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Conserved domains on  [gi|663429556|ref|NP_001287664|]
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ras-GEF domain-containing family member 1B isoform 2 [Homo sapiens]

Protein Classification

Ras-GEF domain-containing protein( domain architecture ID 10153535)

Ras guanine nucleotide exchange factor (Ras-GEF) domain-containing protein activates Ras-like small GTPases by mediating the replacement of GDP with GTP

CATH:  1.10.840.10
Gene Ontology:  GO:0007264|GO:0005085
PubMed:  7786285
SCOP:  4001268

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
208-402 3.39e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


:

Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 3.39e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  208 LAQQLTHIELERLNYIGPEEFVQAFVQKDpldndkscySERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEY 287
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK---------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  288 FIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRsltahss 364
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKTLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 663429556  365 rekiVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFW 402
Cdd:pfam00617 146 ----CIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKRR 179
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
42-166 1.31e-24

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


:

Pssm-ID: 100121  Cd Length: 122  Bit Score: 98.25  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  42 SLEALIQHLVPNVDYyPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQR--LSDPDSDKNQMRKIAPKILQLLTEWTE 119
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenLEYNDWDKKKSKPIRLRVLNVLRTWVE 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 663429556 120 TFPYDF-RDERMMRNLKDLAHRIASGeetyrKNVQQMMQCLIRKLAAL 166
Cdd:cd06224   80 NYPYDFfDDEELLELLEEFLNRLVQE-----GALLQELKKLLRKLLKL 122
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
208-402 3.39e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 3.39e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  208 LAQQLTHIELERLNYIGPEEFVQAFVQKDpldndkscySERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEY 287
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK---------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  288 FIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRsltahss 364
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKTLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 663429556  365 rekiVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFW 402
Cdd:pfam00617 146 ----CIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKRR 179
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
202-453 1.87e-63

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 205.56  E-value: 1.87e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   202 CNDPYTLAQQLTHIELERLNYIGPEEFVQAFVqkdpldndKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHR 281
Cdd:smart00147   3 LLDPKELAEQLTLLDFELFRKIDPSELLGSVW--------GKRSKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDR 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   282 ARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQrs 358
Cdd:smart00147  75 AELLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLpsKYKKlFEELEELLSPERNYKNYREALSSCNL-- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   359 ltahssreKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVF- 437
Cdd:smart00147 153 --------PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSDIQSLLQQLLDh 224
                          250
                   ....*....|....*...
gi 663429556   438 --SEDALYLASYESEGPE 453
Cdd:smart00147 225 ldEEEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
202-448 5.74e-62

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 201.71  E-value: 5.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 202 CNDPYTLAQQLTHIELERLNYIGPEEFVQAFVqkdpldndKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHR 281
Cdd:cd00155    3 SLDPKELAEQLTLLDFELFRKIEPFELLGSLW--------SKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 282 ARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQrs 358
Cdd:cd00155   75 ARLLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLssKLKKlFEELEELVDPSRNFKNYRKLLKSVGP-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 359 ltahssrEKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTV--PV 436
Cdd:cd00155  153 -------NPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLleLI 225
                        250
                 ....*....|..
gi 663429556 437 FSEDALYLASYE 448
Cdd:cd00155  226 LNEDELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
42-166 1.31e-24

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 98.25  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  42 SLEALIQHLVPNVDYyPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQR--LSDPDSDKNQMRKIAPKILQLLTEWTE 119
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenLEYNDWDKKKSKPIRLRVLNVLRTWVE 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 663429556 120 TFPYDF-RDERMMRNLKDLAHRIASGeetyrKNVQQMMQCLIRKLAAL 166
Cdd:cd06224   80 NYPYDFfDDEELLELLEEFLNRLVQE-----GALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
37-132 3.15e-11

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 60.01  E-value: 3.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   37 NLLSGSLEALIQHLVPNvDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAP---KILQL 113
Cdd:pfam00618   1 QVKAGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSV 79
                          90
                  ....*....|....*....
gi 663429556  114 LTEWTETFPYDFRDERMMR 132
Cdd:pfam00618  80 LRHWVENYFSDFNDDPVLL 98
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
40-139 9.77e-11

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 59.27  E-value: 9.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556    40 SGSLEALIQHLVPNvDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHlcvehqRLSDPDSDKNQMRKIAP-----KILQLL 114
Cdd:smart00229   7 GGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLY------RYNAIPPESWVEEKVNPrrvknRVLNIL 79
                           90       100
                   ....*....|....*....|....*.
gi 663429556   115 TEWTETFPYDFRDERMM-RNLKDLAH 139
Cdd:smart00229  80 RTWVENYWEDFEDDPKLiSFLLEFLE 105
 
Name Accession Description Interval E-value
RasGEF pfam00617
RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.
208-402 3.39e-65

RasGEF domain; Guanine nucleotide exchange factor for Ras-like small GTPases.


Pssm-ID: 459872  Cd Length: 179  Bit Score: 207.83  E-value: 3.39e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  208 LAQQLTHIELERLNYIGPEEFVQAFVQKDpldndkscySERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHRARMIEY 287
Cdd:pfam00617   2 LARQLTLIEFELFRKIKPRELLGSAWSKK---------DKKENSPNIEAMIARFNKLSNWVASEILSEEDLKKRAKVIKK 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  288 FIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKVK---TAKFDILEHQMDPSSNFYNYRTALRGAAQRsltahss 364
Cdd:pfam00617  73 FIKIAEHCRELNNFNSLMAILSGLNSSPISRLKKTWELVSkkyKKTLEELEKLMSPSRNFKNYREALSSASPP------- 145
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 663429556  365 rekiVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFW 402
Cdd:pfam00617 146 ----CIPFLGLYLTDLTFIEEGNPDFLEGGLINFEKRR 179
RasGEF smart00147
Guanine nucleotide exchange factor for Ras-like small GTPases;
202-453 1.87e-63

Guanine nucleotide exchange factor for Ras-like small GTPases;


Pssm-ID: 214539  Cd Length: 242  Bit Score: 205.56  E-value: 1.87e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   202 CNDPYTLAQQLTHIELERLNYIGPEEFVQAFVqkdpldndKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHR 281
Cdd:smart00147   3 LLDPKELAEQLTLLDFELFRKIDPSELLGSVW--------GKRSKKSPSPLNLEAFIRRFNEVSNWVATEILKQTTPKDR 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   282 ARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQrs 358
Cdd:smart00147  75 AELLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEKLpsKYKKlFEELEELLSPERNYKNYREALSSCNL-- 152
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   359 ltahssreKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTVPVF- 437
Cdd:smart00147 153 --------PPCIPFLGVLLKDLTFIDEGNPDFLENGLVNFEKRRQIAEILREIRQLQSQPYNLRPNRSDIQSLLQQLLDh 224
                          250
                   ....*....|....*...
gi 663429556   438 --SEDALYLASYESEGPE 453
Cdd:smart00147 225 ldEEEELYQLSLKIEPRV 242
RasGEF cd00155
Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of ...
202-448 5.74e-62

Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. Guanine-nucleotide-exchange factors (GEFs) positively regulate these GTP-binding proteins in response to a variety of signals. GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors.


Pssm-ID: 238087 [Multi-domain]  Cd Length: 237  Bit Score: 201.71  E-value: 5.74e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 202 CNDPYTLAQQLTHIELERLNYIGPEEFVQAFVqkdpldndKSCYSERKKTRNLEAYVEWFNRLSYLVATEICMPVKKKHR 281
Cdd:cd00155    3 SLDPKELAEQLTLLDFELFRKIEPFELLGSLW--------SKKDKNIHLSPNLERFIERFNNLSNWVASEILLCTNPKKR 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 282 ARMIEYFIDVARECFNIGNFNSLMAIISGMNMSPVSRLKKTWAKV--KTAK-FDILEHQMDPSSNFYNYRTALRGAAQrs 358
Cdd:cd00155   75 ARLLSKFIQVAKHCRELNNFNSLMAIVSALSSSPISRLKKTWEVLssKLKKlFEELEELVDPSRNFKNYRKLLKSVGP-- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556 359 ltahssrEKIVIPFFSLLIKDIYFLNEGCANRLPNGHVNFEKFWELAKQVSEFMTWKQVECPFERDRKILQYLLTV--PV 436
Cdd:cd00155  153 -------NPPCVPFLGVYLKDLTFLHEGNPDFLEGNLVNFEKRRKIAEILREIRQLQSNSYELNRDEDILAFLWKLleLI 225
                        250
                 ....*....|..
gi 663429556 437 FSEDALYLASYE 448
Cdd:cd00155  226 LNEDELYELSLE 237
REM cd06224
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also ...
42-166 1.31e-24

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately N-terminal to the RasGef (Cdc25-like) domain. REM contacts the GTPase and is assumed to participate in the catalytic activity of the exchange factor. Proteins with the REM domain include Sos1 and Sos2, which relay signals from tyrosine-kinase mediated signalling to Ras, RasGRP1-4, RasGRF1,2, CNrasGEF, and RAP-specific nucleotide exchange factors, to name a few.


Pssm-ID: 100121  Cd Length: 122  Bit Score: 98.25  E-value: 1.31e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556  42 SLEALIQHLVPNVDYyPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQR--LSDPDSDKNQMRKIAPKILQLLTEWTE 119
Cdd:cd06224    1 TLEALIEHLTSTFDM-PDPSFVSTFLLTYRSFTTPTELLEKLIERYEIAPPenLEYNDWDKKKSKPIRLRVLNVLRTWVE 79
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 663429556 120 TFPYDF-RDERMMRNLKDLAHRIASGeetyrKNVQQMMQCLIRKLAAL 166
Cdd:cd06224   80 NYPYDFfDDEELLELLEEFLNRLVQE-----GALLQELKKLLRKLLKL 122
RasGEF_N pfam00618
RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small ...
37-132 3.15e-11

RasGEF N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this motif/domain N-terminal to the RasGef (Cdc25-like) domain.


Pssm-ID: 459873  Cd Length: 104  Bit Score: 60.01  E-value: 3.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556   37 NLLSGSLEALIQHLVPNvDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHLCVEHQRLSDPDSDKNQMRKIAP---KILQL 113
Cdd:pfam00618   1 QVKAGTLEKLVEYLTST-RIMLDDSFLSTFLLTYRSFTTPAELLELLIERYNIPPPLDLSSDSYWISKKTLPiriRVLSV 79
                          90
                  ....*....|....*....
gi 663429556  114 LTEWTETFPYDFRDERMMR 132
Cdd:pfam00618  80 LRHWVENYFSDFNDDPVLL 98
RasGEFN smart00229
Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine ...
40-139 9.77e-11

Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif; A subset of guanine nucleotide exchange factor for Ras-like small GTPases appear to possess this domain N-terminal to the RasGef (Cdc25-like) domain. The recent crystal structureof Sos shows that this domain is alpha-helical and plays a "purely structural role" (Nature 394, 337-343).


Pssm-ID: 214571  Cd Length: 127  Bit Score: 59.27  E-value: 9.77e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 663429556    40 SGSLEALIQHLVPNvDYYPDRTYIFTFLLSSRLFMHPYELMAKVCHlcvehqRLSDPDSDKNQMRKIAP-----KILQLL 114
Cdd:smart00229   7 GGTLEALIEHLTEA-FDKADPSFVETFLLTYRSFITTQELLQLLLY------RYNAIPPESWVEEKVNPrrvknRVLNIL 79
                           90       100
                   ....*....|....*....|....*.
gi 663429556   115 TEWTETFPYDFRDERMM-RNLKDLAH 139
Cdd:smart00229  80 RTWVENYWEDFEDDPKLiSFLLEFLE 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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