLGLGLV 305
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFV 239
Cdd:cd17325 306 FPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
87-440 |
1.50e-11 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 66.11 E-value: 1.50e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 166
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALL---MALVGSYPVLLVLLFLVGAGYGSV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERS-RMG---AAVYAGAQFGTIISMPLSGLLaeygfdgGWPSIFYVFGIVGTVWSIAFLIFVHED 242
Cdd:cd17475 102 QPGGGRAIMRWFPPRERGlAMGirqTGVPLGGALAAALLPPLALHY-------GWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 243 PsshptiDEREKKYINDSLWGTdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLL 322
Cdd:cd17475 175 P------AASAATESASTLLRS---------LKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGAL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 323 SSLPYLAMWLFSMFISVVADWMISSKRfshtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLnggiySGF 402
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRR------RPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGL-----FAI 308
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 665401411 403 KINHLDLT-------PRFAGFLMSITNCSANLAGLLAPIAAGHLI 440
Cdd:cd17475 309 GWNGLYLTlvaesagPEQAGTALGLANTINFIGIAIGPPLFGLLV 353
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
87-402 |
7.78e-11 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 63.91 E-value: 7.78e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPI 166
Cdd:TIGR00895 46 EWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL---CALATNVTQLLILRFLAGLGLGGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeyGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDP--- 243
Cdd:TIGR00895 123 MPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWL---IPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIdfl 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 244 -SSHPTIDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAILFAHMGHN------------YGYETLMTELPTYMKQ 310
Cdd:TIGR00895 200 vSKRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARItvllwllyfmllVGVYFLTNWLPKLMVE 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 311 vLRFSLKSNGLLSSLPYLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTI 390
Cdd:TIGR00895 280 -LGFSLSLAATGGALFNFGGVIGSIIFGWLAD------RLG----PRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIA 348
|
330
....*....|..
gi 665401411 391 GVGLNGGiYSGF 402
Cdd:TIGR00895 349 GFFVNGG-QSGL 359
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
113-468 |
1.17e-10 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 63.36 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 113 FGILAKKYGSLRFLGYGMLINSVF---AFLVPvaarggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAA 189
Cdd:cd17473 55 AGWLADRFGRKRLLIAGLLLYGIGgvaGLFLD------SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGL 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 190 VYAGAQFGTIISMPLSGLLAEYgfdgGWPSIFYVFGIVGTVWsIAFLIFVHEDPSSHPTIDEREKkyindslwgtdvVKS 269
Cdd:cd17473 129 QSAAMSLGGVVFLLLGGALAEI----GWRAPFLVYLLALPVL-ILVLLFLPEPARKSKSAASPGA------------ATA 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 270 PPIPFKAIiksLPFYAILFAHMGHNYgyeTLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVadwmisSKR 349
Cdd:cd17473 192 AALPWKRV---LPIYFLAFLAMLLFY---VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL------KRR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 350 FSHTATrklinsigqYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYsGF---KINHL---DLTPRFAGFLMSITNC 423
Cdd:cd17473 260 LGKRRL---------LAIGFALMALGFLLLALASGLWVVLLGAILAGLGF-GLllpTLNSWamsLVPPELRGRAMGIVTS 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 665401411 424 SANLAGLLAPIAAGHLISDPSKPmMGQWQIVFFIAAFVYIICGTF 468
Cdd:cd17473 330 AFFLGQFLSPLVLGPLVNLTGGL-SGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
90-472 |
2.01e-10 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 62.63 E-value: 2.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 90 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 169
Cdd:cd17329 32 LSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFA---HSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 170 THAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDggwpsifYVFGIVGTVWSIAFLIFVHEDPSSHPTI 249
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFR-------LLFLAAAVLFLLAALVLLFLLPETRPKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 250 DEREKkyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLA 329
Cdd:cd17329 182 RAAEK-------------TEILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 330 MWLFSMFIsvvadwmisSKRFSHTATRKLInSIG----QYGPGVALIAASYTGCdrALTLAILTIGVGLNGGIYSGFkIN 405
Cdd:cd17329 249 IVLLQFPV---------ARLVERFRLRKIL-MIGillfAIGFAVLAFANTLAVL--ILAMIVLTLGEMLVFPAVQTL-VA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665401411 406 HLdLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpmMGQWQIVFFIAAFVYIICGTFYNIF 472
Cdd:cd17329 316 AL-APPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD------LLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
107-437 |
6.98e-10 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 61.07 E-value: 6.98e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 107 VITQIPFGILA----KKYGSLR-FLGYGMLINSVFA---FLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWI 178
Cdd:COG2211 60 AITDPLIGALSdrtrTRWGRRRpWILIGAIPLALSFvllFTAPDLSPTGKLIYALVTYLLLGLAYTLVNIPYSALGAELT 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 179 P-PNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDG---GWPSIFYVFGIVGTVWSIAFLIFVHEDPSShptidEREK 254
Cdd:COG2211 140 PdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGDaalGYRLTALIFAVLGLLAFLLTFFGTKERPVP-----EEEK 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 255 KYINDSlwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLsslpyLAMWLFS 334
Cdd:COG2211 215 VSLKES-------------LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLL-----LALYFLA 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 335 MFISVVAdWMISSKRFShtatRKLINSIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGF---------KIN 405
Cdd:COG2211 277 ALLGAPL-WPRLAKRFG----KKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLpwamladvvDYD 351
|
330 340 350
....*....|....*....|....*....|..
gi 665401411 406 HLDLTPRFAGFLMSITNCSANLAGLLAPIAAG 437
Cdd:COG2211 352 EWKTGRRREGLYFGIFTFAIKLGQALAGALAG 383
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
83-226 |
1.27e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 1.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 83 SQDGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLG 162
Cdd:cd17316 26 AAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIG 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665401411 163 EGPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAE-YGFDGGWPSIFYVFGI 226
Cdd:cd17316 103 IGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPlLSGDWGWRILFLIGAL 167
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
87-228 |
1.46e-09 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 59.52 E-value: 1.46e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:cd17365 28 DWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA---QSVLQLALLRFLTGLGLGAA 104
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIIsmplSGLLAEYGFDG-GWPSIFYVFGIVG 228
Cdd:cd17365 105 MPNAITLVSEYAPARRRSLAVTLMFCGYPLGAAL----GGFLAAALIPAfGWRSVFLLGGVPP 163
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
91-343 |
2.32e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 59.14 E-value: 2.32e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:cd17489 29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLA---TSVALLLVLRLIHGIGWGAFTTAA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSR----MGAAVYAGAQFGTIISMPLSGLLaeygfdgGWPSIFYVFGIVGTVwSIAFLIFVHEDPSSH 246
Cdd:cd17489 106 ATLVADIIPPSRRGEgigyYGLATTLAMALGPALGLFLYQHL-------GFAVLFIVAAVLALL-ALLLVFLVKDPPPVA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKYINDSLWGtdvvksppipfkaiiKSLPFYAILF-AHMghnyGYETLMTELPTYMKQVLrfsLKSNGLLSSL 325
Cdd:cd17489 178 AEEAEAGTRAFRRLVEK---------------KVLPPALILFlASI----AYGAISTFLPLYAAERG---ISNAGLFFTV 235
|
250
....*....|....*...
gi 665401411 326 PYLAMWLFSMFISVVADW 343
Cdd:cd17489 236 YAIALLLSRPFSGKLSDR 253
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
87-440 |
3.28e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 58.71 E-value: 3.28e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:COG0738 37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALA---PSYPLLLLALFLLGLGLGLL 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGA--AVYAgaqFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIfvhedpS 244
Cdd:COG0738 114 DVAANPYVAALGPETAASRLNLlhAFFS---LGALLGPLLGGLLILLGLSLSWHLPYLILAVLLLLLALLFLR------S 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 245 SHPTIDEREKKyindslwgtdvVKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKsnglLSS 324
Cdd:COG0738 185 KLPEIEEEEEE-----------AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEA----TAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 325 LPYLAMWLFSMFISVVADWMIssKRFSHTATRKLINSIGqygpGVALIAASYTGCDRALTLAILTIGVGlNGGIYSGfkI 404
Cdd:COG0738 250 LGLSLFWGGMTIGRFLGGFLL--KRFGPVRLLRLSALLA----AVGLLLALLAPGPWLALIGLALVGLG-LSLMFPT--I 320
|
330 340 350
....*....|....*....|....*....|....*...
gi 665401411 405 NHL--DLTPRFAGFLMSITNCSANLAGLLAPIAAGHLI 440
Cdd:COG0738 321 FSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLA 358
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
91-237 |
5.08e-09 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 57.95 E-value: 5.08e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA---PSLAFLIAARALQGIGAAAIMPAS 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGTVWSIAFLI 237
Cdd:cd17321 106 LALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLEL---FGWRWIFLInvpIGLVALLLARTFSG 172
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
87-341 |
8.85e-09 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 57.20 E-value: 8.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLIN---SVFAFLVPvaarggGVWGLCAVRFIQGLGE 163
Cdd:cd17320 28 DLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFilaSLLCALAS------SIEQLLIARFLQGLGA 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 164 GPIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEdp 243
Cdd:cd17320 102 AAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLF---FGWRAIFVFLALLGLLLLLLVLLFLPE-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 244 sshpTIDEREKKYINDSLWGTdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLS 323
Cdd:cd17320 177 ----TLPEEKRKPLLSSLLRA---------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLF 243
|
250
....*....|....*...
gi 665401411 324 SLPYLAMWLFSMFISVVA 341
Cdd:cd17320 244 ALNAIALILGSLLNGRLV 261
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
91-252 |
1.18e-07 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.14 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLInSVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:COG2211 262 SAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLL-AALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERS--RMGAAVYAGAQ-----FGTIISMPLSG-LLAEYGFDGGWP----------SIFYVFGIVGTVWS 232
Cdd:COG2211 341 WAMLADVVDYDEWKtgRRREGLYFGIFtfaikLGQALAGALAGlLLALFGYVAGAAqspsaltgirLLFFLLPAVLLLLA 420
|
170 180
....*....|....*....|
gi 665401411 233 IAFLIFVHEDPSSHPTIDER 252
Cdd:COG2211 421 ALLLLFYPLTRERHAEIRAE 440
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
91-341 |
1.78e-07 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 53.37 E-value: 1.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLgeGPIVPCT 170
Cdd:cd17472 30 TPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLL---AAYATSIYGLILGRALQGS--GAISSVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSRmgAAVYAGAQFGT--IISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVwSIAFLIFVHEDPSSHPT 248
Cdd:cd17472 105 MALLADLTREENRTK--AMALIGASIGIafAISMVLGPLLAAH---LGVSGLFLITAILSLV-SLLILLFFVPDPPKIVQ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 249 IDEREKKYindslwgtdvvksppipFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQVlrFSLKSNGLLSSLPYL 328
Cdd:cd17472 179 ISEKEKKK-----------------LKKLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQL--GGGKGQLWKVYLPAI 239
|
250
....*....|...
gi 665401411 329 AMWLFSMFISVVA 341
Cdd:cd17472 240 LIGFILMVPFVIY 252
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
91-469 |
2.30e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 2.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGG--VWGLCAVRFIQGLGEGPIVP 168
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlsLWLLLVLAFLLGIASAFFGP 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 169 CTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeYGFDGgwPSIFYVFGIVGTVWSIAFLIFVHEDPssHPT 248
Cdd:cd06173 112 ARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLL--VALLG--PGGAFAINALSFLLSALLLLFIRRPP--PAA 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 249 IDEREKKYINDSLWGTDVVKSPPIPFKAIIKSLPFYAILFAhmghnygyetLMTELPTYMKQVLRFSLKSNGLLSSLPYL 328
Cdd:cd06173 186 PGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGA----------LTVLLPLLAKEVLGGGAAGYGLLLAAFGV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 329 AMWLFSMFISVVadwmisSKRFSHtatRKLInsigqyGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKIN--- 405
Cdd:cd06173 256 GALLGALLLGRL------SKRRRR---GRLL------LIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPlnt 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665401411 406 --HLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLIsdpskPMMGqWQIVFFIAAFVYIICGTFY 469
Cdd:cd06173 321 llQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA-----DALG-LSAVFLLAGALLLLAALLL 380
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
111-236 |
3.91e-07 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 52.19 E-value: 3.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 111 IPF-GILAKKYGSLRFLGYGMLINSVFAFLvpvAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAA 189
Cdd:cd17503 48 IPLsGWLADRFGTRRLFLTALALFTLGSLL---CGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGL 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 665401411 190 VYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGtVWSIAFL 236
Cdd:cd17503 125 VGLVILLAPAIGPTLGGWLTDN---LSWRWIFYInlpIGILA-LLLAPLL 170
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
87-468 |
7.67e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 51.41 E-value: 7.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPI 166
Cdd:COG2807 47 DLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLA---PSVALLLAGTALIGAGIAVG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIpPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSSH 246
Cdd:COG2807 124 NVLLPGLIKRWF-PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAA---LGWRGALAVWALLALLALLLWLPLLRRRPAAA 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTiderekkyindslwgtdvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQvLRFSLKSNGLLSSLP 326
Cdd:COG2807 200 AA-------------------APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLLSLF 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 327 YLAMWLFSMFISVVADWMisskrfshtATRKLINSIgqygpGVALIAASYTGC----DRALTLAILTIGVGLnGGIYS-- 400
Cdd:COG2807 260 QLAGIPGSLLVPLLADRL---------GDRRPLLLL-----LGLLGLAGLLGLllapGSLPWLWAVLLGLGQ-GGLFPla 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 665401411 401 -GFKINHLDlTPRFAGFLMSITNCSANLAGLLAPIAAGHLISdpskpMMGQWQIVFFIAAFVYIICGTF 468
Cdd:COG2807 325 lTLIGLRAR-TPAEAAALSGMAQSVGYLLAALGPLLVGALHD-----ATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
96-464 |
9.63e-07 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 51.04 E-value: 9.63e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCThAMLA 175
Cdd:cd17330 37 GLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS---RNLWLLFLARFLDGLTGGNVSVAQ-AYIA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 176 KWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLifvhedpsshptiderekk 255
Cdd:cd17330 113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFL------------------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 256 yindslwgtdvvksPPIPFkaiikslpfyaILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSM 335
Cdd:cd17330 174 --------------PPLRR-----------LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 336 FIsvvadWMISSKRFShtaTRKLIN-SIGQYGPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPR-- 412
Cdd:cd17330 229 LL-----IPRLAKRLG---ERKLLRlGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQgk 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 665401411 413 FAGFLMSITncsaNLAGLLAPIAAGHLISDPSKPMmgqwqiVFFIAAFVYII 464
Cdd:cd17330 301 AQGIIQSLQ----SLARIIGPLLAGPLYSFLGPGV------PFLLAAGLLLI 342
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
96-238 |
1.04e-06 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 51.08 E-value: 1.04e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLA 175
Cdd:cd06173 247 GLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLS---PSLWLLLAALFLLGLAGGLFNVPLNTLLQ 323
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 176 KWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIF 238
Cdd:cd06173 324 LRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLLL 383
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
85-245 |
1.92e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 50.35 E-value: 1.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 85 DGEFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCAVRFIQGLGEG 164
Cdd:pfam00083 38 VSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 165 PIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSIFYvfgiVGTVWSIAFLIFVHEDPS 244
Cdd:pfam00083 118 GASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLG----LQLVPALLLIIGLLFLPE 193
|
.
gi 665401411 245 S 245
Cdd:pfam00083 194 S 194
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
87-241 |
2.67e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.48 E-value: 2.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLR--FLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEG 164
Cdd:COG2271 210 VRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRklVLAIGLLLAALALLLLALL---PSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665401411 165 PIVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHE 241
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLLRE 360
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
87-227 |
3.95e-06 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 49.19 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPI 166
Cdd:PRK11551 44 EFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWD---FPSLLVARLLTGVGLGGA 120
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIV 227
Cdd:PRK11551 121 LPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAG---DAAWRHIFYVGGVG 178
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
105-242 |
8.55e-06 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 48.03 E-value: 8.55e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 105 GYVITQ----IPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPP 180
Cdd:cd17476 41 SYSLTVgtfiLIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSP---NFIFFIICRALQGLGPAFLLPNAMALLGRTYPP 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 181 NERSRMGAAVY-AGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFVHED 242
Cdd:cd17476 118 GPRKNIVFSLFgATAPLGFALGGVFGGLFAQL---AWWPWIFWFLAILAAIVAVAAIFWTSPS 177
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
96-270 |
9.88e-06 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 47.71 E-value: 9.88e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYgSLRFLGYGMLINSVfafLVPVA-ARGGGVWGLCAVRFIQGLGEGPIVPCTHAML 174
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQI-SARWLFSSGLVLSG---LTTVAfSGSSSVWVFSILWFLNGLAQGLGWPPCAKIL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 175 AKWIPPNersrmgaavyagaQFGTI-----ISMPLSG----LLAEY-GFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPS 244
Cdd:cd17343 117 RKWFSPS-------------QFGTWwsvlsTSMNLAGslgpILATLlALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPS 183
|
170 180 190
....*....|....*....|....*....|....
gi 665401411 245 SH--PTIDEREKKY------INDSLWgTDVVKSP 270
Cdd:cd17343 184 DVglNNIEEEESKGkkkkspRGESTL-KELLLSP 216
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-236 |
1.54e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 47.04 E-value: 1.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARGGGVWGLCAvrFIQGLGEGPI 166
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLL--LLLGFGLGGL 310
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 167 VPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFdgGWPSIFYVFGIVGTVWSIAFL 236
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
90-310 |
1.81e-05 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 46.91 E-value: 1.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 90 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLinsVFAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPC 169
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLL---LTVLLLAAMALTSGFAALLALRFLAGAASAFVFVF 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 170 THAMLAKWIPPNERSRMGAAVYAGAQFGTIIsmplSGLLAEYGFDGG--WPSIFYVFGIVGTVWSIAFLIFVHEDPSSHP 247
Cdd:cd06180 108 GSNLVLHHATAAGRGHLIGLLFAGVGLGIAL----SGLLVPAGLGGGlsWRAGWLALALLSAVLLLLSFLLLRRGPSAPT 183
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665401411 248 TiderekkyindslwgtdvvksPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMTELPTYMKQ 310
Cdd:cd06180 184 E---------------------ASAAESAPGLNRPLWRLALAYGLFGFGYIITATFLPLIARE 225
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
286-491 |
3.13e-05 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 46.26 E-value: 3.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 286 ILFAHMGHNYGYETLMTELPTYMKQVLRFSLKSNGLLSSLPYLAMWLFSMFISVVADwmisskRFShtatRKLINSIGQY 365
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD------RFG----RRRVLLIGLL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 366 GPGVALIAASYTGCDRALTLAILTIGVGLNGGIYSGFKINHLDLTPRFAGFLMSITNCSANLAGLLAPIAAGHLISDPSk 445
Cdd:pfam07690 71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG- 149
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 665401411 446 pmmgqWQIVFFIAAFVYIICGTFYNIFGSGERQYWDNPEDDEQKPA 491
Cdd:pfam07690 150 -----WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSL 190
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
87-230 |
3.99e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 46.03 E-value: 3.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFY-GYVITQIpFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGeGP 165
Cdd:cd17504 25 EFGTSAAAVSWVLTAYLLvGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN---LPVLIAGRALQGIG-GA 99
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665401411 166 IVPCTHAMLAKWIPPnERSRMGAAVYAG-AQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTV 230
Cdd:cd17504 100 VFPLAFALVREEFPP-ERVPVAQGILSAtFGIGAGIGLPLGGWIVQH---LGWRWIFWTAAPVAVL 161
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
87-227 |
7.19e-05 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 44.88 E-value: 7.19e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPF-GILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGP 165
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLLiPRLAKRLGERKLLRLGLLLAIIGLLLLPFASS---VPLLVLAAAILAFGTGI 280
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665401411 166 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLaeYGFDGGWPSIFYVFGIV 227
Cdd:cd17330 281 VFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPL--YSFLGPGVPFLLAAGLL 340
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
90-239 |
8.32e-05 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 44.86 E-value: 8.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 90 WSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAarGGGVWGLCAVRFIQGLGEGPIVPC 169
Cdd:cd17477 220 LSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLV--PGLPLALLVLLFLWGGAAGPLYTL 297
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 170 THAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWpsiFYVFGIVgtvwSIAFLIFV 239
Cdd:cd17477 298 ALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGL---FLFLAAV----ALLFLLFL 360
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
96-439 |
2.27e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.46 E-value: 2.27e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggvWGLCAVR-FIQGLGEGPIVPCTHAML 174
Cdd:cd17333 34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPS----IYLFVVLmFLAGLGAGILDTGANTFV 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 175 AKWIPPNERSRMgAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPsiFYVFGIVGTVWSIAFLIfvhedpsshPTIDEREK 254
Cdd:cd17333 110 GALFEESSATRL-NVLHGFFGLGALIGPLIATSLLTSELSWSWA--YLIIGLIYLLLAILILL---------TLFPELPS 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 255 KYINDSLWGTDvvKSPPIPFKAIIKSLPFYAILFAHMGHNYGYETLMtelPTYMKQVLRFSLKSNGLLSSLpylamWLFS 334
Cdd:cd17333 178 ARNPQQSVGAF--SASASRLLRNPSIILGALALFLYVGAETAFSSWV---PSYLVEKKHVSDGLAGYLLSG-----FWVG 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 335 MFISVVADWMISSKRFSHTATRkLINSIGQYGPGVALIAASYTGcdraltLAILTIGVGLN-GGIYSGFKINHLDLTPRF 413
Cdd:cd17333 248 ITIGRLLGGPISRRIKPHTLLV-LSGSGALLGLLILLLAPTLVV------GLVATALLGLFmAALFPTILSLGISNLPYA 320
|
330 340
....*....|....*....|....*.
gi 665401411 414 AGFLMSITNCSANLAGLLAPIAAGHL 439
Cdd:cd17333 321 KGKGTSVLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
99-238 |
2.69e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 43.33 E-value: 2.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 99 LSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAARgggVWGLCAVRFIQGLGEGPIVPCTHAMLAKWI 178
Cdd:cd17323 40 VSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN---IAMLIILRFLQGFFGSSPLAIGAGTIADLF 116
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665401411 179 PPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIV-GTVWSIAFLIF 238
Cdd:cd17323 117 TPEERGKAMGVYSLGPLLGPALGPIIGGFITQS---LGWRWIFWFLAIIsGFCLILIFLFL 174
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
87-249 |
3.36e-04 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 42.95 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYG---SLRFLGYGMLINSVFAFLVPvaarggGVWGLCAVRFIQGLGE 163
Cdd:cd17315 28 GFGLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGrrkSLLIAAVLYVIGALLSALAP------NVWVLIVGRFLLGLGV 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 164 GPIVPCTHAMLAKWIPPNERSRMGaavyAGAQFGTIISMpLSGLLAEYGFDGGWPSIFYVFGIVGTVWSIAFLIFVHEDP 243
Cdd:cd17315 102 GLASVLVPLYISEIAPAKIRGALG----TLNQLMITFGI-LLAYLLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLP 176
|
....*.
gi 665401411 244 SSHPTI 249
Cdd:cd17315 177 ESRALL 182
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
91-238 |
3.94e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 42.65 E-value: 3.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGslRFLGYG-----MLINSVFAFLVPVAARGGGVWGLCAVRFIQGLGEGP 165
Cdd:cd17364 37 PSGVSGLVNAAALVGTIIGQLFFGFLGDRFG--RKRVYGveliiMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 166 IVPCTHAMLAKWIPPNERSRMGAAVYA----GAQFGTIISMPLSGLLAEYGFDGGWPSIFYVFGIV---GTVWSIAFLIF 238
Cdd:cd17364 115 DYPLSATIMSEYANKKRRGALIAAVFAmqgfGILAGAIVTLILSAIFEHPLPAGTYHHADLVWRIVlglGAIPALSVLYF 194
|
|
| MFS_SV2 |
cd17363 |
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ... |
91-243 |
1.08e-03 |
|
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340921 [Multi-domain] Cd Length: 474 Bit Score: 41.71 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVaARGGGVWGLCavRFIQGLGEGPIVPCT 170
Cdd:cd17363 32 SNSNKGMLGLIVYLGMMVGAFVWGGLADKLGRKQCLLIALSVNGVFAFLSSF-VQGYGFFLFC--RLLSGIGIGGSIPIV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 171 HAMLAKWIPPNERSR---------MGAAVYAGAQFGTIIsmPLSGllaeYGFDGGWPSIFY---VFGIVGT---VWSIAF 235
Cdd:cd17363 109 FSYFAEFLAREKRGEhlswlcmfwMIGGLYASAMAWAII--PHYG----WGFSMGTAYQFHswrVFVIVCAlpsVASVVA 182
|
....*...
gi 665401411 236 LIFVHEDP 243
Cdd:cd17363 183 LTFMPESP 190
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
91-469 |
1.56e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 40.67 E-value: 1.56e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLR-FLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 169
Cdd:cd17490 29 SLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKlFIIIGLLFTVLASLIMILF---PSPWGLLIARFLSGIAAATWVSF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 170 ThAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYgfdGGWPSIFYV---FGIVGTVwsIAFLIfvhEDPSSH 246
Cdd:cd17490 106 T-VLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEH---FGMRAPFLLaalAGVLGFI--LSLFI---KEERRE 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 247 PTIDEREKKYIndslwgTDVVKSPPIPFKAIIKSLPFYaILFAhmghnygyeTLMTELPTYMKQV--LRFSLksnGLLSS 324
Cdd:cd17490 177 KKPVLTELKEL------LSVLKDKKLLFFSLLAILQQM-ITFS---------TTFGFTPLIAKQLgaSSFQL---GLLSI 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 325 LpylamwlfSMFISVVADWMISSKRFSHTATRKLInSIGQYGPGVALIAASYTGcdrALTL-----AILTIGVGLNGGIY 399
Cdd:cd17490 238 I--------YLLPNALASLLSGTLFYKKLGERNTI-IIGFLLLGAYCFLIPFAP---NLTLlyllqALNGFGTGILFPLL 305
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665401411 400 SGFKINHLDLTPRFA--GFLMSITncsaNLAGLLAPIAAGHLISDPSKpmmgqwQIVFFIAAFVYIICGTFY 469
Cdd:cd17490 306 MSLSIEGVPAEQRSTamGFFQAIY----ALGMFLGPVLVGIISEAFGL------QTGFFVIGVIALLAAILS 367
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
87-247 |
1.73e-03 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 40.72 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 87 EFAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRF-IQGLGEGP 165
Cdd:cd17355 32 EFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA---TSLWQLYLLWGlLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 166 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEygfDGGWPSIFYVFGIVGTVWSIAFLIFVHEDPSS 245
Cdd:cd17355 109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE---AFGWRTALLVLALLALLVLVPVLLLLRRRPAD 185
|
..
gi 665401411 246 HP 247
Cdd:cd17355 186 LA 187
|
|
| synapt_SV2 |
TIGR01299 |
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ... |
23-243 |
2.03e-03 |
|
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.
Pssm-ID: 130366 [Multi-domain] Cd Length: 742 Bit Score: 40.73 E-value: 2.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 23 CFATRYFVTFMLFLGMAnayVMRTNMSVAIVAMVNHTAiksgeaeeyddecgDRDIPIDDSQDGEFAwSSALQGYILSSF 102
Cdd:TIGR01299 159 CGHGRFQWALFFVLGLA---LMADGVEVFVVGFVLPSA--------------EKDLCIPDSGKGMLG-LIVYLGMMVGAF 220
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 103 FYGYvitqipfgiLAKKYGSLRFLGYGMLINSVFAFLVPVaARGGGVWGLCavRFIQGLGEGPIVPCTHAMLAKWIPPNE 182
Cdd:TIGR01299 221 FWGG---------LADKLGRKQCLLICLSVNGFFAFFSSF-VQGYGFFLFC--RLLSGFGIGGAIPIVFSYFAEFLAQEK 288
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665401411 183 RSR---------MGAAVYAGAQFGTIIsmPLSGllaeYGFDGGWPSIFY---VFGIV---GTVWSIAFLIFVHEDP 243
Cdd:TIGR01299 289 RGEhlswlcmfwMIGGIYAAAMAWAII--PHYG----WSFQMGSAYQFHswrVFVIVcafPCVFAIGALTFMPESP 358
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
91-238 |
2.25e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCT 170
Cdd:cd17473 231 SAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALA---SGLWVVLLGAILAGLGFGLLLPTL 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665401411 171 HAMLAKWIPPNERSR-MGA---AVYAGAQFGTIISMPLSGLLaeygfdGGWPSIFYVFGIVGTVWSIAFLIF 238
Cdd:cd17473 308 NSWAMSLVPPELRGRaMGIvtsAFFLGQFLSPLVLGPLVNLT------GGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
94-187 |
3.11e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 39.87 E-value: 3.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 94 LQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAM 173
Cdd:cd17317 26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS---PSYELFLVLRFLVGVTSAGIFTVGFVL 102
|
90
....*....|....
gi 665401411 174 LAKWIPPNERSRMG 187
Cdd:cd17317 103 GMEIVGPKYRSFVG 116
|
|
| MFS_SLCO_OATP |
cd17336 |
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ... |
88-238 |
3.49e-03 |
|
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340894 [Multi-domain] Cd Length: 411 Bit Score: 39.91 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 88 FAWSSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGYGMLINSVFAFL--VPVAargggvwgLCAVRFIQGLGEGP 165
Cdd:cd17336 33 FGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFLlaLPHF--------LFVGQFLLGIGSSP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 166 IVPCTHAMLAKWIPPNERSRMGAAVYAGAQFGTIISMPLSGLLAEYGFDGGWPSI----------------FYVFGIVGT 229
Cdd:cd17336 105 LYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLgitpddprwigawwlgFLILGILLL 184
|
....*....
gi 665401411 230 VWSIAFLIF 238
Cdd:cd17336 185 IVSIPLFFF 193
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
118-292 |
4.11e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 118 KKYGSLRFLGYGMLinsvfAFLVPVAARGGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRmgaaVY----AG 193
Cdd:cd17370 62 GKRKPLVILGYGLS-----ALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGK----AFglhrAL 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 194 AQFGTIISmPLSGLLAEYGFDGGWPSIFYVFGIVGTVwSIAFLIFVHEDPsshptidEREKKYINDSLWGtdVVKSPPIP 273
Cdd:cd17370 133 DTLGAVLG-PLLAALLLYLLGGNYRTIFLLAAIPALL-ALLILLFVVKEY-------PRPPKLRKKSKKT--SLKKLPKA 201
|
170
....*....|....*....
gi 665401411 274 FKAIIKSLPFYAILFAHMG 292
Cdd:cd17370 202 FWLYLLAVALFALGNFSFA 220
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
96-289 |
5.25e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 5.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 96 GYILSSFFYGYVITQIPFGILAKKYGslRFLgygMLINSVFAFLVPVAARG--GGVWGLCAVRFIQGLGEGPIVPCThAM 173
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYG--RKP---MLLRASLGMAIVIGLMAfvTNVWQLLILRLLQGVFSGYVPNAT-AL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 174 LAKWIPpneRSRMGAAV---YAGAQFGTIISMPLSGLLAEygfdggWPSIFYVFGIVGTVWSIAFLI---FVHEDpsshp 247
Cdd:cd17391 113 IASQTP---KEKSGWALgtlSTGVVAGTLIGPLLGGFLAD------LFGIRNVFFITGGLLFLAFLLtlfFVKED----- 178
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 665401411 248 tiderekkyindslwGTDVVKSPPIPFKAIIKSLPFYAILFA 289
Cdd:cd17391 179 ---------------FKPVEKKKMVSTKEVWNSVPNPSLLIS 205
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
91-239 |
6.30e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 6.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 91 SSALQGYILSSFFYGYVITQIPFGILAKKYGSLRFLGY-GMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPC 169
Cdd:cd17490 228 SSFQLGLLSIIYLLPNALASLLSGTLFYKKLGERNTIIiGFLLLGAYCFLIPFA---PNLTLLYLLQALNGFGTGILFPL 304
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665401411 170 THAMLAKWIPPNERS-RMGA--AVYA-GAQFGTIIsmplSGLLAEYgfdGGWPSIFYVFGIVGTVWSIAFLIFV 239
Cdd:cd17490 305 LMSLSIEGVPAEQRStAMGFfqAIYAlGMFLGPVL----VGIISEA---FGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
113-240 |
6.43e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 38.73 E-value: 6.43e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 113 FGILAKKYGSLRFLGYGMLINSVFAFLVPVAargGGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYA 192
Cdd:cd17489 247 SGKLSDRKGPKTVIIPGLLLLALGLLLLSFA---GSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFI 323
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 665401411 193 GAQFGTIISMPLSGLLAEYgfdGGWPSIFYVFGIVGTVwSIAFLIFVH 240
Cdd:cd17489 324 FFDLGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVLL-ALVLYIFLL 367
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
113-308 |
7.22e-03 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 38.76 E-value: 7.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 113 FGILAKKYGSLRFLGYGMLINSVFAFLVPVAArggGVWGLCAVRFIQGLGEGPIVPCTHAMLAKWIPPNERSRMGAAVYA 192
Cdd:PRK12307 73 FGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS---GVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665401411 193 GAQFGTIISMPLSGLLAEYgfdGGWPSIFYvfgiVGTVWSIAFLIFVHEDPSSHPTIderEKKYINDSLWGTDVVKSPPI 272
Cdd:PRK12307 150 GFGIGNIIAAYFMPSFAEA---YGWRAAFF----VGLLPVLLVIYIRARAPESKEWE---EAKLSGKGKHSQSAWSVFSL 219
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 665401411 273 PFKAIIK------SLPFYAILFAHMGHNYGYETLmteLPTYM 308
Cdd:PRK12307 220 SMKGLFNraqfplTLCVFIVLFSIFGANWPIFGL---LPTYL 258
|
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| |
