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Conserved domains on  [gi|665395277|ref|NP_001287568|]
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tau, isoform M [Drosophila melanogaster]

Protein Classification

PHA03247 and Tubulin-binding domain-containing protein( domain architecture ID 10450448)

PHA03247 and Tubulin-binding domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 256-286 1.88e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 1.88e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  256 KKIETLKMDFKdKAKPKVGSTANVKHQPGGG 286
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 296-322 2.73e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|....*...
gi 665395277  296 IQTQKLEI-KAQSKVGSLDNVKHKPGGG 322
Cdd:pfam00418   3 IESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 226-254 6.28e-06

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 6.28e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 665395277  226 KKIVTTKLQW-NAKSKIGSLENAAHKPGGG 254
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 165-195 6.05e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


:

Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 39.70  E-value: 6.05e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  165 VQVGHAPSPnLKAVRSKIGSLDNATYKPGGG 195
Cdd:pfam00418   1 VKIESKKLD-FSKVQSKCGSKDNIKHKPGGG 30
PHA03309 super family cl29689
transcriptional regulator ICP4; Provisional
 98-171 5.71e-03

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03309:

Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 39.07  E-value: 5.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665395277   98 RNGPNSPSSPVKTPTSTSSKPDKSGT-SRPPSATPSNKsAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAP 171
Cdd:PHA03309 1815 RSSSSSSSSSSSSSSSPSSRPSRSATpSLSPSPSPPRR-APVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSP 1888
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 256-286 1.88e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 1.88e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  256 KKIETLKMDFKdKAKPKVGSTANVKHQPGGG 286
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 296-322 2.73e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|....*...
gi 665395277  296 IQTQKLEI-KAQSKVGSLDNVKHKPGGG 322
Cdd:pfam00418   3 IESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 226-254 6.28e-06

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 6.28e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 665395277  226 KKIVTTKLQW-NAKSKIGSLENAAHKPGGG 254
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 165-195 6.05e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 39.70  E-value: 6.05e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  165 VQVGHAPSPnLKAVRSKIGSLDNATYKPGGG 195
Cdd:pfam00418   1 VKIESKKLD-FSKVQSKCGSKDNIKHKPGGG 30
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 98-171 5.71e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 39.07  E-value: 5.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665395277   98 RNGPNSPSSPVKTPTSTSSKPDKSGT-SRPPSATPSNKsAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAP 171
Cdd:PHA03309 1815 RSSSSSSSSSSSSSSSPSSRPSRSATpSLSPSPSPPRR-APVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSP 1888
 
Name Accession Description Interval E-value
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 256-286 1.88e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.64  E-value: 1.88e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  256 KKIETLKMDFKdKAKPKVGSTANVKHQPGGG 286
Cdd:pfam00418   1 VKIESKKLDFS-KVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 296-322 2.73e-07

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 46.25  E-value: 2.73e-07
                          10        20
                  ....*....|....*....|....*...
gi 665395277  296 IQTQKLEI-KAQSKVGSLDNVKHKPGGG 322
Cdd:pfam00418   3 IESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 226-254 6.28e-06

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 42.40  E-value: 6.28e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 665395277  226 KKIVTTKLQW-NAKSKIGSLENAAHKPGGG 254
Cdd:pfam00418   1 VKIESKKLDFsKVQSKCGSKDNIKHKPGGG 30
Tubulin-binding pfam00418
Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, ...
 165-195 6.05e-05

Tau and MAP protein, tubulin-binding repeat; This family includes the vertebrate proteins MAP2, MAP4 and Tau, as well as other animal homologs. MAP4 is present in many tissues but is usually absent from neurons; MAP2 and Tau are mainly neuronal. Members of this family have the ability to bind to and stabilize microtubules. As a result, they are involved in neuronal migration, supporting dendrite elongation, and regulating microtubules during mitotic metaphase. Note that Tau is involved in neurofibrillary tangle formation in Alzheimer's disease and some other dementias. This family features a C-terminal microtubule binding repeat that contains a conserved KXGS motif.


Pssm-ID: 459807 [Multi-domain]  Cd Length: 30  Bit Score: 39.70  E-value: 6.05e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 665395277  165 VQVGHAPSPnLKAVRSKIGSLDNATYKPGGG 195
Cdd:pfam00418   1 VKIESKKLD-FSKVQSKCGSKDNIKHKPGGG 30
PHA03309 PHA03309
transcriptional regulator ICP4; Provisional
 98-171 5.71e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 165564 [Multi-domain]  Cd Length: 2033  Bit Score: 39.07  E-value: 5.71e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665395277   98 RNGPNSPSSPVKTPTSTSSKPDKSGT-SRPPSATPSNKsAPKSRSASKNRLLLKTPEPEPVKKVPMNKVQVGHAP 171
Cdd:PHA03309 1815 RSSSSSSSSSSSSSSSPSSRPSRSATpSLSPSPSPPRR-APVDRSRSGRRRERDRPSANPFRWAPRQRSRADHSP 1888
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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