TSC22 domain family protein 1-like [Caenorhabditis elegans]
Protein Classification
TSC22 domain family protein( domain architecture ID 10471801)
transforming growth factor beta-stimulated clone 22 (TSC22) domain family protein which may be a transcription factor; contains a leucine zipper domain
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| TSC22 | pfam01166 | TSC-22/dip/bun family; |
143-198 | 1.45e-25 | ||
TSC-22/dip/bun family; : Pssm-ID: 460093 Cd Length: 57 Bit Score: 93.53 E-value: 1.45e-25
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| Name | Accession | Description | Interval | E-value | ||
| TSC22 | pfam01166 | TSC-22/dip/bun family; |
143-198 | 1.45e-25 | ||
TSC-22/dip/bun family; Pssm-ID: 460093 Cd Length: 57 Bit Score: 93.53 E-value: 1.45e-25
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| ZIP_TSC22D | cd21936 | leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ... |
142-190 | 1.39e-24 | ||
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409276 Cd Length: 49 Bit Score: 90.70 E-value: 1.39e-24
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| PhaF | COG3937 | Polyhydroxyalkanoate synthesis regulator phasin [Secondary metabolites biosynthesis, transport ... |
134-178 | 5.20e-03 | ||
Polyhydroxyalkanoate synthesis regulator phasin [Secondary metabolites biosynthesis, transport and catabolism, Signal transduction mechanisms]; Pssm-ID: 443138 [Multi-domain] Cd Length: 103 Bit Score: 35.16 E-value: 5.20e-03
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| Name | Accession | Description | Interval | E-value | ||
| TSC22 | pfam01166 | TSC-22/dip/bun family; |
143-198 | 1.45e-25 | ||
TSC-22/dip/bun family; Pssm-ID: 460093 Cd Length: 57 Bit Score: 93.53 E-value: 1.45e-25
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| ZIP_TSC22D | cd21936 | leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; ... |
142-190 | 1.39e-24 | ||
leucine zipper domain found in the TSC22 domain family of leucine zipper transcription factors; The TGF-beta-stimulated clone-22 domain (TSC22D) family includes TSC22D1-4 and similar proteins. They have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. All family members contain a conserved leucine zipper (ZIP) domain located at the C-terminus. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409276 Cd Length: 49 Bit Score: 90.70 E-value: 1.39e-24
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| ZIP_TSC22D4 | cd21941 | leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 ... |
135-194 | 4.23e-16 | ||
leucine zipper domain found in TSC22 domain family protein 4; TSC22 domain family protein 4 (TSC22D4), also called TSC22-related-inducible leucine zipper protein 2 (TILZ2), or Tsc-22-like protein THG-1, is a transcriptional repressor that acts as a molecular determinant of insulin signalling and glucose handling. It also functions in hepatic lipid handling by regulating hepatic very-low-density-lipoprotein (VLDL) release and lipogenic gene expression. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D4. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409281 Cd Length: 74 Bit Score: 69.58 E-value: 4.23e-16
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| ZIP_TSC22D1 | cd21938 | leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 ... |
138-198 | 1.54e-13 | ||
leucine zipper domain found in TSC22 domain family protein 1; TSC22 domain family protein 1 (TSC22D1) is also called cerebral protein 2, regulatory protein TSC-22, TGFB-stimulated clone 22, or transforming growth factor beta-1-induced transcript 4 protein (TGFB1I4). It is a transcriptional repressor that was reported to be present in both the cytoplasmic and the nuclear fraction. It is activated by transcription growth factor-beta1 and other growth factors of osteoblastic cells. TSC22D1 acts on the C-type natriuretic peptide (CNP) promoter. It enhances c-Myc-mediated activation of the telomerase reverse transcriptase (TERT) promoter. This model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D1. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409278 Cd Length: 79 Bit Score: 63.24 E-value: 1.54e-13
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| ZIP_TSC22D2 | cd21939 | leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 ... |
142-194 | 2.75e-12 | ||
leucine zipper domain found in TSC22 domain family protein 2; TSC22 domain family protein 2 (TSC22D2), also called transforming growth factor beta-stimulated clone 22 domain family member 2, or TSC22-related-inducible leucine zipper protein 4 (TILZ4), may participate in the regulation of cell growth. It interacts with pyruvate kinase isoform M2 (PKM2) and WD repeat domain 77 (WDR77). The model corresponds to the conserved leucine zipper (ZIP) domain located at the C-terminus of TSC22D2. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409279 Cd Length: 63 Bit Score: 59.21 E-value: 2.75e-12
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| ZIP_TSC22D3 | cd21940 | leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 ... |
142-198 | 6.99e-10 | ||
leucine zipper domain found in TSC22 domain family protein 3; TSC22 domain family protein 3 (TSC22D3) is also called DSIP-immunoreactive peptide, protein DIP, delta sleep-inducing peptide immunoreactor, glucocorticoid-induced leucine zipper protein (GILZ), TSC-22-like protein, or TSC-22-related protein (TSC-22R). It protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, it plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, it inhibits anti-CD3-induced NFKB1 nuclear translocation. TSC22D3 contains a leucine zipper motif, a Pro/Glu rich domain, and three potential phosphorylation sites. This model corresponds to the leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. Thus, the DNA-binding capability of the ZIP domain is not obvious. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409280 Cd Length: 81 Bit Score: 53.42 E-value: 6.99e-10
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| ZIP_TSC22D-like | cd21927 | leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding ... |
143-183 | 5.70e-05 | ||
leucine zipper found in the TSC22 domain leucine zipper transcription factors, c-Myc-binding protein, and similar proteins; The family includes TGF-beta-stimulated clone-22 domain (TSC22D) leucine zipper transcription factors, TSC22D1-4, as well as c-Myc-binding protein (MycBP). TSC22D proteins have diverse physiological functions, including cell growth, development, homeostasis, and immune regulation. MycBP, also called associate of Myc 1 (AMY-1), is a novel c-Myc binding protein that may control the transcriptional activity of Myc. It stimulates the activation of E box-dependent transcription by Myc. Members of this family contain a conserved leucine zipper (ZIP) domain. Its first helix is not basic and does not contain the consensus sequence, NXX(A)(A)XX(C/S)R, found in most basic region/leucine zipper (bZIP) proteins. In the bZIP family of transcription factors, the leucine zipper acts as a dimerization domain and the upstream basic region as a DNA-binding domain. However, DNA-binding capability of TSC22D family proteins is not obvious, due to the lack of the basic region found in the original bZIP DNA-binding domains. Similar to bZIP, ZIP forms homo- and heterodimers, resulting in many dimers that may have different effects on transcription. Pssm-ID: 409275 Cd Length: 51 Bit Score: 39.42 E-value: 5.70e-05
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| PhaF | COG3937 | Polyhydroxyalkanoate synthesis regulator phasin [Secondary metabolites biosynthesis, transport ... |
134-178 | 5.20e-03 | ||
Polyhydroxyalkanoate synthesis regulator phasin [Secondary metabolites biosynthesis, transport and catabolism, Signal transduction mechanisms]; Pssm-ID: 443138 [Multi-domain] Cd Length: 103 Bit Score: 35.16 E-value: 5.20e-03
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