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Conserved domains on  [gi|734520301|ref|NP_001290059|]
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GAS2-like protein 3 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 44-172 8.94e-92

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409118  Cd Length: 130  Bit Score: 280.96  E-value: 8.94e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  44 EATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEES-GNFPMRKVPCKKDAASGSFFAR 122
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTEElKHFPMRKVPCKKDAPSGSFFAR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 734520301 123 DNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 172
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 213-281 3.19e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


:

Pssm-ID: 460480  Cd Length: 69  Bit Score: 113.46  E-value: 3.19e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734520301  213 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGD--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 281
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
Herpes_BLLF1 super family cl37540
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 309-693 9.54e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


The actual alignment was detected with superfamily member pfam05109:

Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 9.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  309 ARTPQPPEMNPLSAVNMFQKQNSKPSVPVS--IPKSKEKQGRPPGALVPASSLKGGNLGSMSVRSKLPNSPAA------S 380
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSthVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngteS 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  381 SHPKLKSSKGITKKPQAPSNNASSSLASLNPvgkNTSSPALPRTAPCI--------SESPRKCISSPnTPKAkVIP--AQ 450
Cdd:pfam05109 502 KAPDMTSPTSAVTTPTPNATSPTPAVTTPTP---NATSPTLGKTSPTSavttptpnATSPTPAVTTP-TPNA-TIPtlGK 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  451 NSADLPESTLLPNKCS---GKTQPKylkhnhissrDNAVSHLAAHSNSSskcpklPKANIPVRPKPSFQSSAKMTKTSSK 527
Cdd:pfam05109 577 TSPTSAVTTPTPNATSptvGETSPQ----------ANTTNHTLGGTSST------PVVTSPPKNATSAVTTGQHNITSSS 640

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  528 TIATGLgtqsQPSDGAPQAKPVPAQKLKSALN-LNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGP---S 603
Cdd:pfam05109 641 TSSMSL----RPSSISETLSPSTSDNSTSHMPlLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPgnsS 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  604 SLKSPGRTPLSIVSLPQSSTKTQtAPKSAQTVAKSQHSTKGPPRS---GKTPASIRKPPSSVKDADSGDKKPTAKKKEDD 680
Cdd:pfam05109 717 TSTKPGEVNVTKGTPPKNATSPQ-APSGQKTAVPTVTSTGGKANSttgGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNA 795

                         410
                  ....*....|...
gi 734520301  681 DHYFVMTGSKKPR 693
Cdd:pfam05109 796 TTYLPPSTSSKLR 808
 
Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 44-172 8.94e-92

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 280.96  E-value: 8.94e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  44 EATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEES-GNFPMRKVPCKKDAASGSFFAR 122
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTEElKHFPMRKVPCKKDAPSGSFFAR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 734520301 123 DNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 172
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 213-281 3.19e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 113.46  E-value: 3.19e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734520301  213 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGD--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 281
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 211-284 6.23e-28

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 107.15  E-value: 6.23e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 734520301   211 EELHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGD-KILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQ 284
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGDsQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 52-161 6.39e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 53.86  E-value: 6.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301    52 EDLSIWLSGLLG--IKVKAEKLLEELDNGVLLCQLIDVLQNmvktcnseesGNFPMRKVpckkDAASGSFFARDNTANFL 129
Cdd:smart00033   1 KTLLRWVNSLLAeyDKPPVTNFSSDLKDGVALCALLNSLSP----------GLVDKKKV----AASLSRFKKIENINLAL 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 734520301   130 HWCRDIGVDETyLFESEGLVL-HKDPRQVYLCL 161
Cdd:smart00033  67 SFAEKLGGKVV-LFEPEDLVEgPKLILGVIWTL 98
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 48-166 1.41e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 50.36  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301   48 LPMQEDLSIWLSGLL---GIKVKAEKLLEELDNGVLLCQLIDVLQnmvktcnseeSGNFPMRKVPCKKdaasgsFFARDN 124
Cdd:pfam00307   1 LELEKELLRWINSHLaeyGPGVRVTNFTTDLRDGLALCALLNKLA----------PGLVDKKKLNKSE------FDKLEN 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 734520301  125 TANFLHWCR-DIGVDEtYLFESEGLVlHKDPRQVYLCLLEIGR 166
Cdd:pfam00307  65 INLALDVAEkKLGVPK-VLIEPEDLV-EGDNKSVLTYLASLFR 105
SCP1 COG5199
Calponin [Cytoskeleton];
51-166 2.06e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 48.76  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  51 QEDLSIWLSGLLGIKVKAE-KLLEELDNGVLLCqlidvlqnmvKTCNSEESGNFPMR--KVPckkdaasgsFFARDNTAN 127
Cdd:COG5199   15 QKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLC----------RILNEASPLDIKYKesKMP---------FVQMENISS 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 734520301 128 FLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 166
Cdd:COG5199   76 FINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSR 114
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 309-693 9.54e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 9.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  309 ARTPQPPEMNPLSAVNMFQKQNSKPSVPVS--IPKSKEKQGRPPGALVPASSLKGGNLGSMSVRSKLPNSPAA------S 380
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSthVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngteS 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  381 SHPKLKSSKGITKKPQAPSNNASSSLASLNPvgkNTSSPALPRTAPCI--------SESPRKCISSPnTPKAkVIP--AQ 450
Cdd:pfam05109 502 KAPDMTSPTSAVTTPTPNATSPTPAVTTPTP---NATSPTLGKTSPTSavttptpnATSPTPAVTTP-TPNA-TIPtlGK 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  451 NSADLPESTLLPNKCS---GKTQPKylkhnhissrDNAVSHLAAHSNSSskcpklPKANIPVRPKPSFQSSAKMTKTSSK 527
Cdd:pfam05109 577 TSPTSAVTTPTPNATSptvGETSPQ----------ANTTNHTLGGTSST------PVVTSPPKNATSAVTTGQHNITSSS 640

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  528 TIATGLgtqsQPSDGAPQAKPVPAQKLKSALN-LNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGP---S 603
Cdd:pfam05109 641 TSSMSL----RPSSISETLSPSTSDNSTSHMPlLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPgnsS 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  604 SLKSPGRTPLSIVSLPQSSTKTQtAPKSAQTVAKSQHSTKGPPRS---GKTPASIRKPPSSVKDADSGDKKPTAKKKEDD 680
Cdd:pfam05109 717 TSTKPGEVNVTKGTPPKNATSPQ-APSGQKTAVPTVTSTGGKANSttgGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNA 795

                         410
                  ....*....|...
gi 734520301  681 DHYFVMTGSKKPR 693
Cdd:pfam05109 796 TTYLPPSTSSKLR 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 305-673 1.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  305 PDSPARTPQP-----PEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVP-------ASSLKGGNLGSMSVRSK 372
Cdd:PHA03247 2624 PDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqrprrrAARPTVGSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  373 LPNSPAASSHPKLksskgitkkPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCIS--------SPNTPKA 444
Cdd:PHA03247 2704 PPPTPEPAPHALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppttagppAPAPPAA 2774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  445 KVIPAQNSADLPE-STLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMtk 523
Cdd:PHA03247 2775 PAAGPPRRLTRPAvASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL-- 2852

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  524 tsSKTIATGLGTQSQPSDGAPQAKP-VPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGP 602
Cdd:PHA03247 2853 --GGSVAPGGDVRRRPPSRSPAAKPaAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734520301  603 SSLKSPGRTPlsivSLPQSSTKTQTAPKSAQTVAKSQHSTKGPPRSGKTPASIRKPPSSVKDADSGDKKPT 673
Cdd:PHA03247 2931 PPPPPPPRPQ----PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
 
Name Accession Description Interval E-value
CH_GAS2L3 cd21269
calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth ...
 44-172 8.94e-92

calponin homology (CH) domain found in growth arrest-specific protein 2-like 3; Growth arrest-specific protein 2-like 3 (GAS2L3), also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. It contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409118  Cd Length: 130  Bit Score: 280.96  E-value: 8.94e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  44 EATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEES-GNFPMRKVPCKKDAASGSFFAR 122
Cdd:cd21269    1 EATLVPMQEDLSIWLSGMLGKEVKAERFMEELDNGVLLCQLIGVLQSKIKECCSTEElKHFPMRKVPCKKDAPSGSFFAR 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 734520301 123 DNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 172
Cdd:cd21269   81 DNTANFLSWCRAIGVDETYLFESEGLVLHKDPRQVCLCLLEIGRIVSRYG 130
CH_GAS2 cd21267
calponin homology (CH) domain found in growth arrest-specific protein 2; Growth ...
 43-175 4.96e-65

calponin homology (CH) domain found in growth arrest-specific protein 2; Growth arrest-specific protein 2 (GAS-2) may play a role in apoptosis by acting as a cell death substrate for caspases. It contains a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409116  Cd Length: 136  Bit Score: 211.34  E-value: 4.96e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  43 HEATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEES---GNFPMRKVPCKKDAASGSF 119
Cdd:cd21267    1 HEASLLPMKEDLALWLTNLLGKEITAESFMEKLDNGALLCQLAETLQEKFKENSADANkpgKSLPVRKIPCRANAPSGSF 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 734520301 120 FARDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGVEP 175
Cdd:cd21267   81 FARDNTANFLSWCRDVGVGDTCLFESEGLVLHKQPREVCLCLLELGRIAARFGVEP 136
CH_GAS2-like cd21204
calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth ...
 44-172 1.71e-62

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409053  Cd Length: 131  Bit Score: 204.04  E-value: 1.71e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  44 EATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKTCNSEESGNFP--MRKVPCKKDAASGSFFA 121
Cdd:cd21204    1 EEALLPMKEDLAEWLNDLLGDDLTPDNFLDELRNGVVLCQLAQKIQEAAEKAREAGKKNGPppSYKLKCNENAKPGSFFA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 734520301 122 RDNTANFLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYG 172
Cdd:cd21204   81 RDNVANFLRWCRKLGVDEVLLFESEDLVLHKNPRQVLLCLLELARIAARYG 131
CH_GAS2L1_2 cd21268
calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar ...
 44-173 3.33e-33

calponin homology (CH) domain found in GAS2-like protein 1 (GAS2L1), GAS2L2, and similar proteins; This subfamily includes GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2). They may be involved in the cross-linking of microtubules and microfilaments. Members of this subfamily contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409117  Cd Length: 142  Bit Score: 124.35  E-value: 3.33e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  44 EATLLPMQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQNMVKT------CNSEESGNFPMRKVPCKKDAASG 117
Cdd:cd21268    6 EEYLYAMKEDLAEWLNTLYNLDITADNFFEKLETGVLLCKHANNVTRAAREfqaqhpERASPLKLPPREVIFYRPSAKPG 85

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 734520301 118 SFFARDNTANFLHWCR-DIGVDETYLFESEGLVLHKDPRQVYLCLLEIGRIVSRYGV 173
Cdd:cd21268   86 SFQARDNVSNFINWCRqLLGIPEVLLFETDDLVLRKNEKNFVLCLLEVARRGAKFGM 142
GAS2 pfam02187
Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members ...
 213-281 3.19e-30

Growth-Arrest-Specific Protein 2 Domain; The GAR2 domain is common in plakin family members and Gas2 family members. The GAR domain comprises around 57 amino acids and has been shown to bind to microtubules.


Pssm-ID: 460480  Cd Length: 69  Bit Score: 113.46  E-value: 3.19e-30
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734520301  213 LHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGD--KILFIRMLHgKHVMVRVGGGWDTLQGFLLKYDPCR 281
Cdd:pfam02187   1 LDDEVRRIVAQ--CTCPTKFPVEKVGEGKYRFGDsqKLVFVRILR-SHVMVRVGGGWDTLEEYLLKHDPCR 68
GAS2 smart00243
Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain
 211-284 6.23e-28

Growth-Arrest-Specific Protein 2 Domain; GROWTH-ARREST-SPECIFIC PROTEIN 2 Domain


Pssm-ID: 128539  Cd Length: 73  Bit Score: 107.15  E-value: 6.23e-28
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 734520301   211 EELHEAVKHIAEDppCSCSHRFSIEYLSEGRYRLGD-KILFIRMLHGKHVMVRVGGGWDTLQGFLLKYDPCRILQ 284
Cdd:smart00243   1 DKIDDEVKRIVED--CKCPTKFQVEKISEGKYRFGDsQILRLVRILRSTVMVRVGGGWETLDEYLLKHDPCRAKG 73
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 51-166 7.01e-18

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031 [Multi-domain]  Cd Length: 103  Bit Score: 79.30  E-value: 7.01e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  51 QEDLSIWLSGLLG--IKVKAEKLLEELDNGVLLCQLIDVLQNmvktcnseesgnfpmRKVPCKKDAASGSFFARDNTANF 128
Cdd:cd00014    1 EEELLKWINEVLGeeLPVSITDLFESLRDGVLLCKLINKLSP---------------GSIPKINKKPKSPFKKRENINLF 65

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 734520301 129 LHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 166
Cdd:cd00014   66 LNACKKLGLPELDLFEPEDLYEKGNLKKVLGTLWALAL 103
CH_dMP20-like cd21207
calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 ...
 57-166 2.63e-10

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409056 [Multi-domain]  Cd Length: 107  Bit Score: 58.09  E-value: 2.63e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  57 WLSGLLGIKVKAEKLLEE-LDNGVLLCQLIDVLQ-NMVKTCNSeeSGnfpmrkvpckkdaasGSFFARDNTANFLHWCRD 134
Cdd:cd21207   13 WIEAVTGEKLDDGKDYEDvLKDGVILCKLINILKpGSVKKINT--SK---------------MAFKLMENIENFLTACKG 75

                         90       100       110
                 ....*....|....*....|....*....|..
gi 734520301 135 IGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 166
Cdd:cd21207   76 YGVPKTDLFQTVDLYEKKNIPQVTNCLFALGR 107
CH_SCP1-like cd21210
calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar ...
 50-166 1.55e-09

calponin homology (CH) domain found in Saccharomyces cerevisiae transgelin (SCP1) and similar proteins; The family includes transgelins from Saccharomyces cerevisiae and Schizosaccharomyces pombe, which are also called SCP1 and STG1, respectively. Transgelin, also called calponin homolog 1, has actin-binding and actin-bundling activity. It stabilizes actin filaments against disassembly. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409059 [Multi-domain]  Cd Length: 101  Bit Score: 55.45  E-value: 1.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  50 MQEDLSIWLSGLLGIKVKAEKLLEELDNGVLLCQLID-VLQNMVKTCNSeesGNFPmrkvpckkdaasgsFFARDNTANF 128
Cdd:cd21210    1 AEQEAREWIEEVLGEKLAQGDLLDALKDGVVLCKLANrILPADIRKYKE---SKMP--------------FVQMENISAF 63

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 734520301 129 LHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 166
Cdd:cd21210   64 LNAARKLGVPENDLFQTVDLFERKNPAQVLQCLHALSR 101
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
 52-161 6.39e-09

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 53.86  E-value: 6.39e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301    52 EDLSIWLSGLLG--IKVKAEKLLEELDNGVLLCQLIDVLQNmvktcnseesGNFPMRKVpckkDAASGSFFARDNTANFL 129
Cdd:smart00033   1 KTLLRWVNSLLAeyDKPPVTNFSSDLKDGVALCALLNSLSP----------GLVDKKKV----AASLSRFKKIENINLAL 66

                           90       100       110
                   ....*....|....*....|....*....|...
gi 734520301   130 HWCRDIGVDETyLFESEGLVL-HKDPRQVYLCL 161
Cdd:smart00033  67 SFAEKLGGKVV-LFEPEDLVEgPKLILGVIWTL 98
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 48-166 1.41e-07

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 50.36  E-value: 1.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301   48 LPMQEDLSIWLSGLL---GIKVKAEKLLEELDNGVLLCQLIDVLQnmvktcnseeSGNFPMRKVPCKKdaasgsFFARDN 124
Cdd:pfam00307   1 LELEKELLRWINSHLaeyGPGVRVTNFTTDLRDGLALCALLNKLA----------PGLVDKKKLNKSE------FDKLEN 64

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 734520301  125 TANFLHWCR-DIGVDEtYLFESEGLVlHKDPRQVYLCLLEIGR 166
Cdd:pfam00307  65 INLALDVAEkKLGVPK-VLIEPEDLV-EGDNKSVLTYLASLFR 105
CH_LMO7-like cd21208
calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This ...
 57-168 9.12e-07

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409057 [Multi-domain]  Cd Length: 119  Bit Score: 48.10  E-value: 9.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  57 WLSGLLGIKVKAEKLLEELDNGVLLCQLIDVLQ-NMVKTCNSeesgnfpmrkvpCKKDAAsgsffARDNTANFLHWCRDI 135
Cdd:cd21208    8 WIEAVTGKKFPSDDFRESLEDGILLCELINAIKpGSIKKINR------------LPTPIA-----GLDNLNLFLKACEDL 70

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 734520301 136 GVDETYLFES-----------EGLVLHKDP----RQVYLCLLEIGRIV 168
Cdd:cd21208   71 GLKDSQLFDPtdlqdlsnrriATHVRKKEDerrlKNVAITLYWLGRAA 118
SCP1 COG5199
Calponin [Cytoskeleton];
51-166 2.06e-06

Calponin [Cytoskeleton];


Pssm-ID: 227526 [Multi-domain]  Cd Length: 178  Bit Score: 48.76  E-value: 2.06e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  51 QEDLSIWLSGLLGIKVKAE-KLLEELDNGVLLCqlidvlqnmvKTCNSEESGNFPMR--KVPckkdaasgsFFARDNTAN 127
Cdd:COG5199   15 QKEVTLWIETVLGEKFEPPgDLLSLLKDGVRLC----------RILNEASPLDIKYKesKMP---------FVQMENISS 75

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 734520301 128 FLHWCRDIGVDETYLFESEGLVLHKDPRQVYLCLLEIGR 166
Cdd:COG5199   76 FINGLKKLRVPEYELFQTNDLFEAKDLRQVVICLYSLSR 114
CH_LRCH cd21205
calponin homology (CH) domain found in the leucine-rich repeat and calponin homology ...
 68-164 3.71e-05

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409054 [Multi-domain]  Cd Length: 107  Bit Score: 43.06  E-value: 3.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  68 AEKLLEELDNGVLLCQLIDVLQNMVKTCNSEESGNFPmrkvpcKKDAASgsffARDNTANFLHWCRDIGVDETYLFESEG 147
Cdd:cd21205   19 PDDLGEALMDGVVLCHLANHVRPRSVPSIHVPSPAVP------KLSMAK----CRRNVENFLEACRKLGVPEERLCSPGD 88

                         90
                 ....*....|....*..
gi 734520301 148 LVLHKDPRQVYLCLLEI 164
Cdd:cd21205   89 ILEEKGLVRVAVTVQAL 105
CH_IQGAP cd21206
calponin homology (CH) domain found in the IQ motif containing GTPase activating protein ...
 56-161 5.31e-05

calponin homology (CH) domain found in the IQ motif containing GTPase activating protein family; Members of the IQ motif containing GTPase activating protein (IQGAP) family are associated with the Ras GTP-binding protein and act as essential regulators of cytoskeletal function. There are three known IQGAP family members: IQGAP1, IQGAP2, and IQGAP3. They are multi-domain molecules having a calponin-homology (CH) domain which binds F-actin, IQGAP-specific repeats, a single WW domain, four IQ motifs that mediate interactions with calmodulin, and a RasGAP related domain that binds active Rho family GTPases. IQGAP1 negatively regulates Ras family GTPases by stimulating their intrinsic GTPase activity. It lacks GAP activity. Both IQGAP1 and IQGAP2 specifically bind to Cdc42 and Rac1, but not to RhoA. Despite similarities to part of the sequence of RasGAP, neither IQGAP1 nor IQGAP2 interacts with Ras. IQGAP3 regulates the organization of the cytoskeleton under the regulation of Rac1 and Cdc42 in neuronal cells. The depletion of IQGAP3 is shown to impair neurite or axon outgrowth in neuronal cells with disorganized cytoskeleton.


Pssm-ID: 409055 [Multi-domain]  Cd Length: 118  Bit Score: 42.98  E-value: 5.31e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  56 IWLSGLLGIKVKA-EKLLEELDNGVLLCQLIDVLQnmvktcnseesgnfPmRKVPCKKDAASG-SFFARDNTANFLHWCR 133
Cdd:cd21206   15 QWIEACLNEELPPtTEFEEELRNGVVLAKLANKFA--------------P-KLVPLKKIYDVGlQFRHTDNINHFLRALK 79

                         90       100
                 ....*....|....*....|....*...
gi 734520301 134 DIGVDETYLFESEGLVLHKDPRQVYLCL 161
Cdd:cd21206   80 KIGLPKIFHFETTDLYEKKNIPKVIYCL 107
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 309-693 9.54e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 45.68  E-value: 9.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  309 ARTPQPPEMNPLSAVNMFQKQNSKPSVPVS--IPKSKEKQGRPPGALVPASSLKGGNLGSMSVRSKLPNSPAA------S 380
Cdd:pfam05109 422 SKAPESTTTSPTLNTTGFAAPNTTTGLPSSthVPTNLTAPASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPrdngteS 501

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  381 SHPKLKSSKGITKKPQAPSNNASSSLASLNPvgkNTSSPALPRTAPCI--------SESPRKCISSPnTPKAkVIP--AQ 450
Cdd:pfam05109 502 KAPDMTSPTSAVTTPTPNATSPTPAVTTPTP---NATSPTLGKTSPTSavttptpnATSPTPAVTTP-TPNA-TIPtlGK 576

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  451 NSADLPESTLLPNKCS---GKTQPKylkhnhissrDNAVSHLAAHSNSSskcpklPKANIPVRPKPSFQSSAKMTKTSSK 527
Cdd:pfam05109 577 TSPTSAVTTPTPNATSptvGETSPQ----------ANTTNHTLGGTSST------PVVTSPPKNATSAVTTGQHNITSSS 640

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  528 TIATGLgtqsQPSDGAPQAKPVPAQKLKSALN-LNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGP---S 603
Cdd:pfam05109 641 TSSMSL----RPSSISETLSPSTSDNSTSHMPlLTSAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPgnsS 716

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  604 SLKSPGRTPLSIVSLPQSSTKTQtAPKSAQTVAKSQHSTKGPPRS---GKTPASIRKPPSSVKDADSGDKKPTAKKKEDD 680
Cdd:pfam05109 717 TSTKPGEVNVTKGTPPKNATSPQ-APSGQKTAVPTVTSTGGKANSttgGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNA 795

                         410
                  ....*....|...
gi 734520301  681 DHYFVMTGSKKPR 693
Cdd:pfam05109 796 TTYLPPSTSSKLR 808
PHA03247 PHA03247
large tegument protein UL36; Provisional
 305-673 1.60e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.31  E-value: 1.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  305 PDSPARTPQP-----PEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVP-------ASSLKGGNLGSMSVRSK 372
Cdd:PHA03247 2624 PDPPPPSPSPaanepDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPpqrprrrAARPTVGSLTSLADPPP 2703

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  373 LPNSPAASSHPKLksskgitkkPQAPSNNASSSLASLNPVGKNTSSPALPRTAPCISESPRKCIS--------SPNTPKA 444
Cdd:PHA03247 2704 PPPTPEPAPHALV---------SATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARppttagppAPAPPAA 2774

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  445 KVIPAQNSADLPE-STLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSKCPKLPKANIPVRPKPSFQSSAKMtk 523
Cdd:PHA03247 2775 PAAGPPRRLTRPAvASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPL-- 2852

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  524 tsSKTIATGLGTQSQPSDGAPQAKP-VPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKSAFQKTGP 602
Cdd:PHA03247 2853 --GGSVAPGGDVRRRPPSRSPAAKPaAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQ 2930

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 734520301  603 SSLKSPGRTPlsivSLPQSSTKTQTAPKSAQTVAKSQHSTKGPPRSGKTPASIRKPPSSVKDADSGDKKPT 673
Cdd:PHA03247 2931 PPPPPPPRPQ----PPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
 516-694 3.78e-04

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 43.88  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  516 QSSAKMTKTSSKTIAtglgtQSQPSDGAPQAKPVPAQKLKSALNLNQPVSVSSVSPVKATQKSKDKNIVSATKKQPQNKS 595
Cdd:PTZ00108 1156 QRLKSKTKGKASKLR-----KPKLKKKEKKKKKSSADKSKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSGSDQEDDEE 1230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  596 AFQKTGPSSLKSPGRTPLSIVSLPQSST-----------KTQTAPKSAQTVAKSQHSTKGPPRSGKTPASIRKPPSSVKD 664
Cdd:PTZ00108 1231 QKTKPKKSSVKRLKSKKNNSSKSSEDNDefssddlskegKPKNAPKRVSAVQYSPPPPSKRPDGESNGGSKPSSPTKKKV 1310

                         170       180       190
                  ....*....|....*....|....*....|
gi 734520301  665 ADSGDKKPTAKKKedddhyfvmtgSKKPRK 694
Cdd:PTZ00108 1311 KKRLEGSLAALKK-----------KKKSEK 1329
CH_CNN1 cd21282
calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), ...
 51-162 6.53e-04

calponin homology (CH) domain found in calponin-1 and similar proteins; Calponin-1 (CNN1), also called basic calponin, or smooth muscle calponin H1, is a thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C, and tropomyosin. Calponin-1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409131 [Multi-domain]  Cd Length: 108  Bit Score: 39.86  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  51 QEDLSIWLSGLLGIKVkAEKLLEELDNGVLLCQLIDVLQnmvktcnseeSGNFPmrkvpcKKDAASGSFFARDNTANFLH 130
Cdd:cd21282    5 EEELRVWIEGVTGRRI-GDNFMDGLKDGVILCELINKLQ----------PGSVR------KINESTQNWHKLENIGNFIK 67

                         90       100       110
                 ....*....|....*....|....*....|..
gi 734520301 131 WCRDIGVDETYLFESEGLVLHKDPRQVYLCLL 162
Cdd:cd21282   68 AIMHYGVKPHDIFEANDLFENTNHTQVQSTLI 99
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 302-498 7.50e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 39.75  E-value: 7.50e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  302 ESVPDSPARTP--QPPEMNPLSAVNMFQKQNSKPSVPVSIPKSKEKQGRPPGALVPASSLKGGN--------LGSMSVRS 371
Cdd:pfam03154 343 QPLPPAPLSMPhiKPPPTTPIPQLPNPQSHKHPPHLSGPSPFQMNSNLPPPPALKPLSSLSTHHppsahpppLQLMPQSQ 422

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  372 KLPNSPA--------------ASSHPKLKSSKGITKKPQAPSNN--ASSSLASLNPVGKNTS-SPALPRTAPCISESPRK 434
Cdd:pfam03154 423 QLPPPPAqppvltqsqslpppAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGPPTStSSAMPGIQPPSSASVSS 502

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  435 CISSPNTPKAKVIPAQ------NSADLPESTLLPNKCSGKTQPKYLKHNHISSRDNAVSHLAAHSNSSSK 498
Cdd:pfam03154 503 SGPVPAAVSCPLPPVQikeealDEAEEPESPPPPPRSPSPEPTVVNTPSHASQSARFYKHLDRGYNSCAR 572
CH_LRCH4 cd21273
calponin homology (CH) domain found in leucine-rich repeat and calponin homology ...
 68-164 7.54e-03

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409122  Cd Length: 109  Bit Score: 36.80  E-value: 7.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  68 AEKLLEELDNGVLLCQLidvlqnmvktCNSEESGNFPMRKVPCKKDAASGSFFARDNTANFLHWCRDIGVDETYLFeSEG 147
Cdd:cd21273   22 PEDLAEALSNGAVLCQL----------ANQLRPRSVSIIHVPSPAVPKLSKAKCRKNVENFIEACRKMGVPEVDLC-SPS 90

                         90
                 ....*....|....*..
gi 734520301 148 LVLHKDPRQVYLCLLEI 164
Cdd:cd21273   91 DVLLQGPAAVLRTVLAL 107
CH_VAV cd21201
calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic ...
 71-148 8.56e-03

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.


Pssm-ID: 409050  Cd Length: 117  Bit Score: 36.85  E-value: 8.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 734520301  71 LLEELDNGVLLCQLIDVLQ----NMVKTCNseesgNFPMRKvpckkdaasgsFFARDNTANFLHWCRD-IGVDETYLFES 145
Cdd:cd21201   32 LAQALRDGVLLCQLLNRLSpgsvDDREINL-----RPQMSQ-----------FLCLKNIRTFLQACRTvFGLRSADLFEP 95


                 ...
gi 734520301 146 EGL 148
Cdd:cd21201   96 EDL 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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