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Conserved domains on  [gi|665411124|ref|NP_001287644|]
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zydeco, isoform H [Drosophila melanogaster]

Protein Classification

putative sodium/potassium/calcium exchanger( domain architecture ID 1001229)

putative sodium/potassium/calcium exchanger

Gene Ontology:  GO:0005886|GO:0015293|GO:0006811
PubMed:  15163769
TCDB:  2.A.19

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-448 1.02e-53

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 194.06  E-value: 1.02e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124     1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRDSIAYGVTV 80
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDL 571

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    81 AILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQK-------------------CAKGGVKQARSRSRSSNCSIHT 141
Cdd:TIGR00927  572 MMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELwvkeqlsrrpvakvmalgdLSKGDVAEAEHTGERTGEEGER 651

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   142 ----------KNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAV 211
Cdd:TIGR00927  652 pteaegengeESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGE 731

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   212 GLCSGPGAIVQMAPLDDAEAESHVAV------------------------------------------------------ 237
Cdd:TIGR00927  732 IETGEEGEEVEDEGEGEAEGKHEVETegdrketehegeteaegkededegeiqagedgemkgdegaegkvehegeteage 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   238 -----------AAADEGRKEEGYSLLS----------------------------------------------------- 253
Cdd:TIGR00927  812 kdehegqsetqADDTEVKDETGEQELNaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeene 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   254 ------YPKDKScfAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSV 327
Cdd:TIGR00927  892 eplsleWPETRQ--KQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   328 MGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPgqnyVAINSAGLEYSAITL 407
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQP----VPVSSNGLFCAIVLL 1045

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 665411124   408 LSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIE 448
Cdd:TIGR00927 1046 FLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-448 1.02e-53

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 194.06  E-value: 1.02e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124     1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRDSIAYGVTV 80
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDL 571

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    81 AILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQK-------------------CAKGGVKQARSRSRSSNCSIHT 141
Cdd:TIGR00927  572 MMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELwvkeqlsrrpvakvmalgdLSKGDVAEAEHTGERTGEEGER 651

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   142 ----------KNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAV 211
Cdd:TIGR00927  652 pteaegengeESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGE 731

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   212 GLCSGPGAIVQMAPLDDAEAESHVAV------------------------------------------------------ 237
Cdd:TIGR00927  732 IETGEEGEEVEDEGEGEAEGKHEVETegdrketehegeteaegkededegeiqagedgemkgdegaegkvehegeteage 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   238 -----------AAADEGRKEEGYSLLS----------------------------------------------------- 253
Cdd:TIGR00927  812 kdehegqsetqADDTEVKDETGEQELNaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeene 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   254 ------YPKDKScfAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSV 327
Cdd:TIGR00927  892 eplsleWPETRQ--KQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   328 MGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPgqnyVAINSAGLEYSAITL 407
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQP----VPVSSNGLFCAIVLL 1045

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 665411124   408 LSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIE 448
Cdd:TIGR00927 1046 FLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
1-443 3.93e-25

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 104.44  E-value: 3.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAgmTIPLDWWPLTRDSIAYGVTV 80
Cdd:COG0530   17 ISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR--PLAVDRRVLRRDLPFLLLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  81 AILICVMHDERVEWYEALILVSLYAVYLAVMYFDktfqkcakggvkqarsrsrssncsihtknsnekepelvenricqnm 160
Cdd:COG0530   95 LLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRR---------------------------------------------- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 161 aniqlngglnkeqakatstsgagttaisittstmtttlstthsagggggavglcsgpgaivqmaplddaEAESHVAVAAA 240
Cdd:COG0530  129 ---------------------------------------------------------------------ARKEPAWEEVE 139

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 241 DEGRKEEGYSLLsypkdkscfaqftWLIIWpihllfriaipdckkaknnkifpltFIMCIVWIGSLSYVVAWMITIIGDT 320
Cdd:COG0530  140 EELEEKPKMSLW-------------KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARA 181

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 321 LKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPwlikAVFFPIQPGQNYVAINSAGL 400
Cdd:COG0530  182 LGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG----ALITPIPVDPAVLSFDLPVM 257

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 665411124 401 EYSAItllstlflLYLTFSTNKFKLDKKVGTACLVMYLVFMVF 443
Cdd:COG0530  258 LAATL--------LLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 291-446 9.79e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 91.12  E-value: 9.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  291 IFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDIL 370
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665411124  371 LCLGVPWLIKavffPIQPGQNYVAINSAGLEYSAItllSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASL 446
Cdd:pfam01699  81 LVLGLSALIG----PVKVDSLLLKLDLGVLLLVAL---LLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 315-379 4.75e-09

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 57.73  E-value: 4.75e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665411124 315 TIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLI 379
Cdd:PRK10734 198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
 
Name Accession Description Interval E-value
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 1-448 1.02e-53

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 194.06  E-value: 1.02e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124     1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWWPLTRDSIAYGVTV 80
Cdd:TIGR00927  492 ISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNILFVIGTCALFSREILNLTWWPLFRDVSFYILDL 571

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    81 AILICVMHDERVEWYEALILVSLYAVYLAVMYFDKTFQK-------------------CAKGGVKQARSRSRSSNCSIHT 141
Cdd:TIGR00927  572 MMLILFFLDSLIAWWESLLLLLAYALYVFTMKWNKQIELwvkeqlsrrpvakvmalgdLSKGDVAEAEHTGERTGEEGER 651

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   142 ----------KNSNEKEPELVENRICQNMANIQLNGGLNKEQAKATSTSGAGTTAISITTSTMTTTLSTTHSAGGGGGAV 211
Cdd:TIGR00927  652 pteaegengeESGGEAEQEGETETKGENESEGEIPAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETEAEGTEDEGE 731

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   212 GLCSGPGAIVQMAPLDDAEAESHVAV------------------------------------------------------ 237
Cdd:TIGR00927  732 IETGEEGEEVEDEGEGEAEGKHEVETegdrketehegeteaegkededegeiqagedgemkgdegaegkvehegeteage 811

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   238 -----------AAADEGRKEEGYSLLS----------------------------------------------------- 253
Cdd:TIGR00927  812 kdehegqsetqADDTEVKDETGEQELNaenqgeakqdekgvdggggsdggdseeeeeeeeeeeeeeeeeeeeeeeeeene 891

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   254 ------YPKDKScfAQFTWLIIWPIHLLFRIAIPDCKKAKNNKIFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSV 327
Cdd:TIGR00927  892 eplsleWPETRQ--KQAIYLFLLPIVFPLWLTVPDVRRQEARKFFVITFLGSIMWIAMFSYLMVWWAHQVGETIGISEEI 969

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   328 MGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIKAVFFPIQPgqnyVAINSAGLEYSAITL 407
Cdd:TIGR00927  970 MGLTILAAGTSIPDLITSVIVARKGLGDMAVSSSVGSNIFDITVGLPVPWLLFSLINGLQP----VPVSSNGLFCAIVLL 1045

                          570       580       590       600
                   ....*....|....*....|....*....|....*....|.
gi 665411124   408 LSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASLIE 448
Cdd:TIGR00927 1046 FLMLLFVISSIASCKWRMNKILGFTMFLLYFVFLIISVMLE 1086
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 1-379 4.34e-27

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 110.49  E-value: 4.34e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDWwpLTRDSIAYGVTV 80
Cdd:TIGR00367  34 ISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNILLILGLSAIFSPIIVDKDW--LRRDILFYLLVS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   81 AILICVMHDERVEWYEALILVSLYAVYLAVMYfdktfqkcakggvkqarsrsrssncsihtknSNEKEPELvenricqnm 160
Cdd:TIGR00367 112 ILLLFFGLDGQISRIDGVVLLILYIVYLLFLV-------------------------------KNERWVKY--------- 151

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  161 aniqlngglnkeqakatstsgagttaisittstmtttlstthsagggggavglcsgpgaivqmapldDAEAESHVAvaaa 240
Cdd:TIGR00367 152 -------------------------------------------------------------------DTYTEENLD---- 160

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  241 degrkeegysllSYPKDKSCFAQFTWLIIWpihllfriaipdckkaknnkifpltfimcIVWIGSLSYVVAWMITIIGDT 320
Cdd:TIGR00367 161 ------------ENNRRPQIFFSLVLLIIG-----------------------------LIGLVVGSRLLVDGAVKIAEI 199

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 665411124  321 LKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLI 379
Cdd:TIGR00367 200 LGISEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILVGLGVPSLF 258
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
1-443 3.93e-25

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 104.44  E-value: 3.93e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAgmTIPLDWWPLTRDSIAYGVTV 80
Cdd:COG0530   17 ISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALIR--PLAVDRRVLRRDLPFLLLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  81 AILICVMHDERVEWYEALILVSLYAVYLAVMYFDktfqkcakggvkqarsrsrssncsihtknsnekepelvenricqnm 160
Cdd:COG0530   95 LLLLALLLDGTLSRIDGVILLLLYVLYLYYLIRR---------------------------------------------- 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 161 aniqlngglnkeqakatstsgagttaisittstmtttlstthsagggggavglcsgpgaivqmaplddaEAESHVAVAAA 240
Cdd:COG0530  129 ---------------------------------------------------------------------ARKEPAWEEVE 139

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 241 DEGRKEEGYSLLsypkdkscfaqftWLIIWpihllfriaipdckkaknnkifpltFIMCIVWIGSLSYVVAWMITIIGDT 320
Cdd:COG0530  140 EELEEKPKMSLW-------------KALLL-------------------------LVLGLALLVVGARLLVDGAVEIARA 181

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124 321 LKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPwlikAVFFPIQPGQNYVAINSAGL 400
Cdd:COG0530  182 LGVSELVIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIG----ALITPIPVDPAVLSFDLPVM 257

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 665411124 401 EYSAItllstlflLYLTFSTNKFKLDKKVGTACLVMYLVFMVF 443
Cdd:COG0530  258 LAATL--------LLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 291-446 9.79e-22

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 91.12  E-value: 9.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  291 IFPLTFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDIL 370
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 665411124  371 LCLGVPWLIKavffPIQPGQNYVAINSAGLEYSAItllSTLFLLYLTFSTNKFKLDKKVGTACLVMYLVFMVFASL 446
Cdd:pfam01699  81 LVLGLSALIG----PVKVDSLLLKLDLGVLLLVAL---LLLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 1-113 3.28e-15

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 72.64  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDW----WPLTRDSIAY 76
Cdd:pfam01699  33 ISGTVLGLTILALGTSLPELVSSIIAALRGEPDLALGNVIGSNIFNILLVLGLSALIGPVKVDSLLlkldLGVLLLVALL 112

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 665411124   77 GVTVAILICVMHDERVEWYEALILVSLYAVYLAVMYF 113
Cdd:pfam01699 113 LLLLLLLLLLPLFGRLSRFEGLVLLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
5-111 3.38e-15

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 75.94  E-value: 3.38e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   5 VAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIP-----LDWWPLTrdsiayGVT 79
Cdd:COG0530  188 VIGLTIVAIGTSLPELATSIVAARKGEDDLAVGNIIGSNIFNILLVLGIGALITPIPVDpavlsFDLPVML------AAT 261

                         90       100       110
                 ....*....|....*....|....*....|..
gi 665411124  80 VAILICVMHDERVEWYEALILVSLYAVYLAVM 111
Cdd:COG0530  262 LLLLGLLRTGGRIGRWEGLLLLALYLAYLALL 293
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 295-389 6.25e-11

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 64.81  E-value: 6.25e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  295 TFIMCIVWIGSLSYVVAWMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGS-MGICNSIGSNTFDILLCL 373
Cdd:TIGR00845 758 CFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYAdASIGNVTGSNAVNVFLGI 837

                          90       100
                  ....*....|....*....|...
gi 665411124  374 GVPWLIKAVF-------FPIQPG 389
Cdd:TIGR00845 838 GVAWSIAAIYhaangtqFKVSPG 860
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 294-382 2.85e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 61.19  E-value: 2.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124  294 LTFIMCIVWIGSLSYVVAWM---ITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDIL 370
Cdd:TIGR00367   2 LLIGYLILGLILLIYGADLFvksSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMGQPDIGVGNVIGSNIFNIL 81

                          90
                  ....*....|..
gi 665411124  371 LCLGVPWLIKAV 382
Cdd:TIGR00367  82 LILGLSAIFSPI 93
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
317-379 4.12e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 60.53  E-value: 4.12e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 665411124 317 IGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLI 379
Cdd:COG0530   11 LARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGSPDIAVGNVVGSNIANILLILGLAALI 73
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 315-379 4.75e-09

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 57.73  E-value: 4.75e-09
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665411124 315 TIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLI 379
Cdd:PRK10734 198 TVLANYFAISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVLGLPALI 262
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 2-107 4.81e-08

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 54.25  E-value: 4.81e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124    2 SNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAvaaccGIGAG---MTIPLDWWPLTRD-SIAYG 77
Cdd:TIGR00367 203 SEKIIGLTLLAIGTSLPELVVSLAAARKGLGDIAVGNVIGSNIFNILV-----GLGVPslfMPIPVEPLAYNLDaPVMVI 277

                          90       100       110
                  ....*....|....*....|....*....|
gi 665411124   78 VTVAILICVMHDERVEWYEALILVSLYAVY 107
Cdd:TIGR00367 278 VTLLLMLFFKTSMKLGRWEGILLLALYIAY 307
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 291-374 6.97e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 55.00  E-value: 6.97e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   291 IFPLTFIMCIVWIGSLSYVVAwMITIIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDIL 370
Cdd:TIGR00927  461 IFGMMYVFVALAIVCDEYFVP-ALGVITDKLQISEDVAGATFMAAGGSAPELFTSLIGVFISHSNVGIGTIVGSAVFNIL 539


                   ....
gi 665411124   371 LCLG 374
Cdd:TIGR00927  540 FVIG 543
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 316-380 2.10e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 52.73  E-value: 2.10e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665411124 316 IIGDTLKIPDSVMGITFLAAGTSVPEAVSSVIVAKRGHGSMGICNSIGSNTFDILLCLGVPWLIK 380
Cdd:PRK10734  28 ILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIR 92
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 5-54 3.78e-07

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 52.87  E-value: 3.78e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 665411124    5 VAGATFMAAATSAPELFVNVI---GTFITEGDIGVGTIVGSAVFNILAVAACC 54
Cdd:TIGR00845 131 VSNLTLMALGSSAPEILLSVIevcGHNFEAGDLGPSTIVGSAAFNMFIIIAIC 183
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 1-113 4.70e-07

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 51.57  E-value: 4.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   1 MSNDVAGATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAaccGIGAGMTiPLDWWPL--TRDsiaYGV 78
Cdd:PRK10734 206 ISELTIGLTVIAIGTSLPELATAIAGARKGENDIAVGNIIGSNIFNIVIVL---GLPALIS-PGEINPLafSRD---YWV 278

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 665411124  79 TVAI-----LICVMHDERVEWYEALILVSLYAVYLAVMYF 113
Cdd:PRK10734 279 MLLVsvifaLLCWRRKRRIGRGAGALLLGGFIVWLAMLYW 318
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 7-111 8.73e-03

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 38.09  E-value: 8.73e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665411124   7 GATFMAAATSAPELFVNVIGTFITEGDIGVGTIVGSAVFNILAVAACCGIGAGMTIPLDwwpLTRDSIAYGVTVAILI-C 85
Cdd:PRK10734  41 GMTVVGIGTSLPEIIVSVAASLHGQRDLAVGTALGSNITNILLILGLAALIRPFTVHSD---VLRRELPLMLLVSVLAgS 117

                         90       100
                 ....*....|....*....|....*.
gi 665411124  86 VMHDERVEWYEALILVSLYAVYLAVM 111
Cdd:PRK10734 118 VLYDGQLSRSDGIFLLLLAVLWLLFI 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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