NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|665394465|ref|NP_001287405|]
View 

uncharacterized protein Dmel_CG14280, isoform B [Drosophila melanogaster]

Protein Classification

CUB domain-containing protein( domain architecture ID 10035693)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein similar to Bos taurus spermadhesin Z13 and Riftia pachyptila exoskeleton protein RP43

CATH:  2.60.120.290
Gene Ontology:  GO:0005576
PubMed:  8510165|9334740
SCOP:  4002562

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 275-391 2.73e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.11  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465 275 CGD-VTSQQILYFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSrpSNGDCVDDQFIV-SGHNTNFQ-IPILC 351
Cdd:cd00041    1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPG-YRIRLTFEDFDLE--SSPNCSYDYLEIyDGPSTSSPlLGRFC 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665394465 352 GINTGQHIYihvgdSNEGKVYLSVFMKVSGGGRSFNIKVT 391
Cdd:cd00041   78 GSTLPPPII-----SSGNSLTVRFRSDSSVTGRGFKATYS 112
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 126-233 4.59e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSSTKSSimqphqtlknilfgspIKANLILKK 205
Cdd:PHA03247  416 PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDAT----------------RKALDALRE 479

                          90       100
                  ....*....|....*....|....*...
gi 665394465  206 PNAPRSKGKGFLSLFEVikFPNTKCSVS 233
Cdd:PHA03247  480 RRPPEPPGADLAELLGR--HPDTAGTVV 505
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 275-391 2.73e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.11  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465 275 CGD-VTSQQILYFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSrpSNGDCVDDQFIV-SGHNTNFQ-IPILC 351
Cdd:cd00041    1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPG-YRIRLTFEDFDLE--SSPNCSYDYLEIyDGPSTSSPlLGRFC 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665394465 352 GINTGQHIYihvgdSNEGKVYLSVFMKVSGGGRSFNIKVT 391
Cdd:cd00041   78 GSTLPPPII-----SSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
275-352 1.00e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.90  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  275 CGDVTSQQILYFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSRpsNGDCVDDQFIV--SGHNTNFQIPILCG 352
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPG-FRVKLTFQDFELED--HDECGYDYVEIrdGPSASSPLLGRFCG 77
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 285-389 3.88e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 40.07  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465   285 YFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSrpSNGDCVDDQFIV-SGHNT-NFQIPILCGINTGQHIYIh 362
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPG-YRIELQFTDFDLE--SSDNCEYDYVEIyDGPSAsSPLLGRFCGSEAPPPVIS- 77

                           90       100
                   ....*....|....*....|....*..
gi 665394465   363 vgdSNEGKVYLSVFMKVSGGGRSFNIK 389
Cdd:smart00042  78 ---SSSNSLTLTFVSDSSVQKRGFSAR 101
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-233 4.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSSTKSSimqphqtlknilfgspIKANLILKK 205
Cdd:PHA03247  416 PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDAT----------------RKALDALRE 479

                          90       100
                  ....*....|....*....|....*...
gi 665394465  206 PNAPRSKGKGFLSLFEVikFPNTKCSVS 233
Cdd:PHA03247  480 RRPPEPPGADLAELLGR--HPDTAGTVV 505
Neisseria_TspB pfam05616
Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis ...
 126-177 1.48e-03

Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis TspB virulence factor proteins.


Pssm-ID: 283306 [Multi-domain]  Cd Length: 517  Bit Score: 41.23  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSST 177
Cdd:pfam05616 348 PAENPANNPDPDENPGTRPNPEPDPDLNPDANPDTDGQPGTRPDSPAVPDRP 399
 
Name Accession Description Interval E-value
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 275-391 2.73e-09

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 55.11  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465 275 CGD-VTSQQILYFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSrpSNGDCVDDQFIV-SGHNTNFQ-IPILC 351
Cdd:cd00041    1 CGGtLTASTSGTISSPNYPNNYPNNLNCVWTIEAPPG-YRIRLTFEDFDLE--SSPNCSYDYLEIyDGPSTSSPlLGRFC 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665394465 352 GINTGQHIYihvgdSNEGKVYLSVFMKVSGGGRSFNIKVT 391
Cdd:cd00041   78 GSTLPPPII-----SSGNSLTVRFRSDSSVTGRGFKATYS 112
CUB pfam00431
CUB domain;
275-352 1.00e-04

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 41.90  E-value: 1.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  275 CGDVTSQQILYFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSRpsNGDCVDDQFIV--SGHNTNFQIPILCG 352
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPG-FRVKLTFQDFELED--HDECGYDYVEIrdGPSASSPLLGRFCG 77
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 285-389 3.88e-04

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 40.07  E-value: 3.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465   285 YFESPNYPNAVREMMICVLIINVKKGvQQLRLDFQMFELSrpSNGDCVDDQFIV-SGHNT-NFQIPILCGINTGQHIYIh 362
Cdd:smart00042   2 TITSPNYPQSYPNNLDCVWTIRAPPG-YRIELQFTDFDLE--SSDNCEYDYVEIyDGPSAsSPLLGRFCGSEAPPPVIS- 77

                           90       100
                   ....*....|....*....|....*..
gi 665394465   363 vgdSNEGKVYLSVFMKVSGGGRSFNIK 389
Cdd:smart00042  78 ---SSSNSLTLTFVSDSSVQKRGFSAR 101
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-233 4.59e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.39  E-value: 4.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSSTKSSimqphqtlknilfgspIKANLILKK 205
Cdd:PHA03247  416 PTPAPTPVPASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATEPAPDDPDDAT----------------RKALDALRE 479

                          90       100
                  ....*....|....*....|....*...
gi 665394465  206 PNAPRSKGKGFLSLFEVikFPNTKCSVS 233
Cdd:PHA03247  480 RRPPEPPGADLAELLGR--HPDTAGTVV 505
PLN02983 PLN02983
biotin carboxyl carrier protein of acetyl-CoA carboxylase
 130-189 1.47e-03

biotin carboxyl carrier protein of acetyl-CoA carboxylase


Pssm-ID: 215533 [Multi-domain]  Cd Length: 274  Bit Score: 40.59  E-value: 1.47e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 665394465 130 PV--EEPSPQPPTMMVPTPSASPgmqpsSKPRPTGKPSMSPPVPTIPSSTKSSimqpHQTLK 189
Cdd:PLN02983 149 PVvmMQPPPPHAMPPASPPAAQP-----APSAPASSPPPTPASPPPAKAPKSS----HPPLK 201
Neisseria_TspB pfam05616
Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis ...
 126-177 1.48e-03

Neisseria meningitidis TspB protein; This family consists of several Neisseria meningitidis TspB virulence factor proteins.


Pssm-ID: 283306 [Multi-domain]  Cd Length: 517  Bit Score: 41.23  E-value: 1.48e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSST 177
Cdd:pfam05616 348 PAENPANNPDPDENPGTRPNPEPDPDLNPDANPDTDGQPGTRPDSPAVPDRP 399
PRK11633 PRK11633
cell division protein DedD; Provisional
 125-177 2.13e-03

cell division protein DedD; Provisional


Pssm-ID: 236940 [Multi-domain]  Cd Length: 226  Bit Score: 39.99  E-value: 2.13e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 665394465 125 RPTTIPVEEPSPQPptmmVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSST 177
Cdd:PRK11633  98 EPEPAPVEPPKPKP----VEKPKPKPKPQQKVEAPPAPKPEPKPVVEEKAAPT 146
PHA03378 PHA03378
EBNA-3B; Provisional
 125-208 2.26e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.82  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465 125 RPTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPS---MSPPVPTIPSSTKSSImqphqtLKNILFGSPIKANL 201
Cdd:PHA03378 765 RPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTsmqLMPRAAPGQQGPTKQI------LRQLLTGGVKRGRP 838


                 ....*..
gi 665394465 202 ILKKPNA 208
Cdd:PHA03378 839 SLKKPAA 845
PRK14950 PRK14950
DNA polymerase III subunits gamma and tau; Provisional
 125-180 2.95e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237864 [Multi-domain]  Cd Length: 585  Bit Score: 40.56  E-value: 2.95e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 665394465 125 RPTTIPVEEPSPQPPTmmvPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSSTKSS 180
Cdd:PRK14950 380 RPTPAPSTRPKAAAAA---NIPPKEPVRETATPPPVPPRPVAPPVPHTPESAPKLT 432
Trypan_PARP pfam05887
Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei ...
 126-175 3.79e-03

Procyclic acidic repetitive protein (PARP); This family consists of several Trypanosoma brucei procyclic acidic repetitive protein (PARP) like sequences. The procyclic acidic repetitive protein (parp) genes of Trypanosoma brucei encode a small family of abundant surface proteins whose expression is restricted to the procyclic form of the parasite. They are found at two unlinked loci, parpA and parpB; transcription of both loci is developmentally regulated.


Pssm-ID: 368653  Cd Length: 134  Bit Score: 37.85  E-value: 3.79e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 665394465  126 PTTIPVEEPSPQPPtmmvPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPS 175
Cdd:pfam05887  73 PEPEPEPEPEPEPE----PEPEPEPEPEPEPEPEPEPEPEPEPGAATLKS 118
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-172 7.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 7.11e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSmSPPVPT 172
Cdd:PHA03247 2901 PPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQ-PPLAPT 2946
PHA03247 PHA03247
large tegument protein UL36; Provisional
 126-212 7.36e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665394465  126 PTTIPVEEPSPQPPTMMVPTPSASPGMQPSSKPRPTGKPSMSPPVPTIPSSTKSSIMQPHQTLKNILFGSPIKANLILKK 205
Cdd:PHA03247 2897 SFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPR 2976


                  ....*..
gi 665394465  206 PNAPRSK 212
Cdd:PHA03247 2977 FRVPQPA 2983
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH