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Conserved domains on  [gi|665393476|ref|NP_001287217|]
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ER membrane protein complex subunit 1, isoform D [Drosophila melanogaster]

Protein Classification

EMC1 family protein( domain architecture ID 10544306)

ER membrane protein complex 1 (EMC1) family protein is a DUF1620 domain-containing protein, most likely a component of the ER membrane protein complex (EMC)

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EMC1_C pfam07774
ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER ...
702-907 2.43e-95

ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).


:

Pssm-ID: 462261  Cd Length: 214  Bit Score: 298.69  E-value: 2.43e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  702 SENWLAYSYFNE-KLRRTEITTIELYEGKSQANSSVW------SSLQAPPMPLVERQSYILPTIVEALRETITERGITNK 774
Cdd:pfam07774   1 SENWIVYSYFNDePAKRYEIVVVELYESKEPNDRGSLgsaanfSSLDPPPLPHVLSQSYIFPEGIKALAVTQTKQGITSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  775 HVLIGTASGSIVEMPWHLLDPRRPIAS-TTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGLESTCLVVAT 853
Cdd:pfam07774  81 SLLVATESGQIVSLPRRLLDPRRPVRKpTPAEKEEGLIPYDPELPIDPKSVLSHNREVAGVRKIITSPTLLESTSLVFAY 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 665393476  854 GLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAW 907
Cdd:pfam07774 161 GLDLFCTRVAPSKSFDVLSEDFNKIQLLLTVVALLVGVLVTRPLVRRKQLNAKW 214
 
Name Accession Description Interval E-value
EMC1_C pfam07774
ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER ...
702-907 2.43e-95

ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).


Pssm-ID: 462261  Cd Length: 214  Bit Score: 298.69  E-value: 2.43e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  702 SENWLAYSYFNE-KLRRTEITTIELYEGKSQANSSVW------SSLQAPPMPLVERQSYILPTIVEALRETITERGITNK 774
Cdd:pfam07774   1 SENWIVYSYFNDePAKRYEIVVVELYESKEPNDRGSLgsaanfSSLDPPPLPHVLSQSYIFPEGIKALAVTQTKQGITSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  775 HVLIGTASGSIVEMPWHLLDPRRPIAS-TTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGLESTCLVVAT 853
Cdd:pfam07774  81 SLLVATESGQIVSLPRRLLDPRRPVRKpTPAEKEEGLIPYDPELPIDPKSVLSHNREVAGVRKIITSPTLLESTSLVFAY 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 665393476  854 GLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAW 907
Cdd:pfam07774 161 GLDLFCTRVAPSKSFDVLSEDFNKIQLLLTVVALLVGVLVTRPLVRRKQLNAKW 214
 
Name Accession Description Interval E-value
EMC1_C pfam07774
ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER ...
702-907 2.43e-95

ER membrane protein complex subunit 1, C-terminal; This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER).


Pssm-ID: 462261  Cd Length: 214  Bit Score: 298.69  E-value: 2.43e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  702 SENWLAYSYFNE-KLRRTEITTIELYEGKSQANSSVW------SSLQAPPMPLVERQSYILPTIVEALRETITERGITNK 774
Cdd:pfam07774   1 SENWIVYSYFNDePAKRYEIVVVELYESKEPNDRGSLgsaanfSSLDPPPLPHVLSQSYIFPEGIKALAVTQTKQGITSK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665393476  775 HVLIGTASGSIVEMPWHLLDPRRPIAS-TTQGREEGAIPYIPELPLPTESHINYNQTVARLRNIYTAPSGLESTCLVVAT 853
Cdd:pfam07774  81 SLLVATESGQIVSLPRRLLDPRRPVRKpTPAEKEEGLIPYDPELPIDPKSVLSHNREVAGVRKIITSPTLLESTSLVFAY 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 665393476  854 GLDLFVTRVAPSKTFDLLKEDFDYILISIVLVALTSGSLIVKHLASRKLLKQAW 907
Cdd:pfam07774 161 GLDLFCTRVAPSKSFDVLSEDFNKIQLLLTVVALLVGVLVTRPLVRRKQLNAKW 214
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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