|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
52-471 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 627.44 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 52 AILANMGFMISFGIRCNFGAAKTHMYKNYTDPYG---KVHMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK 128
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGgkvIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 129 LFGFGIGVGAFLNILLPYGFKVkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPL 208
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARV-HYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 209 SAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfekpafhptisqeekifiedaighvsnthptirsipwkaivtSKPVWA 288
Cdd:cd17382 160 SGILVQYVGWSSPFYVYGVFGIIWYMFWMLV-------------------------------------------SMPVYA 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 289 IIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKIFNCGGFG 368
Cdd:cd17382 197 IIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGFG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 369 GEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAH-SKH 447
Cdd:cd17382 277 MEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHkTRE 356
|
410 420
....*....|....*....|....
gi 808355682 448 GWTSVFLLASLIHFTGVTFYAVYA 471
Cdd:cd17382 357 EWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
52-471 |
1.85e-119 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 357.70 E-value: 1.85e-119
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 52 AILANMGFMISFGIRCNFGAAKTHM------YKNYTDPYGKVHMH----EFNWTIDELSVMESSYFYGYLVTQIPAGFLA 121
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMvnstatHDNNNTSTDKDTLPveapEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 122 AKFPPNKLFGFGIGVGAFLNILLPYgFKVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAG 201
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPL-AARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 202 AVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFcvtfekpafhptisqeekifiedaighvsnthptirsipwkaiV 281
Cdd:cd17318 160 TVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWF-------------------------------------------F 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 282 TSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKI 361
Cdd:cd17318 197 LVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 362 FNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEA 440
Cdd:cd17318 277 FTSIGFLGPGVFLIALGYLGSNaTLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGA 356
|
410 420 430
....*....|....*....|....*....|...
gi 808355682 441 FTA--HSKHGWTSVFLLASLIHFTGVTFYAVYA 471
Cdd:cd17318 357 IVKndQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
51-471 |
1.82e-91 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 286.29 E-value: 1.82e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 51 LAILANMGFMISFGIRCNFGAAKTHMYKNYTD---------------PYGKVHMH---EFNWTIDELSVMESSYFYGYLV 112
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTlpsnnssnacpehssSPSVEHNEtgkKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 113 TQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVKSDYLVAfIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLAT 192
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIA-VRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 193 TAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFekpafhptisqeekifiedaighvsnthpti 272
Cdd:cd17381 160 ISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVM------------------------------- 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 273 rsipwkaivtskPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKI 352
Cdd:cd17381 209 ------------PLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQN 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 353 LSTTAVRKIFNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAG 431
Cdd:cd17381 277 FSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNySLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPG 356
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 808355682 432 LTCPFVTEAFT-AHSKHGWTSVFLLASLIHFTGVTFYAVYA 471
Cdd:cd17381 357 MVGPVIAKSLThNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
45-476 |
2.59e-79 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 256.59 E-value: 2.59e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 45 CRKRWLLAILANMGFMISFGIRCNFGAAKTHMyKNYTDPYG-----------KVHMHEFNWTIDELSVMESSYFYGYLVT 113
Cdd:TIGR00894 14 CSFRLFLSFLLHICNVIIIAQRICLSLTMVAM-VNKENSTDlaclsaeneldNIKNPNFKWSGALQGLILSSHFYGQIII 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 114 QIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATT 193
Cdd:TIGR00894 93 QIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGG-GIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGM 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 194 AFTGSYAGAVLGLPLSAFLV-SYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPTISQEEKIFIEDAIghVSNTHPTI 272
Cdd:TIGR00894 172 STSGFQLGTFIFLPISGWLCeSWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSL--QGQKGSTR 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 273 RSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKI 352
Cdd:TIGR00894 250 QSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKT 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 353 LSTTAVRKIFNCGGFGGEAAFMLIVAYTTSD-TTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAG 431
Cdd:TIGR00894 330 LSLTAARKIFNGIGGLGPGIFAYALPYLSAAfYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGG 409
|
410 420 430 440
....*....|....*....|....*....|....*....|....*.
gi 808355682 432 LTCPFVTEAF-TAHSKHGWTSVFLLASLIHFTGVTFYAVYASGELQ 476
Cdd:TIGR00894 410 LIASTLAGNIlSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQ 455
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
90-471 |
1.31e-74 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 240.92 E-value: 1.31e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 90 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgFKVKSDYLVAFIQITQGLVQGV 169
Cdd:cd17380 27 KEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL-LAYSSLPLLILSRILLGLGEGV 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 170 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTfekpafhpt 249
Cdd:cd17380 106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 250 isqeekifiedaighvsnthptirsipwkaivtsKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGmKIADSGLLAAIP 329
Cdd:cd17380 177 ----------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVP 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 330 HLVMGCVVLMGGQLADYLRSNKIlSTTAVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHL 409
Cdd:cd17380 222 WLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQ 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 808355682 410 DIAPRYAAILMGFSNGIGTLAGLTCPFVTeAFTAHSKHGWTSVFLLASLIHFTGVTFYAVYA 471
Cdd:cd17380 301 DIAPNYAGIVFGISNTAGTIPGIVGVYLT-GYILEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
46-469 |
1.29e-36 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 139.62 E-value: 1.29e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 46 RKRWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFP 125
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 126 PNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLG 205
Cdd:COG2271 74 RRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 206 LPLSAFLVSYVSWAAPFYLYGVCGVIWAILwfcvtfekpafhptisqeekifiedaighvsnthptirsipwkaivtskP 285
Cdd:COG2271 151 PPLLGWLLAAFGWRAAFLILGLPGLLLALL-------------------------------------------------R 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 286 VWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSnkilsttaVRKIFNCG 365
Cdd:COG2271 182 FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR--------RRKLVLAI 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 366 GFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAP-RYAAILMGFSNGIGTLAGLTCPFVTEAFTAH 444
Cdd:COG2271 254 GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDA 333
|
410 420
....*....|....*....|....*
gi 808355682 445 SkhGWTSVFLLASLIHFTGVTFYAV 469
Cdd:COG2271 334 T--GYQAAFLLLAALALLAALLALL 356
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
48-459 |
1.01e-35 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 136.93 E-value: 1.01e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 48 RWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPN 127
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGAR 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 128 KLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLP 207
Cdd:cd17319 69 KVLAVSMLLWSLFTALTGF---ATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPP 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 208 LSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfekpafhptisqeekifiedaighvsnthptIRSipwkaivtskpVW 287
Cdd:cd17319 146 LSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFY--------------------------------LRQ-----------VW 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 288 AIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKilsttavRKIFNCGGF 367
Cdd:cd17319 183 GLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVIIIGL 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 368 GGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPR-YAAILMGFSNGIGTLAGLTCPFVTEAFTAHSk 446
Cdd:cd17319 256 LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLVDAT- 334
|
410
....*....|...
gi 808355682 447 HGWTSVFLLASLI 459
Cdd:cd17319 335 GSYTAAFLFLAAV 347
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
89-432 |
2.01e-27 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 113.28 E-value: 2.01e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpygFKVKSDYLVAFIQITQGLVQG 168
Cdd:pfam07690 24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL---LFASSLWLLLVLRVLQGLGAG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 169 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFcvTFEKPAFHP 248
Cdd:pfam07690 101 ALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPESK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 249 TISQEEKIFIedaighvsnthptIRSIPWKAIVTSKPVWAIIVanFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAI 328
Cdd:pfam07690 179 RPKPAEEARL-------------SLIVAWKALLRDPVLWLLLA--LLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 329 PHLVMGCVVLMGGQLADYLRSNKILsttavrkIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNH 408
Cdd:pfam07690 244 GGLLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*
gi 808355682 409 LDIAP-RYAAILMGFSNGIGTLAGL 432
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGA 341
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
82-467 |
4.88e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 106.74 E-value: 4.88e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 82 DPYGKVHMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVksdYLVAFIQI 161
Cdd:cd06174 16 SPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF---WLLLLGRF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 162 TQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSY--VSWAAPFYLYGVCGVIWAILWFCV 239
Cdd:cd06174 93 LLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 240 TFEKPafhptisqeekifiEDAIGHVSNTHPTIRSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKI 319
Cdd:cd06174 173 VPDPP--------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 320 ADSGLLAAIPHLVMGCVVLMGGQLADYLRSnkilsttaVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGF 399
Cdd:cd06174 239 AVAGLLLSLFGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGL 310
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808355682 400 AISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHsKHGWTSVFLLASLIHFTGVTFY 467
Cdd:cd06174 311 LPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA-TFGLTGAFLVLAVLLLLAAILL 377
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
46-459 |
1.43e-22 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 99.96 E-value: 1.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 46 RKRWLLAILANMGFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFP 125
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 126 PNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLG 205
Cdd:COG2223 69 PRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVA 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 206 LPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPtisqeekifiedaighvsnTHPTIRSIPWKAIVTSKP 285
Cdd:COG2223 146 AFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA-------------------AAAKASLRDQLEALRDPR 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 286 VWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILsttavrkifnCG 365
Cdd:COG2223 207 FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVL----------LI 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 366 GFGGEAAFMLIVAYTTSDTTAIMALIAAVgmsGFAISGFNVNHLDIAP-----RYAAILMGFSNGIGTLAGLTCPFVTEA 440
Cdd:COG2223 277 VFALMALGLLLLALALGSLWLFLVLFLLL---GLALGGGNGAVFALVPdifptKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
|
410
....*....|....*....
gi 808355682 441 FTAHSkHGWTSVFLLASLI 459
Cdd:COG2223 354 LLDAT-GSYTAAFLVFAVL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
89-431 |
5.82e-21 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 94.27 E-value: 5.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQG 168
Cdd:COG2814 37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 169 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVI-WAILWFCVTFEKPAFH 247
Cdd:COG2814 114 ALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLaLLLLLRLLPESRPAAR 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 248 PTISQEekifiedaighvsnthptirsipWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAA 327
Cdd:COG2814 194 ARLRGS-----------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 328 IPHLVMGCVVLMGGQLADYLRSNKILSttavrkifncGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVN 407
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLL----------IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
|
330 340
....*....|....*....|....*
gi 808355682 408 HLDIAP-RYAAILMGFSNGIGTLAG 431
Cdd:COG2814 321 VAELAPpEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
104-471 |
4.55e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.68 E-value: 4.55e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 104 SSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFKVksdYLVAFIQITQGLVQGVCYPAMHGVWRYWAP 183
Cdd:cd17325 38 AAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY---WQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 184 PMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPTISQEEKIFIEdaig 263
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRS---- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 264 hvsnthptirsiPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQL 343
Cdd:cd17325 191 ------------GLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 344 ADYLRSNKILSTtavrkifncgGFGGEAAFMLIVAYTTSdtTAIMALIAAVGMSGFAISGFNVNHL--DIAPRYA-AILM 420
Cdd:cd17325 259 SDRIGRKPLILI----------GLLLSAVALLLLPLATS--FWLLLLLLALLGLGLGLVFPATLALlaDIVPPEGrGTAM 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 808355682 421 GFSNGIGTLAGLTCPFVTEAFTAHskHGWTSVFLLASLIHFTGVTFYAVYA 471
Cdd:cd17325 327 GLFNTAFSLGMVLGPLLGGFLYDA--FGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
58-453 |
5.02e-10 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 61.62 E-value: 5.02e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 58 GFMISFGIRCNFGAAKTHMyknytdpygkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVG 137
Cdd:TIGR00881 3 GYAAYYLVRKNFALAMPYL------------VEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILC 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 138 AFLNILLpyGFKVKSDYLVAFIQITqGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVS-YV 216
Cdd:TIGR00881 71 AIVNLFF--GFSTSLWVMAALWALN-GIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLY 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 217 SWAAPFYLYGVCGVIWAILWFCVTFEKPAfHPTISQEEKIFIEDAIGHVSNTHP--TIRSIPWKAIVTSKPVWAIIVANF 294
Cdd:TIGR00881 148 SWHWVFIVPGIIAIIVSLICFLLLRDSPQ-SCGLPPAEEMPNEEPDGDAEKKEEelTKKQIFLQYVLLNKVLWYISLGYV 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 295 ARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVRKifnCGGFGGEAAFM 374
Cdd:TIGR00881 227 FVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFM---ALIIVSLLVYW 303
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 375 LIVAyttSDTTAIMALIAAVGMSGFA-ISGFNVNHLDIAPRYAAILMG-----FSNGIGTLAGLTCPFVTEAFtahskhG 448
Cdd:TIGR00881 304 LNPA---ANPLMDLICLFALGFLVYGpQMLIGVIASELAPKKAAGTAAgfvgfFAYLGGILAGLPLGYLADGF------G 374
|
....*
gi 808355682 449 WTSVF 453
Cdd:TIGR00881 375 WAGAF 379
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
48-459 |
2.99e-09 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 59.18 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 48 RWLLAILANMGFMISFGIRCNFGAAKTHMYKNYTdpygkvhmhefnWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPN 127
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYG------------LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPK 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 128 KLFGFGIGVGAFLNILLPYGFKVKSDYLVAFI-QITQGLVQGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGL 206
Cdd:cd17345 69 RFLAIGLILSAIINILIGFVPSATSSVGLMFIlLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVG 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 207 PLSAFLVSYV---SWAAPFYLYGVCGVIWAILWFCVTFEKPAFH--PTISQEEKIFIEDAIGHVSNTHPTIRSIPWKAIV 281
Cdd:cd17345 149 PLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEglPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVL 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 282 TSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGL------LAAIPHlvmgcvVLMGGQLADYLRSNKilst 355
Cdd:cd17345 229 KNKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWafslfeWAAIPG------TLLAGWLSDKLFKGR---- 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 356 tavRKIFNCGGFGGEAAfmLIVAYTTSdTTAIMALIAAVGMsGFAISG----FNVNHLDIAPRYAAI----LMGFSNGIG 427
Cdd:cd17345 299 ---RAPTGIIFMILVIV--ALIVYWLA-PNVLVDLIALIAL-GFLIYGpvmlIGLQALELVPKKAAGtaagLTGLFGYLG 371
|
410 420 430
....*....|....*....|....*....|....*.
gi 808355682 428 --TLAGLTCPFVTEAFtahskhGWTSVF--LLASLI 459
Cdd:cd17345 372 gsVLATALIGIIVDHF------GWNGGFivLLASCI 401
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
186-438 |
6.80e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 54.91 E-value: 6.80e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 186 ERSKLATTAFTGSYAGAVLGLPLSAFLVSYVS------WAAPFYLYGVCGVIWAILWFCVTFEKPAfhptisqeekifie 259
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPV-------------- 209
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 260 daighVSNTHPTIRSIpWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLM 339
Cdd:COG2211 210 -----PEEEKVSLKES-LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPL 283
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 340 GGQLADYLRSnkilsttavRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAavgMSGFAISGFNVNHL----DIAP-- 413
Cdd:COG2211 284 WPRLAKRFGK---------KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAA---LAGIGLGAILVLPWamlaDVVDyd 351
|
250 260 270
....*....|....*....|....*....|.
gi 808355682 414 ------RYAAILMGFSNGIGTLAGLTCPFVT 438
Cdd:COG2211 352 ewktgrRREGLYFGIFTFAIKLGQALAGALA 382
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
90-237 |
9.14e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 54.20 E-value: 9.14e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 90 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpyGFkVKSDYLVAFIQITQGLVQGV 169
Cdd:cd17312 31 EEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GF-STSLWFFAVLWGLNGLFQSM 107
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 808355682 170 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWF 237
Cdd:cd17312 108 GWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILF 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
115-459 |
4.40e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 4.40e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 115 IPAGFLAAKFPPNKLFGFG---IGVGAFLNILLPygfkvkSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPpmERSKLA 191
Cdd:COG2807 71 PLAPRLARRFGLERTLLLAlllLAAGLLLRSLAP------SVALLLAGTALIGAGIAVGNVLLPGLIKRWFP--DRVGLM 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 192 TTAFT-GSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAfhptisqeekifiedaighvsNTHP 270
Cdd:COG2807 143 TGLYTaAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPA---------------------AAAA 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 271 TIRSIPWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEAlGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSN 350
Cdd:COG2807 202 APAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 351 KILSTTAVrkIFNCGGFGGeaafmliVAYTTSDTTAIMALIAAVGMSG-FAISGFNVNHLDIAPRYAAILMGFSNGIGTL 429
Cdd:COG2807 281 RPLLLLLG--LLGLAGLLG-------LLLAPGSLPWLWAVLLGLGQGGlFPLALTLIGLRARTPAEAAALSGMAQSVGYL 351
|
330 340 350
....*....|....*....|....*....|
gi 808355682 430 AGLTCPFVTEAFTAHSkHGWTSVFLLASLI 459
Cdd:COG2807 352 LAALGPLLVGALHDAT-GSWTAALLLLAAL 380
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
89-472 |
6.26e-07 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 51.78 E-value: 6.26e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK-----LFGFGIGVGAFLNILLPYGFKVksdyLVAFIQITQ 163
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRglllgLLLMALGLLLFALAPSYPLLLL----ALFLLGLGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 164 GLVQGVCYP--AMHGvwrywaPPMERSKLATT-AFTGsyAGAVLGLPLSAFLVSY---VSWAAPFYLYGVCGVIWAILWF 237
Cdd:COG0738 111 GLLDVAANPyvAALG------PETAASRLNLLhAFFS--LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFL 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 238 CVTFekpafhPTISQEEKifiedaighvsntHPTIRSIPWKAIVTSKPVWAIIVANFarswtFYLLLQNQL-----TYMK 312
Cdd:COG0738 183 RSKL------PEIEEEEE-------------EAAGSAASLKSLLKNPRLLLGGLAIF-----LYVGAEGAIgdwlpLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 313 EALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTTAVrkifncggfgGEAAFMLIVAYTTSDTTAIMALIA 392
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLAL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 393 AvgmsGFAISGF--NVNHL--DIAPRYAAILMGFSNGIGTLAGLTCPFVTeAFTAHSkHGWTSVFLLAsLIHFTGVTFYA 468
Cdd:COG0738 309 V----GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLI-GFLADA-FGLRAAFLVP-LVCYLLILLLA 381
|
....
gi 808355682 469 VYAS 472
Cdd:COG0738 382 LALK 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
201-459 |
1.49e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 50.65 E-value: 1.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 201 GAVLGLPLSAFLVSyVSWAAPFYLYGVCGVIWAILWFCVtfekpaFHPTISQEEKIFIEDAighvsnthpTIRSIPWkai 280
Cdd:cd17473 136 GGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFL------PEPARKSKSAASPGAA---------TAAALPW--- 196
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 281 vtsKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRSNKILSTtavrk 360
Cdd:cd17473 197 ---KRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAI----- 268
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 361 IFNCGGFGgeaafmLIVAYTTSDTTAIMALIAAVGMsGFAISGFNVNH--LDIAPRYA-AILMGFSNGIGTLAGLTCPFV 437
Cdd:cd17473 269 GFALMALG------FLLLALASGLWVVLLGAILAGL-GFGLLLPTLNSwaMSLVPPELrGRAMGIVTSAFFLGQFLSPLV 341
|
250 260
....*....|....*....|..
gi 808355682 438 TEAFtAHSKHGWTSVFLLASLI 459
Cdd:cd17473 342 LGPL-VNLTGGLSGAFLILGVL 362
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
90-456 |
7.71e-06 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 48.31 E-value: 7.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 90 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGV 169
Cdd:cd17324 27 RDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 170 CYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIwAILWFCVTFEK-PAFHP 248
Cdd:cd17324 104 FWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRLLPSlPPKKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 249 TisqeekifiedAIGHVSNthptirsipWKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAI 328
Cdd:cd17324 183 G-----------SLGLLSS---------LLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 329 PHLVMGCVVLMGGQLADYLRSNKILSttavrkifncGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNH 408
Cdd:cd17324 243 FGVAGVVGSPLAGRLADRGGRRALLI----------ALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRV 312
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 808355682 409 LDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHskHGWTSVFLLA 456
Cdd:cd17324 313 LRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDH--GGWAGVGWVG 358
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
90-349 |
3.97e-05 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 46.07 E-value: 3.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 90 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLpyGFkVKSDYLVAFIQITQGLVQGV 169
Cdd:cd17328 27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS--SF-APNFWQLLLFRALVGIGEAS 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 170 CYPAMHGVWRYWAPPMERSK-LATTAFtGSYAGAVLGLPLSAFLVSYV-SWAAPFYLYGVCGVIWAILWFCVTFEKPafh 247
Cdd:cd17328 104 YSPIAPTIIADLFPKEKRTRaLGVFYF-AIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILLLLFVREPP--- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 248 ptisqeekifiEDAIGHVSNTHPTIRSIP--WKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLL 325
Cdd:cd17328 180 -----------RGAAEGGVMAKSTATSFLadLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGVGDLSSADV 248
|
250 260
....*....|....*....|....*...
gi 808355682 326 AAIPHLVM---GCV-VLMGGQLADYLRS 349
Cdd:cd17328 249 GLIFGAITciaGVLgVLLGGILADRLRR 276
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
49-456 |
5.74e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 45.72 E-value: 5.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 49 WLLAILANMGFMISFGIRCNFGAakthmyknYTDPYgkvhMHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNK 128
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFGV--------FIIPI----IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRR 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 129 LFGFGIGVGAFLNILLPYGFKVKSDYLVAFIqiTQGLVQGVCY-PAMHGVWRYWAPPmERSKLATTAFTGSYAGAVLGLP 207
Cdd:cd17355 70 VMLLGLLLLAAGLVLLALATSLWQLYLLWGL--LGGGGAGTLAaVAFATVAAWWFER-RRGLALGILTAGGGLGSLVFLP 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 208 LSAFLVSYVSWAAPFYLYG-VCGVIWAILWFcVTFEKPAFHPTISqeekifiEDAIGHVSNTHptirsiPWKAIVTSKPV 286
Cdd:cd17355 147 LGAALIEAFGWRTALLVLAlLALLVLVPVLL-LLRRRPADLALRA-------YDDASPASPGS------TLKEALRSASF 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 287 WAIIVANFARSWTFYLLLQNQLTYMKEAlGMKIADSGLLAAiphLVMGCVV---LMGGQLADYLRSNKILSTtavrkifn 363
Cdd:cd17355 213 WLLALAFFLCGFAVVGLIVHLVPYLADR-GISPAAAAVALA---LIGLFNIvgrLLSGWLGDRYSPRRLLAA-------- 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 364 cgGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVN--HLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAF 441
Cdd:cd17355 281 --SYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAAlaARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLL 358
|
410
....*....|....*
gi 808355682 442 TAHSkHGWTSVFLLA 456
Cdd:cd17355 359 YDRT-GSYTAAWALA 372
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
90-235 |
1.90e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 43.65 E-value: 1.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 90 HEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGI---GVGAFLNILLPygfkvkSDYLVAFIQITQGLV 166
Cdd:COG0477 42 ADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLllfGLASLLCGLAP------SPELLIAARALQGIG 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808355682 167 QGVCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAIL 235
Cdd:COG0477 116 AGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVL 184
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
97-456 |
4.30e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 42.71 E-value: 4.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 97 DELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHG 176
Cdd:cd17343 38 SDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSG---SSSVWVFSILWFLNGLAQGLGWPPCAK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 177 VWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKP--AFHPTISQEE 254
Cdd:cd17343 115 ILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPsdVGLNNIEEEE 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 255 KifiedaiGHVSNTHPTIRSIpWKAIVTSKPVWAIIVANFARSWTFYLLLQ-NQLTYMKEALGMKIADSGLLAAIPhlvM 333
Cdd:cd17343 195 S-------KGKKKKSPRGEST-LKELLLSPFLWLLSLGYLVVFGVKTAVTDwGQLFLIQDKGQSALTGSSFMSSLE---V 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 334 GCVV--LMGGQLADYLRSNKILSTTAVRKIFNCGGF--GGEAAFMLIVAYTTSDTT--AIMALIAAVGMSGFA-ISGFNV 406
Cdd:cd17343 264 GGFVgsIAAGYLSDWAVAKHGSSSRGNPRMPLALVFmaGLTVSLHLFRVHITSDSSelFILLLGFLIGFSLYGpIAIFGV 343
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 808355682 407 NHLDIAPRY-----AAILMGFSNGIGTLAGLtcPFVTEAftahSKHGWTSVFLLA 456
Cdd:cd17343 344 IANESAPSHlcgtsHAIVALAANVGGVLAGL--PFSYIA----KHYDWRTAFLLL 392
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
89-237 |
5.77e-04 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 42.18 E-value: 5.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQG 168
Cdd:cd17325 227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPL---ATSFWLLLLLLALLGLGLG 303
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 808355682 169 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWF 237
Cdd:cd17325 304 LVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
89-255 |
5.93e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.29 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGfkvKSDYLVAFIQITQGLVQG 168
Cdd:cd06180 26 LAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALT---SGFAALLALRFLAGAASA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 169 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVL-GLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVTFEKPAFH 247
Cdd:cd06180 103 FVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALsGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAP 182
|
....*...
gi 808355682 248 PTISQEEK 255
Cdd:cd06180 183 TEASAAES 190
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
89-239 |
6.32e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 42.16 E-value: 6.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 89 MHEFNWTIDELSVMESSYFYGYLVTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYGFkVKSDYLVAFIQITQGLVQG 168
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLAL-LPSPALAIALLFLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808355682 169 VCYPAMHGVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCV 239
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
112-459 |
6.43e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.16 E-value: 6.43e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 112 VTQIPAGFLAAKFPPNKLFGFGIGVGAFLNILLPYgfkVKSDYLVAFIQITQGLVQGVCYPAMHGVWRYWAPpmERSKLA 191
Cdd:cd17478 46 LLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGF---APNYWLLLLLVALAGIGSAAFHPEGARLASQAAG--GRRGLA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 192 TTAF-TGSYAGAVLGLPLSAFLVSYVSWAAPFYLYGVCGVIWAILWFCVtfeKPAFHPTISQEEKIFIEDAighvsnthp 270
Cdd:cd17478 121 MSIFsVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRL---RPLKKPEAKKAAAKSSARS--------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 271 tirsipwKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEaLGMKIADSGLLAAIpHLVMGCV-VLMGGQLADYLRS 349
Cdd:cd17478 189 -------TLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVFAGLLLSL-FLFAGAIgTLIGGPLSDRFGR 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 350 NKILSTTavrkifncggFGGEAAFMLIVAYTTSdtTAIMALIAAVGMsgFAISGFNVNHL---DIAPRYAA----ILMGF 422
Cdd:cd17478 260 RRVIIAS----------LLLAAPFLLLFLLTPG--IWSYILLVLAGF--LLFASFPVTVVlaqELLPGNVGlasgLMMGL 325
|
330 340 350
....*....|....*....|....*....|....*..
gi 808355682 423 SNGIGTLAGLTCPFVTEAFTAHSKHGWTSVFLLASLI 459
Cdd:cd17478 326 SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
97-348 |
6.84e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 42.24 E-value: 6.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 97 DELSVMESSYFYGYLVTQIPAGFLAAKFPPNK-LFGFGIGVGAFlnILLPYGFKVKSDYLVafIQITQGLVQGVCYPAMH 175
Cdd:cd17327 41 NQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKwLSVFIVLWGLL--TLLTAAVKNFGGLIA--LRFFLGLFESGVFPGFI 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 176 GVWRYWAPPMERSKLATTAFTGSYAGAVLGLPLSAFLVSYV------SWAAPFYLYGVCGVIWAILWFCVTFEKPAFHPT 249
Cdd:cd17327 117 LYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 250 ISQEEKIFI-----EDAIGHvSNTHPTIRSipWKAIVTSKPVWAIIVANFArSWTFYLLLQNQLTYMKEALGMKIADSGL 324
Cdd:cd17327 197 LTEEEKELAverlrANQTGK-GDQKFKWKQ--IKEAFKDPRTWLLFLFFFC-SQITNNGISNFLPLILKSLGFYSLQTNL 272
|
250 260
....*....|....*....|....
gi 808355682 325 LAAIPHLVMGCVVLMGGQLADYLR 348
Cdd:cd17327 273 LSVPIGALGAVSLLIAALLSDRFK 296
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
109-459 |
1.44e-03 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 41.07 E-value: 1.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 109 GYLVTQIPAGFLAAKFPPNKLFGFG--IGVGAFLNILLPYGFKVksdyLVAFIqITQGLVQGVCYPAMHGVWRYWAPPME 186
Cdd:cd17475 43 GVAVSMLPAGWLLDRFGERRVLAVGllLMGAAALLMALVGSYPV----LLVLL-FLVGAGYGSVQPGGGRAIMRWFPPRE 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 187 RSkLAT----TAFTGSYAGAVLGLPlsaFLVSYVSWAAPFYLYGVCGVIWAILWFcvtfekpAFHPTisqeekifIEDAI 262
Cdd:cd17475 118 RG-LAMgirqTGVPLGGALAAALLP---PLALHYGWRAAFVVAGLVSILAAVLFW-------LFYRE--------PPAAS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 263 GHVSNTHPTIRSIpwKAIVTSKPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHL--VMGCVVLmg 340
Cdd:cd17475 179 AATESASTLLRSL--KEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLggALGRIGL-- 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 341 GQLADYLRSNKilsttAVRKIFNCGGFGGEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHL-DIAP-RYAAI 418
Cdd:cd17475 255 GRVSDRVFGGR-----RRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVaESAGpEQAGT 329
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 808355682 419 LMGFSNGIGTLAGLTCPFVTEAFTAHSkHGWTSVFLLASLI 459
Cdd:cd17475 330 ALGLANTINFIGIAIGPPLFGLLVDAT-HSYAPAWLALALL 369
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
284-464 |
1.95e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 40.66 E-value: 1.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 284 KPVWAIIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLRsnkilsttavRKIFN 363
Cdd:cd17316 177 RRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 364 CGGFGGEAAFMLIVAYTTSDTTAIMaLIAAVGMSGFAISGFNVNHLDIA----PRYAAILMGFSNGIGTLAGLTCPFVTe 439
Cdd:cd17316 247 VIGLILSGILALPLFYLLSGSPTLL-LLLLFILSFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLI- 324
|
170 180
....*....|....*....|....*
gi 808355682 440 AFTAHSKHGWTSVFLLASLIHFTGV 464
Cdd:cd17316 325 ALLLASTGGTGVPALILALLAIVAL 349
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
289-459 |
2.16e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 40.48 E-value: 2.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 289 IIVANFARSWTFYLLLQNQLTYMKEALGMKIADSGLLAAIPHLVMGCVVLMGGQLADYLrsnkilsttAVRKIFNCGGFG 368
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRF---------GRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355682 369 GEAAFMLIVAYTTSDTTAIMALIAAVGMSGFAISGFNVNHLDIAPRYAAILMGFSNGIGTLAGLTCPFVTEAFTAHskHG 448
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--FG 149
|
170
....*....|.
gi 808355682 449 WTSVFLLASLI 459
Cdd:pfam07690 150 WRAAFLILAIL 160
|
|
| |
