MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is ...
509-803
6.97e-160
MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is essential in lipid metabolism, especially in the biogenesis of very low-density lipoproteins and chylomicrons via the transfer of neutral lipids and the assembly of apoB-containing lipoproteins. It is a heterodimer consisting of a large MTP alpha-subunit and a protein disulfide isomerase (PDI) beta-subunit. The MTP large subunit has and N-terminal beta-barrel domain, a central alpha-helical domain and a C-terminal 2-beta-sheet domain. This is the highly conserved MTP C-terminal domain involved in lipid-binding and transfer activity, with preference of neutral 3 chain-containing lipids. The beta-sheets are named A and C and form a sandwich comprising the lipid-binding site between them. Half of the A-sheet interacts with the beta-barrel. This domain also interacts with a' and b' domains of PDI.
:
Pssm-ID: 466086 Cd Length: 258 Bit Score: 465.02 E-value: 6.97e-160
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal ...
1-501
2.10e-127
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.
:
Pssm-ID: 460170 [Multi-domain] Cd Length: 582 Bit Score: 393.56 E-value: 2.10e-127
MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is ...
509-803
6.97e-160
MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is essential in lipid metabolism, especially in the biogenesis of very low-density lipoproteins and chylomicrons via the transfer of neutral lipids and the assembly of apoB-containing lipoproteins. It is a heterodimer consisting of a large MTP alpha-subunit and a protein disulfide isomerase (PDI) beta-subunit. The MTP large subunit has and N-terminal beta-barrel domain, a central alpha-helical domain and a C-terminal 2-beta-sheet domain. This is the highly conserved MTP C-terminal domain involved in lipid-binding and transfer activity, with preference of neutral 3 chain-containing lipids. The beta-sheets are named A and C and form a sandwich comprising the lipid-binding site between them. Half of the A-sheet interacts with the beta-barrel. This domain also interacts with a' and b' domains of PDI.
Pssm-ID: 466086 Cd Length: 258 Bit Score: 465.02 E-value: 6.97e-160
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal ...
1-501
2.10e-127
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.
Pssm-ID: 460170 [Multi-domain] Cd Length: 582 Bit Score: 393.56 E-value: 2.10e-127
MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is ...
509-803
6.97e-160
MTP large subunit, lipid-binding domain; Microsomal triglyceride transfer protein (MTP) is essential in lipid metabolism, especially in the biogenesis of very low-density lipoproteins and chylomicrons via the transfer of neutral lipids and the assembly of apoB-containing lipoproteins. It is a heterodimer consisting of a large MTP alpha-subunit and a protein disulfide isomerase (PDI) beta-subunit. The MTP large subunit has and N-terminal beta-barrel domain, a central alpha-helical domain and a C-terminal 2-beta-sheet domain. This is the highly conserved MTP C-terminal domain involved in lipid-binding and transfer activity, with preference of neutral 3 chain-containing lipids. The beta-sheets are named A and C and form a sandwich comprising the lipid-binding site between them. Half of the A-sheet interacts with the beta-barrel. This domain also interacts with a' and b' domains of PDI.
Pssm-ID: 466086 Cd Length: 258 Bit Score: 465.02 E-value: 6.97e-160
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal ...
1-501
2.10e-127
Lipoprotein amino terminal region; This family contains regions from: Vitellogenin, Microsomal triglyceride transfer protein and apolipoprotein B-100. These proteins are all involved in lipid transport. This family contains the LV1n chain from lipovitellin, that contains two structural domains.
Pssm-ID: 460170 [Multi-domain] Cd Length: 582 Bit Score: 393.56 E-value: 2.10e-127
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
with the same color and shade of the domain or superfamily that provides the annotation. Mouse over the colored bars or triangles to see descriptions of the domains and features.
click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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Modify your query to search against a different database and/or use advanced search options
