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Conserved domains on  [gi|808356852|ref|NP_001293954|]
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Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

Protein Classification

TBC domain-containing protein( domain architecture ID 10193422)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PH-GRAM1_TCB1D9_TCB1D9B cd13351
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 154-253 2.34e-54

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


:

Pssm-ID: 275420  Cd Length: 99  Bit Score: 184.13  E-value: 2.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKeDKKFSFSMF 233
Cdd:cd13351     1 EEKLVNYYSCSYWKGRVPRQGWLYLSVNHLCFYSFLLGKEAKLVIRWTDVTQLEKNNSLLLPDSIKVVTR-DKEHYFSMF 79

                          90       100
                  ....*....|....*....|
gi 808356852  234 LNFEETFQLASQLANIAMKQ 253
Cdd:cd13351    80 LNISETFKLMEQLANLAMRQ 99
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 489-695 9.61e-51

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 9.61e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    489 GVPLQLRGQIWMVCSGAAA-EMALNPGYYRELLHKNQGVYSVALEEIERDLHRSLPEHPAFQQ--GPGIDALRRILTAYA 565
Cdd:smart00164    4 GVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKETAPDDKSIVHQIEKDLRRTFPEHSFFQDkeGPGQESLRRVLKAYA 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    566 FRNPNIGYCQAMNIVGSVLLL-FTKEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGLD 644
Cdd:smart00164   84 LYNPEVGYCQGMNFLAAPLLLvMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGIT 163

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 808356852    645 -DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLKENEKLI 695
Cdd:smart00164  164 pSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
PH-GRAM2_TCB1D9_TCB1D9B cd13354
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 309-406 4.62e-43

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


:

Pssm-ID: 270161  Cd Length: 97  Bit Score: 151.64  E-value: 4.62e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  309 TEKLDGDTQCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSPvSSSQTTQGILLCLRNDATVI 388
Cdd:cd13354     1 DEKLDGSTDCTLWTPYNKRHVWGTLYLSQNYICFTSKVRDLVSLVIPLREVTSVEKADS-SSVSLPNGILITTKSKMTFL 79

                          90
                  ....*....|....*...
gi 808356852  389 FSAVPDRDRVLSKITVFL 406
Cdd:cd13354    80 FAQIKDRDFLVHKISDFL 97
 
Name Accession Description Interval E-value
PH-GRAM1_TCB1D9_TCB1D9B cd13351
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 154-253 2.34e-54

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275420  Cd Length: 99  Bit Score: 184.13  E-value: 2.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKeDKKFSFSMF 233
Cdd:cd13351     1 EEKLVNYYSCSYWKGRVPRQGWLYLSVNHLCFYSFLLGKEAKLVIRWTDVTQLEKNNSLLLPDSIKVVTR-DKEHYFSMF 79

                          90       100
                  ....*....|....*....|
gi 808356852  234 LNFEETFQLASQLANIAMKQ 253
Cdd:cd13351    80 LNISETFKLMEQLANLAMRQ 99
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 489-695 9.61e-51

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 9.61e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    489 GVPLQLRGQIWMVCSGAAA-EMALNPGYYRELLHKNQGVYSVALEEIERDLHRSLPEHPAFQQ--GPGIDALRRILTAYA 565
Cdd:smart00164    4 GVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKETAPDDKSIVHQIEKDLRRTFPEHSFFQDkeGPGQESLRRVLKAYA 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    566 FRNPNIGYCQAMNIVGSVLLL-FTKEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGLD 644
Cdd:smart00164   84 LYNPEVGYCQGMNFLAAPLLLvMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGIT 163

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 808356852    645 -DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLKENEKLI 695
Cdd:smart00164  164 pSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
COG5210 COG5210
GTPase-activating protein [General function prediction only];
461-721 1.69e-43

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 166.13  E-value: 1.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  461 EKWNKYLQEYGTGVCMYRTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELL--HKNQGV-YSVALEEIERD 537
Cdd:COG5210   184 KLWISYLDPNPLSFLPVQLSKLRELIRKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLnlHREAKIpTQEIISQIEKD 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  538 LHRSLPEHPAFQ--QGPGIDALRRILTAYAFRNPNIGYCQAMNIVGSVLLL-FTKEEEAFWLLVAVCER-LLPDYYNTKV 613
Cdd:COG5210   264 LSRTFPDNSLFQteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLvLESEEQAFWCLVKLLKNyGLPGYFLKNL 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  614 VGALVDQGVFSELVERLLPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLKENE 692
Cdd:COG5210   344 SGLHRDLKVLDDLVEELDPELYEHLLREGVVlLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLR 423

                         250       260
                  ....*....|....*....|....*....
gi 808356852  693 KLICESRDDGEILMSLAKYTESIYEGDTV 721
Cdd:COG5210   424 DKLLKLDSDELLDLLLKQLFLHSGKEAWS 452
PH-GRAM2_TCB1D9_TCB1D9B cd13354
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 309-406 4.62e-43

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270161  Cd Length: 97  Bit Score: 151.64  E-value: 4.62e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  309 TEKLDGDTQCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSPvSSSQTTQGILLCLRNDATVI 388
Cdd:cd13354     1 DEKLDGSTDCTLWTPYNKRHVWGTLYLSQNYICFTSKVRDLVSLVIPLREVTSVEKADS-SSVSLPNGILITTKSKMTFL 79

                          90
                  ....*....|....*...
gi 808356852  389 FSAVPDRDRVLSKITVFL 406
Cdd:cd13354    80 FAQIKDRDFLVHKISDFL 97
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 534-695 5.42e-41

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 148.94  E-value: 5.42e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   534 IERDLHRSLPEHPAFQQGPGIDALRRILTAYAFRNPNIGYCQAMN-IVGSVLLLFTKEEEAFWLLVAVCER-LLPDYYNT 611
Cdd:pfam00566   12 IEKDVPRTFPHSFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNfIAAPLLLVYLDEEDAFWCFVSLLENyLLRDFYTP 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   612 KVVGALVDQGVFSELVERLLPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLM-FQVALEMLK 689
Cdd:pfam00566   92 DFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDpDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVlFRVALAILK 171


                   ....*.
gi 808356852   690 ENEKLI 695
Cdd:pfam00566  172 RFREEL 177
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 143-242 5.87e-18

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 80.87  E-value: 5.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   143 EKFHKSFSIPPDEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLER--VSSILFPQSILV 220
Cdd:pfam02893    1 ELFRKKFKLPPEERLIASYSCYLNRDGGPVQGRLYLTNYRLCFRSLPKGWSTKVVIPLVDIEEIEKlkGGANLFPNGIQV 80

                           90       100
                   ....*....|....*....|..
gi 808356852   221 VTKEDKKFSFSMFLNFEETFQL 242
Cdd:pfam02893   81 ETGSNDKFSFAGFVTRDEAIEF 102
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
150-210 1.15e-15

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 72.24  E-value: 1.15e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356852    150 SIPPDEKLVNYYKCCLWKgKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVS 210
Cdd:smart00568    1 KLPEEEKLIADYSCYLSR-TGPVQGRLYISNYRLCFRSNLPGKLTKVVIPLADITRIEKST 60
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
305-366 1.09e-10

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 58.37  E-value: 1.09e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 808356852    305 NLPLTEKLDGDTQCRLFTpydRRHVPGKLFVSANFVCFAS-RTERLVSIVVPLIEVTSIEECS 366
Cdd:smart00568    1 KLPEEEKLIADYSCYLSR---TGPVQGRLYISNYRLCFRSnLPGKLTKVVIPLADITRIEKST 60
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 300-408 1.58e-06

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 48.13  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   300 FRCQFNLPLTEKLDGDTQCRLFTPYdrRHVPGKLFVSANFVCFASR-TERLVSIVVPLIEVTSIEEcsPVSSSQT-TQGI 377
Cdd:pfam02893    3 FRKKFKLPPEERLIASYSCYLNRDG--GPVQGRLYLTNYRLCFRSLpKGWSTKVVIPLVDIEEIEK--LKGGANLfPNGI 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 808356852   378 LLCLRNDATVIFSAVPDRDRVLSKITVFLER 408
Cdd:pfam02893   79 QVETGSNDKFSFAGFVTRDEAIEFILALLKN 109
 
Name Accession Description Interval E-value
PH-GRAM1_TCB1D9_TCB1D9B cd13351
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 154-253 2.34e-54

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275420  Cd Length: 99  Bit Score: 184.13  E-value: 2.34e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKeDKKFSFSMF 233
Cdd:cd13351     1 EEKLVNYYSCSYWKGRVPRQGWLYLSVNHLCFYSFLLGKEAKLVIRWTDVTQLEKNNSLLLPDSIKVVTR-DKEHYFSMF 79

                          90       100
                  ....*....|....*....|
gi 808356852  234 LNFEETFQLASQLANIAMKQ 253
Cdd:cd13351    80 LNISETFKLMEQLANLAMRQ 99
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
 489-695 9.61e-51

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 178.27  E-value: 9.61e-51
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    489 GVPLQLRGQIWMVCSGAAA-EMALNPGYYRELLHKNQGVYSVALEEIERDLHRSLPEHPAFQQ--GPGIDALRRILTAYA 565
Cdd:smart00164    4 GVPPSLRGVVWKLLLNAQPmDTSADKDLYSRLLKETAPDDKSIVHQIEKDLRRTFPEHSFFQDkeGPGQESLRRVLKAYA 83

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852    566 FRNPNIGYCQAMNIVGSVLLL-FTKEEEAFWLLVAVCERLLPDYYNTKVVGALVDQGVFSELVERLLPTVGAQLTRLGLD 644
Cdd:smart00164   84 LYNPEVGYCQGMNFLAAPLLLvMEDEEDAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGIT 163

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 808356852    645 -DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLKENEKLI 695
Cdd:smart00164  164 pSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDVL 215
COG5210 COG5210
GTPase-activating protein [General function prediction only];
461-721 1.69e-43

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 166.13  E-value: 1.69e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  461 EKWNKYLQEYGTGVCMYRTVELHRLLLEGVPLQLRGQIWMVCSGAAAEMALNPGYYRELL--HKNQGV-YSVALEEIERD 537
Cdd:COG5210   184 KLWISYLDPNPLSFLPVQLSKLRELIRKGIPNELRGDVWEFLLGIGFDLDKNPGLYERLLnlHREAKIpTQEIISQIEKD 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  538 LHRSLPEHPAFQ--QGPGIDALRRILTAYAFRNPNIGYCQAMNIVGSVLLL-FTKEEEAFWLLVAVCER-LLPDYYNTKV 613
Cdd:COG5210   264 LSRTFPDNSLFQteISIRAENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLvLESEEQAFWCLVKLLKNyGLPGYFLKNL 343

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  614 VGALVDQGVFSELVERLLPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLMFQVALEMLKENE 692
Cdd:COG5210   344 SGLHRDLKVLDDLVEELDPELYEHLLREGVVlLMFAFRWFLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAILKLLR 423

                         250       260
                  ....*....|....*....|....*....
gi 808356852  693 KLICESRDDGEILMSLAKYTESIYEGDTV 721
Cdd:COG5210   424 DKLLKLDSDELLDLLLKQLFLHSGKEAWS 452
PH-GRAM2_TCB1D9_TCB1D9B cd13354
TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin ...
 309-406 4.62e-43

TBC1 domain family members 9 and 9B (TBC1D9 and TBC1D9B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D9 and TCB1D9B may act as a GTPase-activating proteins for Rab family protein(s). TBC1D9 and TCB1D9B contain two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270161  Cd Length: 97  Bit Score: 151.64  E-value: 4.62e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  309 TEKLDGDTQCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSPvSSSQTTQGILLCLRNDATVI 388
Cdd:cd13354     1 DEKLDGSTDCTLWTPYNKRHVWGTLYLSQNYICFTSKVRDLVSLVIPLREVTSVEKADS-SSVSLPNGILITTKSKMTFL 79

                          90
                  ....*....|....*...
gi 808356852  389 FSAVPDRDRVLSKITVFL 406
Cdd:cd13354    80 FAQIKDRDFLVHKISDFL 97
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
 534-695 5.42e-41

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 148.94  E-value: 5.42e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   534 IERDLHRSLPEHPAFQQGPGIDALRRILTAYAFRNPNIGYCQAMN-IVGSVLLLFTKEEEAFWLLVAVCER-LLPDYYNT 611
Cdd:pfam00566   12 IEKDVPRTFPHSFFFDNGPGQNSLRRILKAYSIYNPDVGYCQGMNfIAAPLLLVYLDEEDAFWCFVSLLENyLLRDFYTP 91

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   612 KVVGALVDQGVFSELVERLLPTVGAQLTRLGLD-DMVALSWFLTVFLSAIKFDAAVRILDLFFFEGARLM-FQVALEMLK 689
Cdd:pfam00566   92 DFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDpDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFVlFRVALAILK 171


                   ....*.
gi 808356852   690 ENEKLI 695
Cdd:pfam00566  172 RFREEL 177
PH-GRAM1_TCB1D8_TCB1D9_family cd13217
TCB1D8 and TCB1D9 family Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators ...
 154-253 7.03e-31

TCB1D8 and TCB1D9 family Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D8, TBC1D8B, TBC1D9 and TBC1D9B may act as a GTPase-activating proteins for Rab family protein(s). They all contain an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275404  Cd Length: 99  Bit Score: 117.15  E-value: 7.03e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKEDKKFsFSMF 233
Cdd:cd13217     1 EEKLVTYYSCSYWKGRVPRQGWLYLSINHLCFYSFLLGSESKLIIRWTEVSDLERTSNTILTDTIKVNTRSKEHP-FSMF 79

                          90       100
                  ....*....|....*....|
gi 808356852  234 LNFEETFQLASQLANIAMKQ 253
Cdd:cd13217    80 LNISETFKLMEQLAQIPDRP 99
PH-GRAM1_TBC1D8B cd13350
TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 155-253 6.94e-30

TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D8B may act as a GTPase-activating protein for Rab family protein(s). TBC1D8B contains an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275419  Cd Length: 99  Bit Score: 114.26  E-value: 6.94e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  155 EKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKEDKKFsFSMFL 234
Cdd:cd13350     2 EKLVTYYSCSYWRGRVPCQGWLYLSTNFLSFYSFLLGSEIKLIISWDEISKLEKTSNVILTESIHVCSRGEDHY-FSMFL 80

                          90
                  ....*....|....*....
gi 808356852  235 NFEETFQLASQLANIAMKQ 253
Cdd:cd13350    81 HINETFLLMEQLANYAVRR 99
PH-GRAM1_TBC1D8 cd13349
TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) ...
 155-253 2.96e-29

TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 1; TBC1D8 may act as a GTPase-activating protein for Rab family protein(s). TBC1D8 contains an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the first repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270156  Cd Length: 99  Bit Score: 112.64  E-value: 2.96e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  155 EKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKEdKKFSFSMFL 234
Cdd:cd13349     2 EKLVTYYSCCCWKGRVPRQGWLYLSINHLCFYSFFLGKELKLLIPWVDVQKLERTSNVFMTDTIRVTTQN-KERDFSMFL 80

                          90
                  ....*....|....*....
gi 808356852  235 NFEETFQLASQLANIAMKQ 253
Cdd:cd13349    81 NIDEVFRIMEQLADVTLRR 99
PH-GRAM2_TCB1D8_TCB1D9_family cd13218
TCB1D8 and TCB1D9 family Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators ...
 310-406 1.73e-19

TCB1D8 and TCB1D9 family Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D8, TBC1D8B, TBC1D9 and TBC1D9B may act as a GTPase-activating proteins for Rab family protein(s). They all contain an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275405  Cd Length: 96  Bit Score: 84.57  E-value: 1.73e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  310 EKLDGDTQCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSpvSSSQTTQGILLCLRNDATVIF 389
Cdd:cd13218     2 EKLKEVHDCFLWTPFSHFHTHGKMFISENYICFASKEGNLCSVIIPLREVLAIEKTN--DSSVLPKPVIISIKGKMAFRF 79

                          90
                  ....*....|....*..
gi 808356852  390 SAVPDRDRVLSKITVFL 406
Cdd:cd13218    80 SELKDRDELVAKLRLKL 96
PH-GRAM_GRAMDC cd13220
GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 153-242 8.93e-19

GRAM domain-containing protein (GRAMDC) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; The GRAMDC proteins are membrane proteins. Nothing is known about its function. Members include: GRAMDC1A, GRAMDC1B, GRAMDC1C, GRAMDC2, GRAMDC3, GRAMDC4, and GRAMDC-like proteins. All of the members, except for GRAMDC4 are included in this hierarchy. Each contains a single PH-GRAM domain at their N-terminus. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275406  Cd Length: 94  Bit Score: 82.17  E-value: 8.93e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  153 PDEKLVNYYKCCLwKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSI-LFPQSILVVTKeDKKFSFS 231
Cdd:cd13220     1 EDERLIDDFSCAL-QRDILLQGRLYISENHLCFYSNIFGWETKLVIPFKDITSIEKKKTAlIFPNAIEITTK-GEKYFFT 78

                          90
                  ....*....|.
gi 808356852  232 MFLNFEETFQL 242
Cdd:cd13220    79 SFLSRDSAYKL 89
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 143-242 5.87e-18

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 80.87  E-value: 5.87e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   143 EKFHKSFSIPPDEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLER--VSSILFPQSILV 220
Cdd:pfam02893    1 ELFRKKFKLPPEERLIASYSCYLNRDGGPVQGRLYLTNYRLCFRSLPKGWSTKVVIPLVDIEEIEKlkGGANLFPNGIQV 80

                           90       100
                   ....*....|....*....|..
gi 808356852   221 VTKEDKKFSFSMFLNFEETFQL 242
Cdd:pfam02893   81 ETGSNDKFSFAGFVTRDEAIEF 102
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
150-210 1.15e-15

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 72.24  E-value: 1.15e-15
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808356852    150 SIPPDEKLVNYYKCCLWKgKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVS 210
Cdd:smart00568    1 KLPEEEKLIADYSCYLSR-TGPVQGRLYISNYRLCFRSNLPGKLTKVVIPLADITRIEKST 60
PH-GRAM cd10570
Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins ...
 154-242 4.99e-13

Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; Myotubularin-related proteins are a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Mutations in this family cause the human neuromuscular disorders myotubular myopathy and type 4B Charcot-Marie-Tooth syndrome. 6 of the 13 MTMRs (MTMRs 5, 9-13) contain naturally occurring substitutions of residues required for catalysis by PTP family enzymes. Although these proteins are predicted to be enzymatically inactive, they are thought to function as antagonists of endogenous phosphatase activity or interaction modules. Most MTMRs contain a N-terminal PH-GRAM domain, a Rac-induced recruitment domain (RID) domain, a PTP domain (which may be active or inactive), a SET-interaction domain, and a C-terminal coiled-coil region. In addition some members contain DENN domain N-terminal to the PH-GRAM domain and FYVE, PDZ, and PH domains C-terminal to the coiled-coil region. The GRAM domain, found in myotubularins, glucosyltransferases, and other putative membrane-associated proteins, is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 275393  Cd Length: 94  Bit Score: 65.87  E-value: 4.99e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKEDKKFSFSMF 233
Cdd:cd10570     1 IEKLGVRFCCALRPRKLPLEGTLYLSTYRLIFSSKADGDETKLVIPLVDITDVEKIAGASFLPSGLIITCKDFRTIKFSF 80


                  ....*....
gi 808356852  234 LNFEETFQL 242
Cdd:cd10570    81 DSEDEAVKV 89
PH-GRAM2_TBC1D8 cd13353
TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) ...
 309-406 8.63e-11

TBC1 domain family member 8 (TBC1D8; also called Vascular Rab-GAP/TBC-containing protein) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D8 may act as a GTPase-activating protein for Rab family protein(s). TBC1D8 contains two N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270160  Cd Length: 96  Bit Score: 59.85  E-value: 8.63e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  309 TEKLDGDTQCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSpvSSSQTTQGILLCLRNDATVI 388
Cdd:cd13353     1 KEKLHEVVDCSLWTPFSRCHTAGRMYTSDSYICFASKEDGSCNVILPLREVVSIEKME--DTSLLPNPIIVSIRSKMAFQ 78

                          90
                  ....*....|....*...
gi 808356852  389 FSAVPDRDRVLSKITVFL 406
Cdd:cd13353    79 FIELKDRDSLVESLLARL 96
GRAM smart00568
domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;
305-366 1.09e-10

domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins;


Pssm-ID: 214725 [Multi-domain]  Cd Length: 60  Bit Score: 58.37  E-value: 1.09e-10
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 808356852    305 NLPLTEKLDGDTQCRLFTpydRRHVPGKLFVSANFVCFAS-RTERLVSIVVPLIEVTSIEECS 366
Cdd:smart00568    1 KLPEEEKLIADYSCYLSR---TGPVQGRLYISNYRLCFRSnLPGKLTKVVIPLADITRIEKST 60
PH-GRAM2_TBC1D8B cd13352
TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 317-402 1.92e-08

TBC1 domain family member 8B (TBC1D8B) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain, repeat 2; TBC1D8B may act as a GTPase-activating protein for Rab family protein(s). TBC1D8B contains an N-terminal PH-GRAM domain and a C-terminal Rab-GTPase-TBC (Tre-2, BUB2p, and Cdc16p) domain. This cd contains the second repeat of the PH-GRAM domain. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270159  Cd Length: 93  Bit Score: 52.93  E-value: 1.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  317 QCRLFTPYDRRHVPGKLFVSANFVCFASRTERLVSIVVPLIEVTSIEECSPvsssqTTQGILLCLRNDATVIFSAVPDRD 396
Cdd:cd13352     9 ECFLWVPFSHFNTHGKMCISENYICFASQDGSLCSVIIPLREVLSIDKTDD-----SSRAVTISTKGKRAFRFTEVKDFE 83


                  ....*.
gi 808356852  397 RVLSKI 402
Cdd:cd13352    84 QLVAKL 89
PH-GRAM_C2-GRAM cd13219
C2 and GRAM domain-containing protein Pleckstrin Homology-Glucosyltransferases, Rab-like ...
 154-241 3.96e-08

C2 and GRAM domain-containing protein Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain; C2GRAM contains two N-terminal C2 domains followed by a single PH-GRAM domain. Since it contains both of these domains it is assumed that this gene cross-links both calcium and phosphoinositide signaling pathways. In general he C2 domain is involved in binding phospholipids in a calcium dependent manner or calcium independent manner. The GRAM domain is found in glucosyltransferases, myotubularins and other putative membrane-associated proteins. The GRAM domain is part of a larger motif with a pleckstrin homology (PH) domain fold.


Pssm-ID: 270039 [Multi-domain]  Cd Length: 111  Bit Score: 52.47  E-value: 3.96e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLwKGKVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVTKEDK------- 226
Cdd:cd13219     1 EEFLINDFSCAL-KRKFLYQGRMFLSARHIGFHSNVFGKKTKFVFLWEDIEEIQESPHSLINPAIVITLRKGRgldagqg 79

                          90       100
                  ....*....|....*....|....*
gi 808356852  227 ----------KFSFSMFLNFEETFQ 241
Cdd:cd13219    80 vppidpdgrlKYKFASFVNRNHAFR 104
GRAM pfam02893
GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other ...
 300-408 1.58e-06

GRAM domain; The GRAM domain is found in in glucosyltransferases, myotubularins and other putative membrane-associated proteins. Note the alignment is lacking the last two beta strands and alpha helix.


Pssm-ID: 397160  Cd Length: 112  Bit Score: 48.13  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852   300 FRCQFNLPLTEKLDGDTQCRLFTPYdrRHVPGKLFVSANFVCFASR-TERLVSIVVPLIEVTSIEEcsPVSSSQT-TQGI 377
Cdd:pfam02893    3 FRKKFKLPPEERLIASYSCYLNRDG--GPVQGRLYLTNYRLCFRSLpKGWSTKVVIPLVDIEEIEK--LKGGANLfPNGI 78

                           90       100       110
                   ....*....|....*....|....*....|.
gi 808356852   378 LLCLRNDATVIFSAVPDRDRVLSKITVFLER 408
Cdd:pfam02893   79 QVETGSNDKFSFAGFVTRDEAIEFILALLKN 109
PH-GRAM2_AGT26 cd13216
Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, ...
 154-231 1.05e-05

Autophagy-related protein 26/Sterol 3-beta-glucosyltransferase Pleckstrin homology (PH) domain, repeat 2; ATG26 (also called UGT51/UDP-glycosyltransferase 51), a member of the glycosyltransferase 28 family, resulting in the biosynthesis of sterol glucoside. ATG26 in decane metabolism and autophagy. There are 32 known autophagy-related (ATG) proteins, 17 are components of the core autophagic machinery essential for all autophagy-related pathways and 15 are the additional components required only for certain pathways or species. The core autophagic machinery includes 1) the ATG9 cycling system (ATG1, ATG2, ATG9, ATG13, ATG18, and ATG27), 2) the phosphatidylinositol 3-kinase complex (ATG6/VPS30, ATG14, VPS15, and ATG34), and 3) the ubiquitin-like protein system (ATG3, ATG4, ATG5, ATG7, ATG8, ATG10, ATG12, and ATG16). Less is known about how the core machinery is adapted or modulated with additional components to accommodate the nonselective sequestration of bulk cytosol (autophagosome formation) or selective sequestration of specific cargos (Cvt vesicle, pexophagosome, or bacteria-containing autophagosome formation). The pexophagosome-specific additions include the ATG30-ATG11-ATG17 receptor-adaptors complex, the coiled-coil protein ATG25, and the sterol glucosyltransferase ATG26. ATG26 is necessary for the degradation of medium peroxisomes. It contains 2 GRAM domains and a single PH domain. PH domains are only found in eukaryotes. They share little sequence conservation, but all have a common fold, which is electrostatically polarized. PH domains also have diverse functions. They are often involved in targeting proteins to the plasma membrane, but few display strong specificity in lipid binding. Any specificity is usually determined by loop regions or insertions in the N-terminus of the domain, which are not conserved across all PH domains. PH domains are found in cellular signaling proteins such as serine/threonine kinase, tyrosine kinases, regulators of G-proteins, endocytotic GTPases, adaptors, as well as cytoskeletal associated molecules and in lipid associated enzymes.


Pssm-ID: 275403  Cd Length: 93  Bit Score: 45.27  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808356852  154 DEKLVNYYKCCLWKGkVPAQGDLFLSVNFLCFHAFMMGNETKIKLKWTDIVRLERVSSILFPQSILVVT---KEDKKFSF 230
Cdd:cd13216     1 TEKLIASYYCYLIRV-LPVYGKLYVSNNYLCFRSLLPGVSTKMILPLRDIENVEKEKGFRFGYSGLVIVikgHEELFFEF 79


                  .
gi 808356852  231 S 231
Cdd:cd13216    80 S 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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