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phosphoribosyl pyrophosphate synthetase, isoform I [Drosophila melanogaster]

Protein Classification

ribose-phosphate diphosphokinase( domain architecture ID 11421473)

ribose-phosphate diphosphokinase catalyzes the transfer of the pyrophosphoryl group from ATP to the 1-hydroxyl of ribose-5-phosphate to form the the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP)

CATH:  3.40.50.2020
EC:  2.7.6.1
Gene Ontology:  GO:0002189|GO:0000287|GO:0004749|GO:0005524|GO:0009156|GO:0016301|GO:0016310|GO:0006015|GO:0009165
PubMed:  11751055|7593598

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 33-369 5.45e-168

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


:

Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 471.08  E-value: 5.45e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  33 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIA 112
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 113 SASRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGF 192
Cdd:COG0462   81 SARRITAVIPYYGYARQDRK-----------------------FRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGF 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 193 FDIPVDNLYAEPAVLKWIKENipEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAI 272
Cdd:COG0462  138 FDIPVDHLYAAPLLADYIKSK--DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCI 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 273 LVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRdCPKIQCIDVSMMFA 352
Cdd:COG0462  216 IVDDMIDTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKR-CDKIKVLSVAPLLA 294

                        330
                 ....*....|....*..
gi 665410164 353 EAVRRTHNGESVSYLFS 369
Cdd:COG0462  295 EAIRRIHEGESVSSLFD 311
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 33-369 5.45e-168

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 471.08  E-value: 5.45e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  33 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIA 112
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 113 SASRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGF 192
Cdd:COG0462   81 SARRITAVIPYYGYARQDRK-----------------------FRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGF 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 193 FDIPVDNLYAEPAVLKWIKENipEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAI 272
Cdd:COG0462  138 FDIPVDHLYAAPLLADYIKSK--DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCI 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 273 LVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRdCPKIQCIDVSMMFA 352
Cdd:COG0462  216 IVDDMIDTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKR-CDKIKVLSVAPLLA 294

                        330
                 ....*....|....*..
gi 665410164 353 EAVRRTHNGESVSYLFS 369
Cdd:COG0462  295 EAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
36-368 2.93e-156

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 441.48  E-value: 2.93e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASAS 115
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 116 RVTAVIPCFPYARQDKKDklagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI 195
Cdd:PRK01259  81 RITAVIPYFGYARQDRKA-----------------------RSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 196 PVDNLYAEPAVLKWIKENIPEwkNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVD 275
Cdd:PRK01259 138 PVDNLYGSPILLEDIKQKNLE--NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVD 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 276 DMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAEAV 355
Cdd:PRK01259 216 DMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAI 295

                        330
                 ....*....|...
gi 665410164 356 RRTHNGESVSYLF 368
Cdd:PRK01259 296 RRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 36-369 1.67e-147

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 419.38  E-value: 1.67e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164   36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIV-QSGSGEINDNLMELLIMINACKIASA 114
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  115 SRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD 194
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKK-----------------------FKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFD 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  195 IPVDNLYAEPAVLKWIKENIpeWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVASMVLVGDVKDKIAIL 273
Cdd:TIGR01251 138 VPVDNLYASPVLAEYLKKKI--LDNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVI 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  274 VDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHmrdCPKIQCIDVSMMFAE 353
Cdd:TIGR01251 216 VDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEKH---KPKVSVISVAPLIAE 292

                         330
                  ....*....|....*.
gi 665410164  354 AVRRTHNGESVSYLFS 369
Cdd:TIGR01251 293 AIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 36-175 9.09e-65

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 201.49  E-value: 9.09e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164   36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASAS 115
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  116 RVTAVIPCFPYARQDKKDKlagsednaeskklakknydwkfrSRAPISAKLVANMLSVAG 175
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDK-----------------------PREPITAKLVADLLEAAG 117
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 202-329 2.28e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 99.39  E-value: 2.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 202 AEPAVLKWIKENIpeWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASM------VLVGDVKDKIAILVD 275
Cdd:cd06223    1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 665410164 276 DMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAisRINNACFEAVVVTNT 329
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
 
Name Accession Description Interval E-value
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 33-369 5.45e-168

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 471.08  E-value: 5.45e-168
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  33 MPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIA 112
Cdd:COG0462    1 MKDLKIFSGNANPELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 113 SASRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGF 192
Cdd:COG0462   81 SARRITAVIPYYGYARQDRK-----------------------FRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGF 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 193 FDIPVDNLYAEPAVLKWIKENipEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAI 272
Cdd:COG0462  138 FDIPVDHLYAAPLLADYIKSK--DLEDLVVVSPDVGGVKRARAFAKRLGAPLAIIDKRRPGANEVEVMNIIGDVEGKTCI 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 273 LVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRdCPKIQCIDVSMMFA 352
Cdd:COG0462  216 IVDDMIDTGGTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPEEKR-CDKIKVLSVAPLLA 294

                        330
                 ....*....|....*..
gi 665410164 353 EAVRRTHNGESVSYLFS 369
Cdd:COG0462  295 EAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
36-368 2.93e-156

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 441.48  E-value: 2.93e-156
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASAS 115
Cdd:PRK01259   1 MKLFAGNANPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRASAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 116 RVTAVIPCFPYARQDKKDklagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI 195
Cdd:PRK01259  81 RITAVIPYFGYARQDRKA-----------------------RSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDI 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 196 PVDNLYAEPAVLKWIKENIPEwkNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVD 275
Cdd:PRK01259 138 PVDNLYGSPILLEDIKQKNLE--NLVVVSPDVGGVVRARALAKRLDADLAIIDKRRPRANVSEVMNIIGDVEGRDCILVD 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 276 DMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMMFAEAV 355
Cdd:PRK01259 216 DMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIRVLSVAPLLAEAI 295

                        330
                 ....*....|...
gi 665410164 356 RRTHNGESVSYLF 368
Cdd:PRK01259 296 RRISNEESVSSLF 308
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 36-369 1.67e-147

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 419.38  E-value: 1.67e-147
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164   36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIV-QSGSGEINDNLMELLIMINACKIASA 114
Cdd:TIGR01251   1 MKIFSGSSNQELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKRASA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  115 SRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD 194
Cdd:TIGR01251  81 KSITAVIPYYGYARQDKK-----------------------FKSREPISAKLVANLLETAGADRVLTVDLHSPQIQGFFD 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  195 IPVDNLYAEPAVLKWIKENIpeWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-KANEVASMVLVGDVKDKIAIL 273
Cdd:TIGR01251 138 VPVDNLYASPVLAEYLKKKI--LDNPVVVSPDAGGVERAKKVADALGCPLAIIDKRRIsATNEVEVMNLVGDVEGKDVVI 215

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  274 VDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHmrdCPKIQCIDVSMMFAE 353
Cdd:TIGR01251 216 VDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEKH---KPKVSVISVAPLIAE 292

                         330
                  ....*....|....*.
gi 665410164  354 AVRRTHNGESVSYLFS 369
Cdd:TIGR01251 293 AIRRIHNNESVSSLFD 308
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 45-368 2.50e-107

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 317.02  E-value: 2.50e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  45 PDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRVTAVIPCF 124
Cdd:PLN02369   1 PALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 125 PYARQDKKDKlagsednaeskklakknydwkfrSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEP 204
Cdd:PLN02369  81 GYARADRKTQ-----------------------GRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQP 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 205 AVLKWIKENIPEWKNSIIVSPDAGGAKRVTSIADRL-NVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDMADTCGT 283
Cdd:PLN02369 138 VILDYLASKTISSPDLVVVSPDVGGVARARAFAKKLsDAPLAIVDKRRQGHNVAEVMNLIGDVKGKVAIMVDDMIDTAGT 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 284 IVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDgHMRDCPKIQCIDVSMMFAEAVRRTHNGES 363
Cdd:PLN02369 218 ITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIPVS-EKNYFPQLTVLSVANLLGETIWRVHDDCS 296


                 ....*
gi 665410164 364 VSYLF 368
Cdd:PLN02369 297 VSSIF 301
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 36-368 1.74e-105

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 313.22  E-value: 1.74e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASAS 115
Cdd:PRK02812  22 LRLFSGSSNPALAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRASAR 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 116 RVTAVIPCFPYARQDKKDklAGSEDnaeskklakknydwkfrsrapISAKLVANMLSVAGADHIITMDLHASQIQGFFDI 195
Cdd:PRK02812 102 QITAVIPYYGYARADRKT--AGRES---------------------ITAKLVANLITKAGADRVLAMDLHSAQIQGYFDI 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 196 PVDNLYAEPAVLKWIKE-NIPEwknSIIVSPDAGGAKRVTSIADRLN-VEFALIHKERKKANEVASMVLVGDVKDKIAIL 273
Cdd:PRK02812 159 PCDHVYGSPVLLDYLASkNLED---IVVVSPDVGGVARARAFAKKLNdAPLAIIDKRRQAHNVAEVLNVIGDVKGKTAIL 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 274 VDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIP--QDGHMrdcPKIQCIDVSMMF 351
Cdd:PRK02812 236 VDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPvpEERRF---PQLKVLSVANML 312

                        330
                 ....*....|....*..
gi 665410164 352 AEAVRRTHNGESVSYLF 368
Cdd:PRK02812 313 GEAIWRIHEESSVSSMF 329
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
34-368 3.83e-105

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 312.25  E-value: 3.83e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  34 PNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIAS 113
Cdd:PRK04923   5 RNLLVFSGNANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRAS 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 114 ASRVTAVIPCFPYARQDKKDKlagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFF 193
Cdd:PRK04923  85 AASVTAVIPYFGYSRQDRRMR----------------------SSRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFF 142

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 194 DIPVDNLYAEPAVLK--WIKENIPewkNSIIVSPDAGGAKRVTSIADRL-NVEFALIHKERKKANEVASMVLVGDVKDKI 270
Cdd:PRK04923 143 DVPVDNVYASPLLLAdiWRAYGTD---NLIVVSPDVGGVVRARAVAKRLdDADLAIIDKRRPRANVATVMNIIGDVQGKT 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 271 AILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCIDVSMM 350
Cdd:PRK04923 220 CVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQLSVAEL 299

                        330
                 ....*....|....*...
gi 665410164 351 FAEAVRRTHNGESVSYLF 368
Cdd:PRK04923 300 LAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
35-368 1.95e-104

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 310.19  E-value: 1.95e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  35 NIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASA 114
Cdd:PRK02269   5 DLKLFALSSNKELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRASA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 115 SRVTAVIPCFPYARQDKKDklagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFD 194
Cdd:PRK02269  85 ESINVVMPYYGYARQDRKA-----------------------RSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFD 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 195 IPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERK--KANEVASMVLVGDVKDKIAI 272
Cdd:PRK02269 142 IPVDHLMGAPLIADYFDRRGLVGDDVVVVSPDHGGVTRARKLAQFLKTPIAIIDKRRSvdKMNTSEVMNIIGNVKGKKCI 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 273 LVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTI--PQDGHMRdcpKIQCIDVSMM 350
Cdd:PRK02269 222 LIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIylPEERLID---KIEQISIADL 298

                        330
                 ....*....|....*...
gi 665410164 351 FAEAVRRTHNGESVSYLF 368
Cdd:PRK02269 299 LGEAIIRIHEKRPLSPLF 316
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
47-372 3.20e-102

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 304.18  E-value: 3.20e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  47 LAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRVTAVIPCFPY 126
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 127 ARQDKKDklagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPVDNLYAEPAV 206
Cdd:PRK03092  81 ARQDKKH-----------------------RGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLL 137

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 207 LKWIKENIPEwKNSIIVSPDAGGAKRVTSIADRL-NVEFALIHKER--KKANEVASMVLVGDVKDKIAILVDDMADTCGT 283
Cdd:PRK03092 138 ADYVRDKYDL-DNVTVVSPDAGRVRVAEQWADRLgGAPLAFIHKTRdpTVPNQVVANRVVGDVEGRTCVLVDDMIDTGGT 216

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 284 IVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRdCPKIQCIDVSMMFAEAVRRTHNGES 363
Cdd:PRK03092 217 IAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDTLPIPEEKR-FDKLTVLSIAPLLARAIREVFEDGS 295


                 ....*....
gi 665410164 364 VSYLFSNVP 372
Cdd:PRK03092 296 VTSLFDGLA 304
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 29-373 3.16e-101

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 306.41  E-value: 3.16e-101
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  29 IHSRMPNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINA 108
Cdd:PTZ00145 113 FEKKMENAILFSGSSNPLLSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMIST 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 109 CKIASASRVTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGADHIITMDLHASQ 188
Cdd:PTZ00145 193 CRRASAKKITAVIPYYGYARQDRK-----------------------LSSRVPISAADVARMIEAMGVDRVVAIDLHSGQ 249

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 189 IQGFFD--IPVDNLYAEPAVLKWIKENiPEWKnSIIVSPDAGGAKRVTSIADRLN------VEFALIHKERKKANEVASM 260
Cdd:PTZ00145 250 IQGFFGprVPVDNLEAQLIGLDYFTKK-DLYK-PVIVSPDAGGVYRARKFQDGLNhrgisdCGIAMLIKQRTKPNEIEKM 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 261 VLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCP 340
Cdd:PTZ00145 328 DLVGNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCK 407

                        330       340       350
                 ....*....|....*....|....*....|...
gi 665410164 341 KIQCIDVSMMFAEAVRRTHNGESVSYLFsNVPY 373
Cdd:PTZ00145 408 KITKLSVSVLVADAIRRIHQKESLNDLF-NVKG 439
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 34-369 1.11e-88

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 270.07  E-value: 1.11e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  34 PNIKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIAS 113
Cdd:PRK02458   8 KQIKLFSLNSNLEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIMIDACKRAS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 114 ASRVTAVIPCFPYARQDKKDKlagsednaeskklakknydwkfrSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFF 193
Cdd:PRK02458  88 ANTVNVVLPYFGYARQDRIAK-----------------------PREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFF 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 194 DIPVDNLYAEPAVLKWIKENIPEWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVlVGDVKDKIAIL 273
Cdd:PRK02458 145 DIPVDNLFTVPLFAKHYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAIIDYAQDDSEREEGYI-IGDVAGKKAIL 223

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 274 VDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIpqDGHMRDCPKIQCIDVSMMFAE 353
Cdd:PRK02458 224 IDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV--ATKERVPKNVTYLSASELIAD 301

                        330
                 ....*....|....*.
gi 665410164 354 AVRRTHNGESVSYLFS 369
Cdd:PRK02458 302 AIIRIHERKPLSPLFA 317
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 38-369 4.21e-79

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 245.98  E-value: 4.21e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  38 VFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASASRV 117
Cdd:PRK00553  12 IFSLSKAKKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIAIDALKRGSAKSI 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 118 TAVIPCFPYARQDKKDKlagsednaeskklakknydwkfrSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDIPV 197
Cdd:PRK00553  92 TAILPYYGYARQDRKTA-----------------------GREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 198 DNLYAEPAVLKWIKENIPEwKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDDM 277
Cdd:PRK00553 149 DILRTYHVFLSRVLELLGK-KDLVVVSPDYGGVKRARLIAESLELPLAIIDKRRPKHNVAESINVLGEVKNKNCLIVDDM 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 278 ADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVV----VTNTIPQDgHMRDCPKIQCIDVSMMFAE 353
Cdd:PRK00553 228 IDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAFKKKLIdklfVSNSIPQT-KFEKKPQFKVVDLAHLYEE 306

                        330
                 ....*....|....*.
gi 665410164 354 AVRRTHNGESVSYLFS 369
Cdd:PRK00553 307 VLLCYANGGSISAIYT 322
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 36-175 9.09e-65

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 201.49  E-value: 9.09e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164   36 IKVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEINDNLMELLIMINACKIASAS 115
Cdd:pfam13793   1 LKIFSGNSNPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRASAK 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  116 RVTAVIPCFPYARQDKKDKlagsednaeskklakknydwkfrSRAPISAKLVANMLSVAG 175
Cdd:pfam13793  81 RITAVIPYFGYARQDRKDK-----------------------PREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 37-333 3.65e-61

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 198.21  E-value: 3.65e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  37 KVFSGTSHPDLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSGEiNDNLMELLIMINACKIASASR 116
Cdd:PRK00934   1 MIIGGSASQLLASEVARLLNTELALVETKRFPDGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 117 VTAVIPCFPYARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSVAGaDHIITMDLHASQIQGFFDIP 196
Cdd:PRK00934  80 ITLVIPYLGYARQDKR-----------------------FKPGEPISARAIAKIISAYY-DRIITINIHEPSILEFFPIP 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 197 VDNLYAEPAVLKWIKENIpewKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLVGDVKDKIAILVDD 276
Cdd:PRK00934 136 FINLDAAPLIAEYIGDKL---DDPLVLAPDKGALELAKEAAEILGCEYDYLEKTRISPTEVEIAPKNLDVKGKDVLIVDD 212

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 665410164 277 MADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQD 333
Cdd:PRK00934 213 IISTGGTMATAIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESE 269
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 216-368 5.02e-47

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 158.44  E-value: 5.02e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  216 EWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKA------------------------------NEVASMVLVGD 265
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAesdevdgrqspppyrsrtvsrslglpeiipKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  266 VKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPQDGHMRDCPKIQCI 345
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|...
gi 665410164  346 DVSMMFAEAVRRTHNGESVSYLF 368
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLF 183
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
46-357 5.63e-42

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 148.55  E-value: 5.63e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  46 DLAQRIVDRLGIDLGKVVTKKFSNLETCVEIGESVRGEDVYIVQSGSgEINDNLMELLIMINACKIASASRVTAVIPCFP 125
Cdd:PRK07199  13 AAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLD-RPDEKLLPLLFAAEAARELGARRVGLVAPYLA 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 126 YARQDKKdklagsednaeskklakknydwkFRSRAPISAKLVANMLSvAGADHIITMD--LH-ASQIQGFFDIPVDNLYA 202
Cdd:PRK07199  92 YMRQDIA-----------------------FHPGEAISQRHFARLLS-GSFDRLVTVDphLHrYPSLSEVYPIPAVVLSA 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 203 EPAVLKWIKENIPEWknsIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVAsmVLVGDV---KDKIAILVDDMAD 279
Cdd:PRK07199 148 APAIAAWIRAHVPRP---LLIGPDEESEQWVAAVAERAGAPHAVLRKTRHGDRDVE--ISLPDAapwAGRTPVLVDDIVS 222

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665410164 280 TCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINNACFEAVVVTNTIPqdgHMRDcpkiqCIDVSMMFAEAVRR 357
Cdd:PRK07199 223 TGRTLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVP---HPSN-----AISLAPLLAEALRR 292
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 61-370 7.34e-37

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 137.01  E-value: 7.34e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  61 KVVTKKFSNLETCVEIGESVRGEDVYIVQ---------SGSGE-----INDNLMELLIMINACKiASASRVTAVIPCFPY 126
Cdd:PRK06827  56 PAKFIRFSNGEAKGEILESVRGKDIYILQdvgnysvtyNMFGEknhmsPDDHFQDLKRTIDAIR-GKARRITVIMPFLYE 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 127 ARQDKKdklagsednaeskklakknydwkfRSRAPISAKLVANMLSVAGADHIITMDLHASQIQGFFDI-PVDNLYAEPA 205
Cdd:PRK06827 135 SRQHKR------------------------KGRESLDCALALQELEELGVDNIITFDAHDPRIENAIPLmGFENLYPSYQ 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 206 VLKWIKENIPE----WKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERK-------KANEVASMVLVGDVKDKIAILV 274
Cdd:PRK06827 191 IIKALLKNEKDleidKDHLMVISPDTGAMDRAKYYASVLGVDLGLFYKRRDysrvvngRNPIVAHEFLGRDVEGKDVLIV 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 275 DDMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGpAISRINNA----CFEAVVVTNTIPQDGHMRDCPKIQCIDVSMM 350
Cdd:PRK06827 271 DDMIASGGSMIDAAKELKSRGAKKIIVAATFGFFTN-GLEKFDKAyeegYFDRIIGTNLVYHPEELLSKPWYIEVDMSKL 349

                        330       340
                 ....*....|....*....|
gi 665410164 351 FAEAVRRTHNGESVSYLFSN 370
Cdd:PRK06827 350 IARIIDALNHDVSLSKLLDP 369
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 202-329 2.28e-25

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 99.39  E-value: 2.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 202 AEPAVLKWIKENIpeWKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASM------VLVGDVKDKIAILVD 275
Cdd:cd06223    1 AGRLLAEEIREDL--LEPDVVVGILRGGLPLAAALARALGLPLAFIRKERKGPGRTPSEpyglelPLGGDVKGKRVLLVD 78

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 665410164 276 DMADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAisRINNACFEAVVVTNT 329
Cdd:cd06223   79 DVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGA--RELASPGDPVYSLFT 130
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 196-299 1.48e-11

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 62.00  E-value: 1.48e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  196 PVDNLYAEPAVLKWIKENIPE------WKNSIIVSPDAGGAKRVTSIADRLNVEFALIHKERKKANEVASMVLV---GDV 266
Cdd:pfam00156   1 SVDEILDNPAILKAVARLAAQinedygGKPDVVVGILRGGLPFAGILARRLDVPLAFVRKVSYNPDTSEVMKTSsalPDL 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 665410164  267 KDKIAILVDDMADTCGTIVHAADRLVEAGATKV 299
Cdd:pfam00156  81 KGKTVLIVDDILDTGGTLLKVLELLKNVGPKEV 113
PLN02297 PLN02297
ribose-phosphate pyrophosphokinase
 46-332 2.71e-10

ribose-phosphate pyrophosphokinase


Pssm-ID: 177934 [Multi-domain]  Cd Length: 326  Bit Score: 60.86  E-value: 2.71e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164  46 DLAQRIVDRLG-IDLGKVVTKKFS----NLEtcVEIGESVRGEDVYIVQSGSGeiNDNLMELLIMINACKIASASRVTAV 120
Cdd:PLN02297  27 ELARKIAAESDaIELGSINWRKFPdgfpNLF--INNAHGIRGQHVAFLASFSS--PAVIFEQLSVIYALPKLFVASFTLV 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 121 IPCFPYARQDKKDKlagSEDNAESKKLAKknydwkFRSRAPISAklvanmlsvAGADHIITMDLHASQIQGFFDIPVDNL 200
Cdd:PLN02297 103 LPFFPTGTSERVER---EGDVATAFTLAR------ILSNIPISR---------GGPTSLVIFDIHALQERFYFGDNVLPC 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 201 YAE--PAVLKWIKEnIPEWKNSIIVSPDAGGAKRVTSIADrlNVEFALIHKERKkaNEVASMVLV-GDVKDKIAILVDDM 277
Cdd:PLN02297 165 FESgiPLLKKRLQQ-LPDSDNIVIAFPDDGAWKRFHKQFE--HFPMVVCTKVRE--GDKRIVRIKeGNPAGRHVVIVDDL 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665410164 278 ADTCGTIVHAADRLVEAGATKVYAILTHGIFSGPAISRINN------ACFEAVVVTNTIPQ 332
Cdd:PLN02297 240 VQSGGTLIECQKVLAAHGAAKVSAYVTHGVFPNESWERFTHdnggpeAGFAYFWITDSCPQ 300
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 221-306 1.10e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 39.58  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410164 221 IIVSPDAGGAKRVTSIADRLNVEFALIHKERKK------ANEVASM------VLVGDVKD------KIAILVDDMADTCG 282
Cdd:PRK07322  55 VLVTPETKGIPLAHALSRRLGKPYVVARKSRKPymqdpiIQEVVSIttgkpqLLVLDGADaeklkgKRVAIVDDVVSTGG 134

                         90       100
                 ....*....|....*....|....*..
gi 665410164 283 TIvHAADRLVE-AGAT--KVYAILTHG 306
Cdd:PRK07322 135 TL-TALERLVErAGGQvvAKAAIFAEG 160
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 236-299 4.49e-03

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 37.52  E-value: 4.49e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 665410164 236 IADRLNV-EFALI------HKERKKANEVASMVLVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKV 299
Cdd:COG2236   49 LADALGVpDLASIrvssytGTAKRLEEPVVKGPLDEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEV 119
PyrE COG0461
Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate ...
 233-306 5.43e-03

Orotate phosphoribosyltransferase [Nucleotide transport and metabolism]; Orotate phosphoribosyltransferase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440229  Cd Length: 201  Bit Score: 37.83  E-value: 5.43e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665410164 233 VTSIADRLNVEFALIHKERKKANEVASmvLVGDVK--DKIAIlVDDMADTCGTIVHAADRLVEAGAT--KVYAILTHG 306
Cdd:COG0461   78 AAAVARALGLPAIFVRKEAKDHGTGGQ--IEGGLLpgERVLV-VEDVITTGGSVLEAVEALREAGAEvvGVAVIVDRE 152
upp PRK00129
uracil phosphoribosyltransferase; Reviewed
 262-302 6.60e-03

uracil phosphoribosyltransferase; Reviewed


Pssm-ID: 234653  Cd Length: 209  Bit Score: 37.38  E-value: 6.60e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 665410164 262 LVGDVKDKIAILVDDMADTCGTIVHAADRLVEAGATKVYAI 302
Cdd:PRK00129 118 LPEDIDERTVIVVDPMLATGGSAIAAIDLLKKRGAKNIKVL 158
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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