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Conserved domains on  [gi|684136402|ref|NP_001288711|]
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leukocyte receptor cluster member 9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MJ1316 pfam04457
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
 65-138 4.96e-24

MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.


:

Pssm-ID: 461317  Cd Length: 75  Bit Score: 95.02  E-value: 4.96e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 684136402   65 RTAADVIQRIRWDPRLDPADFSVGYVDRFLGVREEPFSAFCWDQPLAALGPGVLAVPQHRVRFFRFRGRLVWDR 138
Cdd:pfam04457   2 RTIQDVLNRIRWDPRLDKSKFVVGYLDRFDGIKEVPFSEFTWIEDLIEDDDGELAIPQHRIRYFKRDGEVVWDR 75
AKAP7_NLS super family cl44428
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 297-477 1.27e-12

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


The actual alignment was detected with superfamily member pfam10469:

Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 66.91  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  297 PTHFVALMVTEPGLQAEVTKAQEYLVHVAPHCANFL-VPSQNLHLTLALLRLAGAGEEAAAIGALRRA---LLAPGLNAP 372
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECreeIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  373 PRLSFRKLVLLGP-----HVLCAPP-----SPTLESMAQVLSQRLEAEGLSTLQSPGQLHPHLTVAKVPHGSQVHLPK-- 440
Cdd:pfam10469  81 LSLRFKGLETFNDdpsavRVLYAKVeeddhSPKLQELADRIIRRFQEAGLLVKENNSRVKLHMTLMNTRYRKKKYAKSke 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 684136402  441 -------LEFTLSQEVGCQPLQTLWLCRIGRTG---GPFQPLAEIPL 477
Cdd:pfam10469 161 sfdareiLDEFKDFDFGTQKVSELHLCSMGSSDesdGFYHVEASVKL 207
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 24-39 7.47e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


:

Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 7.47e-05
                          10
                  ....*....|....*.
gi 684136402   24 CRFFLEGRCRFGARCR 39
Cdd:pfam18345   1 CKFFLKGRCRYGDKCR 16
 
Name Accession Description Interval E-value
MJ1316 pfam04457
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
 65-138 4.96e-24

MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.


Pssm-ID: 461317  Cd Length: 75  Bit Score: 95.02  E-value: 4.96e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 684136402   65 RTAADVIQRIRWDPRLDPADFSVGYVDRFLGVREEPFSAFCWDQPLAALGPGVLAVPQHRVRFFRFRGRLVWDR 138
Cdd:pfam04457   2 RTIQDVLNRIRWDPRLDKSKFVVGYLDRFDGIKEVPFSEFTWIEDLIEDDDGELAIPQHRIRYFKRDGEVVWDR 75
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 297-477 1.27e-12

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 66.91  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  297 PTHFVALMVTEPGLQAEVTKAQEYLVHVAPHCANFL-VPSQNLHLTLALLRLAGAGEEAAAIGALRRA---LLAPGLNAP 372
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECreeIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  373 PRLSFRKLVLLGP-----HVLCAPP-----SPTLESMAQVLSQRLEAEGLSTLQSPGQLHPHLTVAKVPHGSQVHLPK-- 440
Cdd:pfam10469  81 LSLRFKGLETFNDdpsavRVLYAKVeeddhSPKLQELADRIIRRFQEAGLLVKENNSRVKLHMTLMNTRYRKKKYAKSke 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 684136402  441 -------LEFTLSQEVGCQPLQTLWLCRIGRTG---GPFQPLAEIPL 477
Cdd:pfam10469 161 sfdareiLDEFKDFDFGTQKVSELHLCSMGSSDesdGFYHVEASVKL 207
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 24-39 7.47e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 7.47e-05
                          10
                  ....*....|....*.
gi 684136402   24 CRFFLEGRCRFGARCR 39
Cdd:pfam18345   1 CKFFLKGRCRYGDKCR 16
COG1531 COG1531
Uncharacterized conserved protein, UPF0248 family [Function unknown];
69-102 9.68e-04

Uncharacterized conserved protein, UPF0248 family [Function unknown];


Pssm-ID: 441140  Cd Length: 78  Bit Score: 37.92  E-value: 9.68e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 684136402  69 DVIQRIRWDPRLDPADFSVGYVDR--FLGVREEPFS 102
Cdd:COG1531    4 ELLNRILWDPRYDREDYEIVYLDRgaPGGLKEIPGS 39
ZnF_C3H1 smart00356
zinc finger;
24-39 2.66e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 35.30  E-value: 2.66e-03
                           10
                   ....*....|....*.
gi 684136402    24 CRFFLEGRCRFGARCR 39
Cdd:smart00356   7 CKFFKRGYCPRGDRCK 22
 
Name Accession Description Interval E-value
MJ1316 pfam04457
MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved ...
 65-138 4.96e-24

MJ1316 RNA cyclic group end recognition domain; RNA repair domain predicted to be involved specifically in the recognition of RNA 3' ends with 2'-3' cyclic phosphate groups.


Pssm-ID: 461317  Cd Length: 75  Bit Score: 95.02  E-value: 4.96e-24
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 684136402   65 RTAADVIQRIRWDPRLDPADFSVGYVDRFLGVREEPFSAFCWDQPLAALGPGVLAVPQHRVRFFRFRGRLVWDR 138
Cdd:pfam04457   2 RTIQDVLNRIRWDPRLDKSKFVVGYLDRFDGIKEVPFSEFTWIEDLIEDDDGELAIPQHRIRYFKRDGEVVWDR 75
AKAP7_NLS pfam10469
AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic ...
 297-477 1.27e-12

AKAP7 2'5' RNA ligase-like domain; AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes. AKAP7_NLS carries the nuclear localization signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains pfam02834. Presumably this domain carried out some as yet unknown enzymatic function.


Pssm-ID: 402204 [Multi-domain]  Cd Length: 207  Bit Score: 66.91  E-value: 1.27e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  297 PTHFVALMVTEPGLQAEVTKAQEYLVHVAPHCANFL-VPSQNLHLTLALLRLAGAGEEAAAIGALRRA---LLAPGLNAP 372
Cdd:pfam10469   1 PTHFLSIPLNSPELRKRLEEFQESVLKQLPGLDESLfIPPEKLHITLLVLVLLDDEEVARAKEALRECreeIKDILNGNP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 684136402  373 PRLSFRKLVLLGP-----HVLCAPP-----SPTLESMAQVLSQRLEAEGLSTLQSPGQLHPHLTVAKVPHGSQVHLPK-- 440
Cdd:pfam10469  81 LSLRFKGLETFNDdpsavRVLYAKVeeddhSPKLQELADRIIRRFQEAGLLVKENNSRVKLHMTLMNTRYRKKKYAKSke 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 684136402  441 -------LEFTLSQEVGCQPLQTLWLCRIGRTG---GPFQPLAEIPL 477
Cdd:pfam10469 161 sfdareiLDEFKDFDFGTQKVSELHLCSMGSSDesdGFYHVEASVKL 207
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 24-39 7.47e-05

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 39.71  E-value: 7.47e-05
                          10
                  ....*....|....*.
gi 684136402   24 CRFFLEGRCRFGARCR 39
Cdd:pfam18345   1 CKFFLKGRCRYGDKCR 16
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 24-39 5.55e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 37.18  E-value: 5.55e-04
                          10
                  ....*....|....*.
gi 684136402   24 CRFFLEGRCRFGARCR 39
Cdd:pfam18044   3 CRYFQKGGCRYGDNCR 18
COG1531 COG1531
Uncharacterized conserved protein, UPF0248 family [Function unknown];
69-102 9.68e-04

Uncharacterized conserved protein, UPF0248 family [Function unknown];


Pssm-ID: 441140  Cd Length: 78  Bit Score: 37.92  E-value: 9.68e-04
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 684136402  69 DVIQRIRWDPRLDPADFSVGYVDR--FLGVREEPFS 102
Cdd:COG1531    4 ELLNRILWDPRYDREDYEIVYLDRgaPGGLKEIPGS 39
ZnF_C3H1 smart00356
zinc finger;
24-39 2.66e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 35.30  E-value: 2.66e-03
                           10
                   ....*....|....*.
gi 684136402    24 CRFFLEGRCRFGARCR 39
Cdd:smart00356   7 CKFFKRGYCPRGDRCK 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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