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Conserved domains on  [gi|665402750|ref|NP_001286712|]
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windpipe, isoform E [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                         90       100
                 ....*....|....*....|...
gi 665402750 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQL 240
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                         90       100
                 ....*....|....*....|...
gi 665402750 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQL 240
LRR_8 pfam13855
Leucine rich repeat;
113-169 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665402750  113 GLKRLNLKHNQLTS---DKLRKLPqHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAI 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddGAFKGLS-NLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-170 1.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  52 CNSTRGLRLTEKTFQSTVP--------VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLkdLGHL-----GKGLKRL 117
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPseftklplVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--FGGLpdsfgSKRLENL 480

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665402750 118 NLKHNQLTS---DKLRKLPQHLQvLNLQHNNIT-HLPLELTHMHQLHQLELSHNAIN 170
Cdd:PLN00113 481 DLSRNQFSGavpRKLGSLSELMQ-LKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-170 1.85e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  80 NLTRLSHL------------LDKLPELTSADLSHNQLKDLGHLGK--GLKRLNLKHNQLTSD-KLRKLPQ-------HLQ 137
Cdd:cd21340   44 FLTNLTHLylqnnqiekienLENLVNLKKLYLGGNRISVVEGLENltNLEELHIENQRLPPGeKLTFDPRslaalsnSLR 123

                         90       100       110
                 ....*....|....*....|....*....|...
gi 665402750 138 VLNLQHNNITHLpLELTHMHQLHQLELSHNAIN 170
Cdd:cd21340  124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-169 1.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.76  E-value: 1.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  72 HSIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLG-HLG--KGLKRLNLKHNQLT--SDKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886  139 KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPeELGnlTNLKELDLSNNQITdlPEPLGNLTN-LEELDLSGNQL 217

                         90       100
                 ....*....|....*....|...
gi 665402750 147 THLPLELTHMHQLHQLELSHNAI 169
Cdd:COG4886  218 TDLPEPLANLTNLETLDLSNNQL 240
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-170 2.05e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.05e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  73 SIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKD----LGHLgKGLKRLNLKHNQLTS--DKLRKLPQhLQVLNLQHNNI 146
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDlpepLGNL-TNLKSLDLSNNQLTDlpEELGNLTN-LKELDLSNNQI 194

                         90       100
                 ....*....|....*....|....
gi 665402750 147 THLPLELTHMHQLHQLELSHNAIN 170
Cdd:COG4886  195 TDLPEPLGNLTNLEELDLSGNQLT 218
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-169 4.46e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 4.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  88 LDKLPELTSADLSHNqlKDLGHLgKGLKRLNLKHNQLTS--DKLRKLPqHLQVLNLQHNNITHLPLELTHMHQLHQLELS 165
Cdd:COG4886   92 LGDLTNLTELDLSGN--EELSNL-TNLESLDLSGNQLTDlpEELANLT-NLKELDLSNNQLTDLPEPLGNLTNLKSLDLS 167


                 ....
gi 665402750 166 HNAI 169
Cdd:COG4886  168 NNQL 171
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
73-152 8.06e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.57  E-value: 8.06e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  73 SIDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTS-DKLRKLPQhLQVLNLQHNNITHL 149
Cdd:COG4886  209 ELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDlPPLANLTN-LKTLDLSNNQLTDL 287


                 ...
gi 665402750 150 PLE 152
Cdd:COG4886  288 KLK 290
LRR_8 pfam13855
Leucine rich repeat;
113-169 4.46e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 4.46e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665402750  113 GLKRLNLKHNQLTS---DKLRKLPqHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAI 169
Cdd:pfam13855   2 NLRSLDLSNNRLTSlddGAFKGLS-NLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 52-170 1.33e-07

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 55.24  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  52 CNSTRGLRLTEKTFQSTVP--------VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLkdLGHL-----GKGLKRL 117
Cdd:PLN00113 403 CRSLRRVRLQDNSFSGELPseftklplVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKF--FGGLpdsfgSKRLENL 480

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665402750 118 NLKHNQLTS---DKLRKLPQHLQvLNLQHNNIT-HLPLELTHMHQLHQLELSHNAIN 170
Cdd:PLN00113 481 DLSRNQFSGavpRKLGSLSELMQ-LKLSENKLSgEIPDELSSCKKLVSLDLSHNQLS 536
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 80-170 1.85e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.85e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  80 NLTRLSHL------------LDKLPELTSADLSHNQLKDLGHLGK--GLKRLNLKHNQLTSD-KLRKLPQ-------HLQ 137
Cdd:cd21340   44 FLTNLTHLylqnnqiekienLENLVNLKKLYLGGNRISVVEGLENltNLEELHIENQRLPPGeKLTFDPRslaalsnSLR 123

                         90       100       110
                 ....*....|....*....|....*....|...
gi 665402750 138 VLNLQHNNITHLpLELTHMHQLHQLELSHNAIN 170
Cdd:cd21340  124 VLNISGNNIDSL-EPLAPLRNLEQLDASNNQIS 155
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
76-176 1.97e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  76 LSHLNLTRLSHlldKLPE-LTSADLSHNQLKDL-GHLGKGLKRLNLKHNQLTSDKlRKLPQHLQVLNLQHNNITHLPLEL 153
Cdd:PRK15370 185 LKILGLTTIPA---CIPEqITTLILDNNELKSLpENLQGNIKTLYANSNQLTSIP-ATLPDTIQEMELSINRITELPERL 260

                         90       100
                 ....*....|....*....|...
gi 665402750 154 THmhQLHQLELSHNAINCSCQTL 176
Cdd:PRK15370 261 PS--ALQSLDLFHNKISCLPENL 281
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 41-169 3.31e-07

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 53.26  E-value: 3.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  41 QHTHKPLYHLKCNST--RGLRLTEKTFQSTVPVHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLG--HLG 111
Cdd:COG5238  178 QNNSVETVYLGCNQIgdEGIEELAEALTQNTTVTTLWLKRNPIGdegaeILAEALKGNKSLTTLDLSNNQIGDEGviALA 257

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665402750 112 KGLK------RLNLKHNQLTSDKLRKLPQHLQV------LNLQHNNITH-----LPLELTHMHQLHQLELSHNAI 169
Cdd:COG5238  258 EALKnnttveTLYLSGNQIGAEGAIALAKALQGnttltsLDLSVNRIGDegaiaLAEGLQGNKTLHTLNLAYNGI 332
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-182 4.00e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 53.01  E-value: 4.00e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  72 HSIDLSHLNLTRLSHLLdKLPELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTSDKLRKLPQH-----LQVLNLQHN 144
Cdd:COG4886  231 ETLDLSNNQLTDLPELG-NLTNLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLlglnsLLLLLLLLN 309

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665402750 145 NITHLPLELTHMHQLHQLELSHNAINCSCQTLEVRNWL 182
Cdd:COG4886  310 LLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLL 347
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
74-169 5.39e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.63  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  74 IDLSHLNLTRLSHLLDKLPELTSADLSHNQLKDLghlgKGLKRLNLKHNQLTSDklrklPQHLQVLNLQHNNITHLPLEL 153
Cdd:COG4886   62 LSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL----TNLTELDLSGNEELSN-----LTNLESLDLSGNQLTDLPEEL 132

                         90
                 ....*....|....*.
gi 665402750 154 THMHQLHQLELSHNAI 169
Cdd:COG4886  133 ANLTNLKELDLSNNQL 148
LRR_8 pfam13855
Leucine rich repeat;
92-146 1.30e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.30e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665402750   92 PELTSADLSHNQLKDLG-----HLgKGLKRLNLKHNQLTS---DKLRKLPQhLQVLNLQHNNI 146
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDdgafkGL-SNLKVLDLSNNLLTTlspGAFSGLPS-LRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-169 1.83e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.40  E-value: 1.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  76 LSHL-NLTRLsHL----------LDKLPELTSADLSHNQLKD----------LGHLGKGLKRLNLKHNQLTSDK-LRKLp 133
Cdd:cd21340   64 LENLvNLKKL-YLggnrisvvegLENLTNLEELHIENQRLPPgekltfdprsLAALSNSLRVLNISGNNIDSLEpLAPL- 141

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 665402750 134 QHLQVLNLQHNNITHL-PLE--LTHMHQLHQLELSHNAI 169
Cdd:cd21340  142 RNLEQLDASNNQISDLeELLdlLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 71-169 5.64e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 5.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  71 VHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLG--HLGKGLKR------LNLKHNQLTSDKLRKLPQHLQ 137
Cdd:COG5238  266 VETLYLSGNQIGaegaiALAKALQGNTTLTSLDLSVNRIGDEGaiALAEGLQGnktlhtLNLAYNGIGAQGAIALAKALQ 345

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 665402750 138 V------LNLQHNNIT--------HLPLELThmhQLHQLELSHNAI 169
Cdd:COG5238  346 EnttlhsLDLSDNQIGdegaialaKYLEGNT---TLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 31-176 9.69e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.12  E-value: 9.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  31 CPADCTCSLSQHTHKPLYHLKCN----STRGLRLTEKTFQSTVP-VHSIDLSHLNLT-----RLSHLLDKLPELTSADLS 100
Cdd:cd00116   94 GPDGCGVLESLLRSSSLQELKLNnnglGDRGLRLLAKGLKDLPPaLEKLVLGRNRLEgasceALAKALRANRDLKELNLA 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750 101 HNQLKDLG--HLGKG------LKRLNLKHNQLTSDKLRKL------PQHLQVLNLQHNNITHLPLE------LTHMHQLH 160
Cdd:cd00116  174 NNGIGDAGirALAEGlkancnLEVLDLNNNGLTDEGASALaetlasLKSLEVLNLGDNNLTDAGAAalasalLSPNISLL 253

                        170
                 ....*....|....*..
gi 665402750 161 QLELSHNAINCS-CQTL 176
Cdd:cd00116  254 TLSLSCNDITDDgAKDL 270
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 63-156 3.22e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 43.63  E-value: 3.22e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  63 KTFQSTVPVHSIDLSHLNLT-----RLSHLLDKLPELTSADLSHNQLKDLGHLG--------KGLKRLNLKHNQLTSDKL 129
Cdd:COG5238  314 EGLQGNKTLHTLNLAYNGIGaqgaiALAKALQENTTLHSLDLSDNQIGDEGAIAlakylegnTTLRELNLGKNNIGKQGA 393

                         90       100
                 ....*....|....*....|....*..
gi 665402750 130 RKLPQHlqvlnLQHNNITHLPLELTHM 156
Cdd:COG5238  394 EALIDA-----LQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 71-169 3.84e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 3.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  71 VHSIDLSHLNLT-RLSHLLDKLPELTSADLSHNQLK-----DLGHLGKGLKRLNLKHNQLTSDKLRKLPQHLQVLNLQHN 144
Cdd:PLN00113  71 VVSIDLSGKNISgKISSAIFRLPYIQTINLSNNQLSgpipdDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSNN 150

                         90       100
                 ....*....|....*....|....*.
gi 665402750 145 NIT-HLPLELTHMHQLHQLELSHNAI 169
Cdd:PLN00113 151 MLSgEIPNDIGSFSSLKVLDLGGNVL 176
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 112-145 7.13e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 37.61  E-value: 7.13e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 665402750  112 KGLKRLNLKHNQLTS-DKLRKLPqHLQVLNLQHNN 145
Cdd:pfam12799   1 PNLEVLDLSNNQITDiPPLAKLP-NLETLDLSGNN 34
LRR_8 pfam13855
Leucine rich repeat;
134-170 1.30e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.30e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665402750  134 QHLQVLNLQHNNITHLPLE-LTHMHQLHQLELSHNAIN 170
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLT 38
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 54-171 1.32e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750  54 STRGLRLTEKTFQSTVPVHSIDLSHLNLTR-LSHLLDKL---PELTSADLSHNQLKDLG--HLGKGLK-------RLNLK 120
Cdd:cd00116   66 IPRGLQSLLQGLTKGCGLQELDLSDNALGPdGCGVLESLlrsSSLQELKLNNNGLGDRGlrLLAKGLKdlppaleKLVLG 145

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665402750 121 HNQLTSDKLRKL------PQHLQVLNLQHNN-----ITHLPLELTHMHQLHQLELSHNAINC 171
Cdd:cd00116  146 RNRLEGASCEALakalraNRDLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLTD 207
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-177 1.45e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 1.45e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 665402750  134 QHLQVLNLQHNNITHLPLeLTHMHQLHQLELSHNAINCSCQTLE 177
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPP-LAKLPNLETLDLSGNNKITDLSDLA 43
LRR_8 pfam13855
Leucine rich repeat;
71-124 2.41e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.41e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665402750   71 VHSIDLSHLNLTRLS-HLLDKLPELTSADLSHNQLKDLG-----HLGKgLKRLNLKHNQL 124
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdGAFKGLSNLKVLDLSNNLLTTLSpgafsGLPS-LRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
49-104 2.46e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.46e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 665402750   49 HLKCNSTRGLRltEKTFQSTVPVHSIDLSHLNLTRLS-HLLDKLPELTSADLSHNQL 104
Cdd:pfam13855   7 DLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSpGAFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 92-127 5.87e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 5.87e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 665402750   92 PELTSADLSHNQLKDLGHLG--KGLKRLNLKHNQLTSD 127
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAklPNLETLDLSGNNKITD 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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