NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|741866098|ref|NP_001290336|]
View 

CWF19-like protein 1 isoform 4 [Homo sapiens]

Protein Classification

CWF19 family protein( domain architecture ID 10215886)

CWF19 family protein belongs to the HIT (Histidine triad) superfamily, similar to human CWF19-like protein 2

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
HIT_like super family cl00228
HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH ...
 83-178 1.16e-35

HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified in the literacture into three major branches: the Hint branch, which consists of adenosine 5' -monophosphoramide hydrolases, the Fhit branch, that consists of diadenosine polyphosphate hydrolases, and the GalT branch consisting of specific nucloside monophosphate transferases. Further sequence analysis reveals several new closely related, yet uncharacterized subgroups.


The actual alignment was detected with superfamily member pfam04677:

Pssm-ID: 469672  Cd Length: 122  Bit Score: 124.41  E-value: 1.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098   83 CWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKYKATLRRFFKSRGKWCVVFE 162
Cdd:pfam04677  14 CWFCLSNPNLEKHLIVSIGNKAYLALPKGPLVSGHCLIIPIQHIPSTLSLDEEVWDEIRNFRKALTLMYKSQGKDAVFFE 93

                          90
                  ....*....|....*..
gi 741866098  163 R-NYKSHHLQLQVIPVP 178
Cdd:pfam04677  94 IaSQRRPHLHIQCIPVP 110
CwfJ_C_2 pfam04676
Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of ...
 198-290 1.04e-19

Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ. CwfJ is part of the Cdc5p complex involved in mRNA splicing.


:

Pssm-ID: 461388  Cd Length: 96  Bit Score: 81.87  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098  198 QQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLFHRI--KKNFPLQFGREVLASeaILNVPdKSDWR-QCQISKEDEE 274
Cdd:pfam04676   4 QHKKLIDTSNKKGFRRSIPKGFPYFHVEFGLDGGYAHVIedEERFPLQFGREVIAG--MLDLP-PRVWRkPCRQSKEEEE 80

                          90
                  ....*....|....*.
gi 741866098  275 TLARRFRKDFEPYDFT 290
Cdd:pfam04676  81 QRVEAFKKAWKKYDWT 96
 
Name Accession Description Interval E-value
CwfJ_C_1 pfam04677
Protein similar to CwfJ C-terminus 1; This region is found in the N terminus of ...
 83-178 1.16e-35

Protein similar to CwfJ C-terminus 1; This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ. CwfJ is part of the Cdc5p complex involved in mRNA splicing.


Pssm-ID: 428062  Cd Length: 122  Bit Score: 124.41  E-value: 1.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098   83 CWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKYKATLRRFFKSRGKWCVVFE 162
Cdd:pfam04677  14 CWFCLSNPNLEKHLIVSIGNKAYLALPKGPLVSGHCLIIPIQHIPSTLSLDEEVWDEIRNFRKALTLMYKSQGKDAVFFE 93

                          90
                  ....*....|....*..
gi 741866098  163 R-NYKSHHLQLQVIPVP 178
Cdd:pfam04677  94 IaSQRRPHLHIQCIPVP 110
CwfJ_C_2 pfam04676
Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of ...
 198-290 1.04e-19

Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ. CwfJ is part of the Cdc5p complex involved in mRNA splicing.


Pssm-ID: 461388  Cd Length: 96  Bit Score: 81.87  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098  198 QQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLFHRI--KKNFPLQFGREVLASeaILNVPdKSDWR-QCQISKEDEE 274
Cdd:pfam04676   4 QHKKLIDTSNKKGFRRSIPKGFPYFHVEFGLDGGYAHVIedEERFPLQFGREVIAG--MLDLP-PRVWRkPCRQSKEEEE 80

                          90
                  ....*....|....*.
gi 741866098  275 TLARRFRKDFEPYDFT 290
Cdd:pfam04676  81 QRVEAFKKAWKKYDWT 96
 
Name Accession Description Interval E-value
CwfJ_C_1 pfam04677
Protein similar to CwfJ C-terminus 1; This region is found in the N terminus of ...
 83-178 1.16e-35

Protein similar to CwfJ C-terminus 1; This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ. CwfJ is part of the Cdc5p complex involved in mRNA splicing.


Pssm-ID: 428062  Cd Length: 122  Bit Score: 124.41  E-value: 1.16e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098   83 CWFCLASPEVEKHLVVNIGTHCYLALAKGGLSDDHVLILPIGHYQSVVELSAEVVEEVEKYKATLRRFFKSRGKWCVVFE 162
Cdd:pfam04677  14 CWFCLSNPNLEKHLIVSIGNKAYLALPKGPLVSGHCLIIPIQHIPSTLSLDEEVWDEIRNFRKALTLMYKSQGKDAVFFE 93

                          90
                  ....*....|....*..
gi 741866098  163 R-NYKSHHLQLQVIPVP 178
Cdd:pfam04677  94 IaSQRRPHLHIQCIPVP 110
CwfJ_C_2 pfam04676
Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of ...
 198-290 1.04e-19

Protein similar to CwfJ C-terminus 2; This region is found in the N terminus of Schizosaccharomyces pombe protein CwfJ. CwfJ is part of the Cdc5p complex involved in mRNA splicing.


Pssm-ID: 461388  Cd Length: 96  Bit Score: 81.87  E-value: 1.04e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 741866098  198 QQIELLEIPEHSDIKQIAQPGAAYFYVELDTGEKLFHRI--KKNFPLQFGREVLASeaILNVPdKSDWR-QCQISKEDEE 274
Cdd:pfam04676   4 QHKKLIDTSNKKGFRRSIPKGFPYFHVEFGLDGGYAHVIedEERFPLQFGREVIAG--MLDLP-PRVWRkPCRQSKEEEE 80

                          90
                  ....*....|....*.
gi 741866098  275 TLARRFRKDFEPYDFT 290
Cdd:pfam04676  81 QRVEAFKKAWKKYDWT 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH