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Conserved domains on  [gi|665409945|ref|NP_001286949|]
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uncharacterized protein Dmel_CG10576, isoform D [Drosophila melanogaster]

Protein Classification

M24 family metallopeptidase( domain architecture ID 320)

M24 family metallopeptidase cleaves amido-, imido-, or amidino-containing bonds, exhibiting a fairly narrow substrate specificity compared to other metallo-aminopeptidases, possibly playing roles in regulation of biological processes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APP_MetAP super family cl00279
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 3-361 8.32e-165

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


The actual alignment was detected with superfamily member TIGR00495:

Pssm-ID: 469704  Cd Length: 390  Bit Score: 467.06  E-value: 8.32e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945    3 DVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYKKEKDLKKGIAFPTCLSV 82
Cdd:TIGR00495   5 DEQQEQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPTCISV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   83 NNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGRQADVILAAYWAVQAALRLLKSGAN 162
Cdd:TIGR00495  85 NNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVKPGNT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  163 NYSLTDAVQQISESYKCKPIEGMLSHELKQFKIDGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDT 242
Cdd:TIGR00495 165 NTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAKDADQ 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  243 KVSIYKKSEE-NYMLKMKASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHT 321
Cdd:TIGR00495 245 RTTIYKRDPSkTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQFKFT 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 665409945  322 VLLMPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPL 361
Cdd:TIGR00495 325 VLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPI 364
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 3-361 8.32e-165

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 467.06  E-value: 8.32e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945    3 DVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYKKEKDLKKGIAFPTCLSV 82
Cdd:TIGR00495   5 DEQQEQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPTCISV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   83 NNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGRQADVILAAYWAVQAALRLLKSGAN 162
Cdd:TIGR00495  85 NNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVKPGNT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  163 NYSLTDAVQQISESYKCKPIEGMLSHELKQFKIDGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDT 242
Cdd:TIGR00495 165 NTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAKDADQ 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  243 KVSIYKKSEE-NYMLKMKASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHT 321
Cdd:TIGR00495 245 RTTIYKRDPSkTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQFKFT 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 665409945  322 VLLMPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPL 361
Cdd:TIGR00495 325 VLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPI 364
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 1.15e-110

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 323.51  E-value: 1.15e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  18 VTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYKKEKDLKKGIAFPTCLSVNNCVCHFSPAKNDAD 97
Cdd:cd01089    1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  98 YTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESY 177
Cdd:cd01089   81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 178 KCKPIEGMLSHELKQfkidgektiiqnpseaqrkehekctfetyevyaidvIVSTGEGVGRekdtkvsiykkseenymlk 257
Cdd:cd01089  161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665409945 258 mkasrallaevktkygnmpfnirsfeeetkarmgVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMPNGVNLVTG 334
Cdd:cd01089  186 ----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLTG 228
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 67-328 2.31e-26

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 109.80  E-value: 2.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  67 EKDLKKGIAFPTCLSVNNCVCHFSPAKNDaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIvvgaAADQKISGRQADVILAA 146
Cdd:PTZ00053 202 ADGLKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTV----AFNPKYDPLLQATKDAT 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 147 YWAVQAA---LRLLKSGAnnysltdAVQQISESY---------KCKPIEGMLSHELKQFKIDGEKTI-IQNPSEAQRKEH 213
Cdd:PTZ00053 277 NTGIKEAgidVRLSDIGA-------AIQEVIESYeveikgktyPIKSIRNLNGHSIGPYIIHGGKSVpIVKGGENTRMEE 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 214 EkctfetyEVYAIDVIVSTGEGVGREkDTKVSIYKKSEENYM--LKMKASRALLAEVKTKYGNMPFNIRSFEEETKAR-- 289
Cdd:PTZ00053 350 G-------ELFAIETFASTGRGYVNE-DLECSHYMKDPGAEFvpLRLPKAKQLLKHINTNFGTLAFCRRWLDRLGQDRhl 421

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 665409945 290 MGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMPNG 328
Cdd:PTZ00053 422 LALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 20-177 1.57e-12

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 66.11  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   20 KYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKvykkekdlkKGIAFPT--CLSVNNCVCHFSPAkndaD 97
Cdd:pfam00557   2 LMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA---------RGPAFPPivASGPNAAIPHYIPN----D 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   98 YTLKAGDVVKIDLGAHIDGFIAV-AAHTIVVGaaadqKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISES 176
Cdd:pfam00557  69 RVLKPGDLVLIDVGAEYDGGYCSdITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEE 143


                  .
gi 665409945  177 Y 177
Cdd:pfam00557 144 A 144
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
24-188 2.77e-12

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 66.18  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  24 AGEIVNKTLKAVIGLCVVDASVREIctqgdNQLTEEtgkvYKKEKDLK------KGiaFP--TCLSVNNCVCHFSPAknd 95
Cdd:COG0024   15 AGRIVAEVLDELAEAVKPGVTTLEL-----DRIAEE----FIRDHGAIpaflgyYG--FPksICTSVNEVVVHGIPS--- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  96 aDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVG--AAADQKIsgrqadvILAAYWAVQAALRLLKSGAnnySLTD---AV 170
Cdd:COG0024   81 -DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGevSPEARRL-------VEVTEEALYAGIAAAKPGN---RLGDighAI 149

                        170
                 ....*....|....*...
gi 665409945 171 QQISESYKCKPIEGMLSH 188
Cdd:COG0024  150 QSYAESNGYSVVREFVGH 167
 
Name Accession Description Interval E-value
crvDNA_42K TIGR00495
42K curved DNA binding protein; Proteins identified by this model have been identified in a ...
 3-361 8.32e-165

42K curved DNA binding protein; Proteins identified by this model have been identified in a number of species as a nuclear (but not nucleolar) protein with a cell cycle dependence. Various names given to members of this family have included cell cycle protein p38-2G4, DNA-binding protein GBP16, and proliferation-associated protein 1. This protein is closely related to methionine aminopeptidase, a cobolt-binding protein. [Unknown function, General]


Pssm-ID: 273105  Cd Length: 390  Bit Score: 467.06  E-value: 8.32e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945    3 DVEKEPEKTIAEDLVVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYKKEKDLKKGIAFPTCLSV 82
Cdd:TIGR00495   5 DEQQEQAYSLSNPEVVTKYKMAGEIANNVLKSVVEACSPGAKVVDICEKGDAFIMEETAKIFKKEKEMEKGIAFPTCISV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   83 NNCVCHFSPAKNDADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGRQADVILAAYWAVQAALRLLKSGAN 162
Cdd:TIGR00495  85 NNCVGHFSPLKSDQDYILKEGDVVKIDLGCHIDGFIALVAHTFVVGVAQEEPVTGRKADVIAAAHLAAEAALRLVKPGNT 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  163 NYSLTDAVQQISESYKCKPIEGMLSHELKQFKIDGEKTIIQNPSEAQRKEHEKCTFETYEVYAIDVIVSTGEGVGREKDT 242
Cdd:TIGR00495 165 NTQVTEAINKVAHSYGCTPVEGMLSHQLKQHVIDGEKVIISNPSDSQKKDHDTAEFEENEVYAVDILVSTGEGKAKDADQ 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  243 KVSIYKKSEE-NYMLKMKASRALLAEVKTKYGNMPFNIRSFEEETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHT 321
Cdd:TIGR00495 245 RTTIYKRDPSkTYGLKMKASRAFFSEIERRFDAMPFTLRNFEDEKRARMGLVECVKHELLQPYPVLYEKEGEFVAQFKFT 324

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 665409945  322 VLLMPNGVNLVTGIPFEAENYVSEYSVAQEELKTLLAQPL 361
Cdd:TIGR00495 325 VLLMPNGPMRITSGEFEPDLYKSEMEVQDPEIKALLASPI 364
PA2G4-like cd01089
Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family ...
 18-334 1.15e-110

Related to aminopepdidase M, this family contains proliferation-associated protein 2G4. Family members have been implicated in cell cycle control.


Pssm-ID: 238522  Cd Length: 228  Bit Score: 323.51  E-value: 1.15e-110
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  18 VTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKVYKKEKDLKKGIAFPTCLSVNNCVCHFSPAKNDAD 97
Cdd:cd01089    1 VTKYKTAGQIANKVLKQVISLCVPGAKVVDLCEKGDKLILEELGKVYKKEKKLEKGIAFPTCISVNNCVCHFSPLKSDAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  98 YTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESY 177
Cdd:cd01089   81 YTLKDGDVVKIDLGCHIDGYIAVVAHTIVVGAEAETPVTGKKADVIAAAHYALEAALRLLRPGNQNSDITEAIQKVIVDY 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 178 KCKPIEGMLSHELKQfkidgektiiqnpseaqrkehekctfetyevyaidvIVSTGEGVGRekdtkvsiykkseenymlk 257
Cdd:cd01089  161 GCTPVEGVLSHQLKR------------------------------------VVSSGEGKAK------------------- 185

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 665409945 258 mkasrallaevktkygnmpfnirsfeeetkarmgVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMPNGVNLVTG 334
Cdd:cd01089  186 ----------------------------------LVECVKHGLLFPYPVLYEKEGEVVAQFKLTVLLTPNGVTVLTG 228
MetAP2 cd01088
Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 20-333 9.63e-55

Methionine Aminopeptidase 2. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238521 [Multi-domain]  Cd Length: 291  Bit Score: 182.45  E-value: 9.63e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  20 KYKLAGEIVNKTLKAVIGLCVVDASVREICTqgdnqlteetgKVYKKEKDLKKGIAFPTCLSVNNCVCHFSPAKNDaDYT 99
Cdd:cd01088    3 KYREAGEIHRQVRKYAQSLIKPGMTLLEIAE-----------FVENRIRELGAGPAFPVNLSINECAAHYTPNAGD-DTV 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 100 LKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADqkisgrqaDVILAAYWAVQAALRLLKSGANNYSLTDAVQQISESYKC 179
Cdd:cd01088   71 LKEGDVVKLDFGAHVDGYIADSAFTVDFDPKYD--------DLLEAAKEALNAAIKEAGPDVRLGEIGEAIEEVIESYGF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 180 KPIEGMLSHELKQFKIDGEKTIiqnPSEAQRKEHekcTFETYEVYAIDVIVSTGEGVGREkDTKVSIYKKSEENyMLKMK 259
Cdd:cd01088  143 KPIRNLTGHSIERYRLHAGKSI---PNVKGGEGT---RLEEGDVYAIEPFATTGKGYVHD-GPECSIYMLNRDK-PLRLP 214

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665409945 260 ASRALLAEVKTKYGNMPFNIRSFEE--ETKARMGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMPNGVNLVT 333
Cdd:cd01088  215 RARKLLDVIYENFGTLPFARRWLDRlgETKLLMALKNLCKAGIVYPYPVLKEISGGYVAQFEHTIIVREDGKEVTT 290
PTZ00053 PTZ00053
methionine aminopeptidase 2; Provisional
 67-328 2.31e-26

methionine aminopeptidase 2; Provisional


Pssm-ID: 240246 [Multi-domain]  Cd Length: 470  Bit Score: 109.80  E-value: 2.31e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  67 EKDLKKGIAFPTCLSVNNCVCHFSPAKNDaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIvvgaAADQKISGRQADVILAA 146
Cdd:PTZ00053 202 ADGLKCGWAFPTGCSLNHCAAHYTPNTGD-KTVLTYDDVCKLDFGTHVNGRIIDCAFTV----AFNPKYDPLLQATKDAT 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 147 YWAVQAA---LRLLKSGAnnysltdAVQQISESY---------KCKPIEGMLSHELKQFKIDGEKTI-IQNPSEAQRKEH 213
Cdd:PTZ00053 277 NTGIKEAgidVRLSDIGA-------AIQEVIESYeveikgktyPIKSIRNLNGHSIGPYIIHGGKSVpIVKGGENTRMEE 349

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945 214 EkctfetyEVYAIDVIVSTGEGVGREkDTKVSIYKKSEENYM--LKMKASRALLAEVKTKYGNMPFNIRSFEEETKAR-- 289
Cdd:PTZ00053 350 G-------ELFAIETFASTGRGYVNE-DLECSHYMKDPGAEFvpLRLPKAKQLLKHINTNFGTLAFCRRWLDRLGQDRhl 421

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 665409945 290 MGVVECVGHKMIEPFQVLYEKPSEIVAQFKHTVLLMPNG 328
Cdd:PTZ00053 422 LALKQLVDAGIVNPYPPLCDVRGSYTSQMEHTILLRPTC 460
APP_MetAP cd01066
A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as ...
 18-203 7.90e-18

A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity compared to other metallo-aminopeptidases, suggesting they play roles in regulation of biological processes rather than general protein degradation.


Pssm-ID: 238514 [Multi-domain]  Cd Length: 207  Bit Score: 81.35  E-value: 7.90e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  18 VTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGkvykkekdlkkGIAFPTCLSVNN--CVCHFSPAknd 95
Cdd:cd01066    1 IARLRKAAEIAEAAMAAAAEAIRPGVTEAEVAAAIEQALRAAGG-----------YPAGPTIVGSGArtALPHYRPD--- 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  96 aDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAadqkiSGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISE 175
Cdd:cd01066   67 -DRRLQEGDLVLVDLGGVYDGYHADLTRTFVIGEP-----SDEQRELYEAVREAQEAALAALRPGVTAEEVDAAAREVLE 140

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 665409945 176 SYKCKPIE--------GMLSHELKQFKiDGEKTIIQ 203
Cdd:cd01066  141 EHGLGPNFghrtghgiGLEIHEPPVLK-AGDDTVLE 175
Peptidase_M24 pfam00557
Metallopeptidase family M24; This family contains metallopeptidases. It also contains ...
 20-177 1.57e-12

Metallopeptidase family M24; This family contains metallopeptidases. It also contains non-peptidase homologs such as the N terminal domain of Spt16 which is a histone H3-H4 binding module.


Pssm-ID: 459852 [Multi-domain]  Cd Length: 208  Bit Score: 66.11  E-value: 1.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   20 KYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKvykkekdlkKGIAFPT--CLSVNNCVCHFSPAkndaD 97
Cdd:pfam00557   2 LMRKAARIAAAALEAALAAIRPGVTERELAAELEAARLRRGGA---------RGPAFPPivASGPNAAIPHYIPN----D 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   98 YTLKAGDVVKIDLGAHIDGFIAV-AAHTIVVGaaadqKISGRQADVILAAYWAVQAALRLLKSGANNYSLTDAVQQISES 176
Cdd:pfam00557  69 RVLKPGDLVLIDVGAEYDGGYCSdITRTFVVG-----KPSPEQRELYEAVLEAQEAAIAAVKPGVTGGDVDAAAREVLEE 143


                  .
gi 665409945  177 Y 177
Cdd:pfam00557 144 A 144
MetAP1 cd01086
Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and ...
 76-188 2.29e-12

Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.


Pssm-ID: 238519 [Multi-domain]  Cd Length: 238  Bit Score: 65.98  E-value: 2.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  76 FP--TCLSVNNCVCHFSPakndADYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGaaadqKISGRQADVILAAYWAVQAA 153
Cdd:cd01086   54 FPksICTSVNEVVCHGIP----DDRVLKDGDIVNIDVGVELDGYHGDSARTFIVG-----EVSEEAKKLVEVTEEALYKG 124

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665409945 154 LRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSH 188
Cdd:cd01086  125 IEAVKPGNRIGDIGHAIEKYAEKNGYSVVREFGGH 159
Map COG0024
Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];
24-188 2.77e-12

Methionine aminopeptidase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 439795 [Multi-domain]  Cd Length: 250  Bit Score: 66.18  E-value: 2.77e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  24 AGEIVNKTLKAVIGLCVVDASVREIctqgdNQLTEEtgkvYKKEKDLK------KGiaFP--TCLSVNNCVCHFSPAknd 95
Cdd:COG0024   15 AGRIVAEVLDELAEAVKPGVTTLEL-----DRIAEE----FIRDHGAIpaflgyYG--FPksICTSVNEVVVHGIPS--- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  96 aDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVG--AAADQKIsgrqadvILAAYWAVQAALRLLKSGAnnySLTD---AV 170
Cdd:COG0024   81 -DRVLKDGDIVNIDVGAILDGYHGDSARTFVVGevSPEARRL-------VEVTEEALYAGIAAAKPGN---RLGDighAI 149

                        170
                 ....*....|....*...
gi 665409945 171 QQISESYKCKPIEGMLSH 188
Cdd:COG0024  150 QSYAESNGYSVVREFVGH 167
PRK05716 PRK05716
methionine aminopeptidase; Validated
 76-188 3.29e-12

methionine aminopeptidase; Validated


Pssm-ID: 235576 [Multi-domain]  Cd Length: 252  Bit Score: 65.93  E-value: 3.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  76 FP--TCLSVNNCVCHFSPAkndaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGaaadqKISGRQADVILAAYWAVQAA 153
Cdd:PRK05716  64 FPksICTSVNEVVCHGIPS----DKVLKEGDIVNIDVTVIKDGYHGDTSRTFGVG-----EISPEDKRLCEVTKEALYLG 134

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 665409945 154 LRLLKSGAnnySLTD---AVQQISESYKCKPIEGMLSH 188
Cdd:PRK05716 135 IAAVKPGA---RLGDighAIQKYAEAEGFSVVREYCGH 169
met_pdase_I TIGR00500
methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. ...
 76-188 3.50e-12

methionine aminopeptidase, type I; Methionine aminopeptidase is a cobalt-binding enzyme. Bacterial and organellar examples (type I) differ from eukaroytic and archaeal (type II) examples in lacking a region of approximately 60 amino acids between the 4th and 5th cobalt-binding ligands. This model describes type I. The role of this protein in general is to produce the mature form of cytosolic proteins by removing the N-terminal methionine. [Protein fate, Protein modification and repair]


Pssm-ID: 129591 [Multi-domain]  Cd Length: 247  Bit Score: 65.83  E-value: 3.50e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945   76 FP--TCLSVNNCVCHFSPAKndadYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGaaadqKISGRQADVILAAYWAVQAA 153
Cdd:TIGR00500  62 FPgsVCISVNEVVIHGIPDK----KVLKDGDIVNIDVGVIYDGYHGDTAKTFLVG-----KISPEAEKLLECTEESLYKA 132

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 665409945  154 LRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSH 188
Cdd:TIGR00500 133 IEEAKPGNRIGEIGAAIQKYAEAKGFSVVREYCGH 167
PRK12896 PRK12896
methionine aminopeptidase; Reviewed
 76-161 1.77e-08

methionine aminopeptidase; Reviewed


Pssm-ID: 237252 [Multi-domain]  Cd Length: 255  Bit Score: 54.84  E-value: 1.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  76 FP--TCLSVNNCVCHFSPAkndaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGaaadqKISGRQADVILAAYWAVQAA 153
Cdd:PRK12896  69 FPgsTCISVNEEVAHGIPG----PRVIKDGDLVNIDVSAYLDGYHGDTGITFAVG-----PVSEEAEKLCRVAEEALWAG 139


                 ....*...
gi 665409945 154 LRLLKSGA 161
Cdd:PRK12896 140 IKQVKAGR 147
PRK12318 PRK12318
methionyl aminopeptidase;
76-188 7.12e-07

methionyl aminopeptidase;


Pssm-ID: 183434 [Multi-domain]  Cd Length: 291  Bit Score: 50.20  E-value: 7.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  76 FPT--CLSVNNCVCHFSPAkndaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGAAADQKisgrqADVILAAYWAVQAA 153
Cdd:PRK12318 104 FPKtiCTSLNEVICHGIPN----DIPLKNGDIMNIDVSCIVDGYYGDCSRMVMIGEVSEIK-----KKVCQASLECLNAA 174

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 665409945 154 LRLLKSGANNYSLTDAVQQISESYKCKPIEGMLSH 188
Cdd:PRK12318 175 IAILKPGIPLYEIGEVIENCADKYGFSVVDQFVGH 209
PepP COG0006
Xaa-Pro aminopeptidase [Amino acid transport and metabolism];
10-161 4.92e-05

Xaa-Pro aminopeptidase [Amino acid transport and metabolism];


Pssm-ID: 439777 [Multi-domain]  Cd Length: 299  Bit Score: 44.81  E-value: 4.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  10 KTIAEdlvVTKYKLAGEIVNKTLKAVIGLCVVDASVREICTQGDNQLTEETGKvykkekdlkkGIAFPT--CLSVNNCVC 87
Cdd:COG0006   74 KSPEE---IELMRKAARIADAAHEAALAALRPGVTEREVAAELEAAMRRRGAE----------GPSFDTivASGENAAIP 140

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 665409945  88 HFSPAkndaDYTLKAGDVVKIDLGAHIDGFIAVAAHTIVVGaaadqKISGRQADVILAAYWAVQAALRLLKSGA 161
Cdd:COG0006  141 HYTPT----DRPLKPGDLVLIDAGAEYDGYTSDITRTVAVG-----EPSDEQREIYEAVLEAQEAAIAALKPGV 205
PRK12897 PRK12897
type I methionyl aminopeptidase;
48-133 1.40e-04

type I methionyl aminopeptidase;


Pssm-ID: 171806  Cd Length: 248  Bit Score: 43.10  E-value: 1.40e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665409945  48 ICTQGDNQLTEETGKVY--KKEKDLKKGIAFPTCLSVNNCVCHFSPakndADYTLKAGDVVKIDLGAHIDGFIAVAAHTI 125
Cdd:PRK12897  35 ITTKEINTFVEAYLEKHgaTSEQKGYNGYPYAICASVNDEMCHAFP----ADVPLTEGDIVTIDMVVNLNGGLSDSAWTY 110


                 ....*...
gi 665409945 126 VVGAAADQ 133
Cdd:PRK12897 111 RVGKVSDE 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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