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Conserved domains on  [gi|665393227|ref|NP_001287169|]
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defective proboscis extension response 16, isoform C [Drosophila melanogaster]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
352-447 4.27e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227   352 VKAGSRVELHCIVRGTleAPKYIFWYRGDQQVTAENEasgaqsgwYTQIDRNifgstehnrNTIGSLVIPLVRKIHSGNY 431
Cdd:smart00410   6 VKEGESVTLSCEASGS--PPPEVTWYKQGGKLLAESG--------RFSVSRS---------GSTSTLTISNVTPEDSGTY 66
                           90
                   ....*....|....*....
gi 665393227   432 TCEPENSAA---ASMQLHV 447
Cdd:smart00410  67 TCAATNSSGsasSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
352-447 4.27e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227   352 VKAGSRVELHCIVRGTleAPKYIFWYRGDQQVTAENEasgaqsgwYTQIDRNifgstehnrNTIGSLVIPLVRKIHSGNY 431
Cdd:smart00410   6 VKEGESVTLSCEASGS--PPPEVTWYKQGGKLLAESG--------RFSVSRS---------GSTSTLTISNVTPEDSGTY 66
                           90
                   ....*....|....*....
gi 665393227   432 TCEPENSAA---ASMQLHV 447
Cdd:smart00410  67 TCAATNSSGsasSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
352-437 5.43e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.48  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227  352 VKAGSRVELHCIVRGTlEAPKYIfWYRGDQQVTAENEasgaqsgwytqidrnifgSTEHNRNTIGSLVIPLVRKIHSGNY 431
Cdd:pfam13927  13 VREGETVTLTCEATGS-PPPTIT-WYKNGEPISSGST------------------RSRSLSGSNSTLTISNVTRSDAGTY 72

                  ....*.
gi 665393227  432 TCEPEN 437
Cdd:pfam13927  73 TCVASN 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
358-439 2.21e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227 358 VELHCIVRGTLEApkYIFWYRGDQQVTAENEasgaqsgwytqidrnifgSTEHNRNTIGSLVIPLVRKIHSGNYTCEPEN 437
Cdd:cd00096    1 VTLTCSASGNPPP--TITWYKNGKPLPPSSR------------------DSRRSELGNGTLTISNVTLEDSGTYTCVASN 60

                 ..
gi 665393227 438 SA 439
Cdd:cd00096   61 SA 62
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
352-447 4.27e-07

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 47.50  E-value: 4.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227   352 VKAGSRVELHCIVRGTleAPKYIFWYRGDQQVTAENEasgaqsgwYTQIDRNifgstehnrNTIGSLVIPLVRKIHSGNY 431
Cdd:smart00410   6 VKEGESVTLSCEASGS--PPPEVTWYKQGGKLLAESG--------RFSVSRS---------GSTSTLTISNVTPEDSGTY 66
                           90
                   ....*....|....*....
gi 665393227   432 TCEPENSAA---ASMQLHV 447
Cdd:smart00410  67 TCAATNSSGsasSGTTLTV 85
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
352-437 5.43e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.48  E-value: 5.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227  352 VKAGSRVELHCIVRGTlEAPKYIfWYRGDQQVTAENEasgaqsgwytqidrnifgSTEHNRNTIGSLVIPLVRKIHSGNY 431
Cdd:pfam13927  13 VREGETVTLTCEATGS-PPPTIT-WYKNGEPISSGST------------------RSRSLSGSNSTLTISNVTRSDAGTY 72

                  ....*.
gi 665393227  432 TCEPEN 437
Cdd:pfam13927  73 TCVASN 78
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
358-439 2.21e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 42.32  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227 358 VELHCIVRGTLEApkYIFWYRGDQQVTAENEasgaqsgwytqidrnifgSTEHNRNTIGSLVIPLVRKIHSGNYTCEPEN 437
Cdd:cd00096    1 VTLTCSASGNPPP--TITWYKNGKPLPPSSR------------------DSRRSELGNGTLTISNVTLEDSGTYTCVASN 60

                 ..
gi 665393227 438 SA 439
Cdd:cd00096   61 SA 62
IgI_6_Dscam cd20959
Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; ...
355-447 2.27e-05

Sixth immunoglobulin domain of the Drosophila melanogaster Dscam protein, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the sixth immunoglobulin domain of the Drosophila melanogaster Down syndrome cell adhesion molecule (DSCAM) protein and similar proteins. Down syndrome cell adhesion molecule (DSCAM) is a cell adhesion molecule that plays critical roles in neural development, including axon guidance and branching, axon target recognition, self-avoidance and synaptic formation. DSCAM belongs to the immunoglobulin superfamily and contributes to defects in the central nervous system in Down syndrome patients. Vertebrate DSCAMs differ from Drosophila Dscam1 in that they lack the extensive alternative splicing that occurs in the insect gene. Drosophila melanogaster Dscam has 38,016 isoforms generated by the alternative splicing of four variable exon clusters, which allows every neuron in the fly to display a distinctive set of Dscam proteins on its cell surface. Drosophila Dscam1 is a cell-surface protein that plays important roles in neural development and axon tiling of neurons. It is shown that thousands of isoforms bind themselves through specific homophilic (self-binding) interactions, a process which mediates cellular self-recognition. Drosophila Dscam2 is also alternatively spliced and plays a key role in the development of two visual system neurons, monopolar cells L1 and L2. This group is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409551  Cd Length: 94  Bit Score: 42.86  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227 355 GSRVELHCIV-RGTLeaPKYIFWYRGDQQVTAENEASGAQSGWYTQIdrnifgstehnrntigsLVIPLVRKIHSGNYTC 433
Cdd:cd20959   17 GMRAQLHCGVpGGDL--PLNIRWTLDGQPISDDLGITVSRLGRRSSI-----------------LSIDSLEASHAGNYTC 77
                         90
                 ....*....|....*..
gi 665393227 434 EPENSAAA---SMQLHV 447
Cdd:cd20959   78 HARNSAGSasyTAPLTV 94
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
352-448 1.71e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.90  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227  352 VKAGSRVELHCIVRGTL-EAPKYIFWYRGDQQVTAENEASGAQSGWYTQIDRNIFGSTEHNRNTIGSLVIPLVRKIHSGN 430
Cdd:pfam07686   8 VALGGSVTLPCTYSSSMsEASTSVYWYRQPPGKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNLTLSDSGT 87
                          90       100
                  ....*....|....*....|..
gi 665393227  431 YTCE----PENSAAASMQLHVL 448
Cdd:pfam07686  88 YTCAvipsGEGVFGKGTRLTVL 109
I-set pfam07679
Immunoglobulin I-set domain;
352-456 2.59e-04

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 39.93  E-value: 2.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227  352 VKAGSRVELHCIVRGTlEAPKyIFWYRGDQQVTaeneasgaQSGWYTQidrnifgsteHNRNTIGSLVIPLVRKIHSGNY 431
Cdd:pfam07679  12 VQEGESARFTCTVTGT-PDPE-VSWFKDGQPLR--------SSDRFKV----------TYEGGTYTLTISNVQPDDSGKY 71
                          90       100
                  ....*....|....*....|....*
gi 665393227  432 TCEPENSAaasmqlhvlsGEYSASA 456
Cdd:pfam07679  72 TCVATNSA----------GEAEASA 86
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
352-438 1.87e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.56  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227  352 VKAGSRVELHCIVRGTLEAPkYIFWYRGDQQVTAENEASGAQsgwytqidrnifgstehNRNTIGSLVIPLVRKIHSGNY 431
Cdd:pfam00047   8 VLEGDSATLTCSASTGSPGP-DVTWSKEGGTLIESLKVKHDN-----------------GRTTQSSLLISNVTKEDAGTY 69

                  ....*..
gi 665393227  432 TCEPENS 438
Cdd:pfam00047  70 TCVVNNP 76
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
352-433 6.24e-03

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 36.54  E-value: 6.24e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393227 352 VKAGSRVELHCIVRGTLEAPkYIFWYRGDQQVTAE---NEASGAQSGWYTQIDRniFgSTEHNRNTIGSLVIPLVRKIHS 428
Cdd:cd00099   10 VQEGESVTLSCEVSSSFSST-YIYWYRQKPGQGPEfliYLSSSKGKTKGGVPGR--F-SGSRDGTSSFSLTISNLQPEDS 85

                 ....*
gi 665393227 429 GNYTC 433
Cdd:cd00099   86 GTYYC 90
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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